LOCUS       NM_145538               1700 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus plasmanylethanolamine desaturase 1 (Peds1), mRNA.
ACCESSION   NM_145538 XM_110428
VERSION     NM_145538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1700)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1700)
  AUTHORS   Lackner,K., Sailer,S., van Klinken,J.B., Wever,E., Pras-Raves,M.L.,
            Dane,A.D., Honsho,M., Abe,Y., Keller,M.A., Golderer,G.,
            Werner-Felmayer,G., Fujiki,Y., Vaz,F.M., Werner,E.R. and
            Watschinger,K.
  TITLE     Alterations in ether lipid metabolism and the consequences for the
            mouse lipidome
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (4), 159285 (2023)
   PUBMED   36690320
REFERENCE   3  (bases 1 to 1700)
  AUTHORS   Werner,E.R., Fernandez-Quintero,M.L., Hulo,N., Golderer,G.,
            Sailer,S., Lackner,K., Werner-Felmayer,G., Liedl,K.R. and
            Watschinger,K.
  TITLE     Essential role of a conserved aspartate for the enzymatic activity
            of plasmanylethanolamine desaturase
  JOURNAL   Cell Mol Life Sci 79 (4), 214 (2022)
   PUBMED   35347434
  REMARK    GeneRIF: Essential role of a conserved aspartate for the enzymatic
            activity of plasmanylethanolamine desaturase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1700)
  AUTHORS   Koch,J., Lackner,K., Wohlfarter,Y., Sailer,S., Zschocke,J.,
            Werner,E.R., Watschinger,K. and Keller,M.A.
  TITLE     Unequivocal Mapping of Molecular Ether Lipid Species by LC-MS/MS in
            Plasmalogen-Deficient Mice
  JOURNAL   Anal Chem 92 (16), 11268-11276 (2020)
   PUBMED   32692545
REFERENCE   5  (bases 1 to 1700)
  AUTHORS   Werner,E.R., Keller,M.A., Sailer,S., Lackner,K., Koch,J.,
            Hermann,M., Coassin,S., Golderer,G., Werner-Felmayer,G.,
            Zoeller,R.A., Hulo,N., Berger,J. and Watschinger,K.
  TITLE     The TMEM189 gene encodes plasmanylethanolamine desaturase which
            introduces the characteristic vinyl ether double bond into
            plasmalogens
  JOURNAL   Proc Natl Acad Sci U S A 117 (14), 7792-7798 (2020)
   PUBMED   32209662
  REMARK    GeneRIF: hese results assign the TMEM189 gene to
            plasmanylethanolamine desaturase and suggest that the previously
            characterized phenotype of Tmem189-deficient mice may be caused by
            a lack of plasmalogens.
REFERENCE   6  (bases 1 to 1700)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1700)
  AUTHORS   Ashley,C., Pastushok,L., McKenna,S., Ellison,M.J. and Xiao,W.
  TITLE     Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked
            ubiquitination
  JOURNAL   Gene 285 (1-2), 183-191 (2002)
   PUBMED   12039045
REFERENCE   8  (bases 1 to 1700)
  AUTHORS   Franko,J., Ashley,C. and Xiao,W.
  TITLE     Molecular cloning and functional characterization of two murine
            cDNAs which encode Ubc variants involved in DNA repair and
            mutagenesis
  JOURNAL   Biochim Biophys Acta 1519 (1-2), 70-77 (2001)
   PUBMED   11406273
REFERENCE   9  (bases 1 to 1700)
  AUTHORS   Thomson,T.M., Lozano,J.J., Loukili,N., Carrio,R., Serras,F.,
            Cormand,B., Valeri,M., Diaz,V.M., Abril,J., Burset,M., Merino,J.,
            Macaya,A., Corominas,M. and Guigo,R.
  TITLE     Fusion of the human gene for the polyubiquitination coeffector UEV1
            with Kua, a newly identified gene
  JOURNAL   Genome Res 10 (11), 1743-1756 (2000)
   PUBMED   11076860
REFERENCE   10 (bases 1 to 1700)
  AUTHORS   Long,M.
  TITLE     A new function evolved from gene fusion
  JOURNAL   Genome Res 10 (11), 1655-1657 (2000)
   PUBMED   11076848
  REMARK    Review article
            Erratum:[Genome Res 2001 Feb;11(2):308]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CR626861.1 and
            AL589870.30.
            
            On Nov 17, 2006 this sequence version replaced NM_145538.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002270.1, AK151326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               CR626861.1         16738-16909         c
            173-292             CR626861.1         9973-10092          c
            293-384             CR626861.1         2333-2424           c
            385-529             AL589870.30        202083-202227       c
            530-742             AL589870.30        200815-201027       c
            743-1700            AL589870.30        199276-200233       c
FEATURES             Location/Qualifiers
     source          1..1700
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.5 cM"
     gene            1..1700
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /note="plasmanylethanolamine desaturase 1"
                     /db_xref="GeneID:407243"
                     /db_xref="MGI:MGI:2142624"
     exon            1..172
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..864
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /EC_number="1.14.19.77"
                     /note="plasmanylethanolamine desaturase; transmembrane
                     protein 189"
                     /codon_start=1
                     /product="plasmanylethanolamine desaturase 1"
                     /protein_id="NP_663513.1"
                     /db_xref="CCDS:CCDS17104.1"
                     /db_xref="GeneID:407243"
                     /db_xref="MGI:MGI:2142624"
                     /translation="MAGAEDAPGRQPELDEDETAEGRRWGAQHAGARELAALYSPGKR
                     FQEWCSVILCFSLIAHNLVHLLLLARWEHTPLVILGVVAGALVADFLSGLVHWGADTW
                     GSVDLPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTQSP
                     ETLEQLYPWECFVFCLTIFGTFTNQIHKWSHTYLGLPYWVTVLQDWHVILPRKHHRIH
                     HVAPHETYFCITTGWLNYPLEVIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK"
     exon            173..292
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /inference="alignment:Splign:2.1.0"
     exon            293..384
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /inference="alignment:Splign:2.1.0"
     exon            385..529
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /inference="alignment:Splign:2.1.0"
     exon            530..742
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1700
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1601..1606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /note="hexamer: AATAGA"
     polyA_site      1628
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /note="major polyA site"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /note="hexamer: AATATA"
     polyA_site      1691
                     /gene="Peds1"
                     /gene_synonym="Kua; Tmem189"
                     /note="major polyA site"
ORIGIN      
        1 ccgccgccgc tgcaggcaga gcgcagcggg cgggccgggc gacgggccat ggcgggcgcc
       61 gaggacgcgc cgggccggca gccggagctg gacgaggacg agacggcgga gggccggcgc
      121 tggggcgcac agcacgcggg agcccgtgag ctggcggcgc tttactcgcc aggcaagcgc
      181 ttccaggagt ggtgttccgt gatcctctgt ttcagtctca tcgcccacaa cttggtccac
      241 ctcctgctgc tggcccgctg ggagcacaca cccctcgtga tcctgggtgt cgttgcaggg
      301 gctctcgtcg ctgacttcct gtccggcctg gtacattggg gtgctgatac atggggttct
      361 gtggacctgc ccattgtcgg gaaggccttc atccggccat tccgggagca ccacattgac
      421 cccacagcca tcacaaggca tgacttcatc gagaccaatg gggacaactg cctggtcacg
      481 ctgctgccac tgctaaacat ggcctacaag ttccggaccc agagcccaga gaccctggag
      541 cagctgtacc cttgggaatg cttcgtcttc tgtctgacca tctttggcac cttcaccaac
      601 cagatccaca agtggtcaca cacatactta gggctgccat actgggtcac cgtcctgcag
      661 gactggcacg tgatcctacc acggaaacac catcgcatcc accacgtggc gccccacgaa
      721 acatacttct gtatcaccac aggctggctc aactaccccc tagaggttat aggcttctgg
      781 cggcgcctgg aggatctcat ccaaggcctg acgggtgaga agccgagagc ggacgacatg
      841 aaatgggcac agaagatcaa gtagcatgtc tggactcttg gtcgccaacc ttcccaaacc
      901 tgaactgaag ccatctgcca aatcccggcg tctctgagct accctccagt gaagagaagt
      961 cccctgggct gggcccgggc acccctagcc cacccccagt gacacagaat acttgagcca
     1021 cccacttttc atttcctctt ctccttttct ttccttgggc cttcctggcc actgagctgc
     1081 tccgaggcca agcctgactg cagacgggag cccagtcctg ctggccagcc ccaccctatg
     1141 catctgctct gcacgcctgc tccctgggcc gatgtagggt cacagacaac aagtggtctg
     1201 tctcggtgac ccagagagcc cccagaacac gtaaatgtcc ctggatcatg attctccctc
     1261 agccctgtag acagacccca gaggcctagg tgggtgggtc accccagctg ccacccaagg
     1321 gaggcagagc tgggcaaagg tcagggggca agctgtcaag gagaggccat gatgccccgc
     1381 ccactctcgg atactctcct ttcccctagt tctcctgtcc atgtgtccag ccacttctga
     1441 ggtctccctg cagagacatc ttcatgggca cagctcttgt gaagggcttg gtcatctggg
     1501 gaagggacac tgtgtccctt ctggccagtg tgtcagagga agaagaataa ggctttttta
     1561 ttcggatttt ttttaaaggt gcttgcttgt caatgtaaat aatagaaagc cttaatatct
     1621 ttctgtaaca tggagtaata ttttaatgtc atgttttgga tgtatataat atatttataa
     1681 cagaggaagc atctccttca
//
