LOCUS       NM_033602               5849 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus pellino 2 (Peli2), mRNA.
ACCESSION   NM_033602
VERSION     NM_033602.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5849)
  AUTHORS   Liu X, Lin Z and Yin X.
  TITLE     Pellino2 accelerate inflammation and pyroptosis via the
            ubiquitination and activation of NLRP3 inflammation in model of
            pediatric pneumonia
  JOURNAL   Int Immunopharmacol 110, 108993 (2022)
   PUBMED   35809381
  REMARK    GeneRIF: Pellino2 accelerate inflammation and pyroptosis via the
            ubiquitination and activation of NLRP3 inflammation in model of
            pediatric pneumonia.
REFERENCE   2  (bases 1 to 5849)
  AUTHORS   Oleszycka E, Rodgers AM, Xu L and Moynagh PN.
  TITLE     Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9
            Signaling Pathway
  JOURNAL   J Immunol 207 (9), 2325-2336 (2021)
   PUBMED   34588221
  REMARK    GeneRIF: Dendritic Cell-Specific Role for Pellino2 as a Mediator of
            TLR9 Signaling Pathway.
REFERENCE   3  (bases 1 to 5849)
  AUTHORS   Ma T, Hou J, Zhou Y, Chen Y, Qiu J, Wu J, Ding J, Han X and Li D.
  TITLE     Dibutyl phthalate promotes juvenile Sertoli cell proliferation by
            decreasing the levels of the E3 ubiquitin ligase Pellino 2
  JOURNAL   Environ Health 19 (1), 87 (2020)
   PUBMED   32738922
  REMARK    GeneRIF: Dibutyl phthalate promotes juvenile Sertoli cell
            proliferation by decreasing the levels of the E3 ubiquitin ligase
            Pellino 2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5849)
  AUTHORS   Humphries F, Bergin R, Jackson R, Delagic N, Wang B, Yang S, Dubois
            AV, Ingram RJ and Moynagh PN.
  TITLE     The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3
            inflammasome
  JOURNAL   Nat Commun 9 (1), 1560 (2018)
   PUBMED   29674674
  REMARK    GeneRIF: The functions of Pellino2 in the NLRP3 pathway are
            dependent on Pellino2 FHA and RING-like domains, with Pellino2
            promoting the ubiquitination of NLRP3 during the priming phase of
            activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5849)
  AUTHORS   Kim TW, Yu M, Zhou H, Cui W, Wang J, DiCorleto P, Fox P, Xiao H and
            Li X.
  TITLE     Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor
            (TLR/IL-1R)-mediated post-transcriptional control
  JOURNAL   J Biol Chem 287 (30), 25686-25695 (2012)
   PUBMED   22669975
  REMARK    GeneRIF: Pellino 2 plays a critical role for TLR/IL-1R-mediated
            post-transcriptional control.
REFERENCE   6  (bases 1 to 5849)
  AUTHORS   Dong W, Liu Y, Peng J, Chen L, Zou T, Xiao H, Liu Z, Li W, Bu Y and
            Qi Y.
  TITLE     The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to
            NF-kappaB from Toll-like receptor 4
  JOURNAL   J Biol Chem 281 (36), 26029-26040 (2006)
   PUBMED   16831874
REFERENCE   7  (bases 1 to 5849)
  AUTHORS   Lau NC, Seto AG, Kim J, Kuramochi-Miyagawa S, Nakano T, Bartel DP
            and Kingston RE.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   8  (bases 1 to 5849)
  AUTHORS   Liu Y, Dong W, Chen L, Xiang R, Xiao H, De G, Wang Z and Qi Y.
  TITLE     BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling
            through interaction with Pellino2
  JOURNAL   J Biol Chem 279 (36), 37436-37444 (2004)
   PUBMED   15213237
REFERENCE   9  (bases 1 to 5849)
  AUTHORS   Yu KY, Kwon HJ, Norman DA, Vig E, Goebl MG and Harrington MA.
  TITLE     Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide
            signaling
  JOURNAL   J Immunol 169 (8), 4075-4078 (2002)
   PUBMED   12370331
  REMARK    GeneRIF: Pellino-2 is a tissue-restricted component of a signaling
            pathway that couples the mouse pelle-like kinase/IL-1
            receptor-associated kinase protein to IL-1- or
            lipopolysaccharide-dependent signaling.
REFERENCE   10 (bases 1 to 5849)
  AUTHORS   Resch K, Jockusch H and Schmitt-John T.
  TITLE     Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for
            the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14
            and human chromosomes 2p13.3 and 14q21, respectively, by physical
            and radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 172-174 (2001)
   PUBMED   11306823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030564.1, AK082342.1 and AC174647.2.
            
            [WARNING] On Oct 7, 2023 this sequence was replaced by NM_033602.3.
            
            On Nov 17, 2006 this sequence version replaced NM_033602.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.237483.1, AK030564.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AK030564.1         48-178
            132-495             AK082342.1         88-451
            496-3339            AK030564.1         543-3386
            3340-5849           AC174647.2         148763-151272
FEATURES             Location/Qualifiers
     source          1..5849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.6 cM"
     gene            1..5849
                     /gene="Peli2"
                     /note="pellino 2"
                     /db_xref="GeneID:93834"
                     /db_xref="MGI:MGI:1891445"
     exon            1..365
                     /gene="Peli2"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..1548
                     /gene="Peli2"
                     /EC_number="2.3.2.27"
                     /note="protein pellino homolog 2; RING-type E3 ubiquitin
                     transferase pellino homolog 2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase pellino homolog 2"
                     /protein_id="NP_291080.2"
                     /db_xref="CCDS:CCDS36901.1"
                     /db_xref="GeneID:93834"
                     /db_xref="MGI:MGI:1891445"
                     /translation="MFSPGQEEPSAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFA
                     LYKRTYASGVKPSTIHMVSTPQASKAISSRGHHSISYTLSRSQTVVVEYTHDKDTDMF
                     QVGRSTESPIDFVVTDTVSGGQNEDAQITQSTISRFACRIVCDRNEPYTARIFAAGFD
                     SSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPQGGFTEESQPGVWREISVCGDVYT
                     LRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHAPTQKHIEALRQEI
                     NAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHSWGHRSDTEANEREC
                     PMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAF
                     HAACPFCATQLVGEQNCIKLIFQGPVD"
     exon            366..495
                     /gene="Peli2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..597
                     /gene="Peli2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..792
                     /gene="Peli2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..981
                     /gene="Peli2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..5849
                     /gene="Peli2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccccccgg cggcgcgcgc tcctcctccc gcggggctct ggtcgccgct cgctttccgt
       61 gccgggtccc gctcgtagcg gccaacgtac ggatagctcc ggggaagccg gcgggcgacg
      121 cgcacagcca cgacggagca gccgcgggac tggccgccca gcgccccgtt cgccgccgtg
      181 ccgttccccg gcgcgctcac cccgttttcg ggatgggagt gtagtggcgg cgcggactcg
      241 gcggggatcg cggcggaggc ggcagcggcg gcggccgagc gcggctccat gttttccccg
      301 ggccaggagg aacccagcgc ccccaacaag gagccggtga aatacgggga gctggtggtc
      361 ctggggtaca atggtgcttt acctaatggt gacaggggca ggaggaaaag cagatttgcc
      421 ctctataagc ggacctacgc cagtggtgtc aaacccagca caatccacat ggtctccaca
      481 ccacaggcgt ccaaggccat cagctccaga ggacatcaca gcatatcgta cacgttgtca
      541 cggagccaga cggtagtggt ggagtacaca cacgataaag acacagacat gtttcaggtg
      601 ggcaggtcaa cagaaagccc cattgacttc gtggtcacag acacggtttc cggcggtcag
      661 aacgaagatg cccagatcac acagagcacc atctctaggt tcgcatgcag gatcgtgtgt
      721 gacaggaacg agccatacac agcacgcata ttcgcggcag gattcgattc ttccaaaaat
      781 atctttcttg gagagaaagc agcaaaatgg aaaaaccctg atggacacat ggatggactc
      841 actaccaacg gtgtcctggt gatgcacccg caaggaggct tcaccgagga atcccagcct
      901 ggagtctgga gagagatctc tgtctgtggg gatgtataca ccttgcgaga gaccaggtcg
      961 gcccagcaga ggggaaagct ggtggaaagt gagaccaacg tcctgcaaga cggctccctc
     1021 attgacctgt gtggggccac tctcctctgg agaaccgcag atggcctttt tcacgctcct
     1081 actcagaagc acatagaagc cctccggcag gagatcaatg cagcccgacc ccagtgcccc
     1141 gtgggcctta acaccctggc cttccccagc atcaaccgga aggaagtggt ggaagagaag
     1201 cagccctggg catacctgag ctgcggccat gtgcacggct accacagctg gggccatcgg
     1261 agcgacacgg aagccaacga gagggagtgt cccatgtgca ggactgtggg cccctacgtc
     1321 cctctctggc tgggctgtga ggcaggattt tatgtcgatg cgggaccccc aactcacgct
     1381 ttcaccccct gcgggcacgt ctgttcagag aagtctgcca agtactggtc gcagatccca
     1441 ctgccccacg gaacgcacgc gtttcacgcc gcctgtccgt tctgcgccac gcagctggtt
     1501 ggtgaacaga actgcatcaa attgattttc caaggtccag tggactgaca ccctggacgg
     1561 ccatctccac ggcattaaca cgttactgtg aagattccgc cactaactgt agattctacc
     1621 tttttgtaat gctgtttgtt aaggggaagg cggactgggt tgggaaatgg gggctggtga
     1681 cgaaatgtgg caggcgctga cagataccac tgtgttttgc atgctcagaa cagcagcatc
     1741 agcatcgtca ctgaggtctg cctgattaaa ctttaatacc tgtgtaataa ttggatctca
     1801 actgccatgc ttttcttttt aactttaggt ttttaaccag attttttccc cctttgtaaa
     1861 cttgggtaag attttacaaa tgtagaagaa atgtactcag caaatgtctc ttagagcaca
     1921 gcctgcagag ccatgtggca caagtgccac acatcctatg atgttcagtg gctgtgaata
     1981 cttgacagtg gctagaatct gacccaatac ctaagggcca cctctgtcag ccctgccaca
     2041 aacacccgtg gacaggaggc gtaggccatg cacttgtctt gaaatctgca gctttttctc
     2101 accttttctt tttaactttg ggtggaagag ggtattcgta tactgttttg ttttactttt
     2161 agtggaattc acttacatac tcattcatca gatacttggc atgtcaaaca aagaatttcc
     2221 ccatggtttt aatctgccct gttatgggct gctcctcatc ttacgtgtca agaagtgact
     2281 ggttggttga ttggttggtt gattgattga ttgatgattg aattcatgag ctgaggggaa
     2341 tggccttgca ctacgggggc tggtgctgct gcagttggca gcagtgggct gtcctaggta
     2401 ctcttgacac cagctttgtc tggacaccag aacacttacg acccaagtgg gatttaaagt
     2461 acgcttttac tttttaaaat ccacttgttg gcacttcaca gaacggtttc cttctcttct
     2521 ccttcttagg aaagacaaaa ttttgtaagc ccagaagcaa caagcgacag tgagattgcc
     2581 atttctgtcc cctaccttcc caccatctgt caccttccct tccagtttaa ggagccccat
     2641 aagttgtttg tttttatttt tttcaatgtt tgcaaatcag actaaaccta aatgtgctga
     2701 tgagatacac ggagcactga gcggcgtgtc tgccgaaatc atttgaaatt cctgattttg
     2761 agagaccaag tgagtgttta ctgaggaata attaaatcag gatttcattg agctgcaatg
     2821 accctctctt tcagtttcat cttgcattga ttaatgatgc ctgaatactc gttttccatg
     2881 cttggtgcca ggagtatctg tggctcccag agtgtcagca tggagagaca ctgctgagct
     2941 tggctgtgtt ccaccccatt cccaaggagg aagtctccag taaaatcagc gtccgctcag
     3001 gtggaccgtc agcagctttg agctgcctgt tttagcgttt gtaaatatag ataatttata
     3061 tgattatgac atatccatac ttgaattggt ttttccatat cttgcccatt agcagatact
     3121 attttgccta ttttcacaaa ttaaacctat gtgactactt ttttcctgaa agcaaaacgg
     3181 taatattaat tgctctgtag cgctgctgct cagtttgatt cagtgtgctg tcattttaaa
     3241 aggagcttta ttttcccatg gagactgttc tgtagtaaga gaggtttggt tttttgtttt
     3301 gttttgtttt gttttaatta tatttatgat gtgaaaatcc aacagcagtc tttttactga
     3361 tatttccctg tgttctacat agattacctg cagacaaaaa agaaaaagaa ataaaggcag
     3421 gcagacagag agagagagag agagagagag agaactttct agagaaacct atagggtgtc
     3481 atctggtgca gccaaaattt ccatccctgt ttttcagagg agggtaaagg atacactcac
     3541 cccaccccac ccccgcctcc ttatatggag atagatagtc tgaggattct tgatgtcctg
     3601 ggattgtctt ctaagataaa gggtcttaca cccagaaaga ttaaatttca cctatccaaa
     3661 aaaagttttg tttttcaagg aagttcacgc tgacaccaga cttctctgtg tagatctgcg
     3721 tagagcatac actcccaaat aaggcaagca cccccgccag tcagaggtca taaccttaca
     3781 aactcagctc aagtgcaggt ggaaactcat aaaccacagg ccttcagtgg cggtcaagcc
     3841 acctgtcgct ttgccttcag tttccaggtg aagtcctgtt ccccctcacc ccagccccct
     3901 gccagaggaa gaaagaggtg tcaacctgca acggcagcca agctgacttg gacaatttct
     3961 gtaaagtcac tttctcccga ggaaaggttt tcaagttaga taacaggtat ggttttgaga
     4021 cgttgttgtt catccaagta gaatgataca gttgagagag aaggaagctt cttcaaggtc
     4081 aactctgtgt gttcagcttt ggtggccgtc acacaaaaga ggaagcccac cccaccccta
     4141 cccccacctg tacataggga aatcaccagc cactcagtct ggtctcagcc tgaccagtcg
     4201 ccttttccac taggtttcca gaagtcaagc cctagtgaca tgcctccata ggtgatattt
     4261 ttttcagttg tttgtgtcat tttcttacac acacacacac acaaaaatca gagtgaatgg
     4321 gatatagctc tgagtatttt tctaatgttt tttattatta ataataataa acggtgctgc
     4381 tgggtcatgc acactgcgtg cacactgcgg ctctcaacat ttcttcaatt tctttcagct
     4441 tttgcaaaaa gggctacagt tcacactgca gaacaagaac taagctttct aggtcttctc
     4501 ccccccccat ccccgtcccc cgtacttttg tggcccgaaa gaattaaaat catttaatat
     4561 aaatagcata tttatatcat tcctcaatag ttaattatag ggtttggtac ctttgtgcct
     4621 cagggaagcc acatgatcta actggttata gactttcagg gttagggcat agagaaagga
     4681 gaaagccatt ggaaacatga tggactccat taaggagacg agctaatcta ggtgcagaag
     4741 aatgccagga ctagcataaa tgtgattgta gtagaacttg tttcccagtg ctagtaggga
     4801 aatcgtttta agttattaca tataccgtat tcggagagtc gagaactctc ctaaagcagc
     4861 aaggccccct gcatgtgtac taagagttgt tccatgatct cactcctgct ttccttcttc
     4921 aaaacagttc ttttcttgag gtgggcacca gaggcgggca gtcatggcac tctcggtcct
     4981 gacgttatgc agccttgcca ctcacggtgg gaattcagac agacaagccc caggcccttg
     5041 atttcaccag atgtgattct gttctgggag ctgccaatcc cctgatccca gagctctgcc
     5101 tttgggctga aggtctgacg ctcctgtggt ggtgagcata ggtcatagct ccagctgttg
     5161 cttgatagcc caaggccaat gagatcactt caggacattt gtaaagcaag ctaaacattt
     5221 cggaaggagt aaaaacggaa gagttctgtc attacttttc agtaacaggt cctcaaaaat
     5281 acctgccctc acgactccct agtgggcagt aggggaaaac gaatatattt tccaggttgc
     5341 ttaactttct aaacaaaaat gaacaatgct gaaaaggatg ctctgccttt taagatgaga
     5401 tcacagattg cttctctgtg ttaaataatc tagaagtcag ggggctggtc ggatttacca
     5461 tgtatagtgt tatgagcagt taaattttat ggctatattt gtaaaatctg ttcttttata
     5521 tttcgtgtca aattgaaaac tttatttctt cactgttgta cctgtggaaa tacaagccat
     5581 tttacaggga aaaaaaatct tcaaaagcta ttaaacaaat ctcaccatgt ttgtaagttg
     5641 tctttagact cttcttatct gtcactggct ttacggggac gctcggtagg acatggatgc
     5701 aaacctagac tttatttata catttctgca gcttccacat gaatccctaa cagacaggat
     5761 tattgtttcg ttatcctctg cacactgcat ctttgatctg agttctgaaa tcgcccaaat
     5821 tttttattaa agaaacttca ttttattaa
//
