LOCUS       NM_011067               5996 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus period circadian clock 3 (Per3), transcript variant 2,
            mRNA.
ACCESSION   NM_011067
VERSION     NM_011067.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5996)
  AUTHORS   Xie,X., Xu,H., Shu,R., Sun,L., Zhang,M., Hu,Q., Zhu,K., Li,Z. and
            Wu,F.
  TITLE     Clock gene Per3 deficiency disrupts circadian alterations of gut
            microbiota in mice
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (12), 2004-2007 (2023)
   PUBMED   37964605
  REMARK    GeneRIF: Clock gene Per3 deficiency disrupts circadian alterations
            of gut microbiota in mice.
REFERENCE   2  (bases 1 to 5996)
  AUTHORS   Ehichioya,D.E., Taufique,S.K.T., Farah,S. and Yamazaki,S.
  TITLE     A time memory engram embedded in a light-entrainable circadian
            clock
  JOURNAL   Curr Biol 33 (23), 5233-5239 (2023)
   PUBMED   37951213
REFERENCE   3  (bases 1 to 5996)
  AUTHORS   Nakamura,T.J., Takasu,N.N., Sakazume,S., Matsumoto,Y., Kawano,N.,
            Pendergast,J.S., Yamazaki,S. and Nakamura,W.
  TITLE     Long days restore regular estrous cyclicity in mice lacking
            circadian rhythms
  JOURNAL   Heliyon 9 (6), e16970 (2023)
   PUBMED   37484286
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5996)
  AUTHORS   Van der Veen,D.R., Laing,E.E., Bae,S.E., Johnston,J.D., Dijk,D.J.
            and Archer,S.N.
  TITLE     A Topological Cluster of Differentially Regulated Genes in Mice
            Lacking PER3
  JOURNAL   Front Mol Neurosci 13, 15 (2020)
   PUBMED   32116548
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5996)
  AUTHORS   Wu,H., Li,L., Chen,K.M., Homolka,D., Gos,P., Fleury-Olela,F.,
            McCarthy,A.A. and Pillai,R.S.
  TITLE     Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic
            Surveillance of NAD-Capped RNAs
  JOURNAL   Cell Rep 29 (13), 4422-4434 (2019)
   PUBMED   31875550
REFERENCE   6  (bases 1 to 5996)
  AUTHORS   Zylka,M.J., Shearman,L.P., Levine,J.D., Jin,X., Weaver,D.R. and
            Reppert,S.M.
  TITLE     Molecular analysis of mammalian timeless
  JOURNAL   Neuron 21 (5), 1115-1122 (1998)
   PUBMED   9856466
REFERENCE   7  (bases 1 to 5996)
  AUTHORS   Sangoram,A.M., Saez,L., Antoch,M.P., Gekakis,N., Staknis,D.,
            Whiteley,A., Fruechte,E.M., Vitaterna,M.H., Shimomura,K.,
            King,D.P., Young,M.W., Weitz,C.J. and Takahashi,J.S.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
REFERENCE   8  (bases 1 to 5996)
  AUTHORS   Takumi,T., Taguchi,K., Miyake,S., Sakakida,Y., Takashima,N.,
            Matsubara,C., Maebayashi,Y., Okumura,K., Takekida,S., Yamamoto,S.,
            Yagita,K., Yan,L., Young,M.W. and Okamura,H.
  TITLE     A light-independent oscillatory gene mPer3 in mouse SCN and OVLT
  JOURNAL   EMBO J 17 (16), 4753-4759 (1998)
   PUBMED   9707434
REFERENCE   9  (bases 1 to 5996)
  AUTHORS   Zylka,M.J., Shearman,L.P., Weaver,D.R. and Reppert,S.M.
  TITLE     Three period homologs in mammals: differential light responses in
            the suprachiasmatic circadian clock and oscillating transcripts
            outside of brain
  JOURNAL   Neuron 20 (6), 1103-1110 (1998)
   PUBMED   9655499
REFERENCE   10 (bases 1 to 5996)
  AUTHORS   Albrecht,U., Sun,Z.S., Eichele,G. and Lee,C.C.
  TITLE     A differential response of two putative mammalian circadian
            regulators, mper1 and mper2, to light
  JOURNAL   Cell 91 (7), 1055-1064 (1997)
   PUBMED   9428527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607143.14.
            
            On Feb 4, 2014 this sequence version replaced NM_011067.2.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            Clock/Arntl heterodimers but then represses this upregulation in a
            feedback loop using Per/Cry heterodimers to interact with
            Clock/Arntl. Polymorphisms in this gene have been linked to sleep
            disorders. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is 1 aa
            shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF050182.1, AB013605.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               AL607143.14        123013-123570       c
            559-704             AL607143.14        122464-122609       c
            705-820             AL607143.14        121581-121696       c
            821-1022            AL607143.14        120177-120378       c
            1023-1071           AL607143.14        116794-116842       c
            1072-1211           AL607143.14        112762-112901       c
            1212-1290           AL607143.14        110818-110896       c
            1291-1397           AL607143.14        108041-108147       c
            1398-1554           AL607143.14        107654-107810       c
            1555-1660           AL607143.14        105018-105123       c
            1661-1789           AL607143.14        103977-104105       c
            1790-1919           AL607143.14        103315-103444       c
            1920-2055           AL607143.14        97757-97892         c
            2056-2171           AL607143.14        97123-97238         c
            2172-2339           AL607143.14        96804-96971         c
            2340-2567           AL607143.14        92447-92674         c
            2568-3259           AL607143.14        91146-91837         c
            3260-3356           AL607143.14        89307-89403         c
            3357-3540           AL607143.14        88155-88338         c
            3541-3691           AL607143.14        87133-87283         c
            3692-5996           AL607143.14        82560-84864         c
FEATURES             Location/Qualifiers
     source          1..5996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 81.53 cM"
     gene            1..5996
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /note="period circadian clock 3"
                     /db_xref="GeneID:18628"
                     /db_xref="MGI:MGI:1277134"
     exon            1..558
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..3775
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     period circadian protein homolog 3; period homolog 3;
                     circadian clock protein PERIOD 3"
                     /codon_start=1
                     /product="period circadian protein homolog 3 isoform 2"
                     /protein_id="NP_035197.2"
                     /db_xref="CCDS:CCDS18978.1"
                     /db_xref="GeneID:18628"
                     /db_xref="MGI:MGI:1277134"
                     /translation="MDPCGDPAVPGGDCPQTRGPGLQGASGQEGPLQGTCVDSSHSEH
                     EDRNRMSEELIMVVQEMKKYFPAERHTKPSTLDALNYALRCVHSVQANSDFFQSLGPR
                     GAHQADVTVYSLEDLTALASEHTSKNTDTFAAVFSFLSGRLVHISEQAALILNSKRGF
                     LKSVHFVDLLAPQDVRAFYAHTAPTQLPFWNNWTQRASQYECAPAKPFFCRICGGGDR
                     EKRHYSPFRILPYLVHVHSSAQPEPEPCCLTLVEKIHSGYEAPRIPVDKRIFTTTHTP
                     GCVFLEVDERAVPLLGYLPQDLIGTSILTYLHPEDRPLMVAIHQKVLKYAGHPPFEHS
                     PVRFCTQNGEYVILDSSWSSFVNPWSRKVSFIIGRHKVRTSPLNEDVFATRIKKAASN
                     DKDIAELQEQIHKLLLQPVHASASSGYGSLGSSGSQEQHVSITSSSESSGHCPEEGQH
                     EQMTLQQVYASVNKIKNVGQQLYIESMARSSVKPVAETCVEPQGGDEQKDFSSSQTLK
                     NKSTTDTGSGGNLQQEQPSSSYQQMNCIDSVIRYLTSYSLPALKRKCISCTNTSSSSE
                     EAKPIPEVDSSQRDTEQLLDIRKQETTGPSTDIEGGAARTLSTAALSVASGISQCSCS
                     STSGHAPPLQSESVAVACKPWALRTKASHLAAGGFKHVGLTAAVLSAHTQKEEQNYVD
                     RFREKILTSPYGCYLQQESRNRAQYSCVQAGSTAKHSRCAGSERQKHKRKKLPAPVDT
                     SSPGAHLCPHVTGLLPDEQHWGPSASPSPLGAGLAFPSALVVPSQTPYLLPSFPLQDM
                     ASQGVGVSAAWGAAAGCPPLSAGPQAVAAFPSAYVDTLMTIFLHNAPLFPLWPPSFSP
                     YPSLGAAGSSELAPLVPAMAPNPEPTTSGHSQRRVEENWEAHSEELPFISSRSSSPLQ
                     LNLLQEEMPAPSESADAVRRGAGPDAKHHCVTGPSGSRSRHCTSGELATATAQQESAA
                     ASGSSASSIYFSSTDYASEVSENRQRPQDRQRDEALPGAAEESIWRMIERTPECVLMT
                     YQVPERGREEVLKQDLEKLQSMEQQQPLFSPAQREELAKVRSWIHSHTAPQEGHLQSC
                     VACEDRGSVGDTAEVLEQHPAEDTS"
     exon            559..704
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            705..820
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1022
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1071
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1211
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1290
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1397
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1554
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1660
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1789
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1919
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2055
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2171
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2339
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2567
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..3259
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..3356
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3540
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3691
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..5996
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5970..5975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /note="hexamer: AATAAA"
     polyA_site      5996
                     /gene="Per3"
                     /gene_synonym="2810049O06Rik; mPer3"
                     /note="major polyA site"
ORIGIN      
        1 gagactggac tgcccgcggg tgggcgaggc tctgcggggc ggcggcgagt tgctcggctg
       61 gcgggacgcc tgcgagcccg cacggccggg cgctgctgcc cctgccttct gcccggtcac
      121 gccggacgtt gctctctgag gtgtttctcg atgctcgccg gcttcccagc aaggacggtg
      181 gaaaagttgt tgcaggctga ccgcgctccc tgagagcccc gctggtggtc cgtccagcca
      241 gcttccgcca tcgagctgtc gctgtagctc gtcaccccag cagagtctgt ggaaatgctg
      301 aggagaaaag tgcccctcag atgagcgtgg tcggcgacca gtctttcccg aaggcgatgg
      361 cagggaccaa aacaagccgg gtttggttgc tagctgcaaa ctgagagaag caggctgagg
      421 gctgccaggc gggatggatc cctgtggaga cccggcagta cctggtggcg actgtcccca
      481 gactagggga ccggggctcc agggggcgtc tggccaggag ggtcctctgc agggcacttg
      541 cgtggacagc agccacagtg aacacgaaga ccgaaacaga atgtctgaag agcttataat
      601 ggttgtccaa gaaatgaaaa agtatttccc agccgagagg cacactaagc ccagtaccct
      661 agatgctctt aactatgccc tgcgctgtgt acacagtgtg caagcaaaca gtgacttttt
      721 ccagagtctc ggtccacgcg gagcacacca ggcagatgtg actgtataca gtcttgagga
      781 cctcaccgct ctggcttctg aacatacttc taagaacaca gataccttcg cggccgtgtt
      841 ttcgtttctg tctggaaggt tagtgcacat ttctgagcag gctgctttga tcctgaattc
      901 taagaggggt ttcctcaaga gcgtgcactt tgtcgacctg cttgcccctc aagacgtgag
      961 ggcgttctac gcgcacactg ctccaactca gcttcctttc tggaacaact ggacccaaag
     1021 agcctcgcag tatgaatgtg caccagcgaa accctttttc tgcagaatct gtggaggtgg
     1081 agacagagag aagaggcatt actccccatt ccggatcctc ccctatttgg ttcatgtaca
     1141 tagctctgcc cagccagaac cagagccttg ctgtctaaca ctggttgaaa agattcactc
     1201 tggttacgaa gctcctcgaa tccctgtaga taaaagaatt tttaccacaa cacacactcc
     1261 aggatgtgtg tttcttgaag tagatgaaag agcagtgcct ttgctgggtt acctacctca
     1321 ggatctgatt ggaacatcga tcttaacata cttgcaccca gaagatcggc ctctgatggt
     1381 tgccatacac caaaaagttt taaagtatgc cggccaccct ccgtttgaac actcgcccgt
     1441 cagattctgc actcagaacg gagagtatgt cattctggat tccagctggt ccagctttgt
     1501 caacccctgg agccggaagg tctccttcat cattggtcga cataaagtcc gaacgagtcc
     1561 attaaatgaa gatgtttttg ccaccagaat aaaaaaggca gccagtaacg acaaagacat
     1621 agcagaatta caagaacaaa ttcacaaact tctcttgcag ccggttcatg ctagtgcttc
     1681 cagtggctac gggagcctgg gcagcagcgg ctcacaggag cagcacgtca gcatcacctc
     1741 ttcgagtgag tccagcgggc actgtccgga ggaaggccag catgagcaga tgaccctgca
     1801 gcaggtctat gccagtgtaa acaaaattaa gaatgtgggc caacagctct acatcgagtc
     1861 catggccaga tcatcagtga agccagtggc agagacgtgc gtggaaccgc agggtggtga
     1921 tgagcagaag gacttttctt cctctcagac actgaaaaat aaaagcacca cggatactgg
     1981 ctccggtggc aatctgcagc aagagcagcc cagctcgtcc tatcagcaga tgaactgtat
     2041 cgacagtgtc atcaggtacc tgacaagcta cagcctcccg gccttgaaaa gaaagtgcat
     2101 ctcctgcaca aacacatctt catcctcaga agaagccaag ccaatcccgg aggtggacag
     2161 cagccagaga gacacggaac agctcctgga catacggaaa caggaaacaa ctggaccatc
     2221 cacagacatc gaaggaggtg ctgctcggac cctgtccacc gccgcactga gcgtggcgtc
     2281 tggcatcagc cagtgcagct gcagcagcac ctctggccac gctccgcccc tacagtcaga
     2341 aagtgttgcc gtggcgtgta agccgtgggc cctgagaacg aaggcctctc acctggctgc
     2401 aggaggattt aagcacgtgg ggctcacagc agctgtcctc tctgcacaca cacagaagga
     2461 agagcagaac tacgttgaca ggttccggga aaagatcctg acctcgccct acggttgcta
     2521 tcttcagcaa gagagcagaa accgtgctca gtactcctgt gttcaagcag ggtccactgc
     2581 taagcacagc agatgtgctg gaagcgagag gcagaagcac aaacgaaaga agttgccagc
     2641 acctgtggac accagcagcc ccggtgccca cctctgtccc catgtcacag gactcctccc
     2701 ggatgagcag cactggggcc catccgctag cccctccccc ctcggcgcag gcttagcatt
     2761 cccctcggcc ctggtagttc ccagccagac cccttatctc ctcccctctt ttcccctcca
     2821 agatatggcc tctcagggag tgggggtctc ggcagcctgg ggagctgcag ccggatgtcc
     2881 acctctgtcc gccggccccc aggctgttgc cgcgttcccc tccgcttacg tggatacttt
     2941 gatgaccatc ttcctgcaca acgcccctct cttccctctg tggccgccct cgttctcccc
     3001 atacccatcc ctgggggccg cagggtcttc tgaactggca cccttagtac cagcaatggc
     3061 tccaaacccg gaaccaacca cttcaggcca cagccaaagg agagtggagg agaactggga
     3121 ggcacacagt gaagagcttc cgttcattag ctcacggagc agttcaccgt tacagttaaa
     3181 tttactccag gaagaaatgc ctgcgccgtc agagtccgca gacgcagtga gaagaggcgc
     3241 tgggccagac gctaagcatc actgtgttac aggtcccagt ggcagtagga gccgtcactg
     3301 cacctctggt gagctggcca cggcaacagc gcagcaggag tctgctgctg cctcaggaag
     3361 cagtgccagc agtatatact tcagtagcac tgactatgct tctgaagtct ctgaaaacag
     3421 acagaggcca caggatagac agagagacga agcccttccc ggggcggctg aagagtccat
     3481 ctggagaatg atagagcgga caccagagtg tgttctcatg acataccagg tgcccgagag
     3541 gggtcgagag gaggtgctga agcaggacct ggagaagctc cagagcatgg aacagcagca
     3601 gcccctgttc tctcccgcgc agagggagga gctggccaag gtgcgctcct ggatccacag
     3661 ccacacagcc cctcaggagg gacacctcca gagctgtgtc gcctgtgaag acagaggttc
     3721 agtgggtgac actgcagagg tcctggaaca gcacccagca gaagacacca gttgagcagc
     3781 tgtaaagatg tcacaccccc tccaggtcac gtgggacaca gagccgtgcg ttacctcacc
     3841 acagtctaac tctgaaacgc cagtcattga cattaaggtc ttccctggct ttgttctggt
     3901 ttggttttgg tggcgctggg gatcaaaccc agggcctcac atccactagg ctggcactct
     3961 ccactgctga cctgtctccc caggtctccc ttcttggttt tcccaaaaca tgagcagacg
     4021 ttggctcttg ttcatgatag taaaacagtc aacaagacgt cttctctaac tcatctgtca
     4081 cctgaagaca ttgggctgtg tctgacagca gatttcagag gtcaccctga gtaagttaca
     4141 gttggaacga gtcgcaggcc ttcgtctcgt ttgctttttt atgttgttac aagatcactt
     4201 tcccactaga atacttgaag aacttctgtc tgtaggttgt gtgtttctca cggggtgtcc
     4261 gtgaacttac cacattgatc taggttttgt acagcatggt gcttctcttc ctgatggtaa
     4321 gacattccag ctttctctca gagcgtcaga gcgcatcatt ccccaggaac tgtgggactc
     4381 gtggctttgg ttgtttgacc ccattctcgt ccatgaagtt cctgtggcag ctgcctttca
     4441 caggggctct ttccttaaga tctgtcagct agccaggact tactccttgg atgactgaag
     4501 ttaagccttg catggcaaaa agcttcttac ccaaacaata gtgttttcaa cagttttaaa
     4561 tattacgtta atgttatcat ggagatgtgt gtgccccggc tcaccaaaac aaacagttaa
     4621 cctttccttt tcaccaaacg acacgatgac gaccagcggt ctgccttttg tttgcccttg
     4681 aagaggggta agagtttggg agactacact taagggagct cggggacccc agctcggtga
     4741 cagcagagtc ccatgagtcc acgctctcca ggcagtttct gcctcagaag tgagtgtgat
     4801 tgttcacgcg tctgtcctct cactgtctgg tgctctggtt taaagaagcc caaagttcct
     4861 tcttgaactc gagatggcag tggagccacc cgtgcaggtc aggaaggaac tgacggggag
     4921 gaggtttaca gtggcctttt cctgcttcac ttcctgcagt ccaacttact tctctttctt
     4981 ttctttttct ttttctttct tctttttttt tttttttttt ttttttggct gttgtttttg
     5041 ctttgtttta ggaacacttt gttctcctct gacagtttat agctattgat aactgtattg
     5101 tcattgtggt caggagactg tcatagaggc cgctgtaccc agtgctccca actctgtggc
     5161 tcagacttct tttctaaaat agtgcttttt ctggaccgca gttctattgg aaggtgtcag
     5221 aaacatttta agatgctgcc tgtgacattt cttggagctt tctggtattg agcagttcct
     5281 gacacgtgtt cctgctgtgt gaacagagag acttctcaga acctagtcca tcctggtagt
     5341 gaagtgattt gggaggcctg cgtttgtcag gttggccttc tctagcgaag ctaccaggat
     5401 ccttctgcgt ttctgtacat acagcagacc tgatggtctc tggttcctgc tggttctgga
     5461 tccccgtttt ctctgcagtt ccttatttcc ttgcctttgt ccacacctta tggagtctgt
     5521 attatgccag gcttgatttg aaaatggtgc tgtagtcagg tctgtaaagt cctttaccac
     5581 gtctcacctc tgctaggatg ccatcagtac accggcaatc tctgctgctg tgggctggtc
     5641 cagcagagcc tgctgccccc catgggggtc atacccagtg gaaactcaag ctcactgact
     5701 tgtgtattaa taactagaga attggtaaga aaagtgtgtg ttgtagactt gaatgtctac
     5761 ataaatattc cccccaaagc tttattttct tgggtcagag gtcaaaattt atgaaaatag
     5821 gatgtgtaaa taaatggatt aaataaaata ttataattca caaggtggca aactttaacc
     5881 aaattggcaa tttgttcata attaactgtg aatttgcttg tacttagtgg acatttatct
     5941 tttcattggg tatctttttg agtaaaaaca ataaacagta tatgtgttca agtgga
//
