LOCUS       NM_028526                727 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphatidylethanolamine binding protein 4 (Pebp4),
            transcript variant 2, mRNA.
ACCESSION   NM_028526
VERSION     NM_028526.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 727)
  AUTHORS   Shi,Q.Q., Huang,Y.H., Li,Y.F., Zhen,S.Y., Li,Y.H., Huang,J.Y.,
            Wang,J.Y. and Zhou,X.Y.
  TITLE     PEBP4 deficiency aggravates LPS-induced acute lung injury and
            alveolar fluid clearance impairment via modulating PI3K/AKT
            signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 133 (2024)
   PUBMED   38472560
  REMARK    GeneRIF: PEBP4 deficiency aggravates LPS-induced acute lung injury
            and alveolar fluid clearance impairment via modulating PI3K/AKT
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 727)
  AUTHORS   Luo,Q., Ling,Y., Li,Y., Qu,X., Shi,Q., Zheng,S., Li,Y., Huang,Y.
            and Zhou,X.
  TITLE     Phosphatidylethanolamine-binding protein 4 deficiency exacerbates
            carbon tetrachloride-induced liver fibrosis by regulating the
            NF-kappaB signaling pathway
  JOURNAL   Front Pharmacol 13, 964829 (2022)
   PUBMED   36120358
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 727)
  AUTHORS   Qu,X.Q., Chen,Q.F., Shi,Q.Q., Luo,Q.Q., Zheng,S.Y., Li,Y.H.,
            Bai,L.Y., Gan,S. and Zhou,X.Y.
  TITLE     Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding
            Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the
            TLR4/NF-kappaB Pathway
  JOURNAL   Front Immunol 13, 901566 (2022)
   PUBMED   35874667
  REMARK    GeneRIF: Hepatocyte-Conditional Knockout of
            Phosphatidylethanolamine Binding Protein 4 Aggravated
            LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-kappaB
            Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 727)
  AUTHORS   He,H., Liu,D., Lin,H., Jiang,S., Ying,Y., Chun,S., Deng,H.,
            Zaia,J., Wen,R. and Luo,Z.
  TITLE     Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted
            protein and has multiple functions
  JOURNAL   Biochim Biophys Acta 1863 (7 Pt A), 1682-1689 (2016)
   PUBMED   27033522
  REMARK    GeneRIF: PEBP4 is a secreted protein and has multiple functions,
            including a role in Akt phosphorylation.
REFERENCE   6  (bases 1 to 727)
  AUTHORS   Zhang,Y., Wang,X., Xiang,Z., Li,H., Qiu,J., Sun,Q., Wan,T., Li,N.,
            Cao,X. and Wang,J.
  TITLE     Promotion of cellular migration and apoptosis resistance by a mouse
            eye-specific phosphatidylethanolamine-binding protein
  JOURNAL   Int J Mol Med 19 (1), 55-63 (2007)
   PUBMED   17143548
  REMARK    GeneRIF: We describe the cloning and functional characterization of
            the mouse homolog of hPEBP4 (mPEBP4). We demonstrate that mPEBP4
            promotes cellular migration and invasion by inhibiting ERK1/2 and
            JNK activation and up-regulating the expression of COX-2.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006750.1 and BC048621.1.
            
            On Oct 29, 2013 this sequence version replaced NM_028526.3.
            
            Transcript Variant: This variant (2) lacks several exons, and its
            3' terminal exon extends past a splice site that is used in variant
            1. This results in a novel 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (b) has a shorter and distinct
            C-terminus, compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048621.1, AK006750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-716               AK006750.1         2-717
            717-727             BC048621.1         695-705
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.1 cM"
     gene            1..727
                     /gene="Pebp4"
                     /gene_synonym="PEBP-4"
                     /note="phosphatidylethanolamine binding protein 4"
                     /db_xref="GeneID:73523"
                     /db_xref="MGI:MGI:1920773"
     exon            1..175
                     /gene="Pebp4"
                     /gene_synonym="PEBP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            176..384
                     /gene="Pebp4"
                     /gene_synonym="PEBP-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..553
                     /gene="Pebp4"
                     /gene_synonym="PEBP-4"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="phosphatidylethanolamine-binding protein 4
                     isoform b precursor"
                     /protein_id="NP_082802.1"
                     /db_xref="GeneID:73523"
                     /db_xref="MGI:MGI:1920773"
                     /translation="MTMKLVAAALCLSLLAAGLWVGLSLTAESIEEGKPGGEKPGGGK
                     PGGSGRGCFLPPLPKEDVSLCRNLEVFYMEMGNISCKIVPKCNLYRQKITAWQAPIVK
                     FHTALDVSELGWLKENVGP"
     exon            385..717
                     /gene="Pebp4"
                     /gene_synonym="PEBP-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      690..695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pebp4"
                     /gene_synonym="PEBP-4"
                     /note="hexamer: CATAAA"
     polyA_site      717
                     /gene="Pebp4"
                     /gene_synonym="PEBP-4"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgtgct ccctctgcaa acattctcta agaattatat aggtcctcaa tagcagttaa
       61 ccttcatccc attagacaaa tactgtgagg gtaccccgaa gggacccctg ccagcttcaa
      121 aacggatcaa gattccccag gagagaacaa cggtagagaa tctaatgtaa acctgttgcc
      181 aagaactatg acaatgaagc tggtcgcagc agcactttgc ttgagcctcc ttgcagccgg
      241 cctgtgggtg ggcctctcat tgacagctga gtccattgaa gaagggaaac ctggaggaga
      301 gaaacctgga ggagggaaac ctggaggcag cggacgagga tgttttctcc caccactgcc
      361 aaaagaagat gtttcactat gcaggaacct agaagttttc tacatggaga tggggaacat
      421 cagctgtaaa attgttccta agtgcaatct atacagacag aagatcacgg cctggcaggc
      481 gccgatagtc aagttccaca cggctttgga tgtgagtgaa ctgggttggc tgaaggagaa
      541 cgtggggccc tgacttgcct ttagttcact tttcttggga acttggaggg ccaggtttgc
      601 aggagtcagg cagctattgc ctggagtggt ggtcaacctc cctaatccta atcctttata
      661 tagttcctca tgtggtggtg actcccaacc ataaaattac tttttgttgc tacttcaaaa
      721 aaaaaaa
//
