LOCUS       NM_001293806            4553 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus peroxisomal biogenesis factor 1 (Pex1), transcript
            variant 1, mRNA.
ACCESSION   NM_001293806 XM_006503605
VERSION     NM_001293806.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4553)
  AUTHORS   Mauriac,S.A., Peineau,T., Zuberi,A., Lutz,C. and Geleoc,G.S.G.
  TITLE     Loss of Pex1 in Inner Ear Hair Cells Contributes to Cochlear
            Synaptopathy and Hearing Loss
  JOURNAL   Cells 11 (24), 3982 (2022)
   PUBMED   36552747
  REMARK    GeneRIF: Loss of Pex1 in Inner Ear Hair Cells Contributes to
            Cochlear Synaptopathy and Hearing Loss.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4553)
  AUTHORS   Li,W., Xie,H., Hu,H., Huang,J. and Chen,S.
  TITLE     PEX1 is a mediator of alpha1-adrenergic signaling attenuating
            doxorubicin-induced cardiotoxicity
  JOURNAL   J Biochem Mol Toxicol 36 (11), e23196 (2022)
   PUBMED   35979984
  REMARK    GeneRIF: PEX1 is a mediator of alpha1-adrenergic signaling
            attenuating doxorubicin-induced cardiotoxicity.
REFERENCE   3  (bases 1 to 4553)
  AUTHORS   Demaret,T., Roumain,M., Ambroise,J., Evraerts,J., Ravau,J.,
            Bouzin,C., Bearzatto,B., Gala,J.L., Stepman,H., Marie,S.,
            Vincent,M.F., Muccioli,G.G., Najimi,M. and Sokal,E.M.
  TITLE     Longitudinal study of Pex1-G844D NMRI mouse model: A robust
            pre-clinical model for mild Zellweger spectrum disorder
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (11), 165900 (2020)
   PUBMED   32693164
REFERENCE   4  (bases 1 to 4553)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4553)
  AUTHORS   Argyriou,C., Polosa,A., Cecyre,B., Hsieh,M., Di Pietro,E., Cui,W.,
            Bouchard,J.F., Lachapelle,P. and Braverman,N.
  TITLE     A longitudinal study of retinopathy in the PEX1-Gly844Asp mouse
            model for mild Zellweger Spectrum Disorder
  JOURNAL   Exp Eye Res 186, 107713 (2019)
   PUBMED   31254513
REFERENCE   6  (bases 1 to 4553)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 4553)
  AUTHORS   Shiozawa,K., Maita,N., Tomii,K., Seto,A., Goda,N., Akiyama,Y.,
            Shimizu,T., Shirakawa,M. and Hiroaki,H.
  TITLE     Structure of the N-terminal domain of PEX1 AAA-ATPase.
            Characterization of a putative adaptor-binding domain
  JOURNAL   J Biol Chem 279 (48), 50060-50068 (2004)
   PUBMED   15328346
  REMARK    GeneRIF: functions as a protein unfoldase in peroxisomal
            biogenesis, using its N-terminal putative adaptor-binding domain
REFERENCE   8  (bases 1 to 4553)
  AUTHORS   Shiozawa,K., Maita,N., Tomii,K., Seto,A., Goda,N., Akiyama,Y.,
            Shimizu,T., Shirakawa,M. and Hiroaki,H.
  TITLE     Crystallographic characterization of the N-terminal domain of PEX1
  JOURNAL   Acta Crystallogr D Biol Crystallogr 60 (Pt 11), 2098-2099 (2004)
   PUBMED   15502339
  REMARK    GeneRIF: crystal structure of pex1
REFERENCE   9  (bases 1 to 4553)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   10 (bases 1 to 4553)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC090845.1, DV646280.1 and AK017309.1.
            
            On Jun 24, 2014 this sequence version replaced XM_006503605.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1559              BC090845.1         1-1559
            1560-1679           DV646280.1         201-320
            1680-4424           BC090845.1         1560-4304
            4425-4553           AK017309.1         1722-1850
FEATURES             Location/Qualifiers
     source          1..4553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 2.26 cM"
     gene            1..4553
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /note="peroxisomal biogenesis factor 1"
                     /db_xref="GeneID:71382"
                     /db_xref="MGI:MGI:1918632"
     exon            1..452
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..4178
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisome biogenesis factor 1; peroxin-1; peroxisomal
                     ATPase PEX1"
                     /codon_start=1
                     /product="peroxisomal ATPase PEX1 isoform 1"
                     /protein_id="NP_001280735.1"
                     /db_xref="CCDS:CCDS80201.1"
                     /db_xref="GeneID:71382"
                     /db_xref="MGI:MGI:1918632"
                     /translation="MWSSDRLAGAGSGGAVVTVAFTNARDCFLHLPRRLVAQLHLLQN
                     QAIEVASDHQPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGDQVFLRPCSHVVS
                     CQQVEVEPLSADDWEILELHAISLEQHLLDQIRIVFPKAVVPIWVDQQTYIFIQIVTL
                     MPAAPYGRLETNTKLLIQPKTRQAKESTFPKEGDAHGQVHSYGREQKGLSKELQTRQL
                     HTNSEGITASNGRDPKVPGGPLKPSWWAVLGSMLSFGPDSKQESAWGSLELGAFKNMQ
                     SQAAPLEGTFRVCQVQPPSARTTTATSVFHKHCTAHVFPWDQEYFDVEPSFTVTYGKL
                     VKLHSPKQQQDKSKQGVLLPDKEKQLSKSPDHKQISSNRSEEAAEACVLKVVWNGLEE
                     LKNATEFTESLELLHRGKVWIPDDLRKRLNIEMHAVVRITPLETTPKIPRSLKLQPRE
                     NLPKDVNEETIKTVFSSWVQQSATTMLPLVISKEERIKLEIKDGLREFSLSTVHSQEK
                     EKEEGKTVFVLSSILLQKISVQVLLEPMIKEEQSAEIDFLLPSLTLSSLGGVSALGAS
                     AMEHITHSLLGRPLSRQLMALVAGLRNGALLITGGKGSGKSTFAKAICKEAQDTLDAR
                     VETVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSVPEQEHSPE
                     AVQSQRLAHALNDMIKEFVSTGSLVALIATSQLQQSLHPSLVSAQGIHTFQCVQHLQP
                     PNPEQRCEILHSVVKNKLGCDISNFPDLDLQCIAKDTEAFVARDFTVLVDRAIHSSLS
                     RQHSSSREDLTLTTSDFQKALRGFLPASLRNVNLHKPRDLGWDKIGGLHEVRQILMDT
                     IQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIKGPELLSK
                     YIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGV
                     EGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSLALADD
                     VDLQHVASVTDSFTGADLKALLYNAQLEALQGRLLPSGLPDGGSSSDSDLSLSSMVFL
                     NHSSGSDDSAGDGECGLEQSLLSLEMSEILPDESKFNMYRLYFGSSYESELGNGTPSD
                     LSSHCLSAPSSVTQDLPAAPGKDPLFTQHPVFRTPSQEGCQDLTQEQRDQLRAEISII
                     KGRYRSQSGEDESLNQPGPIKTTFAISQAHLMTALAHTRPSISEDEGKEFAELYENFQ
                     NPKKRKNQSGTVFRTGQKVTLA"
     exon            453..596
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..680
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..795
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1559
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1679
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1803
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1913
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..1996
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2129
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2226
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2397
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2552
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2742
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2909
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3044
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3109
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3252
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3356
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3533
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3764
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3962
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..4093
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4553
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4267..4272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /note="hexamer: AATAAA"
     polyA_site      4290
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
     regulatory      4398..4403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /note="hexamer: ATTAAA"
     polyA_site      4418
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
                     /note="major polyA site"
     polyA_site      4553
                     /gene="Pex1"
                     /gene_synonym="5430414H02Rik; E330005K07Rik; ZWS1"
ORIGIN      
        1 ctggatgcca tcttgccggc tctagtcccc cgcgccagaa caacatccgc cagccgcgct
       61 cctctgagtc caataagaga gcaggatgga ccaggcgtgc taggattggc tgaaggatcg
      121 accccatcga cgatcatctc ctgagagcga gaattcgacg agcgacgtgc cgccccctag
      181 agcttcggag gtggcccgag ggtgacagcg gccgggcgtg ggaagagggg ggcgggcctg
      241 atcgatgttc tcgggttccg acgctctcac ctgacgagaa gccggtggac tccgctctcc
      301 ggtgagagtt gaaccttggg acaatgtgga gcagcgatcg cttagcgggt gcggggtctg
      361 gtggggcggt cgtgacggtg gccttcacga atgctcggga ctgcttcctg catctgccgc
      421 ggcgcctcgt ggcccagctt cacctgctgc agaatcaagc tatagaagtg gccagcgatc
      481 accagcctac ctacctgagc tgggtggaag gcaggcattt taatgatcaa agtgaaaatg
      541 tggcagaaat taatagacaa gttggccaga aacttggact ctcaagcgga gatcaggtgt
      601 ttctcaggcc ttgttcccat gtggtatctt gccaacaggt tgaagtggag cctctctcag
      661 cagatgactg ggaaatactg gagctgcacg ccatttccct tgaacagcat cttctggatc
      721 agattcgaat agttttcccc aaagctgttg ttcccatctg ggttgaccag cagacctaca
      781 tatttatcca gatcgtcact ctgatgccag ctgcccctta tggaaggcta gaaactaaca
      841 ccaaactcct tattcagcca aagacacgcc aagccaaaga gagcacattt ccaaaagaag
      901 gagatgcaca cggacaagtt catagttatg ggcgagaaca gaaaggattg tcaaaggaat
      961 tacaaaccag gcagcttcat acgaactcag agggtatcac tgcatccaat ggaagagacc
     1021 caaaagtccc aggtggcccg ttgaagccaa gctggtgggc tgtgctcgga agcatgcttt
     1081 cctttgggcc tgacagtaaa caggagtcag cctggggctc gttggaactc ggtgctttca
     1141 aaaacatgca gtcacaggct gcccctctgg aaggtacttt cagagtatgc caagtccagc
     1201 cacctagtgc gcgtaccacc accgctacct ctgtgtttca caaacactgc accgcccacg
     1261 tatttccttg ggaccaagaa tactttgatg tggagcccag ctttactgtg acctatggaa
     1321 aactagttaa gctacattct ccaaaacaac agcaagacaa aagtaagcag ggtgtcctgt
     1381 tgcctgacaa agagaagcag ctgtccaagt ctccagatca taagcagatc agctccaacc
     1441 gcagtgagga ggctgctgag gcctgtgtgc tgaaggtagt ctggaatgga ctcgaggagt
     1501 tgaagaatgc cacagagttc accgaaagtc tagagcttct ccaccgtggg aaagtctgga
     1561 ttccagatga cctgagaaag agactaaata tagaaatgca tgcagtagtc agaataactc
     1621 cactggaaac cacgcctaaa atcccaagat ctctgaaatt acaacctaga gagaacttac
     1681 ctaaagacgt caatgaagaa actataaaaa cagtgttctc atcttgggta cagcagtccg
     1741 ctaccacgat gcttcctttg gtaatatcaa aggaagagcg tattaagctg gaaattaaag
     1801 atgggctgag agagttctct ctgagtacag ttcattctca ggaaaaagaa aaggaagaag
     1861 gaaaaactgt gtttgtgttg agttccatcc tgctgcagaa gatctcagta caagtccttc
     1921 tagagcccat gataaaagaa gaacagagtg cggaaatcga ctttcttctt ccctctttaa
     1981 cgctgagctc tttgggggga gtgagtgcct taggtgcatc tgcaatggag cacatcactc
     2041 acagtctcct gggacgcccg ttgtctaggc agctgatggc cctcgttgca ggacttagga
     2101 atggcgctct tttgatcact ggaggaaagg gaagcgggaa gtcaacattc gcgaaagcca
     2161 tctgcaagga agcacaggac actctggatg cccgtgtgga gacagtcgac tgcaaggctt
     2221 tacgaggaaa aaggcttgaa agcatacaaa aagcgctaga ggtggctttc tcagaggccg
     2281 cctggaggca gccatctgtc attctgctgg atgacctgga cctcattgcc ggactgccaa
     2341 gtgtccccga gcaggagcac agccctgaag cggtgcagag ccagcggctt gcacatgctt
     2401 tgaacgatat gatcaaagag tttgtttcca cgggaagctt ggtggcactc atcgccacga
     2461 gccagctcca gcagtctctg cacccttccc ttgtgtctgc tcaaggaatc cacacgtttc
     2521 aatgtgtcca gcaccttcag cctcccaatc cggaacagag atgtgaaatt ctgcacagtg
     2581 ttgtgaagaa taaactgggc tgtgatataa gcaatttccc tgacttggac ctgcagtgca
     2641 tagctaaaga cacagaagcg tttgtggctc gtgactttac agttcttgtg gaccgagcca
     2701 tacactcttc tctctctcgc cagcatagct cctctaggga agacttgact ttaacaacat
     2761 cagacttcca aaaggctctc cgtggattcc ttcctgcttc tctgcgaaat gtcaacttgc
     2821 ataaacctag agacctgggc tgggacaaga ttggtggatt acatgaagtt cggcagatcc
     2881 tcatggatac tatccagtta ccagccaagt acccagaatt atttgcaaac ttacccatac
     2941 gacagaggac aggaatactg ctttatggtc ctccagggac aggaaaaact ttacttgctg
     3001 gggtagttgc aagagagagt ggaatgaatt ttattagtat taagggacca gagttactca
     3061 gcaaatatat tggcgcaagt gagcaagctg ttcgagatgt tttcatcaga gcacaggctg
     3121 caaagccctg cattcttttc tttgatgagt ttgagtccat cgctcctcga agaggccatg
     3181 acaacacagg ggttacagac cgagtagtca accagttgct gacacagtta gacggagtag
     3241 aaggcttaca gggagtttat gtgctggctg ctactagtcg ccctgacttg atcgaccctg
     3301 ccctgttgcg gcctggcaga ctggataaat gtgtatactg ccctcctcca gatcaggtgt
     3361 cccgtcttga gattttaact gtcctcagca agtctctagc tctggcagat gacgtggacc
     3421 ttcagcacgt ggcgtcggtc accgactcgt tcactggagc ggatctgaaa gctctgctgt
     3481 acaacgctca gctggaggcc ttgcagggac ggctgctgcc cagtgggctt cccgatggag
     3541 gctccagctc tgacagtgac ctgagtctgt cttcaatggt ctttcttaac cacagcagtg
     3601 gttccgacga ctccgctgga gatggagaat gtggcttaga gcaatccctg ctttctctcg
     3661 agatgtctga gatccttcca gacgaatcaa aattcaatat gtaccggctc tactttggaa
     3721 gctcgtatga atcggagctt ggaaatggga ccccttctga cttgagctca cactgtctgt
     3781 ctgcaccaag ctccgtgact caggatttac ctgcagctcc tgggaaagac ccgttattta
     3841 cacaacatcc tgtgttcagg acaccttccc aagaaggctg ccaagacctc acccaggagc
     3901 agagagatca gctgagggca gagatcagca tcatcaaagg cagataccgg agccaaagtg
     3961 gagaggatga atcccttaac cagcctggac caatcaaaac cacttttgct attagccagg
     4021 cacatttaat gactgcactt gcccacacaa gaccgtctat tagtgaagat gaagggaagg
     4081 aatttgctga gctgtatgag aactttcaaa atccaaagaa gagaaaaaat caaagtggaa
     4141 cagtgtttcg aactggacag aaagtaactt tagcataaaa tacacttctg attttctaga
     4201 tgtgtttgtt ttaatggtct gtccctaagt tgtaactata aaaatgatgt aaaaattttt
     4261 taatttaata aatttggtta atctataaaa tcacagactg gaaagtgctg tgattctgct
     4321 caggactacc tgagattaac agtgcaggct aaaggaagtg atttgtaaca gatcgtttat
     4381 tttattccca agtctgtatt aaatccttaa tgatattacg tcaatggtgg acctcatttg
     4441 ttttctttta gaggcactca cagacccaga gtcactgatt ttctggcttt tggcagattg
     4501 tatgccttgt aacttcttga ttgttttggg aaaagataca ttctattatc gtc
//
