LOCUS       NM_008820               1851 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus peptidase D (Pepd), transcript variant 1, mRNA.
ACCESSION   NM_008820
VERSION     NM_008820.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Pellegrinelli,V., Figueroa-Juarez,E., Samuelson,I., U-Din,M.,
            Rodriguez-Fdez,S., Virtue,S., Leggat,J., Cubuk,C., Peirce,V.J.,
            Niemi,T., Campbell,M., Rodriguez-Cuenca,S., Blazquez,J.D.,
            Carobbio,S., Virtanen,K.A. and Vidal-Puig,A.
  TITLE     Defective extracellular matrix remodeling in brown adipose tissue
            is associated with fibro-inflammation and reduced diet-induced
            thermogenesis
  JOURNAL   Cell Rep 42 (6), 112640 (2023)
   PUBMED   37318951
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Hodgson,R., Crockford,T.L., Bhandari,A., Kepple,J.D., Back,J.,
            Cawthorne,E., Abeler-Dorner,L., Laing,A.G., Clare,S., Speak,A.,
            Adams,D.J., Dougan,G., Hayday,A.C., Deobagkar-Lele,M., Cornall,R.J.
            and Bull,K.R.
  TITLE     Prolidase Deficiency Causes Spontaneous T Cell Activation and
            Lupus-like Autoimmunity
  JOURNAL   J Immunol 210 (5), 547-557 (2023)
   PUBMED   36637239
  REMARK    GeneRIF: Prolidase Deficiency Causes Spontaneous T Cell Activation
            and Lupus-like Autoimmunity.
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Pellegrinelli,V., Rodriguez-Cuenca,S., Rouault,C.,
            Figueroa-Juarez,E., Schilbert,H., Virtue,S., Moreno-Navarrete,J.M.,
            Bidault,G., Vazquez-Borrego,M.C., Dias,A.R., Pucker,B., Dale,M.,
            Campbell,M., Carobbio,S., Lin,Y.H., Vacca,M., Aron-Wisnewsky,J.,
            Mora,S., Masiero,M.M., Emmanouilidou,A., Mukhopadhyay,S.,
            Dougan,G., den Hoed,M., Loos,R.J.F., Fernandez-Real,J.M.,
            Chiarugi,D., Clement,K. and Vidal-Puig,A.
  TITLE     Dysregulation of macrophage PEPD in obesity determines adipose
            tissue fibro-inflammation and insulin resistance
  JOURNAL   Nat Metab 4 (4), 476-494 (2022)
   PUBMED   35478031
  REMARK    GeneRIF: Dysregulation of macrophage PEPD in obesity determines
            adipose tissue fibro-inflammation and insulin resistance.
REFERENCE   5  (bases 1 to 1851)
  AUTHORS   Insolia,V., Priori,E.C., Gasperini,C., Coppa,F., Cocchia,M.,
            Iervasi,E., Ferrari,B., Besio,R., Maruelli,S., Bernocchi,G.,
            Forlino,A. and Bottone,M.G.
  TITLE     Prolidase enzyme is required for extracellular matrix integrity and
            impacts on postnatal cerebellar cortex development
  JOURNAL   J Comp Neurol 528 (1), 61-80 (2020)
   PUBMED   31246278
  REMARK    GeneRIF: Prolidase enzyme is required for extracellular matrix
            integrity and impacts on postnatal cerebellar cortex development.
REFERENCE   6  (bases 1 to 1851)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   7  (bases 1 to 1851)
  AUTHORS   Pack,S.D., Zhdanova,N.S., Sukoyan,M.A. and Serov,O.L.
  TITLE     Chromosomal and regional localization of the genes for UMPH2, APRT,
            PEPD, PEPS, PSP, and PGP in mink: comparison with man and mouse
  JOURNAL   Cytogenet Cell Genet 50 (2-3), 127-131 (1989)
   PUBMED   2776480
REFERENCE   8  (bases 1 to 1851)
  AUTHORS   Yang-Feng,T.L., Schneider,J.W., Lindgren,V., Shull,M.M., Benz,E.J.
            Jr., Lingrel,J.B. and Francke,U.
  TITLE     Chromosomal localization of human Na+, K+-ATPase alpha- and
            beta-subunit genes
  JOURNAL   Genomics 2 (2), 128-138 (1988)
   PUBMED   2842249
REFERENCE   9  (bases 1 to 1851)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   10 (bases 1 to 1851)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     Comparative gene mapping in man and mouse: assignment of the genes
            for lactate dehydrogenase-A, peptidase-D, and isocitrate
            dehydrogenase-2 to mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 22 (1-6), 577-580 (1978)
   PUBMED   752544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124574.4 and AC149058.7.
            
            On Feb 24, 2023 this sequence version replaced NM_008820.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51014.1, BC131973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC124574.4         150204-150251
            49-232              AC124574.4         159126-159309
            233-360             AC124574.4         162178-162305
            361-424             AC124574.4         172479-172542
            425-472             AC149058.7         141633-141680       c
            473-534             AC149058.7         138671-138732       c
            535-579             AC149058.7         129717-129761       c
            580-655             AC149058.7         114739-114814       c
            656-702             AC149058.7         112616-112662       c
            703-771             AC149058.7         63286-63354         c
            772-849             AC149058.7         62549-62626         c
            850-998             AC149058.7         52828-52976         c
            999-1183            AC149058.7         43464-43648         c
            1184-1375           AC149058.7         40438-40629         c
            1376-1851           AC149058.7         39613-40088         c
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 20.7 cM"
     gene            1..1851
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /note="peptidase D"
                     /db_xref="GeneID:18624"
                     /db_xref="MGI:MGI:97542"
     exon            1..48
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1513
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /EC_number="3.4.13.9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     xaa-Pro dipeptidase; imidodipeptidase; prolidase; proline
                     dipeptidase; X-pro dipeptidase; peptidase 4"
                     /codon_start=1
                     /product="xaa-Pro dipeptidase isoform 1"
                     /protein_id="NP_032846.2"
                     /db_xref="CCDS:CCDS21143.1"
                     /db_xref="GeneID:18624"
                     /db_xref="MGI:MGI:97542"
                     /translation="MASTVRPSFSLGNETLKVPLALFALNRQRLCERLRKNGAVQAAS
                     AVVLQGGEEMQRYCTDTSIIFRQESFFHWAFGVVESGCYGVIDVDTGKSTLFVPRLPD
                     SYATWMGKIHSKEYFKEKYAVDDVQYTDEIASVLTSRNPSVLLTLRGVNTDSGSVCRE
                     ASFEGISKFNVNNTILHPEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMK
                     EYEMESLFQHYCYSRGGMRHTSYTCICCSGENAAVLHYGHAGAPNDRTIKDGDICLFD
                     MGGEYYCFASDITCSFPANGKFTEDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLAD
                     RIHLEELARIGLLSGSVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYPEGVERIDEP
                     GLRSLRTARHLEPGMVLTVEPGIYFIDHLLDQALADPAQACFFNQEVLQRFRNFGGVR
                     IEEDVVVTDSGMELLTCVPRTVEEIEACMAGCDKASVPFSGQK"
     exon            49..232
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            233..360
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            361..424
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            425..472
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            473..534
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            535..579
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            580..655
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            656..702
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            703..771
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            772..849
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            850..998
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1183
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1375
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1851
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /note="hexamer: AATAAA"
     polyA_site      1851
                     /gene="Pepd"
                     /gene_synonym="dal; Pep-4; Pep4"
                     /note="major polyA site"
ORIGIN      
        1 gcactccacg tgacgctagc gccgagtgaa catggcgtcc actgtgcgcc cttccttctc
       61 cctggggaat gagaccctga aggtgccact ggcactattc gccctgaaca ggcagcgcct
      121 gtgtgagagg ctgaggaaga atggagctgt acaggccgcc tcagctgtcg tgttgcaggg
      181 cggggaagag atgcaacggt actgcaccga tacctccatc atcttccgcc aggagtcctt
      241 ctttcactgg gccttcggtg tcgtcgagtc aggctgctat ggtgtcatcg atgtggacac
      301 tggaaaatca accctgtttg tgcccaggct tcctgatagc tacgccacct ggatgggaaa
      361 gatccattcc aaggagtatt tcaaggagaa gtacgctgtg gatgatgtcc agtacacgga
      421 tgagattgcc agtgtcctga cctcacggaa cccctctgtc ctcctcactt tgcgcggtgt
      481 caacacagac agtggcagtg tctgcaggga ggcctccttc gagggcatta gcaagttcaa
      541 tgtcaacaac acgattcttc acccagagat cgtggaatgc cgagtgttca agacagacat
      601 ggaactagag gttttgcgct acacaaatcg gatctccagc gaggcccacc gtgaggtaat
      661 gaaggctgta aaagtgggga tgaaggaata cgagatggaa agcctgttcc agcattattg
      721 ttactctagg ggcggcatgc gccacacctc ttacacctgt atctgctgta gcggtgagaa
      781 cgcggccgtg ctgcactatg gccatgctgg agcccccaat gaccggacga tcaaggatgg
      841 agatatttgc ctgttcgaca tgggtggcga gtactactgc tttgcttctg acatcacctg
      901 ctccttccca gccaacggca agttcacaga ggaccagaag gccatctacg aagcagtgct
      961 caggagctgc agaactgtca tgagcactat gaagccaggg gtctggtggc ctgatatgca
     1021 tcggctggct gaccgtatcc acctggagga actggcacgc attggcctcc tgagtggcag
     1081 tgtggatgcc atgctccagg tccacctggg agcagtattc atgccacatg gacttggcca
     1141 ctttctgggc ctagatgtgc acgacgtggg aggctaccct gagggtgtag agcgcatcga
     1201 tgaacctggc ctgcgaagcc tgcgtacggc aaggcacctg gagccgggca tggtgctgac
     1261 tgtggagcca ggcatctact tcattgacca cctcttggac caggccctgg cagacccggc
     1321 ccaagcctgc ttctttaacc aagaggtcct gcagcgcttc cgcaacttcg gtggggtgcg
     1381 gatcgaggaa gatgttgtcg tgactgacag cggcatggag ctgctgacat gtgtaccccg
     1441 gactgtggag gaaatcgaag cgtgcatggc aggctgcgac aaggcatctg tgcccttctc
     1501 tggccaaaag tagagccagc tgagacactc agtgagactg ggccctggcc ttgtaagctc
     1561 tgtgatgtca gcctgcccat ggcaccccaa aagcaagatc ctggagatca catttgatcc
     1621 taccaaaacc actgctgctg tttctgagaa aagaaagcat tttattcacc tgcaagatca
     1681 catccctagc tttgattttg cttaaatgat agggacttaa gagtgctgat tgaagaaaga
     1741 tcctattctt aggtctaact cgatttttgt gctcagggaa gatgcactga tgtcttcaaa
     1801 aaaaaatcaa catgcagaat ggaatttgca ataaaggctt ttctaaaact g
//
