LOCUS       NM_172835               1937 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus pellino 3 (Peli3), transcript variant 1, mRNA.
ACCESSION   NM_172835
VERSION     NM_172835.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Kim,Y.M., Kim,H.Y., Ha Thi,H.T., Kim,J., Lee,Y.J., Kim,S.J. and
            Hong,S.
  TITLE     Pellino 3 promotes the colitis-associated colorectal cancer through
            suppression of IRF4-mediated negative regulation of TLR4 signalling
  JOURNAL   Mol Oncol 17 (11), 2380-2395 (2023)
   PUBMED   37341064
  REMARK    GeneRIF: Pellino 3 promotes the colitis-associated colorectal
            cancer through suppression of IRF4-mediated negative regulation of
            TLR4 signalling.
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Le,L., Shan,H., Lin,Y., Xia,W., Ma,X., Jiang,C., Shi,Z. and Xu,Y.
  TITLE     The Ubiquitination of RIPK2 is Mediated by Peli3 and Negatively
            Regulates the Onset of Infectious Osteomyelitis
  JOURNAL   Jpn J Infect Dis 76 (4), 240-245 (2023)
   PUBMED   37121674
  REMARK    GeneRIF: The Ubiquitination of RIPK2 is Mediated by Peli3 and
            Negatively Regulates the Onset of Infectious Osteomyelitis.
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   Lee,J., Ha,J., Kim,J.H., Seo,D., Kim,M., Lee,Y., Park,S.S.,
            Choi,D., Park,J.S., Lee,Y.J., Yang,S., Yang,K.M., Jung,S.M.,
            Hong,S., Koo,S.H., Bae,Y.S., Kim,S.J. and Park,S.H.
  TITLE     Peli3 ablation ameliorates acetaminophen-induced liver injury
            through inhibition of GSK3beta phosphorylation and mitochondrial
            translocation
  JOURNAL   Exp Mol Med 55 (6), 1218-1231 (2023)
   PUBMED   37258579
REFERENCE   5  (bases 1 to 1937)
  AUTHORS   Murphy,M.B., Xiong,Y., Pattabiraman,G., Manavalan,T.T., Qiu,F. and
            Medvedev,A.E.
  TITLE     Pellino-3 promotes endotoxin tolerance and acts as a negative
            regulator of TLR2 and TLR4 signaling
  JOURNAL   J Leukoc Biol 98 (6), 963-974 (2015)
   PUBMED   26310831
  REMARK    GeneRIF: Pellino-3 is involved in endotoxin tolerance and functions
            as a negative regulator of Toll-like receptor 2/4 signaling.
REFERENCE   6  (bases 1 to 1937)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1937)
  AUTHORS   Yang,S., Wang,B., Humphries,F., Jackson,R., Healy,M.E., Bergin,R.,
            Aviello,G., Hall,B., McNamara,D., Darby,T., Quinlan,A.,
            Shanahan,F., Melgar,S., Fallon,P.G. and Moynagh,P.N.
  TITLE     Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and
            protective effects in colitis
  JOURNAL   Nat Immunol 14 (9), 927-936 (2013)
   PUBMED   23892723
  REMARK    GeneRIF: Our findings identify RIP2 as a substrate for Pellino3 and
            Pellino3 as an important mediator in the Nod2 pathway and regulator
            of intestinal inflammation.
REFERENCE   8  (bases 1 to 1937)
  AUTHORS   Banon-Rodriguez,I., Saez de Guinoa,J., Bernardini,A., Ragazzini,C.,
            Fernandez,E., Carrasco,Y.R., Jones,G.E., Wandosell,F. and
            Anton,I.M.
  TITLE     WIP regulates persistence of cell migration and ruffle formation in
            both mesenchymal and amoeboid modes of motility
  JOURNAL   PLoS One 8 (8), e70364 (2013)
   PUBMED   23950925
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1937)
  AUTHORS   Yang,S., Wang,B., Tang,L.S., Siednienko,J., Callanan,J.J. and
            Moynagh,P.N.
  TITLE     Pellino3 targets RIP1 and regulates the pro-apoptotic effects of
            TNF-alpha
  JOURNAL   Nat Commun 4, 2583 (2013)
   PUBMED   24113711
  REMARK    GeneRIF: Pellino3 targets RIP1 and regulates the pro-apoptotic
            effects of TNF-alpha.
REFERENCE   10 (bases 1 to 1937)
  AUTHORS   Siednienko,J., Jackson,R., Mellett,M., Delagic,N., Yang,S.,
            Wang,B., Tang,L.S., Callanan,J.J., Mahon,B.P. and Moynagh,P.N.
  TITLE     Pellino3 targets the IRF7 pathway and facilitates autoregulation of
            TLR3- and viral-induced expression of type I interferons
  JOURNAL   Nat Immunol 13 (11), 1055-1062 (2012)
   PUBMED   23042151
  REMARK    GeneRIF: Pellino3 targets the IRF7 pathway and facilitates
            autoregulation of TLR3- and viral-induced expression of type I
            interferons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY128359.1, AK044418.1 and BY452323.1.
            
            On Jun 21, 2008 this sequence version replaced NM_172835.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044418.1, BC028931.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BY128359.1         1-54
            55-1932             AK044418.1         2-1879
            1933-1937           BY452323.1         419-423
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.17 cM"
     gene            1..1937
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /note="pellino 3"
                     /db_xref="GeneID:240518"
                     /db_xref="MGI:MGI:1924963"
     exon            1..155
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /inference="alignment:Splign:2.1.0"
     exon            156..308
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /inference="alignment:Splign:2.1.0"
     exon            309..438
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /inference="alignment:Splign:2.1.0"
     exon            439..540
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /inference="alignment:Splign:2.1.0"
     exon            541..735
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /inference="alignment:Splign:2.1.0"
     exon            736..924
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1937
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1907..1912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /note="hexamer: TATAAA"
     polyA_site      1936
                     /gene="Peli3"
                     /gene_synonym="6030441F14Rik; A930011L17"
                     /note="major polyA site"
ORIGIN      
        1 acatccctcc ctcctccggg cctcgggtgt ccccgtgacg aggctgcacc gagcagccgc
       61 gggccgggcc catcccgccg cggcagtccc ggggcgcagt agaggtgagg cgggtggggg
      121 ccagcagcac acagagagcc ccagaacgcc gccagaatgg tgctggaagg aaaccctgac
      181 gtgggatccc cccggacctc agacctccag cacccgggga gccagggctc ttgcatcctg
      241 tcttgtcctg gtgaagaagc actggcaggc gaggagccca tcaagtatgg tgaactcatc
      301 gttctgggct acaatgggtg tctggcaagt ggagacaagg gccgccgccg aagccgcctg
      361 gcactgagcc gccggccaca tgccaacgga gtgaagccag atgtcatgca ccacatctcc
      421 acaccactcg tctccaaggc cctgagtaac cgaggccagc acagcatctc attcacactg
      481 tcccggagtc actcagtcat agtggagtac acacatgaca gcgacaaaga catgttccag
      541 attggccgct ctactgaaaa catgattgac tttgtggtaa cagacacatc tcctggtgga
      601 ggggctacag agggcccttc tgcccaaagt accatctccc gctatgcctg cagaattctc
      661 tgtgaccgcc ggccacccta tactgcccga atctacgctg ctggctttga tgcctctagc
      721 aacatctttc ttggagagcg ggcagccaaa tggaggactc cggatggtct gatggacggc
      781 ttgacaacca atggggttct ggtgatgcac ccagcaggtg gcttctccga ggactctgcc
      841 ccaggtgtct ggagggagat ttctgtctgc gggaatgtgt acacgctgcg ggatagccga
      901 tcagctcagc agcgggggaa gctggtggaa aacgaatcca acgtcctgca agacggttcg
      961 ctcatcgacc tgtgtggggc cacactgttg tggcgcactc cggctgggtt gctgagggca
     1021 cccacactga aacaactaga ggcccagcga caggaggcca acgcagcacg gccccagtgc
     1081 cccgtgggcc ttagcacctt ggccttcccc agcccagccc gtggccgcac agcacccgac
     1141 aaacagcaac cctgggtcta cgtccgttgt ggtcatgtcc atggctatca cggctggggc
     1201 tgccggaggg aacaaggccc ccaggagcga gagtgtcctc tctgccgcct tgtgggaccc
     1261 tatgtgcccc tgtggctcgg tcaggaggcc ggtctctgcc tggaccctgg gccacccagc
     1321 cacgcttttg caccctgtgg ccacgtctgt tctgagaaga ctgcccgcta ctgggctcag
     1381 acaccgctgc cgcacggcac ccatgctttc cacgctgcct gccccttctg tggagcttgg
     1441 ctcaccggtg agcttggctg tgtccgcctc attttccagg ggccactgga ctaggctctc
     1501 cgggaccctt gctgccatgc tcgcctgccc acccaggtcc cccatctcct gctgttcaga
     1561 gggagctctg catgtgggac tctgcctgct ggcaataacc acgccagttg gaagcattgg
     1621 atgggctgtg gccctcccct cggctctcgc ctctcagagg gtcactgaga tctcgatccc
     1681 aggcatactg atagggactt tagcaccagc tctgccccag gctgatggag ggcaccccat
     1741 gcctctgccc tccctggagt accctacatc atgccgcata cactgtgccc ctgggggaat
     1801 gaaggggcca tggcccccga cctccagctt agactggttg tgccctgaac ctgccaatgc
     1861 aggaacagct attcctccct cctgctgctg ctgccgtggg ttactctata aaccttgctg
     1921 ctcagctgcc cttaaag
//
