LOCUS       NM_023523               1212 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus peroxisomal trans-2-enoyl-CoA reductase (Pecr),
            transcript variant 1, mRNA.
ACCESSION   NM_023523
VERSION     NM_023523.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1212)
  AUTHORS   Luo,Q., Qiu,L., Zhan,K., Zeng,L., Liao,S., Li,C., Mei,Z. and Lv,L.
  TITLE     Peroxisomal trans-2-enoyl-CoA inhibits proliferation, migration and
            invasion of hepatocellular carcinoma cells
  JOURNAL   Acta Histochem 125 (2), 152002 (2023)
   PUBMED   36724637
  REMARK    GeneRIF: Peroxisomal trans-2-enoyl-CoA inhibits proliferation,
            migration and invasion of hepatocellular carcinoma cells.
            Erratum:[Acta Histochem. 2024 Jan;126(1):152130. doi:
            10.1016/j.acthis.2023.152130.. PMID: 38177047]
REFERENCE   2  (bases 1 to 1212)
  AUTHORS   Cossette,S.M., Gastonguay,A.J., Bao,X., Lerch-Gaggl,A., Zhong,L.,
            Harmann,L.M., Koceja,C., Miao,R.Q., Vakeel,P., Chun,C., Li,K.,
            Foeckler,J., Bordas,M., Weiler,H., Strande,J., Palecek,S.P. and
            Ramchandran,R.
  TITLE     Sucrose non-fermenting related kinase enzyme is essential for
            cardiac metabolism
  JOURNAL   Biol Open 4 (1), 48-61 (2014)
   PUBMED   25505152
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1212)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1212)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1212)
  AUTHORS   Amery,L., Mannaerts,G.P., Subramani,S., Van Veldhoven,P.P. and
            Fransen,M.
  TITLE     Identification of a novel human peroxisomal 2,4-dienoyl-CoA
            reductase related protein using the M13 phage protein VI phage
            display technology
  JOURNAL   Comb Chem High Throughput Screen 4 (7), 545-552 (2001)
   PUBMED   11669066
REFERENCE   6  (bases 1 to 1212)
  AUTHORS   Das,A.K., Uhler,M.D. and Hajra,A.K.
  TITLE     Molecular cloning and expression of mammalian peroxisomal
            trans-2-enoyl-coenzyme A reductase cDNAs
  JOURNAL   J Biol Chem 275 (32), 24333-24340 (2000)
   PUBMED   10811639
  REMARK    GeneRIF: a paper describing the functions of peroxisomal trans
            2-enoyl CoA reductase
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY286611.1, AK010260.1, AK162100.1 and CB723327.1.
            
            On Oct 6, 2017 this sequence version replaced NM_023523.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF242204.1, AK010260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY286611.1         2-18
            18-369              AK010260.1         2-353
            370-635             AK162100.1         311-576
            636-1188            AK010260.1         620-1172
            1189-1212           CB723327.1         398-421
FEATURES             Location/Qualifiers
     source          1..1212
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.46 cM"
     gene            1..1212
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /note="peroxisomal trans-2-enoyl-CoA reductase"
                     /db_xref="GeneID:111175"
                     /db_xref="MGI:MGI:2148199"
     exon            1..229
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1017
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /EC_number="1.3.1.38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     perosisomal 2-enoyl-CoA reductase"
                     /codon_start=1
                     /product="peroxisomal trans-2-enoyl-CoA reductase isoform
                     1"
                     /protein_id="NP_076012.3"
                     /db_xref="CCDS:CCDS35607.1"
                     /db_xref="GeneID:111175"
                     /db_xref="MGI:MGI:2148199"
                     /translation="MGSWKTGQSYLAAGLLKNQVAVVTGGGTGIGKAVSRELLHLGCN
                     VVIASRKLDRLTAAVDELRASLPPSSSAEVSAIQCNIRKEEEVSNLVKSTLAKYGKIN
                     FLVNNGGGQFMAPVEDITAKGWHAVIETNLTGTFYMCKEVYNSWMREHGGSIVNIIVL
                     LNNGFPTAAHTGAAREGVYNLTKSMALAWASSGVRINCVAPGTIYSQTAVDNYGEMGQ
                     TLFEMAFDSIPAKRLGVPEEISPLVCFLLSPAASYITGQLINVDGGQALYTHAFSIPD
                     HDNWPVGAGDLSIVKRIKESFKKKAKL"
     exon            230..363
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            364..529
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            530..611
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            612..708
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            709..819
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            820..931
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1193
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1170..1175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /note="hexamer: AATAAA"
     polyA_site      1193
                     /gene="Pecr"
                     /gene_synonym="2400003B18Rik; TERP"
                     /note="major polyA site"
ORIGIN      
        1 ggggtctgtt tggttacgtg gccaaggact gctactaata gagctacttc tgaggaacac
       61 gtggtctagc tttagcaaga actcagagac agacactttg tggccatggg ctcttggaag
      121 actggtcaga gctacctagc ggccgggttg ctgaagaacc aagtggccgt ggtcaccggc
      181 gggggcacag gcattggaaa agccgtctcc cgggagctcc tgcacctggg gtgtaacgtg
      241 gtcattgctt cccggaagct ggacagacta actgctgctg tggatgaact gagagcctct
      301 ctgcctccct ccagctccgc tgaagtctcc gccatacagt gcaacatcag gaaagaagaa
      361 gaggtgagta atctggtcaa atctacctta gctaagtatg gtaagatcaa cttcttggtc
      421 aacaatggag gaggccagtt catggctcct gtggaagaca tcactgcgaa gggatggcat
      481 gctgtgatag aaaccaacct gacaggcacc ttctacatgt gcaaagaagt ttacaattcc
      541 tggatgagag agcacggagg gtcgattgtc aatatcattg tccttcttaa taatgggttt
      601 ccaacagccg cgcacactgg agcggcaaga gaaggtgttt acaacctcac aaaatccatg
      661 gctttggcgt gggccagcag cggagtgagg atcaactgtg tcgctcctgg gaccatttac
      721 tcccagactg ctgttgacaa ctatggcgaa atgggacaaa ccttatttga gatggccttt
      781 gacagtatcc cagctaagcg ccttggagtc cccgaggaga tctcccctct ggtatgtttc
      841 ctgctgtccc ctgcggcttc ctatatcact ggacagttga tcaatgtgga tggaggccag
      901 gctctgtaca ctcacgcctt cagcataccg gatcatgaca actggcctgt aggagctggg
      961 gacctttcta ttgtcaagag gataaaggaa tcttttaaga agaaagccaa gctctaacta
     1021 agccaaggaa acagccaccc atcttgttcc tgcgtgcctt agcgccttga gaatgtttcc
     1081 tacttcacaa gagcttatga tttctgtgtg tggggggtgg gggatcactt taatgttaat
     1141 agctttatct ttgcaaagac tgctcccaaa ataaatgtct cttcctgtgc aaaaaaaaaa
     1201 aaaaaaaaaa aa
//
