LOCUS       NM_018858               1217 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphatidylethanolamine binding protein 1 (Pebp1),
            mRNA.
ACCESSION   NM_018858
VERSION     NM_018858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Cheng,Y., Zhang,Z., Gao,P., Lai,H., Zhong,W., Feng,N., Yang,Y.,
            Yu,H., Zhang,Y., Han,Y., Dong,J., He,Z., Huang,R. and Zhai,Q.
  TITLE     AAV induces hepatic necroptosis and carcinoma in diabetic and obese
            mice dependent on Pebp1 pathway
  JOURNAL   EMBO Mol Med 15 (7), e17230 (2023)
   PUBMED   37272212
  REMARK    GeneRIF: AAV induces hepatic necroptosis and carcinoma in diabetic
            and obese mice dependent on Pebp1 pathway.
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Madokoro,Y., Kato,D., Tsuda,Y., Arakawa,I., Suzuki,K., Sato,T.,
            Mizuno,M., Uchida,Y., Ojika,K. and Matsukawa,N.
  TITLE     Direct Enhancement Effect of Hippocampal Cholinergic
            Neurostimulating Peptide on Cholinergic Activity in the Hippocampus
  JOURNAL   Int J Mol Sci 24 (10), 8916 (2023)
   PUBMED   37240261
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Ye,J.J., Wei,S.L., Wei,Y.Y., Zhang,D.W., Sun,L., Wu,H.M.,
            Shen,J.L., Yu,L., Wang,Y. and Fei,G.H.
  TITLE     RKIP suppresses the influenza A virus-induced airway inflammatory
            response via the ERK/MAPK pathway
  JOURNAL   Int J Mol Med 51 (1) (2023)
   PUBMED   36382638
  REMARK    GeneRIF: RKIP suppresses the influenza A virusinduced airway
            inflammatory response via the ERK/MAPK pathway.
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Suzuki,K., Ohi,Y., Sato,T., Tsuda,Y., Madokoro,Y., Mizuno,M.,
            Adachi,K., Uchida,Y., Haji,A., Ojika,K. and Matsukawa,N.
  TITLE     Reduction of glutamatergic activity through cholinergic dysfunction
            in the hippocampus of hippocampal cholinergic neurostimulating
            peptide precursor protein knockout mice
  JOURNAL   Sci Rep 12 (1), 19161 (2022)
   PUBMED   36357544
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1217)
  AUTHORS   Hengst,U., Albrecht,H., Hess,D. and Monard,D.
  TITLE     The phosphatidylethanolamine-binding protein is the prototype of a
            novel family of serine protease inhibitors
  JOURNAL   J Biol Chem 276 (1), 535-540 (2001)
   PUBMED   11034991
REFERENCE   9  (bases 1 to 1217)
  AUTHORS   Matsukawa,N., Tooyama,I., Kimura,H., Yamamoto,T., Tsugu,Y.,
            Oomura,Y. and Ojika,K.
  TITLE     Increased expression of hippocampal cholinergic neurostimulating
            peptide-related components and their messenger RNAs in the
            hippocampus of aged senescence-accelerated mice
  JOURNAL   Neuroscience 88 (1), 79-92 (1999)
   PUBMED   10051191
REFERENCE   10 (bases 1 to 1217)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083063.1.
            
            [WARNING] On Mar 11, 2025 this sequence was replaced by
            NM_018858.3.
            
            On Jan 12, 2006 this sequence version replaced NM_018858.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083063.1, AB046417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.88 cM"
     gene            1..1217
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Pbp1; Pbpr; Rkip"
                     /note="phosphatidylethanolamine binding protein 1"
                     /db_xref="GeneID:23980"
                     /db_xref="MGI:MGI:1344408"
     exon            1..156
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Pbp1; Pbpr; Rkip"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..585
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Pbp1; Pbpr; Rkip"
                     /note="Raf-1 kinase inhibitor protein; HCNPpp; PEBP-1;
                     Raf-1 inhibitor protein"
                     /codon_start=1
                     /product="phosphatidylethanolamine-binding protein 1"
                     /protein_id="NP_061346.2"
                     /db_xref="CCDS:CCDS39234.1"
                     /db_xref="GeneID:23980"
                     /db_xref="MGI:MGI:1344408"
                     /translation="MAADISQWAGPLCLQEVDEPPQHALRVDYAGVTVDELGKVLTPT
                     QVMNRPSSISWDGLDPGKLYTLVLTDPDAPSRKDPKFREWHHFLVVNMKGNDISSGTV
                     LSDYVGSGPPSGTGLHRYVWLVYEQEQPLSCDEPILSNKSGDNRGKFKVETFRKKYNL
                     GAPVAGTCYQAEWDDYVPKLYEQLSGK"
     exon            157..266
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Pbp1; Pbpr; Rkip"
                     /inference="alignment:Splign:2.1.0"
     exon            267..367
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Pbp1; Pbpr; Rkip"
                     /inference="alignment:Splign:2.1.0"
     exon            368..1182
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Pbp1; Pbpr; Rkip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1160..1165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Pbp1; Pbpr; Rkip"
                     /note="hexamer: AATAAA"
     polyA_site      1182
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Pbp1; Pbpr; Rkip"
                     /note="major polyA site"
ORIGIN      
        1 gccttccaac tctccatcgc catggccgcc gacatcagcc agtgggccgg gcccttgtgc
       61 ttgcaggagg tggacgagcc gccccagcac gccctgcggg tcgactacgc cggggtgacg
      121 gtggacgagc tgggcaaagt gctaacgccc acccaggtta tgaacaggcc cagcagcatt
      181 tcatgggacg gccttgatcc tgggaaactc tacaccctgg tcctcacaga ccccgatgct
      241 cccagcagga aggatcccaa attcagggag tggcaccact tcctggtggt caacatgaag
      301 ggtaatgaca ttagcagtgg cactgtcctc tcagattatg tgggctccgg gcctcccagt
      361 ggcacaggtc tccaccgcta tgtctggctg gtgtacgagc aggaacagcc gctgagctgc
      421 gacgagccca ttctcagcaa caagtctgga gacaatcgcg gcaagttcaa ggtggagacc
      481 ttccgcaaga agtataacct gggagccccg gtggcgggca cgtgctacca agccgagtgg
      541 gatgactatg tgcccaagct gtacgagcag ctgtcaggga agtaggggtg ctgcacaggg
      601 gcccccacag ccttgttaag ttgtgtaaag catgctcttc cccccgcccc cttgctaccc
      661 tctcattggg agttcttagc tgtgctagga tagaggttta gggtgtcttc cctcttgctg
      721 ccagccgtca cgattctgga tagtcccatc ccaggttctg tttgattgag tttaggttcc
      781 gtctggggag gggtctaatg ttctgatgga gtcattctgt tgttgatata aaaaaagcaa
      841 ctctgaaaaa ggaagcactc cgccaggatc aggtctagag gagagctgga gctggtggtg
      901 tctgtgagtg gttgaacaag gaaactgtcc agaaccgggc acagtggggt ctttaagggc
      961 cctgtccccc aactgagaca actcaagact cccatcttag ctgagccctg actgtccaga
     1021 tcaggtggct gcgtaggtat caagtgtcta aagaacagtg ctgctgtgga gagagaccct
     1081 cttaagcccc ttgcttctca gtggggtagg caaaagtcac ctgagctgcc gagtgtgttg
     1141 atcctccttg tcaagtacaa ataaaaaggc attgcattca gaaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaaaaaa
//
