LOCUS       NM_001370859            2810 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus proline and glutamate rich with coiled coil 1
            (Percc1), transcript variant 1, mRNA.
ACCESSION   NM_001370859
VERSION     NM_001370859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Oz-Levi,D., Olender,T., Bar-Joseph,I., Zhu,Y., Marek-Yagel,D.,
            Barozzi,I., Osterwalder,M., Alkelai,A., Ruzzo,E.K., Han,Y.,
            Vos,E.S.M., Reznik-Wolf,H., Hartman,C., Shamir,R., Weiss,B.,
            Shapiro,R., Pode-Shakked,B., Tatarskyy,P., Milgrom,R., Schvimer,M.,
            Barshack,I., Imai,D.M., Coleman-Derr,D., Dickel,D.E., Nord,A.S.,
            Afzal,V., van Bueren,K.L., Barnes,R.M., Black,B.L., Mayhew,C.N.,
            Kuhar,M.F., Pitstick,A., Tekman,M., Stanescu,H.C., Wells,J.M.,
            Kleta,R., de Laat,W., Goldstein,D.B., Pras,E., Visel,A., Lancet,D.,
            Anikster,Y. and Pennacchio,L.A.
  TITLE     Noncoding deletions reveal a gene that is critical for intestinal
            function
  JOURNAL   Nature 571 (7763), 107-111 (2019)
   PUBMED   31217582
  REMARK    GeneRIF: Percc1-knockout mice displayed phenotypes similar to those
            observed upon intestine-critical region (ICR) deletion in mice and
            patients, whereas an ICR-driven Percc1 transgene was sufficient to
            rescue the phenotypes found in mice that lacked the ICR; noncoding
            deletions identify a gene (Percc1) that is critical for intestinal
            function
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KY964488.1 and AC130711.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KY964488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2790              KY964488.1         1-2790
            2791-2810           AC130711.3         158153-158172       c
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17"
     gene            1..2810
                     /gene="Percc1"
                     /gene_synonym="Gm38655"
                     /note="proline and glutamate rich with coiled coil 1"
                     /db_xref="GeneID:102643076"
                     /db_xref="MGI:MGI:5621540"
     exon            1..195
                     /gene="Percc1"
                     /gene_synonym="Gm38655"
                     /inference="alignment:Splign:2.1.0"
     exon            196..2810
                     /gene="Percc1"
                     /gene_synonym="Gm38655"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1067
                     /gene="Percc1"
                     /gene_synonym="Gm38655"
                     /note="proline and glutamage-rich protein with a coiled
                     coil domain; protein LOC105371045 homolog"
                     /codon_start=1
                     /product="protein PERCC1"
                     /protein_id="NP_001357788.1"
                     /db_xref="CCDS:CCDS89018.1"
                     /db_xref="GeneID:102643076"
                     /db_xref="MGI:MGI:5621540"
                     /translation="MAAGVIRSVCDFRLPLPSHESFLPIDLEAPEISEEEEEEEEEEE
                     EEEEEEEVDQDQQGEGSQGCGPDSQSSGVVPQDPSSPETPMQLLRFSELISGDIQRYF
                     GRKDTGQDPDAQDIYADSQPASCSARDLYYADLVCLAQDGPPEDEEAAEFRMHLPGGP
                     EGQVHRLGHRGDRVPPLGPLAELFDYGLRQFSRPRISACRRLRLERKYSHITPMTQRK
                     LPPSFWKEPVPNPLGLLHVGTPDFSDLLASWSAEGGSELQSGGTQGLEGTQLAEV"
     regulatory      2773..2778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Percc1"
                     /gene_synonym="Gm38655"
                     /note="hexamer: ATTAAA"
     polyA_site      2810
                     /gene="Percc1"
                     /gene_synonym="Gm38655"
                     /note="major polyA site"
ORIGIN      
        1 gtgaggcagt ctttgggtac tccccccgca gggctctggt tgctgggcgc taaaacaaac
       61 gggctctgtt tgcccagtct gcgatgacaa tgccgttgcc aaatatttgc cagcctcagg
      121 cagttgtgga gcccagctat aaatgcttgc gccccaggtg gaggtgggcc tgctgagtga
      181 gctctgcagt ctcagcttgt gtctgctgct ccagggaacc ccagaatttt ggggacctca
      241 acaagatggc tgctggtgtt atacggtctg tctgtgactt ccggctgccc ctaccatcac
      301 atgagtcctt cctgcccata gacctggagg ctccagaaat ttctgaagaa gaggaggagg
      361 aagaagaaga ggaagaggaa gaggaggaag aagaagaggt agaccaggac cagcaaggtg
      421 aggggtcaca gggctgtggc ccagactccc agagctcagg agtagtccct caggacccca
      481 gcagccctga gaccccaatg cagcttctgc gcttctcaga gctcattagt ggtgacatcc
      541 agcggtattt tggacgcaag gacacagggc aagacccaga tgcccaagac atctatgctg
      601 acagccaacc agccagctgc tctgcccggg atctctacta tgctgatctg gtatgcctgg
      661 cacaggatgg gcccccagag gatgaggagg ctgctgagtt caggatgcat ttacctgggg
      721 ggcctgaggg tcaggtgcac aggctgggcc acagaggaga cagggtgcca ccactgggcc
      781 ccctggctga gctctttgat tatggccttc ggcagttctc caggcctaga atatcagctt
      841 gccgaagact aaggctagag cggaagtata gccacattac tcccatgacc caaagaaaat
      901 tgcctccatc cttctggaag gagcctgtgc ccaacccact aggcctactg cacgtgggca
      961 caccagattt tagtgatcta ctggccagct ggtctgctga gggtggttct gagctgcaga
     1021 gtggaggcac ccaaggcctg gaggggacac agttggctga ggtctagtga gtaggcaagt
     1081 caggagtgtg ccggggcaga gtggccattt ctaccctcag aacaacccag cacctcctgc
     1141 ctgtagcaca ggccctgccc tagtaggtct gtctaagtag tcatgcagtt agtgctctct
     1201 caagaggaga gcaggccatg aggatctgaa attgtgccaa gcctggaact gttgccacca
     1261 gtactgagag gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga
     1321 gagagagaga gagcccttat ccagacccgc cacacctggc taccagctcc ggctcttggt
     1381 ggaccccact atacacagca ggcctcagga ctctgcccag gggaagtgaa tggaactcag
     1441 gcaagaacta tggatcgcct gtacaccctt gcccttcatt atgaggccat ttccgagatg
     1501 caagtcagtg gcacagagca gctgggttgg gtctaaaacc aggccagccc tcctgtctct
     1561 gttgggctag agctggtggt tccatgtgtt gtgtcctcag ccaggcgggt ggcaggatta
     1621 ggggccacac gcagagtcca ggttttcttg agaggctaga agagggacac tgcctggtca
     1681 cagggacact gcctgatcac acagaaacct actagatgct cactctccag attcacgctc
     1741 acaagtggct tccttggcac ttcagtgtta gtgagtgggt gggtggggct gaggatgtct
     1801 gaggaccctg tcctcagtct tcacatttgt cctcataggc aacaggggta tgtcctgaga
     1861 ggtgtggcct gggtgcccct gcacacaact cccagggaac ctgagagctt gaccttgcac
     1921 gaggcggggc aggaggggtc cttcaggtct aataacctca ggccttctga gtgtggtccc
     1981 tctcactact tgacaccctt gtcaggcctg tgagctgtgg aaaagccatt ccatcagata
     2041 acaggagact ctggcgccag taggtacaag aactggcatg tttatttctg gaacacagtc
     2101 agagatgtga cctcatatgc aggcttccac tgggtcatcg ctgaggtcac tccgggcctt
     2161 ttctgggcca ccaagttcaa gaggaatctc ttccaacgaa gccacctgcc cagagacgtg
     2221 gctcatacac aacacagccc ctgtggctgt gctactaccc ttgggagacc caggctctca
     2281 gctgcccacc tcacagcctg gtacactccc caggagttca cagagaccat tgcgtccagg
     2341 gctacgtcct tgatgaagaa ccgctgcctc accagggaca tgaatacccg cttgctgccc
     2401 agggtcagtg gccagggacc ctcctcactc cacaggcgca gcatgctctc acgcagggtt
     2461 gcaatctcct ctgtgcgctg caagtgcaga gagatggggc caagaggacc catggagagc
     2521 aagacaagta cagagaagtg ggacttggat cacagtggtg ggtggcagat gtgtgtatgt
     2581 ggggactgct cctgtagagg aagcccagtg ggggggggca gttttcacct ccaggaagca
     2641 ctgttcagca ccacccagct aatgtattcc ggggccctgg agagatggga acagagcgac
     2701 tcggggcagg ctggcagagt gtgaggggtc agcggttctc ccagagtttt ctctcaccag
     2761 cttggtctca ttattaaact tcaggttctg gatggttttg ttggcctgaa
//
