LOCUS       NM_011065               4681 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus period circadian clock 1 (Per1), transcript variant 1,
            mRNA.
ACCESSION   NM_011065
VERSION     NM_011065.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4681)
  AUTHORS   Sun,J., Zhang,Y., Adams,J.A., Higgins,C.B., Kelly,S.C., Zhang,H.,
            Cho,K.Y., Johnson,U.G., Swarts,B.M., Wada,S.I., Patti,G.J.,
            Shriver,L.P., Finck,B.N., Herzog,E.D. and DeBosch,B.J.
  TITLE     Hepatocyte Period 1 dictates oxidative substrate selection
            independent of the core circadian clock
  JOURNAL   Cell Rep 43 (10), 114865 (2024)
   PUBMED   39412985
  REMARK    GeneRIF: Hepatocyte Period 1 dictates oxidative substrate selection
            independent of the core circadian clock.
REFERENCE   2  (bases 1 to 4681)
  AUTHORS   Kon,K., Ode,K.L., Mano,T., Fujishima,H., Takahashi,R.R., Tone,D.,
            Shimizu,C., Shiono,S., Yada,S., Matsuzawa,K., Yoshida,S.Y., Yoshida
            Garcon,J., Kaneko,M., Shinohara,Y., Yamada,R.G., Shi,S.,
            Miyamichi,K., Sumiyama,K., Kiyonari,H., Susaki,E.A. and Ueda,H.R.
  TITLE     Cortical parvalbumin neurons are responsible for homeostatic sleep
            rebound through CaMKII activation
  JOURNAL   Nat Commun 15 (1), 6054 (2024)
   PUBMED   39025867
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4681)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4681)
  AUTHORS   Chen,Y., Liu,Z., Chen,H., Wen,Y., Fan,L. and Luo,M.
  TITLE     Rhythm gene PER1 mediates ferroptosis and lipid metabolism through
            SREBF2/ALOX15 axis in polycystic ovary syndrome
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167182 (2024)
   PUBMED   38653359
  REMARK    GeneRIF: Rhythm gene PER1 mediates ferroptosis and lipid metabolism
            through SREBF2/ALOX15 axis in polycystic ovary syndrome.
REFERENCE   5  (bases 1 to 4681)
  AUTHORS   Wu,Q., Ren,Q., Wang,X., Bai,H., Tian,D., Gao,G., Wang,F., Yu,P. and
            Chang,Y.Z.
  TITLE     Cellular iron depletion enhances behavioral rhythm by limiting
            brain Per1 expression in mice
  JOURNAL   CNS Neurosci Ther 30 (2), e14592 (2024)
   PUBMED   38385622
  REMARK    GeneRIF: Cellular iron depletion enhances behavioral rhythm by
            limiting brain Per1 expression in mice.
REFERENCE   6  (bases 1 to 4681)
  AUTHORS   Shigeyoshi,Y., Taguchi,K., Yamamoto,S., Takekida,S., Yan,L.,
            Tei,H., Moriya,T., Shibata,S., Loros,J.J., Dunlap,J.C. and
            Okamura,H.
  TITLE     Light-induced resetting of a mammalian circadian clock is
            associated with rapid induction of the mPer1 transcript
  JOURNAL   Cell 91 (7), 1043-1053 (1997)
   PUBMED   9428526
REFERENCE   7  (bases 1 to 4681)
  AUTHORS   Shearman,L.P., Zylka,M.J., Weaver,D.R., Kolakowski,L.F. Jr. and
            Reppert,S.M.
  TITLE     Two period homologs: circadian expression and photic regulation in
            the suprachiasmatic nuclei
  JOURNAL   Neuron 19 (6), 1261-1269 (1997)
   PUBMED   9427249
REFERENCE   8  (bases 1 to 4681)
  AUTHORS   Tei,H., Okamura,H., Shigeyoshi,Y., Fukuhara,C., Ozawa,R., Hirose,M.
            and Sakaki,Y.
  TITLE     Circadian oscillation of a mammalian homologue of the Drosophila
            period gene
  JOURNAL   Nature 389 (6650), 512-516 (1997)
   PUBMED   9333243
REFERENCE   9  (bases 1 to 4681)
  AUTHORS   Sun,Z.S., Albrecht,U., Zhuchenko,O., Bailey,J., Eichele,G. and
            Lee,C.C.
  TITLE     RIGUI, a putative mammalian ortholog of the Drosophila period gene
  JOURNAL   Cell 90 (6), 1003-1011 (1997)
   PUBMED   9323128
REFERENCE   10 (bases 1 to 4681)
  AUTHORS   Ishida,N., Nishimatsu,S., Saida,K. and Mitsui,Y.
  TITLE     Mouse hexamer repeat sequences homologous to the Drosophila
            'period' gene
  JOURNAL   Nucleic Acids Res 16 (8), 3581 (1988)
   PUBMED   3131739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF022992.2, BC091645.1 and BP772916.1.
            
            On Jul 19, 2017 this sequence version replaced NM_011065.4.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            Clock/Arntl heterodimers but then represses this upregulation in a
            feedback loop using Per/Cry heterodimers to interact with
            Clock/Arntl. Polymorphisms in this gene may increase the risk of
            getting certain cancers. Two transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF022992.2, SRR9219379.26217.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3788              AF022992.2         1-3788
            3789-4614           BC091645.1         3451-4276
            4615-4681           BP772916.1         33-99               c
FEATURES             Location/Qualifiers
     source          1..4681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.37 cM"
     gene            1..4681
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /note="period circadian clock 1"
                     /db_xref="GeneID:18626"
                     /db_xref="MGI:MGI:1098283"
     exon            1..60
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            61..468
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..4069
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /note="circadian clock protein PERIOD 1; circadian
                     pacemaker protein Rigui; period homolog 1"
                     /codon_start=1
                     /product="period circadian protein homolog 1"
                     /protein_id="NP_035195.2"
                     /db_xref="CCDS:CCDS24882.1"
                     /db_xref="GeneID:18626"
                     /db_xref="MGI:MGI:1098283"
                     /translation="MSGPLEGADGGGDPRPGEPFCPGGVPSPGAPQHRPCPGPSLADD
                     TDANSNGSSGNESNGPESRGASQRSSHSSSSGNGKDSALLETTESSKSTNSQSPSPPS
                     SSIAYSLLSASSEQDNPSTSGCSSEQSARARTQKELMTALRELKLRLPPERRGKGRSG
                     TLATLQYALACVKQVQANQEYYQQWSLEEGEPCAMDMSTYTLEELEHITSEYTLRNQD
                     TFSVAVSFLTGRIVYISEQAGVLLRCKRDVFRGARFSELLAPQDVGVFYGSTTPSRLP
                     TWGTGTSAGSGLKDFTQEKSVFCRIRGGPDRDPGPRYQPFRLTPYVTKIRVSDGAPAQ
                     PCCLLIAERIHSGYEAPRIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAP
                     VLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGFVHPWSR
                     KVAFVLGRHKVRTAPLNEDVFTPPAPSPAPSLDSDIQELSEQIHRLLLQPVHSSSPTG
                     LCGVGPLMSPGPLHSPGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLFIE
                     SRAKPPPRPRLLATGTFKAKVLPCQSPNPELEVAPVPDQASLALAPEEPERKETSGCS
                     YQQINCLDSILRYLESCNIPSTTKRKCASSSSYTASSASDDDKQRAGPVPVGAKKDPS
                     SAMLSGEGATPRKEPVVGGTLSPLALANKAESVVSVTSQCSFSSTIVHVGDKKPPESD
                     IIMMEDLPGLAPGPAPSPAPSPTVAPDPTPDAYRPVGLTKAVLSLHTQKEEQAFLNRF
                     RDLGRLRGLDTSSVAPSAPGCHHGPIPPGRRHHCRSKAKRSRHHHHQTPRPETPCYVS
                     HPSPVPSSGPWPPPPATTPFPAMVQPYPLPVFSPRGGPQPLPPAPTSVSPATFPSPLV
                     TPMVALVLPNYLFPTPPSYPYGVSQAPVEGPPTPASHSPSPSLPPPPLSPPHRPDSPL
                     FNSRCSSPLQLNLLQLEESPRTEGGAAAGGPGSSAGPLPPSEETAEPEARLVEVTESS
                     NQDALSGSSDLLELLLQEDSRSGTGSAASGSLGSGLGSGSGSGSHEGGSTSASITRSS
                     QSSHTSKYFGSIDSSEAEAGAARARTEPGDQVIKCVLQDPIWLLMANADQRVMMTYQV
                     PSRDAASVLKQDRERLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPRALDVTACVDC
                     GSSVQDPGHSDDPLFSELDGLGLEPMEEGGGEGGGCGVGGGGGDGGEEAQTQIGAKGS
                     SSQDSAMEEEEQGGGSSSPALPAEENSTS"
     exon            469..567
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            568..722
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            723..844
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1046
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1098
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1241
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1320
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1427
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1581
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1690
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1822
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1928
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2100
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2231
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2411
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2645
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..3262
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3449
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3639
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3790
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..4670
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4640..4645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /note="hexamer: AATACA"
     polyA_site      4670
                     /gene="Per1"
                     /gene_synonym="Hftm; m-rigui; mPer1; Per"
                     /note="major polyA site"
ORIGIN      
        1 gcggagcttc tgggttgcgg gccgaaacgg caagcggatg gagggcgctc gaacggccag
       61 gtgtcgtgat taaattagtc agccctcaga gacaggcgtc ctacctcctt tatccagacc
      121 tcaaaagccc cgttgtgcac ccgtggtggc ttcttcacct tccctgtttc gtcctccact
      181 gtatggccca gacatgagtg gtcccctaga aggggccgat gggggaggag accccaggcc
      241 cggagaacct ttttgtcctg gaggagtccc atcccctggg gccccgcagc accggccttg
      301 tccaggcccc agcctggctg atgacactga tgcaaacagc aatggctcaa gtggcaatga
      361 gtccaacgga cccgagtcca ggggcgcatc tcagcggagt tctcatagtt cctcttctgg
      421 caatggcaag gactcagctc tgctggagac cactgagagc agcaagagta caaactcaca
      481 gagcccatcc ccacccagca gctccattgc ctacagcctc ctgagtgcga gctcagagca
      541 ggacaaccca tctaccagtg gctgcagcag tgaacagtca gctcgagcca ggacccagaa
      601 agaactcatg actgcacttc gggagctcaa acttcgactg ccaccagagc gtcggggcaa
      661 gggccgctct gggaccttgg ccacactgca gtacgctctg gcctgtgtca agcaggttca
      721 ggctaaccag gaatattacc agcagtggag tctggaggag ggtgagcctt gtgccatgga
      781 catgtctact tacaccctgg aggaattgga gcatatcaca tccgaataca cacttcgaaa
      841 ccaggacacc ttctctgtgg ctgtgtcctt cctgacaggc cggattgtct atatttcgga
      901 gcaggcaggt gtcctgctgc gttgcaaacg ggatgtgttt cggggtgccc gcttctcaga
      961 gctcctggct ccccaggatg tgggtgtctt ctatggctct actacaccat ctcgactgcc
     1021 cacctggggc actggcacct ctgcaggttc aggtctcaag gacttcaccc aggaaaagtc
     1081 tgtcttctgc cgaatcagag gaggtcctga ccgggatcca gggcctcggt accagccatt
     1141 ccgcctaacc ccatatgtga ccaagattcg ggtctcagat ggagcccctg cacagccgtg
     1201 ctgcctactc attgccgagc gcatccactc tggttatgaa gctccccgga tccctcctga
     1261 caagaggatc ttcaccaccc gacacacacc aagctgcctc ttccaggatg tagatgaaag
     1321 ggctgcccca ctgctgggtt accttcccca ggatctcctg ggggctccag tacttctctt
     1381 tctacatcct gaggaccgac ccctcatgct ggccattcat aagaagatac tgcagctggc
     1441 aggccagccc tttgaccatt cccctattcg cttctgtgct cggaacgggg aatatgtcac
     1501 catggacacc agctgggccg gttttgtgca cccctggagc cgcaaggtgg ctttcgtgtt
     1561 gggtcgccat aaagtgcgca cggcacccct gaatgaggac gtcttcactc ccccagcccc
     1621 cagcccagct ccgtccctgg actctgatat ccaggagctc tcagagcaga tccatcgatt
     1681 gctgctgcag cctgtgcaca gctccagccc cacggggctc tgtggagttg gccctctgat
     1741 gtcccctggt cctctacaca gccctggctc ctccagtgat agcaatgggg gggacgctga
     1801 ggggcctggg cctcctgctc cagtgacttt ccagcagatc tgtaaggatg tgcatctggt
     1861 aaagcaccag ggacaacagc tcttcattga atctcgggcc aagcccccac cccggccccg
     1921 cctccttgct acaggtacat tcaaagccaa agtccttccc tgccagtccc caaaccccga
     1981 actggaggtg gccccagttc ctgaccaagc ctcgttagcc ttggcccctg aggagccaga
     2041 gaggaaagaa acctctggct gttcctacca gcagatcaac tgcctggaca gcatcctcag
     2101 gtatttggag agctgcaaca ttcccagtac aaccaagcgt aaatgtgcct cctcctcctc
     2161 ctacactgcc tcttcagcct ctgatgatga caagcagagg gcaggtccag ttcctgtggg
     2221 ggccaagaaa gatccgtcgt cagcaatgct gtctggggag ggggcaactc ctcggaagga
     2281 gccagtggtg ggaggcaccc tgagcccgct cgccctggcc aataaggcag agagcgtggt
     2341 gtccgtcacc agtcagtgta gcttcagctc caccatcgtc catgtgggag acaagaagcc
     2401 cccggagtcg gacatcatca tgatggaaga cctgcctggc ctggcccctg gcccagcccc
     2461 cagtccggcc cccagcccca cagtagcccc tgacccaacc ccagatgctt atcgcccagt
     2521 gggtctgacc aaggccgtgc tgtccctgca cacacagaag gaagagcaag ccttcctcaa
     2581 ccgcttcaga gatcttggca ggcttcgtgg acttgacacc tcttctgtgg ccccctcagc
     2641 ccctggctgc caccatggcc ccattccccc tggtcgccga caccactgcc gatctaaagc
     2701 aaagcgttcc cgccaccacc accaccagac cccccggccc gaaactccct gctatgtctc
     2761 ccatccttca cctgtgccct cttctggacc ctggccaccc ccaccagcca cgaccccctt
     2821 cccagcaatg gtccagccct acccactccc agtattctcc cctcgaggag gaccccagcc
     2881 ccttccccct gcccctacat ctgtgtcccc tgctaccttc ccttctccct tagtgacccc
     2941 aatggtggcc ttggtgctcc ctaactatct attccctacc ccacctagtt atccatatgg
     3001 ggtgtcccag gcccctgttg aggggccacc cacgcctgct tcccactcgc cctctccatc
     3061 cctgccccca ccacctctca gcccccccca ccgcccagac tccccactgt tcaactcgag
     3121 atgcagctcc ccactccagc tcaatctgct gcagcttgag gagtcccccc gcacggaggg
     3181 gggcgctgct gcaggaggcc caggaagcag tgctgggccc ctgcctccca gtgaggagac
     3241 tgctgagcca gaggccagat tggtggaggt tactgagtcg tccaatcagg atgcactttc
     3301 aggctccagc gacctgctgg agctactgct ccaagaagac tctcgctcgg gcacaggctc
     3361 cgcagcctca ggctccctgg gctctggcct gggctctggg tctggttcag gatcccacga
     3421 agggggaagc acctcagcca gcatcacccg cagcagtcag agcagccata caagcaagta
     3481 ctttggcagc atcgactctt ccgaggctga agctggggct gctcgggcca ggactgagcc
     3541 tggggaccag gtcattaagt gtgtgctcca ggaccccatc tggctgctca tggccaatgc
     3601 cgaccagcgt gtcatgatga cataccaggt gccgtccagg gatgcagcct ctgtgctgaa
     3661 gcaagaccgg gagaggctcc gggccatgca gaaacagcag ccacggttct cagaggacca
     3721 gaggcgggaa ctgggtgctg tgcactcctg ggtccggaag ggccagctgc ctcgggccct
     3781 tgatgtgacg gcgtgtgtgg actgtggcag cagcgttcaa gatcctggcc actctgatga
     3841 ccccctcttc tcagaactgg atggattggg gctggagccc atggaagagg gtggaggcga
     3901 gggtggtggg tgtggtgttg gcggtggtgg gggtgatggt ggtgaggagg cccagaccca
     3961 aattggggct aagggttcaa gctctcagga ctctgccatg gaggaagaag agcaaggtgg
     4021 gggctcatcc agcccagctt tacctgcaga agaaaacagc accagctaga ctccattttg
     4081 gggccgctta cagcagtcta atgagaggct tcctttcgac catgttgggg ttcttataac
     4141 tcaagataca gctggaccaa ccaataggaa actgccccag cttctcccaa catagggggc
     4201 tggaccccca ttaccagccc aggcacagga gctgcctcta gcttcttagc agagtggaag
     4261 ttctcagccc catttggagg attgtccacg cccgtcccac tgaggagacg ggcgggtctt
     4321 cggttaaggt tgctgacaag ctgctgaagt ggtctgtcca aatcccagct gagcctgagt
     4381 cccagtcgca gggttggggc tgcacttatt tatttgggag agacagctca ctctcccacc
     4441 tcaccccaag atgggaggag gggaacctgg gatctgtgta ggatccaggt ccgtgaaccc
     4501 ctagctgctc cagggtgggg gaggttggtg gaccatggag tccctggtgc tgcccctcag
     4561 gtgggaccca ggtgttctca gctctaccct ctaccaatga catttgtgtt tttgatattg
     4621 tgtctgttat ttttttttta atacaaaatg acaaaatgaa aaaccaaaaa aaaaaaaaaa
     4681 a
//
