LOCUS       NM_001305157            3333 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus platelet/endothelial cell adhesion molecule 1
            (Pecam1), transcript variant 3, mRNA.
ACCESSION   NM_001305157 XM_006532470
VERSION     NM_001305157.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3333)
  AUTHORS   Beckroge,T., Jux,B., Seifert,H., Theobald,H., De Domenico,E.,
            Paulusch,S., Beyer,M., Schlitzer,A., Mass,E. and Kolanus,W.
  TITLE     Impaired primitive erythropoiesis and defective vascular
            development in Trim71-KO embryos
  JOURNAL   Life Sci Alliance 8 (4), e202402956 (2025)
   PUBMED   39909558
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3333)
  AUTHORS   Scavuzzo,M.A., Szlachcic,W.J., Hill,M.C., Ziojla,N.M., Teaw,J.,
            Carlson,J.C., Tiessen,J., Chmielowiec,J., Martin,J.F. and
            Borowiak,M.
  TITLE     Pancreatic organogenesis mapped through space and time
  JOURNAL   Exp Mol Med 57 (1), 204-220 (2025)
   PUBMED   39779976
REFERENCE   3  (bases 1 to 3333)
  AUTHORS   Feng,W., Hong,N., Wu,Y., Huang,J., Zhang,Q., Liu,G., Qian,Z.,
            Chen,Y., Jin,L., Ding,X., Zhao,P., Chen,A.F. and Yu,Y.
  TITLE     Deficiency of Sox7 leads to congenital aortic stenosis via abnormal
            valve remodeling
  JOURNAL   J Mol Cell Cardiol 199, 81-94 (2025)
   PUBMED   39746830
REFERENCE   4  (bases 1 to 3333)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   5  (bases 1 to 3333)
  AUTHORS   Park,C.J., Oh,J.E., Lin,P., Zhou,S., Bunnell,M., Bikorimana,E.,
            Spinella,M.J., Lim,H.J. and Ko,C.J.
  TITLE     A Dynamic Shift in Estrogen Receptor Expression During Granulosa
            Cell Differentiation in the Ovary
  JOURNAL   Endocrinology 166 (2) (2025)
   PUBMED   39834231
REFERENCE   6  (bases 1 to 3333)
  AUTHORS   Yan,H.C., Baldwin,H.S., Sun,J., Buck,C.A., Albelda,S.M. and
            DeLisser,H.M.
  TITLE     Alternative splicing of a specific cytoplasmic exon alters the
            binding characteristics of murine platelet/endothelial cell
            adhesion molecule-1 (PECAM-1)
  JOURNAL   J Biol Chem 270 (40), 23672-23680 (1995)
   PUBMED   7559536
REFERENCE   7  (bases 1 to 3333)
  AUTHORS   Canete Soler,R., Gui,Y.H., Linask,K.K. and Muschel,R.J.
  TITLE     MMP-9 (gelatinase B) mRNA is expressed during mouse neurogenesis
            and may be associated with vascularization
  JOURNAL   Brain Res Dev Brain Res 88 (1), 37-52 (1995)
   PUBMED   7493406
REFERENCE   8  (bases 1 to 3333)
  AUTHORS   Collo,G., Domanico,S.Z., Klier,G. and Quaranta,V.
  TITLE     Gradient of integrin alpha 6A distribution in the myocardium during
            early heart development
  JOURNAL   Cell Adhes Commun 3 (2), 101-113 (1995)
   PUBMED   7583004
REFERENCE   9  (bases 1 to 3333)
  AUTHORS   Kwee,L., Baldwin,H.S., Shen,H.M., Stewart,C.L., Buck,C., Buck,C.A.
            and Labow,M.A.
  TITLE     Defective development of the embryonic and extraembryonic
            circulatory systems in vascular cell adhesion molecule (VCAM-1)
            deficient mice
  JOURNAL   Development 121 (2), 489-503 (1995)
   PUBMED   7539357
REFERENCE   10 (bases 1 to 3333)
  AUTHORS   Bogen,S.A., Baldwin,H.S., Watkins,S.C., Albelda,S.M. and Abbas,A.K.
  TITLE     Association of murine CD31 with transmigrating lymphocytes
            following antigenic stimulation
  JOURNAL   Am J Pathol 141 (4), 843-854 (1992)
   PUBMED   1415479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY781761.1, AK084527.1, AK169431.1 and BE692027.1.
            
            On Feb 26, 2015 this sequence version replaced XM_006532470.1.
            
            Transcript Variant: This variant (3) contains an alternate 3'
            coding exon, which results in a frameshift, compared to variant 1.
            It encodes isoform 3 which has a longer and distinct C-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164143
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY781761.1         2-23
            23-924              AK084527.1         2-903
            925-2360            AK084527.1         905-2340
            2361-2383           AK169431.1         2040-2062
            2384-3328           AK084527.1         2341-3285
            3329-3333           BE692027.1         9-13                c
FEATURES             Location/Qualifiers
     source          1..3333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 69.92 cM"
     gene            1..3333
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /note="platelet/endothelial cell adhesion molecule 1"
                     /db_xref="GeneID:18613"
                     /db_xref="MGI:MGI:97537"
     exon            1..263
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..2413
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; platelet endothelial cell adhesion molecule"
                     /codon_start=1
                     /product="platelet endothelial cell adhesion molecule
                     isoform 3 precursor"
                     /protein_id="NP_001292086.1"
                     /db_xref="CCDS:CCDS79069.1"
                     /db_xref="GeneID:18613"
                     /db_xref="MGI:MGI:97537"
                     /translation="MLLALGLTLVLYASLQAEENSFTINSIHMESLPSWEVMNGQQLT
                     LECLVDISTTSKSRSQHRVLFYKDDAMVYNVTSREHTESYVIPQARVFHSGKYKCTVM
                     LNNKEKTTIEYEVKVHGVSKPKVTLDKKEVTEGGVVTVNCSLQEEKPPIFFKIEKLEV
                     GTKFVKRRIDKTSNENFVLMEFPIEAQDHVLVFRCQAGILSGFKLQESEPIRSEYVTV
                     QESFSTPKFEIKPPGMIIEGDQLHIRCIVQVTHLVQEFTEIIIQKDKAIVATSKQSSE
                     AVYSVMAMVEYSGHYTCKVESNRISKASSIMVNITELFPKPKLEFSSSRLDQGELLDL
                     SCSVSGTPVANFTIQKEETVLSQYQNFSKIAEESDSGEYSCTAGIGKVVKRSGLVPIQ
                     VCEMLSKPSIFHDAKSEIIKGHAIGISCQSENGTAPITYHLMKAKSDFQTLEVTSNDP
                     ATFTDKPTRDMEYQCRADNCHSHPAVFSEILRVRVIAPVDEVVISILSSNEVQSGSEM
                     VLRCSVKEGTSPITFQFYKEKEDRPFHQAVVNDTQAFWHNKQASKKQEGQYYCTASNR
                     ASSMRTSPRSSTLAVRVFLAPWKKGLIAVVVIGVVIATLIVAAKCYFLRKAKAKQKPV
                     EMSRPAAPLLNSNSEKISEPSVEANSHYGYDDVSGNDAVKPINQNKDPQNMDVEYTEV
                     EVSSLEPHQALGTRATETVYSEIRKVDPNLMENRYSRTEGSLNGT"
     exon            264..290
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..584
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..887
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1163
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1412
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1688
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1976
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2084
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2112
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2186
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2240
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2303
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2360
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2383
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..3333
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3306..3311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /note="hexamer: AATAAA"
     polyA_site      3329
                     /gene="Pecam1"
                     /gene_synonym="Cd31; Pecam; PECAM-1"
                     /note="major polyA site"
ORIGIN      
        1 ttggtttcca gctatggccg ccattacctg acaagtacca gagctggtct ctgcgcgcct
       61 ggagaggttg tcagagttgt ttctgctttt cacacagcag gcttctggtc tgtggcaggc
      121 aagagaattc tgcccctgag gcatggccgg aagacagaac tagctgagtg cttcagtctg
      181 cagaagtctt tcaggattca gctgaggtgg gcctcagtcg gcagacaaga tgctcctggc
      241 tctgggactc acgctggtgc tctatgcaag cctccaggct gaggaaaact ccttcaccat
      301 caacagcatc catatggaaa gcctgccatc atgggaggtg atgaatgggc agcaactgac
      361 cctggagtgc cttgtggaca tcagcaccac ctcgaaaagc aggtctcagc accgggtgct
      421 gttctataag gacgatgcga tggtgtataa cgtcacctcc agggagcaca ccgagagcta
      481 cgtcattcct caggctcggg tcttccactc cgggaagtac aaatgcacag tgatgctgaa
      541 caacaaggaa aaaaccacga ttgagtacga ggtgaaggtg catggcgtat ccaagcccaa
      601 ggtgacactg gacaaaaagg aggtgacaga aggcggggtc gtgacggtca attgttcctt
      661 gcaagaagaa aagccaccga tcttttttaa aattgaaaaa ttagaagtgg ggacaaagtt
      721 tgtcaagcga aggatagata agacctccaa cgagaacttt gtgctcatgg aattccccat
      781 tgaggcgcag gaccacgtgt tagtgtttcg ctgccaagct gggatcctgt ccggattcaa
      841 attgcaggag tcagaaccca tcaggagtga atacgtcacc gtgcaggagt ccttctccac
      901 tcccaagttt gaaatcaagc cccctgggat gatcatagaa ggggaccagc tgcacattag
      961 gtgcatagtt caagtgacac acttggtcca ggagtttaca gaaattatca tccaaaaaga
     1021 caaggcgatt gtagccacct ccaagcaaag cagtgaagct gtctactcag tcatggccat
     1081 ggtcgagtac agtggacact acacctgcaa agtggaatca aaccgtatct ccaaagccag
     1141 tagcatcatg gtcaacataa cagagctgtt tcccaagccg aagttagagt tctcctccag
     1201 tcgtctggac caaggggagt tgttggacct gtcctgctcc gtctcgggca cacctgtagc
     1261 caacttcacc atccagaagg aagagacggt cttgtcgcag tatcagaatt tcagcaagat
     1321 cgccgaggag agtgacagcg gggagtacag ctgtactgca ggcatcggca aagtggtcaa
     1381 gagaagcggc ctggtaccga tccaggtgtg cgaaatgctc tcgaagccca gtatttttca
     1441 tgatgccaag tctgagatca taaaaggaca tgccataggc atcagctgcc agtccgaaaa
     1501 tggaactgca cccatcactt accaccttat gaaagcaaag agtgacttcc agactctcga
     1561 ggtgacctcc aatgacccag caacattcac agataagccc accagagaca tggaatacca
     1621 gtgcagagcg gataattgcc attcccaccc cgcggtgttc agcgagatcc tgagggtcag
     1681 ggtgatagcc ccagtggatg aagttgtgat ttccatcctg tcgagtaacg aggtacagtc
     1741 tggaagtgaa atggtacttc ggtgctctgt gaaagagggg acgagcccaa tcacgtttca
     1801 gttttacaaa gaaaaggagg acagaccctt ccaccaagcg gtcgtgaatg acacccaagc
     1861 gttttggcac aacaaacaag ctagcaagaa gcaggaagga cagtactact gtacagcctc
     1921 caacagagcc agcagtatga ggaccagtcc ccgaagcagc actcttgcag tcagagtctt
     1981 ccttgcccca tggaagaaag ggctcattgc ggtggttgtc attggagtgg tcatcgccac
     2041 cttaatagtt gcagccaaat gctacttcct gaggaaagcc aaggccaaac agaaacccgt
     2101 ggagatgtcc aggccagctg ctccacttct gaactccaac agcgagaaga tttctgagcc
     2161 tagtgtggaa gccaacagcc attacggtta tgatgatgtt tctggaaatg atgcagtaaa
     2221 acccataaat caaaataaag acccccagaa catggatgta gaatacacag aagtggaagt
     2281 gtcctccctt gagcctcacc aagctctggg aacgagagcc acagagacgg tgtacagtga
     2341 gatccggaag gtcgacccta atctcatgga aaacagatac tctagaacgg aaggctccct
     2401 taatggaact taagacagtc aaggcagtgc acgtccctgg gaggtcgtcc atgtcccgag
     2461 aagagcagcc gattcctgga ttgcgagagt cctgtgcacg tatttatgag cctgtcccca
     2521 ccgaaagcag taatccttca ggccaagcca tccaatttta aaccccgctg ccttgttcat
     2581 gttgggtata cagagactca gaggcgctag ttaatggcca gcctgacctg tcttccttgt
     2641 gtttcggggg gtgaaaggag gttccaggag aataatgccc tggaatattc tgaggctgaa
     2701 atgttgtgtc tcggatagac agagtacttc tccgtgggtc ctcctgcaca gaagccccct
     2761 tctgctctgt tgtcaatcac tgggttagtt ttttgttttg ttttgtttct gttgttctct
     2821 tctttctggg ttgatcttaa tctttggaaa tacacagtgc tgctcaggtt tgcctggttc
     2881 ccctgtgtga ccttcccccc cacacacaca caaagtcaac cagctgactg ggagcaatgc
     2941 tcgtggaatg gccagtcact tgaagacaga cctcaagcca gcaatggcaa ctggagcgag
     3001 cacttaaagc gcaccttgat cttcctttcc gttccatgcc gaaggcccaa agaagagaaa
     3061 tggctggcta caacaactgt tattattttt ttaatagtaa aaggaaatat gtacttttct
     3121 cactaatttt tctttattta ttccccacta aagaaacggt ttcctaaggt ctgagctgtt
     3181 tcccagggtg ggctagagtg ggtgggcagg agctgccgac attttgtgta ctatacctaa
     3241 ccctcctcgc cttctccgtt tgcctcagcc acccggctcc agggcccctg aggggagttg
     3301 tattaaataa aattgatttt tactcttcag tta
//
