LOCUS       NM_022889               2911 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pescadillo ribosomal biogenesis factor 1 (Pes1), mRNA.
ACCESSION   NM_022889
VERSION     NM_022889.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2911)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2911)
  AUTHORS   Zhou,J., Lu,Y., Lin,Y., Li,C., Liu,J., Jiang,Z. and Chen,K.
  TITLE     Overexpression of hepatic pescadillo 1 in obesity induces lipid
            dysregulation by inhibiting autophagy
  JOURNAL   Transl Res 258, 1-15 (2023)
   PUBMED   36775058
  REMARK    GeneRIF: Overexpression of hepatic pescadillo 1 in obesity induces
            lipid dysregulation by inhibiting autophagy.
REFERENCE   3  (bases 1 to 2911)
  AUTHORS   Cheng,L., Yuan,B., Ying,S., Niu,C., Mai,H., Guan,X., Yang,X.,
            Teng,Y., Lin,J., Huang,J., Jin,R., Wu,J., Liu,B., Chang,S.,
            Wang,E., Zhang,C., Hou,N., Cheng,X., Xu,D., Yang,X., Gao,S. and
            Ye,Q.
  TITLE     PES1 is a critical component of telomerase assembly and regulates
            cellular senescence
  JOURNAL   Sci Adv 5 (5), eaav1090 (2019)
   PUBMED   31106266
  REMARK    GeneRIF: PES1 facilitates telomerase assembly by promoting direct
            interaction between TERT and TR without affecting TERT and TR
            levels
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2911)
  AUTHORS   Nakaguro,M., Kiyonari,S., Kishida,S., Cao,D., Murakami-Tonami,Y.,
            Ichikawa,H., Takeuchi,I., Nakamura,S. and Kadomatsu,K.
  TITLE     Nucleolar protein PES1 is a marker of neuroblastoma outcome and is
            associated with neuroblastoma differentiation
  JOURNAL   Cancer Sci 106 (3), 237-243 (2015)
   PUBMED   25557119
  REMARK    GeneRIF: These data suggest that PES1 is a marker of neuroblastoma
            outcome, that it regulates neuroblastoma cell proliferation, and is
            associated with neuroblastoma differentiation.
REFERENCE   5  (bases 1 to 2911)
  AUTHORS   Wang,M., Anikin,L. and Pestov,D.G.
  TITLE     Two orthogonal cleavages separate subunit RNAs in mouse ribosome
            biogenesis
  JOURNAL   Nucleic Acids Res 42 (17), 11180-11191 (2014)
   PUBMED   25190460
REFERENCE   6  (bases 1 to 2911)
  AUTHORS   Prisco,M., Maiorana,A., Guerzoni,C., Calin,G., Calabretta,B.,
            Voit,R., Grummt,I. and Baserga,R.
  TITLE     Role of pescadillo and upstream binding factor in the proliferation
            and differentiation of murine myeloid cells
  JOURNAL   Mol Cell Biol 24 (12), 5421-5433 (2004)
   PUBMED   15169904
  REMARK    GeneRIF: effects of PES1 and UBF1 expression on the growth and
            differentiation of cell lines derived from 32D cells, an
            interleukin-3 (IL-3)-dependent murine myeloid cell line
REFERENCE   7  (bases 1 to 2911)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2911)
  AUTHORS   Lerch-Gaggl,A., Haque,J., Li,J., Ning,G., Traktman,P. and
            Duncan,S.A.
  TITLE     Pescadillo is essential for nucleolar assembly, ribosome
            biogenesis, and mammalian cell proliferation
  JOURNAL   J Biol Chem 277 (47), 45347-45355 (2002)
   PUBMED   12237316
  REMARK    GeneRIF: Data show that pescadillo associates with several
            structures that are associated with nucleogenesis, and that loss of
            function results in embryonic lethality due to disrupted ribosome
            biosynthesis.
REFERENCE   9  (bases 1 to 2911)
  AUTHORS   Kinoshita,Y., Jarell,A.D., Flaman,J.M., Foltz,G., Schuster,J.,
            Sopher,B.L., Irvin,D.K., Kanning,K., Kornblum,H.I., Nelson,P.S.,
            Hieter,P. and Morrison,R.S.
  TITLE     Pescadillo, a novel cell cycle regulatory protein abnormally
            expressed in malignant cells
  JOURNAL   J Biol Chem 276 (9), 6656-6665 (2001)
   PUBMED   11071894
REFERENCE   10 (bases 1 to 2911)
  AUTHORS   Haque,J., Boger,S., Li,J. and Duncan,S.A.
  TITLE     The murine Pes1 gene encodes a nuclear protein containing a BRCT
            domain
  JOURNAL   Genomics 70 (2), 201-210 (2000)
   PUBMED   11112348
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL807395.8.
            
            On Nov 17, 2006 this sequence version replaced NM_022889.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029075.1, BC004844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AL807395.8         34984-35069
            87-166              AL807395.8         39272-39351
            167-320             AL807395.8         40442-40595
            321-430             AL807395.8         41634-41743
            431-602             AL807395.8         44206-44377
            603-692             AL807395.8         44458-44547
            693-809             AL807395.8         46538-46654
            810-884             AL807395.8         46749-46823
            885-971             AL807395.8         47044-47130
            972-1102            AL807395.8         47297-47427
            1103-1228           AL807395.8         47781-47906
            1229-1413           AL807395.8         48025-48209
            1414-1571           AL807395.8         48635-48792
            1572-1733           AL807395.8         48880-49041
            1734-2911           AL807395.8         49836-51013
FEATURES             Location/Qualifiers
     source          1..2911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.79 cM"
     gene            1..2911
                     /gene="Pes1"
                     /note="pescadillo ribosomal biogenesis factor 1"
                     /db_xref="GeneID:64934"
                     /db_xref="MGI:MGI:1890613"
     exon            1..86
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            87..166
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..320
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..430
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..602
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..692
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..809
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..884
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..971
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1102
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1228
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1413
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1571
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1733
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..2911
                     /gene="Pes1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2102..2107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pes1"
                     /note="hexamer: ATTAAA"
     polyA_site      2128
                     /gene="Pes1"
                     /note="major polyA site"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pes1"
                     /note="hexamer: CATAAA"
     polyA_site      2410
                     /gene="Pes1"
     polyA_site      2856
                     /gene="Pes1"
     polyA_site      2894
                     /gene="Pes1"
     polyA_site      2911
                     /gene="Pes1"
ORIGIN      
        1 ggcacgtgcg ggaggaagta gctctggtgt tctggctgcc ttgaatttct caacgtggag
       61 ctatgggagg tctggagaag aagaagtatg aacgaggctc tgccaccaat tatatcaccc
      121 gaaacaaggc caggaagaag ctgcagctga gcctgcctga cttcaggcgg ctgtgcatcc
      181 tgaaaggtat ttatcctcac gaacccaagc ataagaagaa agttaacaag ggttccacag
      241 cagcccggac attttacctt atcaaagaca ttaaattcct cctccatgag cccatcgtca
      301 acaagttccg agagtacaag gtgtttgttc ggaagctccg caaagcctat ggaaagagcg
      361 aatggaatgc tgtggagcgc ctgaaggaca ataaaccctg ctacaaactt gaccacattg
      421 tcaaggagcg gtaccccaca tttatcgatg ctctgcggga cctcgatgat gccctgtcaa
      481 tgtgcttcct cttctccacc ttccctcgga ctggcaagtg tcatgtgcag accattcagt
      541 tgtgccgtag gctcactgtg gagttcctgc actatgtcat cactgcccga gccctgcgca
      601 aggtcttcct gtccattaaa ggcatttatt atcaggctga ggtgctgggt cagcccatcg
      661 tatggattgc accctatgct ttctcccatg atcatccgac agatgtggac tacagggtca
      721 tggccacctt cactgagttc tataccacgc tcctgggctt tgtcaacttc cgtctctacc
      781 agtcactcaa ccttcactac ccaccaaagc ttgaaggtca agcccaagca gagacaaaga
      841 tcagcgagga cacatatgca ttggactctg agagctctat ggagaaactg gctgccctca
      901 gtgccagcct ggcccgagtg gtggtgcctg ctatagagga ggctgaggct gatgaattcc
      961 ctactgatgg ggaggtgaca gcacaggagg aagatcggaa gaaagagctg gaggcacagg
     1021 aaaagcacaa gaaactcttt gaaggcctga agttcttcct gaaccgagag gtgccccgtg
     1081 aagcattggc cttcatcatc aggagttttg gtggggatgt atcctgggac aagtctctgt
     1141 gtatcggagc cacctatgac gtcacagact catgcatcac ccaccagatt gttgaccggc
     1201 cggggcagca aacccccatc attggcaggt actatgtaca gccccagtgg gtctttgact
     1261 gtgtgaatgc ccggctcctc ctccctgtgg cagagtactt ccccgggatg cagctgcccc
     1321 cacatctttc acccttcgta tctgagaagg aaggagatta cattccccct gagaagctga
     1381 agctcctggc tctgcagcgg ggagaagacc caggacactt ggaagaggag gaggaggagg
     1441 atgaagatga tgacaacgaa ggtgatgttg cagcggaaaa tgaagaggaa gatgtggaag
     1501 ttgaatcgga ggaggaggag gaggaggagg tgcacctttc ggccttggag cagcacaggc
     1561 tggaagagaa gaaaccccag gttatggccg gcactgtgaa gctggaagac aagcagcggc
     1621 tggcccagga ggaagagagt gaggctaagc gcttggccat catgatgatg aaaaagcgag
     1681 agaagtacct ttaccaaaag atcatgtttg gcaagcggcg caaaatccga gaggccaaca
     1741 agctggcaga gaagaggaaa gcccatgatg atgctgtgag gtctgagaaa aaggccaaga
     1801 ggacaaggcc cgtgtgagct ccagttgtcc ctcactgaga tttggacttg gcagaagcaa
     1861 gctagtgaaa cacacataca caccagccag cactctcata ctttggtggt atgtggctag
     1921 ccccagccgc ctttgtggtt catgccagtg cctgggcaaa gagacctcaa cccaacgcag
     1981 ttcttaatcc aggagtccgt ctgacatcct cattttcctt ggctttctac agcctcctac
     2041 atagctgtgc ccatcctgtg ctcaggatgc tgttgcggag tgagggtggt gagcttttat
     2101 tattaaatgg ttggatcttt acagccaatt ggattctgtg ttcagaagcc tccctgggat
     2161 tggagaggtg tcatcctctc caatccagat gggttcaggc acactaggac tcccgagttc
     2221 aaggaaggta gaaaagacac aggttctggg cttgggtttc agtcacactt gccctggcct
     2281 ggttcctgtt tcagctcagg ctctactctg aacctccttc ctcaagttag ggttggaagt
     2341 tctggaacct tcccacaagc agtatgcttg tccaattcag tcatggtcca taaacaactg
     2401 tcttccctca cttcctgctg gagttcctga gaaggtgaaa ggaggcatct aagttgaggt
     2461 ttcctttgct gtgatgaagc accataacca aaaagtaagc tggggagaaa agtatgtatg
     2521 gctcacactt ccacattgta tgtacaaaag tgtgtatggc tcacacttcc acattgtatg
     2581 tacaaaagtg tgtatggctc acacttccac attgtatgta caaaagtgtg tatggctcac
     2641 acttccacat tgtatgtaca aaagtgtgta tggctcacac ttccacattg tatgtacaaa
     2701 agtgtatatg gctcacactt ccacattgta tgtacaaaag tgtgtatggc tcacacttcc
     2761 acattgtatg tacaaaagtg tgtatggctc acacttccac attgtatgta caaaagtgta
     2821 tatggctcgc atttccacat tgtatgtgca aaagtatgta tggctcacac ttccacattg
     2881 tatgtacaaa agtatgtatg gttcacactt c
//
