LOCUS       NM_022032               1901 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus PERP, TP53 apoptosis effector (Perp), mRNA.
ACCESSION   NM_022032
VERSION     NM_022032.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Patel,N., Alkeraye,S., Alobeid,E., Alshidi,T., Helaby,R.,
            Abdulwahab,F., Shamseldin,H.E. and Alkuraya,F.S.
  TITLE     Confirming the recessive inheritance of PERP-related
            erythrokeratoderma
  JOURNAL   Clin Genet 97 (4), 661-665 (2020)
   PUBMED   31898316
  REMARK    GeneRIF: Confirming the recessive inheritance of PERP-related
            erythrokeratoderma.
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Bowen,M.E., McClendon,J., Long,H.K., Sorayya,A., Van Nostrand,J.L.,
            Wysocka,J. and Attardi,L.D.
  TITLE     The Spatiotemporal Pattern and Intensity of p53 Activation Dictates
            Phenotypic Diversity in p53-Driven Developmental Syndromes
  JOURNAL   Dev Cell 50 (2), 212-228 (2019)
   PUBMED   31178404
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Zhou,Y., Leng,X., He,Y., Li,Y., Liu,Y., Liu,Y., Zou,Q., Shi,G. and
            Wang,Y.
  TITLE     Loss of Perp in T Cells Promotes Resistance to Apoptosis of T
            Helper 17 Cells and Exacerbates the Development of Experimental
            Autoimmune Encephalomyelitis in Mice
  JOURNAL   Front Immunol 9, 842 (2018)
   PUBMED   29740445
  REMARK    GeneRIF: Perp deletion promoted Th17 responses and exacerbated the
            development and severity of experimental autoimmune
            encephalomyelitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Hemann,M.T., Zilfou,J.T., Zhao,Z., Burgess,D.J., Hannon,G.J. and
            Lowe,S.W.
  TITLE     Suppression of tumorigenesis by the p53 target PUMA
  JOURNAL   Proc Natl Acad Sci U S A 101 (25), 9333-9338 (2004)
   PUBMED   15192153
  REMARK    GeneRIF: In contrast to p53 shRNAs, PUMA shRNAs were unable to
            cooperate with oncogenic ras in transformation
REFERENCE   7  (bases 1 to 1901)
  AUTHORS   Reczek,E.E., Flores,E.R., Tsay,A.S., Attardi,L.D. and Jacks,T.
  TITLE     Multiple response elements and differential p53 binding control
            Perp expression during apoptosis
  JOURNAL   Mol Cancer Res 1 (14), 1048-1057 (2003)
   PUBMED   14707288
REFERENCE   8  (bases 1 to 1901)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1901)
  AUTHORS   Ihrie,R.A., Reczek,E., Horner,J.S., Khachatrian,L., Sage,J.,
            Jacks,T. and Attardi,L.D.
  TITLE     Perp is a mediator of p53-dependent apoptosis in diverse cell types
  JOURNAL   Curr Biol 13 (22), 1985-1990 (2003)
   PUBMED   14614825
REFERENCE   10 (bases 1 to 1901)
  AUTHORS   Attardi,L.D., Reczek,E.E., Cosmas,C., Demicco,E.G., McCurrach,M.E.,
            Lowe,S.W. and Jacks,T.
  TITLE     PERP, an apoptosis-associated target of p53, is a novel member of
            the PMP-22/gas3 family
  JOURNAL   Genes Dev 14 (6), 704-718 (2000)
   PUBMED   10733530
  REMARK    GeneRIF: A paper describing the identification of Perp (p53
            Apoptosis Effector Related to PMP22).  Perp was found as a novel
            target gene of the p53 tumor suppressor, which is selectively
            induced during apoptosis compared to cell cycle arrest.
            Erratum:[Genes Dev 2000 Jul 15;14(14):1835]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC158630.5.
            
            On Oct 19, 2007 this sequence version replaced NM_022032.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF249870.1, AK003734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               AC158630.5         94568-94903
            337-477             AC158630.5         103034-103174
            478-1901            AC158630.5         105147-106570
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 7.97 cM"
     gene            1..1901
                     /gene="Perp"
                     /gene_synonym="1110017A08Rik; KCP1; KRTCAP1; PIGPC1; THW"
                     /note="PERP, TP53 apoptosis effector"
                     /db_xref="GeneID:64058"
                     /db_xref="MGI:MGI:1929938"
     exon            1..336
                     /gene="Perp"
                     /gene_synonym="1110017A08Rik; KCP1; KRTCAP1; PIGPC1; THW"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..704
                     /gene="Perp"
                     /gene_synonym="1110017A08Rik; KCP1; KRTCAP1; PIGPC1; THW"
                     /note="p53 apoptosis-associated target; KCP-1;
                     keratinocyte-associated protein 1; p53 apoptosis effector
                     related to Pmp22"
                     /codon_start=1
                     /product="p53 apoptosis effector related to PMP-22"
                     /protein_id="NP_071315.1"
                     /db_xref="CCDS:CCDS23714.1"
                     /db_xref="GeneID:64058"
                     /db_xref="MGI:MGI:1929938"
                     /translation="MLRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSNHIQT
                     SSLWWRCFDEGGGSGSYDDGCQSLMEYAWGRAAAATLFCGFIILCICFILSFFALCGP
                     QMLVFLRVIGGLLALAAIFQIISLVIYPVKYTQTFRLHDNPAVNYIYNWAYGFGWAAT
                     IILIGCSFFFCCLPNYEDDLLGAAKPRYFYPPA"
     exon            337..477
                     /gene="Perp"
                     /gene_synonym="1110017A08Rik; KCP1; KRTCAP1; PIGPC1; THW"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1901
                     /gene="Perp"
                     /gene_synonym="1110017A08Rik; KCP1; KRTCAP1; PIGPC1; THW"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Perp"
                     /gene_synonym="1110017A08Rik; KCP1; KRTCAP1; PIGPC1; THW"
                     /note="hexamer: AATAAA"
     polyA_site      1901
                     /gene="Perp"
                     /gene_synonym="1110017A08Rik; KCP1; KRTCAP1; PIGPC1; THW"
                     /note="major polyA site"
ORIGIN      
        1 ggggccgcgt cttcggggga gccgcctctt cctttagtcg cggtgtcagc gctcgcagga
       61 ccactcttgg ccgctgctcc tgcccggcgt tcctccgctc cgcgcccgcc gccaccgacg
      121 acatgctgcg ctgcggcctg gcctgcgagc gctgcaggtg gatcctgccc ctgctgctgc
      181 tcagcgccat cgccttcgac atcatcgcgc tggccggccg cggctggctg cagtctagca
      241 accacatcca gacatcgtcg ctttggtgga ggtgtttcga cgagggcggc ggcagcggct
      301 cctacgacga tggctgccag agcctcatgg agtacgcatg gggacgagca gctgcagcca
      361 cgcttttctg tggctttatc atcctgtgca tctgcttcat tctctcgttc ttcgccctgt
      421 gtggacccca gatgcttgtt ttcctgagag tcattggagg cctcctcgca ctggctgcca
      481 tattccagat catctccctg gtaatctacc ccgtgaagta cacacagacc ttcaggcttc
      541 acgataaccc tgctgttaat tacatctata actgggccta tggcttcgga tgggcggcca
      601 ccatcatctt gattggttgt tccttcttct tctgctgcct ccccaactac gaggatgacc
      661 ttttgggggc cgccaagccc aggtacttct atcccccagc ctaatgtggg aggaagagcc
      721 tgagaaaagc ctgctgcaag atggatctga ggaggaaact gttctccaag gcacaaggaa
      781 cctacgtttg ggcaatgttc atatgatcag aaatgttaga ataaatgcta aagaaaattc
      841 ttcataatta gtgttaagtt tcatgtatgt cgtgtggagt taaaaagact tgaattctgt
      901 ttgctaagta tatgctaatt tttccttatg tcaattctat accatttaag cttcatttgt
      961 taaagaatat gcctgtgaaa cttgataagg tagaaatgca gcagcctctc atttaataat
     1021 ctgatggggc ttctgttttt ccacatagaa tgggttgttt ctgctaaggg ctacagagga
     1081 ggaaagtcac tggcaaaact tccatgacca aatatcctga aattagtttg ttttttttta
     1141 aaagacctta ttttgagttt tcagttacat aaagaagcag aagcagattg gtttcctaag
     1201 tgagcatcat ttgtgagaat ttttagtcag tgttttgaac aattattgtt tttctaagct
     1261 tcatgttgac tttctctgat gcgtagaaaa gtgttctaac gtggctgagg ttaagccgct
     1321 gtcattactg aaatgctaag aattttcctc ttttcccgta gtgtagaggg gtagggtgtg
     1381 ggcagaagcc gtgttagcac atctgtagta ttgtgtgtgt atgcttagaa ccagcgtaga
     1441 ccggatggga ggatggacta ggcctaatcc ctcccaactg gtggatgtga agaggtcagg
     1501 taggaaggca caggagggtc accactgtca cagcagtgcc atgcagacat cctaggagaa
     1561 gacatggcag tgtttcttct cagtgcttct tcccttaact gagctctgct cacagacagc
     1621 tagaatagat tttaactgaa acagaaacct aaatgtaatt aaaaacctgg tcttccttgg
     1681 taagcagact taaaatatct gtatagtaca tgcaagtgga aaatttggga atgcgtgtct
     1741 ctgaatacat accggaaggg ctactattac ctttttctta ccatttatac ttacctaatg
     1801 gaaacgagct tgttttaact atcagaacac tattttgtaa ggtgctgcaa agacagttga
     1861 agttttcatt accaatttcc ccaataaacc aggtgttcaa a
//
