LOCUS       NM_134058               1588 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus pelota mRNA surveillance and ribosome rescue factor
            (Pelo), mRNA.
ACCESSION   NM_134058
VERSION     NM_134058.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1588)
  AUTHORS   Gao,P., Hao,J.L., Xie,Q.W., Han,G.Q., Xu,B.B., Hu,H., Sa,N.E.,
            Du,X.W., Tang,H.L., Yan,J. and Dong,X.M.
  TITLE     PELO facilitates PLK1-induced the ubiquitination and degradation of
            Smad4 and promotes the progression of prostate cancer
  JOURNAL   Oncogene 41 (21), 2945-2957 (2022)
   PUBMED   35437307
  REMARK    GeneRIF: PELO facilitates PLK1-induced the ubiquitination and
            degradation of Smad4 and promotes the progression of prostate
            cancer.
REFERENCE   2  (bases 1 to 1588)
  AUTHORS   Elkenani,M., Nyamsuren,G., Toischer,K., Adham,I.M. and Mohamed,B.A.
  TITLE     Perturbed differentiation of murine embryonic stem cells upon
            Pelota deletion due to dysregulated FOXO1/beta-catenin signaling
  JOURNAL   FEBS J 288 (10), 3317-3329 (2021)
   PUBMED   33245852
  REMARK    GeneRIF: Perturbed differentiation of murine embryonic stem cells
            upon Pelota deletion due to dysregulated FOXO1/beta-catenin
            signaling.
REFERENCE   3  (bases 1 to 1588)
  AUTHORS   Terrey,M., Adamson,S.I., Chuang,J.H. and Ackerman,S.L.
  TITLE     Defects in translation-dependent quality control pathways lead to
            convergent molecular and neurodevelopmental pathology
  JOURNAL   Elife 10, e66904 (2021)
   PUBMED   33899734
  REMARK    GeneRIF: Defects in translation-dependent quality control pathways
            lead to convergent molecular and neurodevelopmental pathology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1588)
  AUTHORS   O'Connell,A.E., Gerashchenko,M.V., O'Donohue,M.F., Rosen,S.M.,
            Huntzinger,E., Gleeson,D., Galli,A., Ryder,E., Cao,S., Murphy,Q.,
            Kazerounian,S., Morton,S.U., Schmitz-Abe,K., Gladyshev,V.N.,
            Gleizes,P.E., Seraphin,B. and Agrawal,P.B.
  TITLE     Mammalian Hbs1L deficiency causes congenital anomalies and
            developmental delay associated with Pelota depletion and 80S
            monosome accumulation
  JOURNAL   PLoS Genet 15 (2), e1007917 (2019)
   PUBMED   30707697
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1588)
  AUTHORS   Liakath-Ali,K., Mills,E.W., Sequeira,I., Lichtenberger,B.M.,
            Pisco,A.O., Sipila,K.H., Mishra,A., Yoshikawa,H., Wu,C.C., Ly,T.,
            Lamond,A.I., Adham,I.M., Green,R. and Watt,F.M.
  TITLE     An evolutionarily conserved ribosome-rescue pathway maintains
            epidermal homeostasis
  JOURNAL   Nature 556 (7701), 376-380 (2018)
   PUBMED   29643507
REFERENCE   6  (bases 1 to 1588)
  AUTHORS   Nyamsuren,G., Kata,A., Xu,X., Raju,P., Dressel,R., Engel,W.,
            Pantakani,D.V. and Adham,I.M.
  TITLE     Pelota regulates the development of extraembryonic endoderm through
            activation of bone morphogenetic protein (BMP) signaling
  JOURNAL   Stem Cell Res 13 (1), 61-74 (2014)
   PUBMED   24835669
  REMARK    GeneRIF: Results indicate that PELO plays an important role in the
            establishment of pluripotency and differentiation of ESCs into ExEn
            lineage through activation of BMP signaling.
REFERENCE   7  (bases 1 to 1588)
  AUTHORS   Abler,L.L., Keil,K.P., Mehta,V., Joshi,P.S., Schmitz,C.T. and
            Vezina,C.M.
  TITLE     A high-resolution molecular atlas of the fetal mouse lower
            urogenital tract
  JOURNAL   Dev Dyn 240 (10), 2364-2377 (2011)
   PUBMED   21905163
REFERENCE   8  (bases 1 to 1588)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (bases 1 to 1588)
  AUTHORS   Adham,I.M., Sallam,M.A., Steding,G., Korabiowska,M., Brinck,U.,
            Hoyer-Fender,S., Oh,C. and Engel,W.
  TITLE     Disruption of the pelota gene causes early embryonic lethality and
            defects in cell cycle progression
  JOURNAL   Mol Cell Biol 23 (4), 1470-1476 (2003)
   PUBMED   12556505
  REMARK    GeneRIF: Pelo is required for the maintenance of genomic stability
REFERENCE   10 (bases 1 to 1588)
  AUTHORS   Shamsadin,R., Adham,I.M. and Engel,W.
  TITLE     Mouse pelota gene (Pelo): cDNA cloning, genomic structure, and
            chromosomal localization
  JOURNAL   Cytogenet Genome Res 97 (1-2), 95-99 (2002)
   PUBMED   12438745
  REMARK    GeneRIF: cDNA cloning, genomic structure, and chromosomal
            localization
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC175538.1, BC050209.1, BB767039.1 and AI854576.1.
            
            On Jan 15, 2008 this sequence version replaced NM_134058.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050209.1, AK170635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC175538.1         169755-169955       c
            202-1056            BC050209.1         115-969
            1057-1565           BB767039.1         32-540
            1566-1588           AI854576.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1588
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 64.61 cM"
     gene            1..1588
                     /gene="Pelo"
                     /note="pelota mRNA surveillance and ribosome rescue
                     factor"
                     /db_xref="GeneID:105083"
                     /db_xref="MGI:MGI:2145154"
     exon            1..965
                     /gene="Pelo"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1397
                     /gene="Pelo"
                     /note="pelota homolog"
                     /codon_start=1
                     /product="protein pelota homolog"
                     /protein_id="NP_598819.2"
                     /db_xref="CCDS:CCDS26788.1"
                     /db_xref="GeneID:105083"
                     /db_xref="MGI:MGI:2145154"
                     /translation="MKLVRKDIEKDNAGQVTLVPEEPEDMWHTFNLVQVGDSLRASTI
                     RKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTI
                     ELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHVCLVTPSMTLTR
                     AKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHINFEVVKCVLVASPGFVREQFC
                     DYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVK
                     ALDDFYKMLQHEPDRAFYGLKQVERANEALAIDTLLISDELFRHQDVATRSRYVRLVD
                     SVKENAGTVRIFSSLHVSGEQLGQLTGVAAILRFPVPELSDQEDDSSSEED"
     exon            966..1572
                     /gene="Pelo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1546..1551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pelo"
                     /note="hexamer: AATAAA"
     polyA_site      1572
                     /gene="Pelo"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtcccg agagttgact cgtgctgagc gtgaggtttg ccgcgccgcg cgtgggccag
       61 cgcgcggaga cttgagaaaa agcgtggggt aaaagtgctg tcccgagctg caagagttag
      121 aggtagtgtt tccttccggg cctgagcccg ccgccccttc cctgccccgg ccccccctcc
      181 tggggacacc cccccccccc ctagcgtccc ctgttctgaa ctgagcccct gctgaggtca
      241 tgaagctcgt gaggaaggat atcgagaagg acaatgcggg ccaggtcacc ctcgtccccg
      301 aggagcccga ggacatgtgg cacaccttca atttagtgca ggtgggcgac agcctgcgcg
      361 cctccaccat ccgcaaggtc cagaccgagt cctccacagg cagcgtgggg agcaaccgtg
      421 tccgcaccac cctcaccctt tgcgtggagg ccatcgactt cgactcccag gcctgccagc
      481 tgcgggtgaa ggggaccaat atccaagaga atgagtatgt caagatgggg gcttaccaca
      541 ccatcgaact ggagcccaac cgccagttca ccctggccaa gaaacagtgg gacagtgtgg
      601 ttctggaacg catcgagcag gcttgcgacc cggcgtggag cgctgatgtg gcagctgtgg
      661 tcatgcagga gggcctggcc cacgtctgct tagtcacgcc cagcatgacc cttacccggg
      721 ccaaggtgga ggtgaacatc cccaggaaac ggaaaggcaa ctgctcccag catgaccggg
      781 ccctggagcg gttctatgaa caggtggtcc aggccatcca gcgccacata aacttcgagg
      841 ttgtaaagtg cgttctggtg gccagccctg gattcgtgcg agagcagttc tgcgattaca
      901 tgtttcagca agctgtgaag acggacaata aagtgctcct ggaaaaccgc tccaaattcc
      961 ttcaggtgca cgcctcctct ggacacaagt actccctgaa agaggccctc tgcgacccta
     1021 ctgtagcgag ccgcctttca gacacaaagg cagcgggcga agtaaaagcc ttggatgact
     1081 tctacaaaat gttacagcac gagcccgacc gagcgttcta tggactcaag caggtggaga
     1141 gggccaacga agccttggcc atagacactt tgctcatcag tgacgagctc ttccggcatc
     1201 aggatgtggc cacccggagc cggtatgtca ggctagtgga cagtgtgaag gagaatgcgg
     1261 gcaccgtaag gatattctct agtctccatg tgtcggggga acagctgggc cagctgacgg
     1321 gagtagccgc cattctccgc ttcccagtgc cagaactttc tgaccaagag gatgattcaa
     1381 gttctgaaga ggattaagac tggcagttaa tagtttcttc cctggttttc tcagcatcct
     1441 tggcaggtgc cagagcagca cttgttgatc ctgctggggt ttcttgtgtg ttgggttcac
     1501 attaagtgtt ttatgatttg gtgggcagga catgtattca aattaaataa atcacgacga
     1561 tgtccaagct taaaaaaaaa aaaaaaaa
//
