LOCUS       NM_023324               3501 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus pellino 1 (Peli1), mRNA.
ACCESSION   NM_023324 NM_030015
VERSION     NM_023324.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3501)
  AUTHORS   Hwang,S., Park,J., Koo,S.Y., Lee,S.Y., Jo,Y., Ryu,D., Go,H. and
            Lee,C.W.
  TITLE     The ubiquitin ligase Pellino1 targets STAT3 to regulate
            macrophage-mediated inflammation and tumor development
  JOURNAL   Nat Commun 16 (1), 1256 (2025)
   PUBMED   39893188
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3501)
  AUTHORS   Yoon,D.S., Oh,S.E., Lee,K.M., Jung,S., Ko,E.A., Kim,T.G., Park,K.H.
            and Lee,J.W.
  TITLE     Age-Related Decrease in Pellino-1 Expression Contributes to
            Osteoclast-Mediated Bone Loss
  JOURNAL   Adv Biol (Weinh) 8 (7), e2400210 (2024)
   PUBMED   38712476
  REMARK    GeneRIF: Age-Related Decrease in Pellino-1 Expression Contributes
            to Osteoclast-Mediated Bone Loss.
REFERENCE   3  (bases 1 to 3501)
  AUTHORS   Jia,Y., Zhu,G., Qiu,C., Lai,J.M., Shen,Y., Jin,S.W., Yang,X.,
            Zhu,H.P., Hu,B.C., Ye,X.M. and Mo,S.J.
  TITLE     Pellino1 orchestrates gut-kidney axis to perpetuate septic acute
            kidney injury through activation of STING pathway and NLRP3
            inflammasome
  JOURNAL   Life Sci 345, 122604 (2024)
   PUBMED   38580196
  REMARK    GeneRIF: Pellino1 orchestrates gut-kidney axis to perpetuate septic
            acute kidney injury through activation of STING pathway and NLRP3
            inflammasome.
REFERENCE   4  (bases 1 to 3501)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3501)
  AUTHORS   Hou,Y., Shi,P., Du,H., Zhu,C., Tang,C., Que,L., Zhu,G., Liu,L.,
            Chen,Q., Li,C., Shao,G., Li,Y. and Li,J.
  TITLE     HNF4alpha ubiquitination mediated by Peli1 impairs FAO and
            accelerates pressure overload-induced myocardial hypertrophy
  JOURNAL   Cell Death Dis 15 (2), 135 (2024)
   PUBMED   38346961
  REMARK    GeneRIF: HNF4alpha ubiquitination mediated by Peli1 impairs FAO and
            accelerates pressure overload-induced myocardial hypertrophy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3501)
  AUTHORS   Capellini,T.D., Dunn,M.P., Passamaneck,Y.J., Selleri,L. and Di
            Gregorio,A.
  TITLE     Conservation of notochord gene expression across chordates:
            insights from the Leprecan gene family
  JOURNAL   Genesis 46 (11), 683-696 (2008)
   PUBMED   18798549
REFERENCE   7  (bases 1 to 3501)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   8  (bases 1 to 3501)
  AUTHORS   Jiang,Z., Johnson,H.J., Nie,H., Qin,J., Bird,T.A. and Li,X.
  TITLE     Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling
            through its interaction with the IL-1 receptor-associated kinase 4
            (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6
            (TRAF6) complex
  JOURNAL   J Biol Chem 278 (13), 10952-10956 (2003)
   PUBMED   12496252
REFERENCE   9  (bases 1 to 3501)
  AUTHORS   Fuchs,S., Resch,K., Thiel,C., Ulbrich,M., Platzer,M., Jockusch,H.
            and Schmitt-John,T.
  TITLE     Comparative transcription map of the wobbler critical region on
            mouse chromosome 11 and the homologous region on human chromosome
            2p13-14
  JOURNAL   BMC Genet 3, 14 (2002)
   PUBMED   12174196
REFERENCE   10 (bases 1 to 3501)
  AUTHORS   Resch,K., Jockusch,H. and Schmitt-John,T.
  TITLE     Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for
            the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14
            and human chromosomes 2p13.3 and 14q21, respectively, by physical
            and radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 172-174 (2001)
   PUBMED   11306823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152900.1, AL669979.13 and AW124934.1.
            
            On or before Sep 8, 2006 this sequence version replaced
            NM_030015.1, NM_023324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151660.1, AK152900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2591              AK152900.1         2-2592
            2592-3076           AL669979.13        62815-63299
            3077-3501           AW124934.1         1-425               c
FEATURES             Location/Qualifiers
     source          1..3501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 13.81 cM"
     gene            1..3501
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /note="pellino 1"
                     /db_xref="GeneID:67245"
                     /db_xref="MGI:MGI:1914495"
     exon            1..355
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /inference="alignment:Splign:2.1.0"
     exon            356..495
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1681
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /EC_number="2.3.2.27"
                     /note="protein pellino homolog 1; RING-type E3 ubiquitin
                     transferase pellino homolog 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase pellino homolog 1"
                     /protein_id="NP_075813.2"
                     /db_xref="CCDS:CCDS24462.1"
                     /db_xref="GeneID:67245"
                     /db_xref="MGI:MGI:1914495"
                     /translation="MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALF
                     KRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQI
                     GRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERSPPFTARIYAAGFDS
                     SKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSL
                     RETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEIN
                     AARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECP
                     MCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFH
                     AACPFCAHQLAGEQGYIRLIFQGPLD"
     exon            496..625
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /inference="alignment:Splign:2.1.0"
     exon            626..727
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /inference="alignment:Splign:2.1.0"
     exon            728..925
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1114
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..3485
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3462..3467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /note="hexamer: AGTAAA"
     polyA_site      3485
                     /gene="Peli1"
                     /gene_synonym="2810468L03Rik; A930031K15Rik; D11Ertd676e"
                     /note="major polyA site"
ORIGIN      
        1 agtgacccaa aggcggttcg aggcggaggg accgtcgggg gcgccgccgc cgccttctcc
       61 agcgccagca acagcagcag cagcggcagc gacaacagca gcagcggcag cagcggccgt
      121 gcggcgccac cggatctgcc tgcagcccgg ggagctcacc acaaagcggg cccgagcctc
      181 cctctctagt ccgcgctcgg ctctgcgttc cactcggcct cgcggggctc ggcggctggc
      241 gggaaggcgg cgggctccgc tggtgcctgc gttcaaccgg tgctcgcgcc gcccccgcgc
      301 cccgggtgtc cgtgcggcgg gccgagctgg cgttccggcc accagcagtc gtccggaaat
      361 aatgcaaaag gtgtctcaag gctcctgacc agtgaacaga gatttgagaa agacagccaa
      421 gctcatgttt tctcctgatc aagaaaatca tccttccaaa gccccagtaa aatatggcga
      481 actcattgtc ttaggatata atggatctct cccaaacggt gatagaggaa ggaggaaaag
      541 taggtttgct ttgtttaaaa gacctaaggc aaatggggtg aagcctagca ccgtgcacat
      601 tgcatgtact cctcaggctg ccaaggcaat aagcaacaag gaccagcata gcatatcata
      661 tactttatct cgagcccaga cggtggtggt tgaatatact catgacagca acactgatat
      721 gtttcagatt ggtcggtcaa ctgaaagtcc tattgatttt gtagtaactg acaccgttcc
      781 tggaagtcag agtaattccg acacgcagtc agtacaaagc actatatcaa gatttgcctg
      841 taggatcata tgtgagcgca gtcccccctt tacagctcgg atttatgctg cagggtttga
      901 ttcatcaaaa aacatctttc ttggggagaa ggctgccaag tggaagacat ctgatgggca
      961 gatggatggc ttgaccacta atggagttct tgtgatgcat ccacgtaatg ggttcacaga
     1021 agactccaaa cctggaatat ggagagaaat atcagtatgt gggaacgtct tcagtctgcg
     1081 tgaaaccaga tcagctcagc agagaggaaa gatggtggaa attgaaacca atcagctaca
     1141 agatggctcc ttaattgacc tttgtggtgc aaccttgctg tggcgtactg cagaaggcct
     1201 ttcccatact cctactgtga agcacttaga agctttaaga caggagatca atgcagctcg
     1261 gccgcagtgc cctgtagggt tcaacacact agccttcccc agtatgaaga ggaaggatgt
     1321 tgtagatgaa aagcaaccat gggtatatct aaactgcggc catgtccatg gttatcataa
     1381 ctggggaaac aaagaagaac gtgacggcaa agatcgtgaa tgtcctatgt gtaggtctgt
     1441 tggtccctat gtccctctgt ggcttggatg tgaagctgga ttttatgtgg acgccggccc
     1501 tcccacccat gcctttagcc cctgtgggca cgtgtgttca gaaaagacaa cggcttactg
     1561 gtcccagatc ccacttcctc atggtacgca cacttttcat gcagcctgcc ccttctgtgc
     1621 acatcagttg gctggtgaac aaggctatat cagacttatt ttccaaggac ctttagacta
     1681 gcagctgtcc tccaggactg cattgtaagt ttataagcta agtgattggg tttgctaacc
     1741 gaccccttgt ccatgtaagt ttctctgctc tggtcatttg cattaagatg aagaattttt
     1801 taaatattta taagcaattt ctgagaaaaa tctgggaaac tcaagcaaag gaatttttga
     1861 aagttccaga cttctgaact ctgagttttg aaaatctatt ttgagaaaaa aaagacatag
     1921 tttaatttga tgccttcctt tgtttagtgt tcttgaatca ccgcccaccc tcagtgttga
     1981 gaggttgtgc tgtagaactg agggtctgtt ggttcaaact atgttagttt acaatttgtt
     2041 gcagacattg taaaatacag caacatgtat attaattttt ctatttatct ttatcataga
     2101 aagtacctta gaatgttgtg ataggctagc atggtaatga tggtgtcaca catttggtgt
     2161 gagtggtagg gtagtgagca caaggctcaa aggtttgcaa agttaaggag aaagacagga
     2221 gagcttcccc cccccccagc cccataatta ggggatattt cataaaacca gaatatttca
     2281 taaaaccaga ttcatattaa ttaccattgt ctaaaaggtg tttgttttta accatattga
     2341 cgttaaccag aaaatggttt ttttccttaa tctttctctc aagtgtagta ctagaacaaa
     2401 agttaatgct aagaaacgtt ttatatgctc ctttgaatat gcaatttaat ctagatgatc
     2461 tatttttctc ccatgataac tgatctgttt ttagtgccag caacatttgg caagtttatt
     2521 tttttggata taaactgtgg ttcatctgtt cactgtttct aaaaaaaaaa agaaaaaaaa
     2581 gaaaaaagaa aagaaaaaag aaaaaaatcc tatgagaaag tgaagaaatt aacaagaaaa
     2641 ttacttgatt tgctctagaa aaattaaata aaaagtgttt tgttaattat tctgtatttg
     2701 gattattcca ggcattagaa catctagagc tgtaaagggt tggctgcaat ggtacctccc
     2761 tttgtagccc agcagaccag ccttaactgt gggcttgact cctcaggagc tggcctcagt
     2821 gtgactcatg gaaatgtttg cttagcggat gaaagtgagg acacaccgca ggggctgctg
     2881 ttctcttcct ccatatgtgc tgtgcaggac agtttcttct caccgtagcc tttttaaatg
     2941 caccagaagt acagacagtt gcactacacc aaaccctttc aacacttgta gaaatcagca
     3001 cactgtagat tagacggaat catctttcag tcctttgact tcttttcctt aagtttgaaa
     3061 aattgtataa taattgacta ctgtcaaatt tttgtatgtg gtagtatagc tttaatttat
     3121 cttactacat taacgttttg attttaaaaa attaaaacaa aaaaagtcac ttagaagcca
     3181 tgaactattt tattttattg tcaatttttc ttgttttgaa aattatcatt tgggttcact
     3241 caggaaatgc atgtcaagat ctgtattata agttatctgt gatgtatcag tagctgctgg
     3301 ttattaccct tttttcaagg aaatttcgtt gatttgaagt tttctggtta caaactttgt
     3361 gaccaatgca aggaaaccaa gtcctgtgtt gtgttttgtc atttctgttg aggctctata
     3421 ttgtagctta atttttattt gcaattaatt tattcaaact aagtaaatac ttttcaaaat
     3481 agctaaaaaa aaaaaaaaaa a
//
