LOCUS       NM_011066               5845 bp    mRNA    linear   ROD 10-APR-2023
DEFINITION  Mus musculus period circadian clock 2 (Per2), mRNA.
ACCESSION   NM_011066
VERSION     NM_011066.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5845)
  AUTHORS   Kong X, Luxwolda M, Hut RA and Meerlo P.
  TITLE     Adrenalectomy prevents the effects of social defeat stress on PER2
            rhythms in some peripheral tissues in male mice
  JOURNAL   Horm Behav 150, 105326 (2023)
   PUBMED   36764158
  REMARK    GeneRIF: Adrenalectomy prevents the effects of social defeat stress
            on PER2 rhythms in some peripheral tissues in male mice.
REFERENCE   2  (bases 1 to 5845)
  AUTHORS   Miyake T, Inoue Y, Shao X, Seta T, Aoki Y, Nguyen Pham KT, Shichino
            Y, Sasaki J, Sasaki T, Ikawa M, Yamaguchi Y, Okamura H, Iwasaki S
            and Doi M.
  TITLE     Minimal upstream open reading frame of Per2 mediates phase fitness
            of the circadian clock to day/night physiological body temperature
            rhythm
  JOURNAL   Cell Rep 42 (3), 112157 (2023)
   PUBMED   36882059
  REMARK    GeneRIF: Minimal upstream open reading frame of Per2 mediates phase
            fitness of the circadian clock to day/night physiological body
            temperature rhythm.
REFERENCE   3  (bases 1 to 5845)
  AUTHORS   Park J, Lee K, Kim H, Shin H and Lee C.
  TITLE     Endogenous circadian reporters reveal functional differences of
            PERIOD paralogs and the significance of PERIOD:CK1 stable
            interaction
  JOURNAL   Proc Natl Acad Sci U S A 120 (6), e2212255120 (2023)
   PUBMED   36724252
  REMARK    GeneRIF: Endogenous circadian reporters reveal functional
            differences of PERIOD paralogs and the significance of PERIOD:CK1
            stable interaction.
REFERENCE   4  (bases 1 to 5845)
  AUTHORS   Alexandrou AT, Duan Y, Xu S, Tepper C, Fan M, Tang J, Berg J,
            Basheer W, Valicenti T, Wilson PF, Coleman MA, Vaughan AT, Fu L,
            Grdina DJ, Murley J, Wang A, Woloschak G and Li JJ.
  TITLE     PERIOD 2 regulates low-dose radioprotection via
            PER2/pGSK3beta/beta-catenin/Per2 loop
  JOURNAL   iScience 25 (12), 105546 (2022)
   PUBMED   36465103
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5845)
  AUTHORS   Yoshioka H, Tominaga S, Suzui M, Shinohara Y, Maeda T and Miura N.
  TITLE     Involvement of Npas2 and Per2 modifications in zinc-induced acute
            diurnal toxicity in mice
  JOURNAL   J Toxicol Sci 47 (12), 547-553 (2022)
   PUBMED   36450499
  REMARK    GeneRIF: Involvement of Npas2 and Per2 modifications in
            zinc-induced acute diurnal toxicity in mice.
REFERENCE   6  (bases 1 to 5845)
  AUTHORS   Takumi T, Taguchi K, Miyake S, Sakakida Y, Takashima N, Matsubara
            C, Maebayashi Y, Okumura K, Takekida S, Yamamoto S, Yagita K, Yan
            L, Young MW and Okamura H.
  TITLE     A light-independent oscillatory gene mPer3 in mouse SCN and OVLT
  JOURNAL   EMBO J 17 (16), 4753-4759 (1998)
   PUBMED   9707434
REFERENCE   7  (bases 1 to 5845)
  AUTHORS   Sassone-Corsi,P.
  TITLE     Molecular clocks: mastering time by gene regulation
  JOURNAL   Nature 392 (6679), 871-874 (1998)
   PUBMED   9582067
REFERENCE   8  (bases 1 to 5845)
  AUTHORS   Takumi T, Matsubara C, Shigeyoshi Y, Taguchi K, Yagita K,
            Maebayashi Y, Sakakida Y, Okumura K, Takashima N and Okamura H.
  TITLE     A new mammalian period gene predominantly expressed in the
            suprachiasmatic nucleus
  JOURNAL   Genes Cells 3 (3), 167-176 (1998)
   PUBMED   9619629
REFERENCE   9  (bases 1 to 5845)
  AUTHORS   Albrecht U, Sun ZS, Eichele G and Lee CC.
  TITLE     A differential response of two putative mammalian circadian
            regulators, mper1 and mper2, to light
  JOURNAL   Cell 91 (7), 1055-1064 (1997)
   PUBMED   9428527
REFERENCE   10 (bases 1 to 5845)
  AUTHORS   Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF Jr and Reppert SM.
  TITLE     Two period homologs: circadian expression and photic regulation in
            the suprachiasmatic nuclei
  JOURNAL   Neuron 19 (6), 1261-1269 (1997)
   PUBMED   9427249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY315400.1, AK044658.1, AF035830.1, AK159847.1 and AF036893.1.
            
            [WARNING] On May 9, 2023 this sequence was replaced by NM_011066.4.
            
            On Jul 25, 2007 this sequence version replaced NM_011066.2.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            Clock/Arntl heterodimers but then represses this upregulation in a
            feedback loop using Per/Cry heterodimers to interact with
            Clock/Arntl. Polymorphisms in this gene may increase the risk of
            getting certain cancers and have been linked to sleep disorders.
            [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165556.1, AF036893.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               BY315400.1         3-214
            213-830             AK044658.1         158-775
            831-3997            AF035830.1         778-3944
            3998-5347           AK159847.1         3987-5336
            5348-5845           AF036893.1         5319-5816
FEATURES             Location/Qualifiers
     source          1..5845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..5845
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /note="period circadian clock 2"
                     /db_xref="GeneID:18627"
                     /db_xref="MGI:MGI:1195265"
     exon            1..156
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..395
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..3948
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /note="period 2; circadian clock protein PERIOD 2; period
                     homolog 2"
                     /codon_start=1
                     /product="period circadian protein homolog 2"
                     /protein_id="NP_035196.2"
                     /db_xref="CCDS:CCDS35663.1"
                     /db_xref="GeneID:18627"
                     /db_xref="MGI:MGI:1195265"
                     /translation="MNGYVDFSPSPTSPTKEPGAPQPTQAVLQEDVDMSSGSSGNENC
                     STGRDSQGSDCDDNGKELRMLVESSNTHPSPDDAFRLMMTEAEHNPSTSGCSSEQSAK
                     ADAHKELIRTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSE
                     SQPCSVDVPSYSMEQVEGITSEYIVKNADMFAVAVSLVSGKILYISNQVASIFHCKKD
                     AFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVCSGLDSFTQECMEEKSFFCRVSVGK
                     HHENEIRYQPFRMTPYLVKVQEQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTT
                     HTPNCLFQAVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQAGGQPFD
                     YSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAASPCPEE
                     KTPHPSVQELTEQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGQEESH
                     RRRSGIFKTSGKIQTKSHVSHESGGQKEASVAEMQSSPPAQVKAVTTIERDSSGASLP
                     KASFPEELAYKNQPPCSYQQISCLDSVIRYLESCSEAATLKRKCEFPANIPSRKATVS
                     PGLHSGEAARPSKVTSHTEVSAHLSSLTLPGKAESVVSLTSQCSYSSTIVHVGDKKPQ
                     PELETVEDMASGPESLDGAAGGLSQEKGPLQKLGLTKEVLAAHTQREEQGFLQRFREV
                     SRLSALQAHCQNYLQERSRAQASDRGLRNTSGLESSWKKTGKNRKLKSKRVKTRDSSE
                     STGSGGPVSHRPPLMGLNATAWSPSDTSQSSCPSAPFPTAVPAYPLPVFQAPGIVSTP
                     GTVVAPPAATHTGFTMPVVPMGTQPEFAVQPLPFAAPLAPVMAFMLPSYPFPPATPNL
                     PQAFLPSQPHFPAHPTLASEITPASQAEFPSRTSTLRQPCACPVTPPAGTVALGRASP
                     PLFQSRGSSPLQLNLLQLEEAPEGSTGAAGTLGTTGTAASGLDCTSGTSRDRQPKAPP
                     TCNEPSDTQNSDAISTSSDLLNLLLGEDLCSATGSALSRSGASATSDSLGSSSLGFGT
                     SQSGAGSSDTSHTSKYFGSIDSSENNHKAKMIPDTEESEQFIKYVLQDPIWLLMANTD
                     DSIMMTYQLPSRDLQAVLKEDQEKLKLLQRSQPRFTEGQRRELREVHPWVHTGGLPTA
                     IDVTGCVYCESEEKGNICLPYEEDSPSPGLCDTSEAKEEEGEQLTGPRIEAQT"
     exon            396..461
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..616
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..738
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..940
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..992
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1135
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1214
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1321
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1475
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1584
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1710
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1795
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1958
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2065
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2230
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2470
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..3267
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3454
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3647
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3798
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..5837
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgcggtc acgttttcca ctatgtgaca gcggagggcg acgcggcggc agcggcgcta
       61 ctgggactag cggctccggg cggctgcggc gcaggccgag cgcaccaagt gacgggccga
      121 gcaagggaca gacgcgcggg ttgacgcggc gaagcgctta ttccagagcc cgacatgaat
      181 ggatacgtgg acttctcccc aagtcccacc agtcccacca aggagccagg ggcacctcag
      241 cccacccagg ctgtgctcca ggaagacgtg gacatgagca gtggctccag cggaaacgag
      301 aactgctcca cgggacggga ctctcagggc agtgactgcg acgacaatgg gaaggagctg
      361 cggatgctcg tggaatcttc caacactcac cccagccctg atgatgcctt cagactcatg
      421 atgacagagg cagagcacaa cccctccacg agcggctgca gtagtgagca gtctgccaaa
      481 gctgacgcac acaaagaact gataaggacc ctgaaggagc tgaaggtcca cctccctgca
      541 gacaagaagg ccaaggggaa ggccagcacg ctggcaacct tgaagtatgc cctgcggagc
      601 gtgaagcagg tgaaggctaa tgaggagtac taccagctgc taatgtccag tgagagccag
      661 ccctgcagtg tggatgtgcc ttcctacagc atggagcagg ttgagggcat tacctccgag
      721 tatatcgtga agaacgcgga tatgtttgct gtggctgtgt ccctggtttc tgggaagatc
      781 ctgtacatct ctaaccaagt ggcctccatc tttcactgta agaaggacgc cttcagtgat
      841 gccaagtttg tggagttcct ggctcctcat gacgtcagtg tgttccacag ctacaccacc
      901 ccttacaagc ttccgccctg gagtgtgtgc agcggcttag attctttcac tcaggagtgc
      961 atggaggaga aatctttttt ctgccgtgtc agtgttggga aacaccacga gaatgagatt
     1021 cgctaccagc ccttccgcat gacaccctac ctggtcaagg tgcaagagca gcagggtgct
     1081 gagagccagc tctgctgcct gctgctggca gagagggtac actcgggcta tgaagcgcct
     1141 agaatccctc ctgagaagag gatcttcaca acaacccaca caccaaactg cttgttccag
     1201 gctgtggatg aaagggcggt ccccctcctg ggctatctac ctcaggatct gatcgagacg
     1261 cctgtgctcg tgcagctcca ccccagcgac cggcccttga tgctcgccat ccacaagaag
     1321 atcctacagg ccggtggaca gcctttcgat tattctccca ttcgattccg cacccgcaac
     1381 ggggagtaca tcacactgga cactagctgg tccagcttca tcaacccgtg gagcaggaag
     1441 atatctttca tcattgggag gcacaaagtc agggtaggcc ctttgaatga ggatgtgttc
     1501 gcagcctccc cgtgcccaga ggagaagact ccgcacccca gcgttcagga gctcacagaa
     1561 caaatccacc ggctactgat gcagcctgtc ccccacagcg gctccagtgg ctatgggagc
     1621 ctgggcagta acggatccca cgaacacctc atgagccaga catcatccag cgacagcaat
     1681 ggccaagagg agtctcaccg gaggagatcc ggaattttta aaaccagtgg caagattcaa
     1741 accaaaagtc acgtttctca tgagtctgga ggacagaagg aagcatctgt tgcagaaatg
     1801 caaagcagcc ccccagctca ggtgaaagct gtcaccacca tagaaaggga cagctcaggg
     1861 gccagcctac ccaaggccag cttcccagag gaactagcct ataagaacca gcctccttgc
     1921 tcctaccagc agatcagctg cctggacagt gtcatcaggt acctggagag ctgcagcgag
     1981 gcagccaccc tgaaaaggaa gtgcgagttc ccagccaaca tcccatcccg gaaggccaca
     2041 gtcagccccg ggctgcactc tggagaggca gcgcggccct ccaaggtgac cagccacaca
     2101 gaggtcagtg ctcacctgag ctccctgacg ctgccaggca aggccgagag tgtggtgtcc
     2161 ctcaccagcc agtgcagcta cagcagcacc atcgtgcatg tgggcgacaa aaagccacag
     2221 cccgagctag agacggtaga agatatggcc agtgggcccg agtccctgga tggtgcggcc
     2281 ggcggcctca gccaagaaaa ggggcctctt cagaagttgg gcctcaccaa ggaagttctg
     2341 gctgcacata cacagagaga ggagcagggc ttcctgcaga ggttcaggga ggtgagcagg
     2401 ctcagtgccc tgcaggctca ctgccagaac tatctccagg agcggtcccg agcccaggcg
     2461 agtgatcgag gactaagaaa tacttctgga ctagagtcat cttggaaaaa aactggaaag
     2521 aacaggaaac tgaagtcaaa acgcgtcaag actcgggact cttctgagag cacagggtct
     2581 ggaggaccag tgtcccaccg acctcccctc atgggcctga atgccacagc ctggtcaccc
     2641 tccgacacat cccagtccag ctgcccctct gcacccttcc ccaccgcagt gccagcttac
     2701 cccctacctg tgttccaggc acccggaata gtatccacac cagggacggt ggtggcgcca
     2761 cctgcagcca cccacactgg cttcaccatg cctgttgtgc ctatgggcac ccagcctgaa
     2821 ttcgcagtgc agcccctgcc attcgctgcc cctttggctc ctgtcatggc cttcatgctg
     2881 cccagctacc cgttcccacc agcaacccca aacctgcctc aggccttcct ccccagccag
     2941 cctcactttc cagcccaccc cacacttgcc tccgaaataa ctcctgcctc ccaggctgag
     3001 ttccctagtc ggacctcgac gctcagacag ccgtgcgctt gcccagtcac ccctccagcc
     3061 ggcacagtgg ccctgggcag agcctcccca ccgctcttcc agtccagagg cagtagtccc
     3121 ctacaactta acctgcttca gctagaggag gcgcctgaag gcagcactgg agccgcaggg
     3181 accctgggga ccacagggac agcagcttct ggtctggact gcacatctgg cacatctcgg
     3241 gatcggcagc caaaggcacc tccaacatgc aacgagccct cagacactca gaacagtgat
     3301 gccatctcca cgtcaagtga cctgctcaac ctccttctgg gcgaggacct ctgctcggcc
     3361 actggctcag ccctgtctag aagcggggca tccgccacct cagactctct gggctccagc
     3421 tcgctgggct tcggcacatc ccaaagtggg gcaggcagta gtgacacaag tcacaccagc
     3481 aaatactttg gaagcattga ctcttcagag aataatcaca aagcaaaaat gatcccagac
     3541 acggaggaaa gcgagcagtt cattaagtac gtcttgcagg accccatctg gctgctgatg
     3601 gccaacacag acgacagcat catgatgaca taccagctgc cctcccggga tctccaggcg
     3661 gtgttgaagg aggaccagga gaagctgaag ctgctgcaga ggtcccagcc ccggttcaca
     3721 gagggccaga ggcgagagct ccgagaggtt catccgtggg tccacactgg gggcctgcct
     3781 acggccatcg atgtgacagg ctgtgtttac tgcgagagtg aggagaaagg caacatttgc
     3841 ctgccatatg aggaagacag tccttccccg ggactctgtg atacctcaga agccaaagag
     3901 gaggaaggtg aacagctgac aggccccagg atagaggccc agacgtaacc ctgtccccca
     3961 gccagaggtc gacattagac ggtgctcgga agagggggaa gatcttgtgg tttctaatca
     4021 catggaccca tacctacact gctttttttt gttttaggaa aaacaaaaaa caaaaacacc
     4081 atagttttct ggcggtggaa caaaactgag gggaggttta ggaggaaatc catttttgta
     4141 ttaaaataga aatacggaat ttgggggatg gggtgagatt cgtcattgaa cttgagactg
     4201 aggtggtctg tgttgtcatg gaggctgcct catggtcctc aggagtgtct tgacctccat
     4261 gaaacctctt tccagtgtgc caatgtcctc tggcccctgt ggattgttct gaaacataac
     4321 accaggatgt ggcaggtaac agggaagcca caagaggcta tccaccaagg gcccagcttt
     4381 ctggaacttt ctcacagtgt gattgtatct cccaagcaga gagaccatct ctcctgacat
     4441 cctctcagtg tgttccctta cgtggtttgg agcatggtgt agcagctttg gcttcaggtc
     4501 ctgcctgtgg tggtcaacat tccagtctga catggcttct gttcgtcaac aaagttgaaa
     4561 tgcctgctct ggactagtgg agctcagtgg cttctgcaaa cgatgcccac catcagacta
     4621 gcacccccac actgtacatt tctctgctgt tcttgtatcc tttttagacc attgtggcca
     4681 gtgtgcagag agagctgtgg catcatcagc catgttgccg tgtctgcatg gtggcctctg
     4741 caagccaggc tttgttgctg tagaggacac cgtcacgtgt ttgttctttg gttggactct
     4801 ctcagacatt agctcccagc agaaagcagc cactgagcac ggaggagagg gcacccacac
     4861 tgctgccctg agttctccag tttgcaggga gctcagcctc ccactctata tgtatatact
     4921 cctagctact gtggcttcgg gtctctgtca catctatctg tgctgctggt cctcagatca
     4981 ctggaacctg tggagagaag gggacctctc tgcccagctc tacaaaactt tatgctgcat
     5041 cagacatcca aagattgttc cgacatgctt gcgggtgacc cctggtggaa cgagacatca
     5101 ccagtgagga atcattggac ttaaaagtag acaaagcctg gagcagagga agctgtttcc
     5161 tgagtctgaa gtggctactg gggacatgtc ctgctgtagt tggttttcat ggtaaagcca
     5221 tctgaggcct gaatattacc cctatttttc ataaacacaa gaactctatt ttttttatta
     5281 aagcaacacc acctttcaca gtgatcaggt agtagccatg ttttaaagga aattcaatgt
     5341 tacagacagc tgcctctctg accagtctga tcctaagggt agatagaaga tggtctaagc
     5401 ctacgcttgt tacttaaaca caaaactgcc aaaaccttct ctcttctctc ttgaatgttt
     5461 accatcagcg ttattttatg attatttaat atatagtcct tgattgttaa ctgctaagaa
     5521 gttgacttcc taggataatt ttgtgaatct gtttacaaga tgccaagcat ccagccctgt
     5581 tttctttaga atgtgtgctt acacgggtgt cctaagacat tctctatttt aaactgagcc
     5641 ttctttttaa tgtaaataag ctctcagagt ttgtgcgatg atgattcgtg agccttgccg
     5701 gacaagaggt ttgttcatgc gcaaaccaaa cgtaccttca cccagtgcaa tatatttgtg
     5761 tgactgcttg tgtcttttta tgactttttt gccttttaga aaattgttaa ataaagcaag
     5821 tatattttta ttttcaaaaa aaaaa
//
