LOCUS       NM_001348209            1313 bp    mRNA    linear   ROD 19-MAR-2024
DEFINITION  Mus musculus preproenkephalin (Penk), transcript variant 2, mRNA.
ACCESSION   NM_001348209 XM_006537675
VERSION     NM_001348209.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1313)
  AUTHORS   Mortessagne,P., Cartier,E., Balia,M., Fevre,M., Corailler,F.,
            Herry,C., Abrous,D.N., Battefeld,A. and Pacary,E.
  TITLE     Genetic labeling of embryonically-born dentate granule neurons in
            young mice using the PenkCre mouse line
  JOURNAL   Sci Rep 14 (1), 5022 (2024)
   PUBMED   38424161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1313)
  AUTHORS   Mas-Orea,X., Rey,L., Battut,L., Bories,C., Petitfils,C., Abot,A.,
            Gheziel,N., Wemelle,E., Blanpied,C., Motta,J.P., Knauf,C.,
            Barreau,F., Espinosa,E., Aloulou,M., Cenac,N., Serino,M.,
            Mouledous,L., Fazilleau,N. and Dietrich,G.
  TITLE     Proenkephalin deletion in hematopoietic cells induces intestinal
            barrier failure resulting in clinical feature similarities with
            irritable bowel syndrome in mice
  JOURNAL   Commun Biol 6 (1), 1168 (2023)
   PUBMED   37968381
  REMARK    GeneRIF: Proenkephalin deletion in hematopoietic cells induces
            intestinal barrier failure resulting in clinical feature
            similarities with irritable bowel syndrome in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1313)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1313)
  AUTHORS   Wang,Q., Wang,Y., Kuo,H.C., Xie,P., Kuang,X., Hirokawa,K.E.,
            Naeemi,M., Yao,S., Mallory,M., Ouellette,B., Lesnar,P., Li,Y.,
            Ye,M., Chen,C., Xiong,W., Ahmadinia,L., El-Hifnawi,L., Cetin,A.,
            Sorensen,S.A., Harris,J.A., Zeng,H. and Koch,C.
  TITLE     Regional and cell-type-specific afferent and efferent projections
            of the mouse claustrum
  JOURNAL   Cell Rep 42 (2), 112118 (2023)
   PUBMED   36774552
REFERENCE   5  (bases 1 to 1313)
  AUTHORS   Liau,E.S., Jin,S., Chen,Y.C., Liu,W.S., Calon,M., Nedelec,S.,
            Nie,Q. and Chen,J.A.
  TITLE     Single-cell transcriptomic analysis reveals diversity within
            mammalian spinal motor neurons
  JOURNAL   Nat Commun 14 (1), 46 (2023)
   PUBMED   36596814
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1313)
  AUTHORS   Shapiro,S.D., Griffin,G.L., Gilbert,D.J., Jenkins,N.A.,
            Copeland,N.G., Welgus,H.G., Senior,R.M. and Ley,T.J.
  TITLE     Molecular cloning, chromosomal localization, and bacterial
            expression of a murine macrophage metalloelastase
  JOURNAL   J Biol Chem 267 (7), 4664-4671 (1992)
   PUBMED   1537850
REFERENCE   7  (bases 1 to 1313)
  AUTHORS   Vitale,M., Vashishtha,A., Linzer,E., Powell,D.J. and Friedman,J.M.
  TITLE     Molecular cloning of the mouse CCK gene: expression in different
            brain regions and during cortical development
  JOURNAL   Nucleic Acids Res 19 (1), 169-177 (1991)
   PUBMED   2011497
REFERENCE   8  (bases 1 to 1313)
  AUTHORS   Kilpatrick,D.L., Zinn,S.A., Fitzgerald,M., Higuchi,H., Sabol,S.L.
            and Meyerhardt,J.
  TITLE     Transcription of the rat and mouse proenkephalin genes is initiated
            at distinct sites in spermatogenic and somatic cells
  JOURNAL   Mol Cell Biol 10 (7), 3717-3726 (1990)
   PUBMED   2355920
REFERENCE   9  (bases 1 to 1313)
  AUTHORS   Kwon,B.S. and Weissman,S.M.
  TITLE     cDNA sequences of two inducible T-cell genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1963-1967 (1989)
   PUBMED   2784565
REFERENCE   10 (bases 1 to 1313)
  AUTHORS   Zurawski,G., Benedik,M., Kamb,B.J., Abrams,J.S., Zurawski,S.M. and
            Lee,F.D.
  TITLE     Activation of mouse T-helper cells induces abundant
            preproenkephalin mRNA synthesis
  JOURNAL   Science 232 (4751), 772-775 (1986)
   PUBMED   2938259
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135111.1, AK161272.1 and CX236539.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_001348209.2.
            
            On Jan 19, 2017 this sequence version replaced XM_006537675.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161272.1, SRR1660813.279786.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AK135111.1         2-28
            28-1293             AK161272.1         2-1267
            1294-1313           CX236539.1         630-649
FEATURES             Location/Qualifiers
     source          1..1313
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 2.31 cM"
     gene            1..1313
                     /gene="Penk"
                     /gene_synonym="ENK; Penk1; PPA"
                     /note="preproenkephalin"
                     /db_xref="GeneID:18619"
                     /db_xref="MGI:MGI:104629"
     exon            1..181
                     /gene="Penk"
                     /gene_synonym="ENK; Penk1; PPA"
                     /inference="alignment:Splign:2.1.0"
     exon            182..322
                     /gene="Penk"
                     /gene_synonym="ENK; Penk1; PPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..991
                     /gene="Penk"
                     /gene_synonym="ENK; Penk1; PPA"
                     /note="proenkephalin-A; spermatogenic-specific
                     proenkephalin; preproenkephalin 1"
                     /codon_start=1
                     /product="proenkephalin-A precursor"
                     /protein_id="NP_001335138.1"
                     /db_xref="CCDS:CCDS17946.1"
                     /db_xref="GeneID:18619"
                     /db_xref="MGI:MGI:104629"
                     /translation="MARFLRLCTWLLALGSCLLATVQAECSQDCAKCSYRLVRPGDIN
                     FLACTLECEGQLPSFKIWETCKDLLQVSRPEFPWDNIDMYKDSSKQDESHLLAKKYGG
                     FMKRYGGFMKKMDELYPMEPEEEANGGEILAKRYGGFMKKDADEGDTLANSSDLLKEL
                     LGTGDNRAKDSHQQESTNNDEDMSKRYGGFMRSLKRSPQLEDEAKELQKRYGGFMRRV
                     GRPEWWMDYQKRYGGFLKRFAESLPSDEEGENYSKEVPEIEKRYGGFMRF"
     exon            323..1294
                     /gene="Penk"
                     /gene_synonym="ENK; Penk1; PPA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggctgtg gccgccgcca gcaaggcagg cgcacagagc cccgctgccc agcgacgctg
       61 cccggcgcct cgcagagctc cccgacgcgg ccgctttaca cttgccttct ttctttctct
      121 tgcagagtgg catctggtac acgctcttcc agtaacctgc gccatctgga gcaacggcag
      181 ccccatggcg cggttcctga ggctttgcac ctggctgctg gcgcttgggt cctgcctcct
      241 ggctacagtg caggcggaat gcagccagga ctgcgctaaa tgcagctacc gcctggttcg
      301 cccaggcgac atcaatttcc tggcgtgcac actggaatgt gaaggacagc tgccttcttt
      361 caaaatctgg gagacctgca aggatctcct gcaggtgtcc aggcccgagt tcccttggga
      421 taacatcgac atgtacaaag acagcagcaa acaggatgag agccacttgc tagccaagaa
      481 gtacggaggc ttcatgaaac ggtacggagg cttcatgaag aagatggacg agctatatcc
      541 catggagcca gaagaagaag cgaacggagg agagatcctt gccaagaggt atggcggctt
      601 catgaagaag gatgcagatg agggagacac cttggccaac tcctccgatc tgctgaaaga
      661 gctactggga acgggagaca accgtgcgaa agacagccac caacaagaga gcaccaacaa
      721 tgacgaagac atgagcaaga ggtatggggg cttcatgaga agcctcaaaa gaagccccca
      781 actggaagat gaagcaaaag agctgcagaa gcgctacggg ggcttcatga gaagggtggg
      841 acgccccgag tggtggatgg actaccagaa gaggtatggg ggcttcctga agcgctttgc
      901 tgagtctctg ccctccgatg aagaaggcga aaattactcg aaagaagttc ctgagataga
      961 gaaaagatac gggggcttta tgcggttctg aagccctttt ccagcagtga ccccgacccc
     1021 cactagcctg ctccatcccc catgagcaac tgccttgtca atgatgtttc ttgtcacatg
     1081 ctgctttgtg ctgtacagtt gcccccgtgg tctagataac tacactgcct gaaagctgtg
     1141 attttagggt ctgtgttctt ttgagtcttg aagctcagta ttggtctctt atggctatgt
     1201 tgttatcaat agtttgttac ctcatctctc ctgacgaaac atcaataaat gcttatttgt
     1261 atataaatat aataaacccg tgaccccaac tgcaaaaaaa aaaaaaaaaa aaa
//
