LOCUS       NM_029231               3443 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus proline, glutamic acid and leucine rich protein 1
            (Pelp1), mRNA.
ACCESSION   NM_029231
VERSION     NM_029231.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3443)
  AUTHORS   He,K.X., Xu,L., Ning,J.Z. and Cheng,F.
  TITLE     MiR-195-5p is involved in testicular ischemia/reperfusion injury by
            directly targeting PELP1 and regulating spermatogonia pyroptosis
  JOURNAL   Int Immunopharmacol 121, 110427 (2023)
   PUBMED   37290329
  REMARK    GeneRIF: MiR-195-5p is involved in testicular ischemia/reperfusion
            injury by directly targeting PELP1 and regulating spermatogonia
            pyroptosis.
REFERENCE   2  (bases 1 to 3443)
  AUTHORS   Sareddy,G.R., Zhang,Q., Wang,R., Scott,E., Zou,Y., O'Connor,J.C.,
            Chen,Y., Dong,Y., Vadlamudi,R.K. and Brann,D.
  TITLE     Proline-, glutamic acid-, and leucine-rich protein 1 mediates
            estrogen rapid signaling and neuroprotection in the brain
  JOURNAL   Proc Natl Acad Sci U S A 112 (48), E6673-E6682 (2015)
   PUBMED   26627258
  REMARK    GeneRIF: PELP1 is essential for the extranuclear signaling and
            neuroprotective actions of 17-beta estradiol in the hippocampal CA1
            region after global cerebral ischemia.
REFERENCE   3  (bases 1 to 3443)
  AUTHORS   Cortez,V., Samayoa,C., Zamora,A., Martinez,L., Tekmal,R.R. and
            Vadlamudi,R.K.
  TITLE     PELP1 overexpression in the mouse mammary gland results in the
            development of hyperplasia and carcinoma
  JOURNAL   Cancer Res 74 (24), 7395-7405 (2014)
   PUBMED   25377474
  REMARK    GeneRIF: These results further support the hypothesis that PELP1
            deregulation has the potential to promote breast tumorigenesis in
            vivo and represent a novel model for future investigation into
            molecular mechanisms of PELP1-mediated tumorigenesis.
REFERENCE   4  (bases 1 to 3443)
  AUTHORS   Fanis,P., Gillemans,N., Aghajanirefah,A., Pourfarzad,F.,
            Demmers,J., Esteghamat,F., Vadlamudi,R.K., Grosveld,F.,
            Philipsen,S. and van Dijk,T.B.
  TITLE     Five friends of methylated chromatin target of
            protein-arginine-methyltransferase[prmt]-1 (chtop), a complex
            linking arginine methylation to desumoylation
  JOURNAL   Mol Cell Proteomics 11 (11), 1263-1273 (2012)
   PUBMED   22872859
  REMARK    GeneRIF: Recruitment of the protein complex 5FMC to Zbp-89, a
            zinc-finger transcription factor, affects its sumoylation status
            and transactivation potential.[5FMC]
REFERENCE   5  (bases 1 to 3443)
  AUTHORS   Rambaud,J., Desroches,J., Balsalobre,A. and Drouin,J.
  TITLE     TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor
            NGFI-B/Nur77
  JOURNAL   J Biol Chem 284 (21), 14147-14156 (2009)
   PUBMED   19321449
REFERENCE   6  (bases 1 to 3443)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   7  (bases 1 to 3443)
  AUTHORS   Balasenthil,S. and Vadlamudi,R.K.
  TITLE     Functional interactions between the estrogen receptor coactivator
            PELP1/MNAR and retinoblastoma protein
  JOURNAL   J Biol Chem 278 (24), 22119-22127 (2003)
   PUBMED   12682072
  REMARK    GeneRIF: Functional study of human homolog.
REFERENCE   8  (bases 1 to 3443)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 3443)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3443)
  AUTHORS   Vadlamudi,R.K., Wang,R.A., Mazumdar,A., Kim,Y., Shin,J., Sahin,A.
            and Kumar,R.
  TITLE     Molecular cloning and characterization of PELP1, a novel human
            coregulator of estrogen receptor alpha
  JOURNAL   J Biol Chem 276 (41), 38272-38279 (2001)
   PUBMED   11481323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596096.7.
            
            On Jan 24, 2023 this sequence version replaced NM_029231.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128966.1, BC090620.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AL596096.7         92342-92614         c
            274-338             AL596096.7         88835-88899         c
            339-444             AL596096.7         88205-88310         c
            445-594             AL596096.7         84495-84644         c
            595-666             AL596096.7         84228-84299         c
            667-726             AL596096.7         81059-81118         c
            727-877             AL596096.7         80644-80794         c
            878-1007            AL596096.7         80221-80350         c
            1008-1095           AL596096.7         80028-80115         c
            1096-1184           AL596096.7         79593-79681         c
            1185-1301           AL596096.7         79396-79512         c
            1302-1449           AL596096.7         79134-79281         c
            1450-1609           AL596096.7         78864-79023         c
            1610-1665           AL596096.7         78238-78293         c
            1666-1872           AL596096.7         77880-78086         c
            1873-3303           AL596096.7         76340-77770         c
            3304-3443           AL596096.7         75461-75600         c
FEATURES             Location/Qualifiers
     source          1..3443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..3443
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /note="proline, glutamic acid and leucine rich protein 1"
                     /db_xref="GeneID:75273"
                     /db_xref="MGI:MGI:1922523"
     exon            1..273
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..3396
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /note="modulator of non-genomic activity of estrogen
                     receptor"
                     /codon_start=1
                     /product="proline-, glutamic acid- and leucine-rich
                     protein 1"
                     /protein_id="NP_083507.3"
                     /db_xref="CCDS:CCDS24945.1"
                     /db_xref="GeneID:75273"
                     /db_xref="MGI:MGI:1922523"
                     /translation="MAAAVLSGASAGSPAGAPGGPGGLSAVGSGPRLRLLLLESISGL
                     LQPRTASPVAPVHPPIQWAPHLPGLMCLLRLHGTAGGAQNLSALGALVNLSNAHLGSI
                     KTRFEGLCLLSLLIGESPTELFQQHCVSWLRSIQQVLQSQDSPSTMELAVAVLRDLLR
                     HASQLPTLFRDISTNHLPGLLTSLLGLRPECEQSALEGMKACVTYFPRACGSLKGKLA
                     SFFLSRLDSLNPQLQQLACECYSRLPSLGAGFSQGLKHTENWEQELHSLLTSLHSLLG
                     SLFEETEPAPVQSEGPGIEMLLSHSEDGNTHVLLQLRQRFSGLARCLGLMLSSEFGAP
                     VSVPVQEILDLICRILGISSKNINLLGDGPLRLLLLPSLHLEALDLLSALILACGSRL
                     LRFGALISRLLPQVLNAWSTGRDTLAPGQERPYSTIRTKVYAILELWVQVCGASAGML
                     QGGASGEALLTHLLSDISPPADALKLCSTRGSSDGGLQSGKPSAPKKLKLDMGEALAP
                     PSQRKGDRNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMSVQQGEVL
                     GSSPYNSSCCRLGLYRLLLALLLAPSPRCPPPLACALKAFSLGQWEDSLEVSSFCSEA
                     LVTCAALTHPRVPPLQSSGPACPTPAPVPPPEAPSSFRAPAFHPPGPMPSIGAVPSTG
                     PLPSAGPIPTVGSMASTGQVPSRPGPPATANHLGLSVPGLVSVPPRLLPGPENHRAGS
                     GEDPVLAPSGTPPPSIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVP
                     EGLPSLPPAPPSGTPPPAAPAGPPTASPPVPAKEDSEELPATPGPPPPPPPPPPPASG
                     PVTLPPPQLVPEGTPGGGGPTAMEEDLTVININSSDEEEEEEEEEEEEDEDEEEEDFE
                     EEEEDEEEYFEEEEEEEEFEEEFEEEEGELEEEEEEEEEELDEVEDVEFGSAGEVEEG
                     GPPPPTLPPALPPSDSPKVQPEAEPEPGLLLEVEEPGPEEVPGPETAPTLAPEVLPSQ
                     EEGEQEVGSPAAGPPQELVEESSAPPALLEEGTEGGGDKVPPPPETPAEEMETEAEVP
                     APQEKEQDDTAAMLADFIDCPPDDEKPPPATEPDS"
     exon            274..338
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            339..444
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            445..594
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            595..666
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            667..726
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            727..877
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1007
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1095
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1184
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1301
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1449
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1609
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1665
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1872
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..3303
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3443
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3426..3431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /note="hexamer: AATAAA"
     polyA_site      3443
                     /gene="Pelp1"
                     /gene_synonym="4930563C04Rik; MNAR"
                     /note="major polyA site"
ORIGIN      
        1 acgccattgc tcgagcctgt gaagatggcg gcggccgttc ttagtggggc ctctgcgggc
       61 tccccagctg gggctcctgg cgggcccggg ggtctctctg cggtgggatc cggcccgcgt
      121 ctgcgtctgc tgctgttaga gagcatttcc gggttgttac agccgcgaac ggcgtccccc
      181 gtggcccctg tgcatccccc aatccagtgg gccccgcatt tgcccgggct catgtgctta
      241 ttgaggctgc atgggacggc aggtggggcg cagaatcttt cagctcttgg ggcattggtg
      301 aatctcagta atgcacatct tggctccatc aaaactcggt ttgaaggcct gtgtctgctg
      361 tccttgttga taggggagag ccccacagag ttattccagc aacattgtgt ttcttggctt
      421 cggagcatcc agcaggtgct gcagtctcag gactcaccgt ccaccatgga gctggctgtg
      481 gctgtcctga gggatctgct ccgacatgca tcccagcttc ctaccctgtt tcgggacatc
      541 tccaccaacc accttcctgg gcttcttact tccttgctgg gcctcagacc agagtgtgaa
      601 caatcagctt tggagggaat gaaggcttgt gtgacctatt ttcctcgggc ctgtggctct
      661 ctaaaaggaa agctggcttc ctttttcctg tctcgattgg attccctgaa ccctcagctc
      721 caacagctgg cctgcgagtg ttactccagg ttgccctcgt taggtgctgg cttttcccag
      781 ggactgaagc acacagagaa ctgggaacag gagctgcaca gcctgctgac ctcactgcac
      841 agcttactgg ggtccctgtt tgaggaaaca gagcctgctc ctgtgcagag tgaaggccct
      901 ggaatagaga tgctgctttc ccactcagaa gatggtaaca cccatgtcct cctccagctt
      961 cggcagaggt tttcaggcct ggcccgttgc ctggggctca tgctcagctc tgagtttggg
     1021 gctcctgtgt ccgttcctgt gcaggaaatc ctggacctca tctgccggat ccttggtatc
     1081 agtagcaaga atattaactt gcttggagat ggtcccctca ggttgctgct gctgccttct
     1141 ctgcaccttg aggccttgga cttgctctct gccctgatcc ttgcgtgtgg aagtcgactt
     1201 ttgcgttttg gtgccctgat cagccggctg cttccccagg ttctcaatgc ctggagcact
     1261 gggagggata ctctagctcc aggccaggag aggccttaca gcaccattcg gaccaaagtg
     1321 tatgctatct tagagctatg ggtgcaggtt tgtggggcct cagcaggtat gcttcaggga
     1381 ggagcctctg gagaagcctt gctcacccac ctgctcagtg acatctcccc tccagctgat
     1441 gctcttaagc tatgcagtac caggggaagc tctgatggag gtttgcaaag tgggaagcca
     1501 agtgctccta agaagctcaa gctcgatatg ggggaagctt tggctccacc cagccaaagg
     1561 aaaggagata ggaatgccaa cagtgacgtg tgcgcagctg cactgagagg cctcagtcgg
     1621 accatcctta tgtgcgggcc tctcatcaag gaggagactc acaggagact tcatgatcta
     1681 gtcctgcccc tggtcatgag tgtccagcag ggtgaggtcc tgggcagctc tccttacaac
     1741 agttcctgct gtcgcctcgg gctctaccgc ctgctgctgg ctttattgct ggcaccttcc
     1801 cctcggtgcc ctcctcctct tgcctgtgcc ctgaaagctt tctctcttgg ccaatgggaa
     1861 gatagtcttg aggtctcctc tttttgctca gaagctctgg tgacctgtgc tgctctgaca
     1921 cacccccgag tacctcctct acagagctca ggccctgcct gccccactcc tgcccccgtc
     1981 cctcctcctg aggccccatc ttcattcagg gccccggcct tccatcctcc aggccccatg
     2041 ccctccatag gtgctgtgcc atccacaggc ccattaccct cagcaggccc cattcccaca
     2101 gtaggctcta tggcgtccac aggccaagtg ccctctcgcc ctggacctcc agcaacagcc
     2161 aaccatttag gcctctctgt cccaggcctg gtatctgttc cacccaggct ccttcctggc
     2221 cctgaaaacc accgtgcagg ctccggtgag gatcctgtcc ttgctcctag tgggacccct
     2281 ccgcctagca tacctccaga tgaaactttt ggggggagag tacctaggcc agcctttgtc
     2341 cactacgata aggaggaggc atctgatgta gagatctcct tggaaagcga ctctgatgac
     2401 agtgtggtga ttgtacctga ggggcttccc tccctgccac ctgcaccacc ctcaggcact
     2461 cctccccctg cggctcctgc cggcccacca acagcctcac ctcctgtgcc agctaaggag
     2521 gattctgaag aactgcctgc aaccccaggg cctccacccc cacccccacc cccaccccca
     2581 ccggcctctg gtcctgtgac acttcctcca ccccagctgg tccctgaagg gactcctgga
     2641 gggggaggac ccacagccat ggaagaagat ttgacagtta ttaatatcaa cagcagtgat
     2701 gaagaggagg aggaggaaga ggaagaggag gaagaagatg aagatgagga agaagaagac
     2761 tttgaggaag aggaagaaga tgaagaagaa tattttgaag aggaagaaga ggaagaagag
     2821 tttgaggagg aatttgagga ggaagaaggt gaattagaag aggaagaaga agaggaggaa
     2881 gaagagttag atgaggtaga agatgtggag tttggttcag caggggaggt ggaagaaggt
     2941 ggacctccac ccccaacact gccacctgct ctgccacctt cagactcgcc caaagtacag
     3001 cctgaggcag aacctgaacc tgggctctta ttggaagttg aggagccagg gccagaggag
     3061 gtgcctgggc ctgagactgc tcctaccctg gcccctgaag tgctcccctc ccaggaggag
     3121 ggggagcagg aagtgggaag ccctgcagca gggccacctc aggagcttgt tgaagagtcc
     3181 tctgctcccc ctgccctgct ggaagagggg actgagggtg gaggtgacaa agtgccaccc
     3241 ccaccggaga cacctgcaga agaaatggag acagaagcag aagttccagc tcctcaggaa
     3301 aaggagcaag atgatacagc tgccatgctg gctgatttca tcgattgtcc ccctgacgat
     3361 gagaagccac cacctgctac agagcctgac tcgtagcccc ttctgcaccc cgtcactttg
     3421 tatccaataa agttctgtct gta
//
