LOCUS       NM_172417               3849 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus PPARGC1 and ESRR induced regulator, muscle 1 (Perm1),
            mRNA.
ACCESSION   NM_172417
VERSION     NM_172417.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3849)
  AUTHORS   Oka,S.I., Sreedevi,K., Shankar,T.S., Yedla,S., Arowa,S., James,A.,
            Stone,K.G., Olmos,K., Sabry,A.D., Horiuchi,A., Cawley,K.M.,
            O'very,S.A., Tong,M., Byun,J., Xu,X., Kashyap,S., Mourad,Y.,
            Vehra,O., Calder,D., Lunde,T., Liu,T., Li,H., Mashchek,J.A.,
            Cox,J., Saijoh,Y., Drakos,S.G. and Warren,J.S.
  TITLE     PERM1 regulates energy metabolism in the heart via
            ERRalpha/PGC-1alpha axis
  JOURNAL   Front Cardiovasc Med 9, 1033457 (2022)
   PUBMED   36419485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3849)
  AUTHORS   Huang,C.Y., Oka,S.I., Xu,X., Chen,C.F., Tung,C.Y., Chang,Y.Y.,
            Mourad,Y., Vehra,O., Ivessa,A., Yehia,G., Romanienko,P., Hsu,C.P.
            and Sadoshima,J.
  TITLE     PERM1 regulates genes involved in fatty acid metabolism in the
            heart by interacting with PPARalpha and PGC-1alpha
  JOURNAL   Sci Rep 12 (1), 14576 (2022)
   PUBMED   36028747
  REMARK    GeneRIF: PERM1 regulates genes involved in fatty acid metabolism in
            the heart by interacting with PPARalpha and PGC-1alpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3849)
  AUTHORS   Bock,T., Turk,C., Aravamudhan,S., Keufgens,L., Bloch,W.,
            Rozsivalova,D.H., Romanello,V., Nogara,L., Blaauw,B.,
            Trifunovic,A., Braun,T. and Kruger,M.
  TITLE     PERM1 interacts with the MICOS-MIB complex to connect the
            mitochondria and sarcolemma via ankyrin B
  JOURNAL   Nat Commun 12 (1), 4900 (2021)
   PUBMED   34385433
  REMARK    GeneRIF: PERM1 interacts with the MICOS-MIB complex to connect the
            mitochondria and sarcolemma via ankyrin B.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3849)
  AUTHORS   Cho,Y., Tachibana,S., Lam,K., Arita,Y., Khosrowjerdi,S., Zhang,O.,
            Liang,A., Li,R., Andreyev,A., Murphy,A.N. and Ross,R.S.
  TITLE     Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects
            against hypoxia/reoxygenation-induced damage in mice
  JOURNAL   J Biol Chem 297 (1), 100825 (2021)
   PUBMED   34029594
  REMARK    GeneRIF: Perm1 promotes cardiomyocyte mitochondrial biogenesis and
            protects against hypoxia/reoxygenation-induced damage in mice.
            Erratum:[J Biol Chem. 2021 Sep;297(3):101121. doi:
            10.1016/j.jbc.2021.101121.. PMID: 34464737]
REFERENCE   5  (bases 1 to 3849)
  AUTHORS   Aravamudhan,S., Turk,C., Bock,T., Keufgens,L., Nolte,H., Lang,F.,
            Krishnan,R.K., Konig,T., Hammerschmidt,P., Schindler,N.,
            Brodesser,S., Rozsivalova,D.H., Rugarli,E., Trifunovic,A.,
            Bruning,J., Langer,T., Braun,T. and Kruger,M.
  TITLE     Phosphoproteomics of the developing heart identifies PERM1 - An
            outer mitochondrial membrane protein
  JOURNAL   J Mol Cell Cardiol 154, 41-59 (2021)
   PUBMED   33549681
REFERENCE   6  (bases 1 to 3849)
  AUTHORS   Akashi,S., Morita,A., Mochizuki,Y., Shibuya,F., Kamei,Y. and
            Miura,S.
  TITLE     Citrus hassaku Extract Powder Increases Mitochondrial Content and
            Oxidative Muscle Fibers by Upregulation of PGC-1alpha in Skeletal
            Muscle
  JOURNAL   Nutrients 13 (2), 497 (2021)
   PUBMED   33546195
  REMARK    GeneRIF: Citrus hassaku Extract Powder Increases Mitochondrial
            Content and Oxidative Muscle Fibers by Upregulation of PGC-1alpha
            in Skeletal Muscle.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3849)
  AUTHORS   Oka,S.I., Sabry,A.D., Horiuchi,A.K., Cawley,K.M., O'Very,S.A.,
            Zaitsev,M.A., Shankar,T.S., Byun,J., Mukai,R., Xu,X., Torres,N.S.,
            Kumar,A., Yazawa,M., Ling,J., Taleb,I., Saijoh,Y., Drakos,S.G.,
            Sadoshima,J. and Warren,J.S.
  TITLE     Perm1 regulates cardiac energetics as a downstream target of the
            histone methyltransferase Smyd1
  JOURNAL   PLoS One 15 (6), e0234913 (2020)
   PUBMED   32574189
  REMARK    GeneRIF: Perm1 regulates cardiac energetics as a downstream target
            of the histone methyltransferase Smyd1.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3849)
  AUTHORS   Muller,S., Perdikari,A., Dapito,D.H., Sun,W., Wollscheid,B.,
            Balaz,M. and Wolfrum,C.
  TITLE     ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige
            Adipocyte Formation
  JOURNAL   Front Endocrinol (Lausanne) 11, 387 (2020)
   PUBMED   32595605
  REMARK    GeneRIF: ESRRG and PERM1 Govern Mitochondrial Conversion in
            Brite/Beige Adipocyte Formation.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3849)
  AUTHORS   Cho,Y., Tachibana,S., Hazen,B.C., Moresco,J.J., Yates,J.R. 3rd,
            Kok,B., Saez,E., Ross,R.S., Russell,A.P. and Kralli,A.
  TITLE     Perm1 regulates CaMKII activation and shapes skeletal muscle
            responses to endurance exercise training
  JOURNAL   Mol Metab 23, 88-97 (2019)
   PUBMED   30862473
  REMARK    GeneRIF: These findings identify Perm1 as a muscle-specific
            regulator of exercise-induced signaling and Perm1 levels as tuners
            of the skeletal muscle response to exercise.
REFERENCE   10 (bases 1 to 3849)
  AUTHORS   Cho,Y., Hazen,B.C., Russell,A.P. and Kralli,A.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1
            (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in
            muscle 1 (Perm1) is a tissue-specific regulator of oxidative
            capacity in skeletal muscle cells
  JOURNAL   J Biol Chem 288 (35), 25207-25218 (2013)
   PUBMED   23836911
  REMARK    GeneRIF: a role for Perm1 acting downstream of PGC-1alpha and ERRs
            to regulate muscle-specific pathways important for energy
            metabolism and contractile function.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036660.1, BC117871.1, AK009747.2 and AI597030.1.
            
            On Nov 30, 2007 this sequence version replaced NM_172417.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2597              AK036660.1         3-2599
            2598-2950           BC117871.1         2472-2824
            2951-3840           AK009747.2         222-1111
            3841-3849           AI597030.1         1-9                 c
FEATURES             Location/Qualifiers
     source          1..3849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 88.62 cM"
     gene            1..3849
                     /gene="Perm1"
                     /gene_synonym="2310042D19Rik"
                     /note="PPARGC1 and ESRR induced regulator, muscle 1"
                     /db_xref="GeneID:74183"
                     /db_xref="MGI:MGI:1921433"
     exon            1..49
                     /gene="Perm1"
                     /gene_synonym="2310042D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            50..2518
                     /gene="Perm1"
                     /gene_synonym="2310042D19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..2757
                     /gene="Perm1"
                     /gene_synonym="2310042D19Rik"
                     /note="PGC-1 and ERR-induced regulator in muscle 1;
                     peroxisome proliferator-activated receptor gamma
                     coactivator 1 and estrogen-related receptor-induced
                     regulator in muscle 1; PPARGC1 and ESRR-induced regulator
                     in muscle 1"
                     /codon_start=1
                     /product="PGC-1 and ERR-induced regulator in muscle
                     protein 1"
                     /protein_id="NP_766005.2"
                     /db_xref="CCDS:CCDS51406.1"
                     /db_xref="GeneID:74183"
                     /db_xref="MGI:MGI:1921433"
                     /translation="MDNFQYSVQLSDREWAEFSATADECGLLQADLASGDEPLSSDID
                     QGDSSGSSPPGPPPLFTGQLVSQGRGQQSRELEDVAAQQLVSRSQCEPVLALEASHQV
                     AGTSTQSEAPLFPSLDSVCPGQALSFPGPATCRDKMQRLLQGPAPSSPSKAPHSPESP
                     GHSDNPQSSPDSLEASPRNPGRKKRRAVGAKGTKHSGSLDSAATQMSSPQLTRPKEAL
                     MSGTLMAKAQQDKPQPDSTSPEQMAREESGLDLSTPILITEQDQIRKTSRAALHVVSK
                     PVQEVHPDVPMASPNVSTRASKPQPDVALPKPASKPQSDIASSTHPFTPDVSLSTLAF
                     KCQPNTNQSTPASEPDMALSTPASEPDTALSTPASEPDTALSTPASEPDTALSTPASR
                     SQLVKAEFASACTPGLHVDLSAAGSEIKPEVSSSMPAAVDVLRTDLPRSVSKTESKES
                     VSIPVKPSLSPISQAEAAMVDTGVSVPPGGSIEKPAGQFSAGSSGESCLGPVQAPKKK
                     KVRFSMAIPSHEDSGSGEPTGSPFLTPEQPPVPRTAAGSRGGSAAWDAVAVAPRLPQP
                     RILKHLPPPVSSVSAEAESGNCFAVTLPEAYEFFFCDTIEEEDEDVEDEEAASQALDE
                     VQWPDTCEFFFRDSRAQRSRCQRGHSPVSPPRADTVAPVPPEGLVPISIPEVYEHFFT
                     EEGFGHRQPAATPMQTSELSREGGLEASTKPVSPTAEHLSLTVRKAGELRSPLTSFTF
                     SQNDMCLVFVAFATWAVRTSDLQAPDAWKTVLLANIGTISAIRYFRRQVGRGHSGRPR
                     SSSSSNPSC"
     exon            2519..2644
                     /gene="Perm1"
                     /gene_synonym="2310042D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..3842
                     /gene="Perm1"
                     /gene_synonym="2310042D19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3823..3828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Perm1"
                     /gene_synonym="2310042D19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3842
                     /gene="Perm1"
                     /gene_synonym="2310042D19Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggcctctag atgatagctc catggcccta gctggctgct gagaaccagg actgtgacag
       61 tgtgtcgcag tactgttatt tggagttgaa ttggaaatag gggaaacgga agtagatatc
      121 tcactcagaa gaatgaagta gaagaagctg gaagaagcaa agtctgtccc gtggttcttc
      181 cagatagaaa tggactgcca gggagggggc aggtgctaca aggtcaggca ggatggtggc
      241 agtgtgtgct acttagtaca tggatcctgg atttgtgaag accctgcctg gcccaaagtc
      301 ttgccgtcac tccagcaccg ttgctgatgt gcaatggaca acttccagta cagcgtccag
      361 ctcagcgatc gggagtgggc cgagttttca gccactgctg atgagtgtgg cctcttgcag
      421 gctgacctgg cctctggtga cgagcccttg tccagtgaca ttgaccaagg ggacagcagt
      481 ggaagcagcc cccctgggcc cccacccctc ttcactgggc agctggtttc ccaagggagg
      541 ggacaacaga gccgtgagtt ggaggacgtg gctgctcagc agctggtcag caggtctcag
      601 tgtgagcctg tcctggctct ggaggccagt catcaggtag ccggcacgtc cacacagtca
      661 gaggcccctc tgttccccag cttagacagt gtctgtcctg gccaggcctt gtcctttcca
      721 gggccggcaa cttgcagaga caagatgcag aggcttttgc aaggccctgc ccctagctct
      781 cccagtaaag cccctcatag tcctgagtcc cctggccata gcgacaaccc tcagagttcc
      841 cctgacagcc tcgaagcttc accgcggaac cctggtcgta agaagaggcg tgctgtaggt
      901 gccaagggga ccaagcactc cggatctctg gactctgctg ctacccagat gagctcccca
      961 cagcttacca ggcccaagga ggctctcatg tctgggacac tgatggcaaa agcccagcag
     1021 gataagccac agcctgactc cacgagtcct gaacagatgg ccagagagga gtcaggcttg
     1081 gatctttcta cacctattct gataactgaa caagatcaga tcagaaagac atccagagct
     1141 gcgttacatg tggtatccaa acctgtccag gaagttcacc cagatgtccc catggcctca
     1201 ccaaatgtgt ctacacgtgc ctccaagcct caacccgacg tggctttgcc taaacctgcc
     1261 tccaagccgc agtctgacat agcttcgtct acacatccct tcacgcctga cgtgtctttg
     1321 tccacacttg ccttcaaatg tcaacccaat acaaatcagt ctacacccgc ctctgagcct
     1381 gacatggctt tgtctacacc tgcctctgag cctgacacgg ctttgtctac acccgcctct
     1441 gagcctgaca cggctttgtc tacacccgcc tctgagcctg acacggcttt gtctacaccc
     1501 gcctctaggt cgcaactggt gaaggctgaa tttgcgtctg cttgcacacc tggattgcat
     1561 gtggacctct ctgcagcagg ctcagagatc aagccagaag tttcttcctc tatgcctgcc
     1621 gcagtggatg tgcttcgtac agatctgcct cgttctgttt caaagactga gtctaaagag
     1681 agtgtgtcta tacctgttaa gccttcttta tcccctattt cccaggctga agctgccatg
     1741 gtggatacag gtgtgtctgt acctccaggg ggaagcattg agaagccagc agggcagttc
     1801 tcagcagggt cctcaggaga gtcctgccta ggtcccgtcc aagcccccaa gaagaagaaa
     1861 gtacgatttt ccatggctat ccccagccat gaagactcag ggtcagggga gcctacaggt
     1921 tcacccttcc taaccccgga gcagccccca gttcccagga cagcagcagg aagccgtggg
     1981 gggtctgcag cctgggatgc tgtggctgtc gcgccccgac tcccccagcc tcggatcctc
     2041 aagcacctgc ctcctcctgt atcctctgta tcagcagagg ctgagtctgg aaactgcttt
     2101 gcagtgactc tccctgaggc ctacgagttc ttcttctgtg acaccattga ggaggaagat
     2161 gaagacgtag aggacgaaga ggcagccagc caagccctgg atgaagtcca atggcctgac
     2221 acatgcgagt ttttttttcg ggatagcaga gcccaaagat caagatgtca gaggggacac
     2281 tctccagtct caccaccaag agcagacacc gtggcacctg tcccccctga aggcttggtg
     2341 cctatttcca tccctgaggt ctatgaacac ttcttcactg aggaaggatt tgggcacaga
     2401 cagcctgcgg ccactcctat gcagacctca gagctttcca gggaaggagg gcttgaggca
     2461 tccaccaagc ctgtttcacc tacagcggaa catcttagct taacagtcag gaaggcaggg
     2521 gaactacgga gccccctcac ttcatttacg ttcagtcaaa acgacatgtg cctggtgttt
     2581 gttgcctttg ccacttgggc tgtgagaacc tcagatctac aagccccaga tgcttggaaa
     2641 acagtcttgc tcgccaacat tggcaccatc tctgctatcc gctacttccg ccgtcaggtt
     2701 gggagaggcc atagtggcag accgagatcc agttccagct caaaccccag ctgctaggag
     2761 ccaggctggc ctggtgaagc atggagcacg aagacgaacc caggtgacaa ggacaagatg
     2821 ttgctcttct ctccactctt tgatccctgt cttctaaggc atgtaggaag gagacagtgc
     2881 ccttggtact gatttactta gactcaacct aagggtccag tcactgacta aggccaaggg
     2941 cattttccat acctgaaagt gggcactaag caaggagctg ggtaatagga tatcagaatt
     3001 gcaaggaaaa actacagggc acctagcaaa tttgaattta catgaaattc ctgaaatgta
     3061 cttatatgaa gaaatgggca ccctgccttt tgtctgatca taaataaaaa tgagcagcag
     3121 aagagggctc tacagtaagt gtcaaagcaa caaggcccct ctggacatgt ctaggccgag
     3181 atgaggctac caagtgtctt caaagctaga gggaggcagt ctgccctatt gaaaggcagg
     3241 cttggctggc tagggcctcc aaggccctga tccctgatcc ctgcacagct tgtgcaagcc
     3301 tggcctaagt cagtgactag gttctagggc agtggttctc agccttccta atggtgaacc
     3361 ctttaatagt ttctcctgtt gtagtactcc tcaaccataa tattattttc attgtgactt
     3421 cataactgaa attttgctac tgttatgaat cataatataa atatttttgg agctagaggg
     3481 ttctgtgcca caggttgaaa accattgctc tagggtatgc tccaggggtg gtttctgggg
     3541 cttctgcaat gtgggatcta tggggcaggg ttggatattc tccaagagcc ccggacagga
     3601 tatccataga atgtaatagc atcctatgga aggattgcct cctgatacta aagggagctt
     3661 gaaggaagcc aaggttggga gaagttgcag agtgggaagg taggcgaagg gactgaggtg
     3721 acacagtgat agtcagttca gggtggggtt ctacccaaga tagcagataa aggtccttag
     3781 gatggtggat tactctggct gctcagaggg gaacacagca ccaataaaat ctctttctcg
     3841 ttaaaaaaa
//
