LOCUS       NM_172924              10994 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus pseudopodium-enriched atypical kinase 1 (Peak1), mRNA.
ACCESSION   NM_172924
VERSION     NM_172924.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10994)
  AUTHORS   Zuidema,A., Atherton,P., van der Poel,S., Kreft,M., Song,J.Y.,
            Bierbooms,M., Verhoeven,S., Papagianni,C., Kroese,L., Ali,R.B.,
            Huijbers,I., Carvalho,B. and Sonnenberg,A.
  TITLE     Colorectal carcinoma progression is not influenced by the
            pseudokinase PEAK1
  JOURNAL   Sci Rep 14 (1), 27663 (2024)
   PUBMED   39532961
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10994)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 10994)
  AUTHORS   Wang,H., Lapek,J., Fujimura,K., Strnadel,J., Liu,B., Gonzalez,D.J.,
            Zhang,W., Watson,F., Yu,V., Liu,C., Melo,C.M., Miller,Y.I.,
            Elliott,K.C., Cheresh,D.A. and Klemke,R.L.
  TITLE     Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by
            modulating GATA2-dependent VEGFR2 transcription
  JOURNAL   Cell Discov 4, 26 (2018)
   PUBMED   29872538
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10994)
  AUTHORS   Wang,Y., Kelber,J.A., Tran Cao,H.S., Cantin,G.T., Lin,R., Wang,W.,
            Kaushal,S., Bristow,J.M., Edgington,T.S., Hoffman,R.M., Bouvet,M.,
            Yates,J.R. 3rd and Klemke,R.L.
  TITLE     Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton
            and cancer progression [corrected]
  JOURNAL   Proc Natl Acad Sci U S A 107 (24), 10920-10925 (2010)
   PUBMED   20534451
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13556]
REFERENCE   5  (bases 1 to 10994)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   6  (bases 1 to 10994)
  AUTHORS   Caenepeel,S., Charydczak,G., Sudarsanam,S., Hunter,T. and
            Manning,G.
  TITLE     The mouse kinome: discovery and comparative genomics of all mouse
            protein kinases
  JOURNAL   Proc Natl Acad Sci U S A 101 (32), 11707-11712 (2004)
   PUBMED   15289607
REFERENCE   7  (bases 1 to 10994)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 10994)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    Review article
REFERENCE   9  (bases 1 to 10994)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 10994)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ186507.1, AK048912.1, AK035440.1, AK173328.1, AC160935.2,
            AK004211.1 and AW457766.1.
            
            On Oct 5, 2007 this sequence version replaced NM_172924.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090133.1, SRR17253012.3186613.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CJ186507.1         1-12
            13-658              AK048912.1         2-647
            659-2714            AK035440.1         649-2704
            2715-3684           AK035440.1         2706-3675
            3685-3889           AK048912.1         3672-3876
            3890-7219           AK173328.1         432-3761
            7220-7220           AC160935.2         66608-66608
            7221-8337           AK173328.1         3763-4879
            8338-8458           AK004211.1         514-634
            8459-9867           AK173328.1         4999-6407
            9868-9868           AC160935.2         69256-69256
            9869-10977          AK173328.1         6408-7516
            10978-10994         AW457766.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..10994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.13 cM"
     gene            1..10994
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /note="pseudopodium-enriched atypical kinase 1"
                     /db_xref="GeneID:244895"
                     /db_xref="MGI:MGI:2442366"
     exon            1..110
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /inference="alignment:Splign:2.1.0"
     exon            111..174
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /inference="alignment:Splign:2.1.0"
     exon            175..332
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /inference="alignment:Splign:2.1.0"
     exon            333..3568
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..5660
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /EC_number="2.7.10.2"
                     /note="tyrosine-protein kinase SgK269; sugen kinase 269;
                     NKF3 kinase family member"
                     /codon_start=1
                     /product="inactive tyrosine-protein kinase PEAK1"
                     /protein_id="NP_766512.2"
                     /db_xref="CCDS:CCDS52804.1"
                     /db_xref="GeneID:244895"
                     /db_xref="MGI:MGI:2442366"
                     /translation="MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDSEKTPITHGSGK
                     TNANHSNNHRVRSTGNFRPPVAKKPTIAVKPTMMVADGQSVCGELSIQEHCENKPVIL
                     GWNQNKTSLSQKPLNNNSEGDAEGFGSDPQQCANNDSAQKISNNNNGLTEVLKEIAGL
                     EATPPVRGNETNARETFLGRINDCYKRSLERKIPPSCMTGSMKDSQGKHVILSGSAEV
                     ISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQPRFANF
                     RANTLSPVRFFVSKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSGVSYGQGSV
                     QSTISSDCTSPGSSFTEESRSETASSLSQKVCNGGISPGNPGNSKDIAETESNFESPP
                     GNNEEKDESLTSKSSVKVPETHKAVLALRLQEKDGKIAVHTEKPESKASTDIAGQAVT
                     ISLVPVEEQTKPYRVVNLEQPLCKPYTVVDVSAAMASEHLGRPKIKGSSSTPNSPVTS
                     PALTPGQINAHLKKSSAIRYQEVWTSSTSPRQKIPKIELSTGGPGPNVPPRKNCHKSA
                     PTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPSYARSSKNAIKVP
                     IVINPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVSDSTPSKLTDC
                     PQAKGFSNSTERKRGSVAQKVQEFNNCLNRGQSSPQRSYSSTHSSPAKIQRPTQEPAG
                     KTEGAQGSQVPGSSSNSTREKASAVLCQIVASIQPPQTPPEAPQSSPKACSVEELYAV
                     PPDADTTKSIPKNPPVRPKSLFTSQSSGEGEAHQTTESPTAKIQKDPSTKPVTSPPSK
                     LVTSAQSEPPPPFPPPRSTSSPYHASNLLQRHFTNWTKPTSPTRSTEAESILHSEGSR
                     RAADAKPKRWISFKSFFRRRKTDEEEEKEKEREKGKLVGLDGTVIHMLPPPPVQRHHW
                     FTEAKGEASEKPAIVFMYRCDPDQGHLSVDQSKAGAEKGRAEEVLLRNSEEKKSSYLP
                     SQIPDKACSRVTHEVAGELSPRDPRTPAGKQDGTSVTPTLPPPDLEREEEKDDTLDPT
                     DVSPCSATYSNLGQSRAAMIPPKHPRHPKGAVDDAIAFGEKTDQEGLNASQPTPPPLP
                     KKMIRANTEPISKDLQKAMESSLCVMANPTYDIDPNWDASSAGSSISYELKGLDVESY
                     ESLERPLHKERPVPSAANSISSLATLSVKDRFSNSMESLSSRRGLSYRQTRSIQKPQR
                     QALYRGLDNREEVVGKLRSLHTDALKRLAVKCEDLFMAGQKDQLRFGVDSWSDFRLTS
                     DKPCCEAGDAVYYTASYAKDPLSNYAVKICKSKAKESQQYYHSLAVRQSLPVHFNIQQ
                     DCGHFLAEVPSRLLPWEDPDAPEKAEDGTEDSEEEGKAETLGGNPEPCSETEPSQKEN
                     QRVTNRKQRSHVVVITREVPHLTVADFVRDSLAHHGNSPDLYERQVCLLLLQLCSGLE
                     HLKPYHVTHCDLRLENLLLVQHQPGGAAQGPSPADPCPTLACPTRLIVSNFSQAKQKS
                     HLVDPQILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDENPELKEKEYT
                     RTDLPRIPLRSPYSWGLQQLASCLLNPNPSERILISDAKGILQCLLWGPREDLFQIFT
                     TSATLAQKNALLQNWLDIKRTLLMIKFAEKSLDREGGISLEDWLCAQYLAFATTDSLS
                     YIVKILQYR"
     exon            3569..3753
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..4496
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /inference="alignment:Splign:2.1.0"
     exon            4497..10982
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10954..10959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /note="hexamer: AATAAA"
     polyA_site      10982
                     /gene="Peak1"
                     /gene_synonym="1110049L02Rik; 9530046P14; C230081A13Rik;
                     mKIAA2002; SGK269"
                     /note="major polyA site"
ORIGIN      
        1 gagtagttag ttagttgtgt cagttgctcg gtggaggcgg ccgcgatcac cagaaagggg
       61 acgggacagg aggcaatgct gaatatcgca acggcttgtg ctcccctcag gtgtctgtcc
      121 aacccaggac ttatgcgcta gatgtttctt ggtagcttgc ctagaaaacc caagtaaaca
      181 tcggtacttt cagaatatag gaatgagagg caaggaagaa aggacattca tcatacgaag
      241 atttgaatca ctttgaaact gtaaagggat gtagcacttg ctgccaaact accttgctca
      301 ccagaatgaa ggaagtgctt cagcattaaa tgattgatcg tacttagagg agctgctatg
      361 acaacataag gaggtgaaaa ctcacagatg caaatgcaag tcttgctatg cactgaagga
      421 aaagcattgt ctgcgaagtt ctatttttaa aaatgtctgc ttgtaacacc tttactgaac
      481 acgtttggaa acctggcgaa tgcaagaatt gctttaaacc taaaagcttg caccagcttc
      541 ctccagactc tgagaagacg cccatcaccc acggcagtgg gaaaactaat gccaatcaca
      601 gtaacaacca ccgagtcagg agcacgggca acttccggcc ccctgtggct aaaaagccca
      661 ccatcgctgt gaagcccact atgatggtgg cagatgggca aagcgtgtgt ggcgagctaa
      721 gcatccagga acactgtgag aacaagcctg tcatcctggg gtggaaccaa aacaagacgt
      781 ccctgagcca gaaaccactt aacaacaatt ctgaaggtga tgctgaaggc tttggcagtg
      841 atcctcagca gtgtgccaat aatgacagtg cacagaagat atccaataac aacaacgggc
      901 taactgaagt gctaaaggag atagcgggcc tggaagccac ccctccggtc agaggaaatg
      961 aaacaaacgc cagagaaaca ttcttgggaa gaataaatga ttgctacaaa cgatcgttgg
     1021 aaagaaagat cccacccagt tgcatgaccg ggagcatgaa ggactctcag ggcaaacacg
     1081 tcatcctgag cgggagcgcc gaggtcatca gtaacgaagg gggcaggttc tgctaccctg
     1141 agttctccag tggtgaggag agtgaggaag atgtgctttt cagtaacatg gaggaggagc
     1201 atgagagctg ggatgagagc gatgaagagc tgttggccat ggagattcgc atgagagggc
     1261 agcctcgctt tgctaacttc agggcaaaca ccctgtctcc tgttcgattc tttgtgagca
     1321 aaaagtggaa tactatcccc ttacggaata agtctctgca gagaatctgt gctgtggact
     1381 atgacgacag ctatgatgaa atcctgaatg gttatgagga aaattctggg gtctcctatg
     1441 gtcaaggaag cgttcagagc acaatatcat ctgactgcac atcaccaggc tcctccttca
     1501 cagaagagtc acgctctgaa acagccagca gtttatccca gaaggtctgt aatgggggga
     1561 tatctcctgg taacccagga aattctaagg acatagcaga aactgagtct aattttgaaa
     1621 gtcctcctgg taacaatgag gagaaggacg aatcactgac ttccaaaagc tcggtgaaag
     1681 ttccagagac gcacaaagct gtccttgctc tccgtttaca ggagaaggat ggcaagattg
     1741 cagtacatac tgagaagcca gagagcaaag cttctacaga tatcgctggc caggcagtca
     1801 ccataagcct cgtcccagta gaagaacaga caaagcccta ccgtgtggta aatctggaac
     1861 agccgctgtg taagccatat accgttgtgg atgtgtcggc agccatggcc agcgagcacc
     1921 tggggcgacc caagataaaa ggttcatctt ctactccaaa ctctccagtt acatcacctg
     1981 cattgacacc aggacaaata aatgcccatc tcaaaaaatc cagtgcaatc cgataccagg
     2041 aagtgtggac gtccagcacc agtccacgac aaaagatccc taaaatagaa ttaagtactg
     2101 ggggacctgg gccaaatgtc cctccaagga aaaactgcca taagtcggcg cccacttcac
     2161 ccacggctac aaacatctcc tctaaaacca tccctgttaa gtcacctaat ttgtctgaaa
     2221 taaaatttaa tagttacaac aatgccggga tgccaccttt tcccattatc atccatgatg
     2281 agccatccta tgcccggagt tccaaaaatg ccattaaagt ccccattgtt attaatccaa
     2341 atgcgtatga caatctcgcc atctacaaaa gttttctggg aacaagtgga gaactctctg
     2401 tgaaggaaaa aaccacaagc gtaataagcc atacttacga agaaatagaa actgaaagca
     2461 aagtgtctga tagcaccccc agcaagctca cagactgtcc ccaagctaaa gggttttcca
     2521 acagcacaga gcggaaaaga ggctcagtag cgcagaaggt gcaggagttt aacaattgtc
     2581 tcaacagagg tcagtcttct ccacaaagaa gctacagttc cacccacagc tccccagcaa
     2641 aaatccagag acccactcaa gagcctgcgg gcaaaacgga aggggcacaa gggtctcagg
     2701 tgccaggcag cagcagcaac agcactaggg agaaagcaag cgccgtccta tgtcagattg
     2761 tggcatctat ccaacccccc cagactcctc cagaagcacc tcaatctagc cctaaggctt
     2821 gcagtgtgga agagctttat gccgttcccc cagatgcaga tactacaaaa agtattccta
     2881 aaaacccacc agtcagaccc aaatctcttt ttacatctca gtctagtggg gaaggtgagg
     2941 cccatcagac cacagaaagc cctactgcca aaattcagaa agatccatcc acgaagccag
     3001 tgacttctcc tccctccaaa ttagtgacga gcgcccagag tgagccaccg cctccctttc
     3061 ccccaccacg gtctacttcc tccccttacc atgcaagtaa cctgttgcaa aggcatttta
     3121 ccaattggac gaagccaacc agtcctaccc gatcaacaga agctgaatca attttgcact
     3181 ctgaaggcag caggcgagcc gctgatgcaa aacctaaacg ctggatatca tttaaaagct
     3241 tcttccgccg ccgcaaaaca gatgaggaag aagagaagga gaaagagcga gagaaaggga
     3301 agctggtggg cctggacggg acagtcatcc acatgctgcc gccccctcca gtccagcgcc
     3361 atcactggtt cacagaggcc aaaggagagg ccagcgagaa gcctgctata gtcttcatgt
     3421 acaggtgtga ccctgaccaa ggccacctca gtgtggacca aagcaaggct ggggcagaga
     3481 aaggaagagc agaggaggtg ttactgcgga actcggaaga gaagaaaagt agctatcttc
     3541 catcacagat tcctgacaaa gcttgcagtc gtgtgaccca tgaagtggca ggagaacttt
     3601 ctcctcggga tccaagaact cctgctggga agcaagatgg cacttcagtc acaccaacac
     3661 tgcctccacc tgacctggaa agggaagaag aaaaagatga cactttggat cctactgacg
     3721 tgagtccctg cagtgcaacc tacagcaacc taggacaatc tcgagcagct atgatacctc
     3781 ccaagcatcc acggcatccc aagggagcgg tggatgatgc cattgccttt ggagagaaga
     3841 cagaccaaga aggactgaat gcttcccaac ccacaccacc cccactgcca aagaaaatga
     3901 tacgagccaa taccgagccc atctccaaag accttcagaa agccatggaa agcagtcttt
     3961 gcgtcatggc taatcccacc tacgatattg atcccaactg ggatgccagc agtgctgggt
     4021 cttctattag ctatgaactc aagggactag acgttgagtc ttatgaatcc ttggagagac
     4081 ctttgcataa ggagagaccc gttccttcag cagcaaacag tatctccagc ctagccactc
     4141 tcagtgttaa ggacagattt tctaacagta tggagtcact ctccagtcga cgtggtctct
     4201 cctatagaca gactcgaagc atccagaagc cacagagaca agcactttat cgaggacttg
     4261 acaatcggga ggaagtggtg ggtaaactcc gaagccttca tacagatgcc ttgaagagac
     4321 tggcagttaa atgtgaagac ctcttcatgg ctgggcagaa agaccaactc cgctttggag
     4381 tagacagctg gtcagacttc aggctaacca gcgacaaacc gtgctgcgaa gctggagatg
     4441 cggtttacta cactgcctcg tatgcaaaag atccactcag taactatgca gtcaagatct
     4501 gcaagagcaa agctaaggag tctcagcagt attaccatag cctggctgtc cggcagagtc
     4561 tgcctgtgca ttttaacatc cagcaggatt gtggccattt ccttgctgaa gtccctagtc
     4621 gtctgcttcc ctgggaggat cctgatgctc ctgaaaaggc agaggatggc actgaagaca
     4681 gcgaagaaga ggggaaggca gaaactttgg ggggaaatcc tgagccctgc tctgaaacag
     4741 agccatccca gaaagagaac caacgagtca caaacaggaa acaaagaagc cacgttgtgg
     4801 tcatcaccag ggaggttccc catctcactg tggccgactt cgtgcgagat tctttggccc
     4861 atcatgggaa cagccctgac ttgtatgaga ggcaagtgtg tctgctgctc ttacagctgt
     4921 gctctgggct tgagcacctc aagccctacc acgtcacgca ctgcgatctt cgcctggaga
     4981 acttgctgct tgtccagcac caacctgggg gagctgccca gggcccttct cctgcagacc
     5041 cttgccccac cttagcttgt cctacaaggc tcattgtgag taacttctct caggccaagc
     5101 agaagagcca cctggtggac ccccagatcc tccgagacca gtcccgcctt gccccagaga
     5161 tcatcacggc cacccagtat aagaagtgtg atgaattcca gacgggcatt ctcatctatg
     5221 agatgctgca cctgcccaac ccttttgacg agaacccgga gctgaaggag aaggagtaca
     5281 cgcgcacaga tctgcctcgg atccctctcc gctccccgta ctcctggggt ctacagcagc
     5341 ttgctagctg cctcctgaat cccaaccctt ctgagcgcat cctcatttct gacgccaaag
     5401 gcatcctcca atgtctgctc tggggccccc gagaagatct ctttcaaatc ttcaccacct
     5461 ctgcaaccct cgcacagaag aacgctctgc tccaaaactg gttagacatc aagcgaaccc
     5521 tgctgatgat caagttcgcg gagaagtccc tggacagaga ggggggcatc agcctggagg
     5581 actggctttg tgctcagtat ctggcctttg ccactacaga ctccctgagc tatattgtaa
     5641 aaatcctgca ataccgttaa tatggcccgg gcattgcttt tattgttaaa tatctccacc
     5701 ttcctcatgt taccctcatg tccctgtcct ggtatccact cagaatttaa ggaaaggaaa
     5761 gaagccaact gccacccttg tccagggaca tgggctccat tcagcaaggt cacctacagc
     5821 tttctacagt gaatggctga gtgtttcttt actgtacagc agttcagctg cacaaacatg
     5881 cagtcacctt cccttggagc atttgtcatc ccaatagtct cacaaatgtg gggtaaaaag
     5941 tgaaaaatgc acagccatga aggagcagct cccatggaat gatctcacca agctgcatac
     6001 acctcttcca taactctgaa gctcgcctgc attaactagc tagcagtaca cacatcacca
     6061 acctcagctg tcacccacta atgctctcac agcagattcc tctcccttga agtgaccacc
     6121 tctttcccta gaggacatcc cattatcctt cttggctccg ttgtagtcac tggggactag
     6181 cctttgctct ggcatacagt gaaaggaggg gaccctacat agagagccac ccggcagccg
     6241 caaccctgct gccactgctt cactgtcctt caccttcacc ctgtcccgcc tgctgaagtt
     6301 tgggtttatc attcacttct tgtggtggcc cattacaaag ctgaccaaag gtggtatcac
     6361 cgatgcctca gcaggatgaa atatagtcca gagattatga atagttggca ggatatgaag
     6421 aaataatgtc cttatgtgtg caattctcca ggggccctca gggaacagac tttcaagtac
     6481 tgttctttga ttcctgtcag acctacccgc atggcagcca ggcctggtgg tgtctgtctg
     6541 agtcagagtt tcttccccca caagcagtaa ttggccagct tccttccgtc agtaagccgg
     6601 tattaactag tctgccaaat gctgtcggca acagccctga gtgagatggt tatccgttta
     6661 gcgtcaccat caccttagaa agctacccga agctggctat tggaatggcc ggaagacaag
     6721 gggaatggga aaggtcacga agatggctga cctgttcctc ggagtgcgag cctcttccag
     6781 aaagactgcc tcccagagtg agtggcacgt tgctcctaag actctgcagt gggtctggag
     6841 ctcggctcac aggaaggctg atggctgcag tgggtgactg agagttgttc cccgtggagc
     6901 ccgggctctc ccgtgaatta tgtgcaattt ttgtatgtat ttttaagctg tatattacag
     6961 tgtttatgtt gcaactttcc atgagtgaga actgcagaag cctttctgtc ttcccttggc
     7021 acatatttgc gctaagaggc gagtgtcctt tccacctgtg tgtatgtaca ctcatgtgct
     7081 tgttttattc aaaactgtga gtctctgttt acttcaccct tgaaatccca agagtcactt
     7141 gaatggtaag tgagtatgcg tgtggaacca accatgttgc atgcacatgc tggagctagg
     7201 cttctgggaa agcaacctac agtggggtag acagatccat tttgtatacc ttgccagtga
     7261 agaaaaccca gaaagccctg gtccaccagc gccgagttgt cttaaagcca agactgattt
     7321 tgtgcagtat tatttgggtg gcaccttagt ggccttggaa acttgtagac ttttaacatt
     7381 tttaacagcc tttcacatga ttcaccttta tcaaagagga tcaaaaaagg agaatgtatt
     7441 ttattatgca ttttaaaaga gaacggtatg tgtgaggctg catatggagg gtggcttgtg
     7501 ttcctggcta gtgctctgga ctcccaggaa agagagctgg ttggcccaca gtgtcttgtg
     7561 tctcctacac agaatgacca tggagagggc agccatgagt catggctgca ccatgcccag
     7621 caggctaggg tttgagtcag cttacatagc ccatggtcac agaactccct gcctaatgat
     7681 gcactgaact ggctgcataa agaccactga ccatgtcagc gggcacagtc cttcactttc
     7741 cacagtactt gcagattgag acataccttc tccacgtcac gctcatggtg ccttgcccat
     7801 gtaaatctga atgttgacta tttaatgagg ttacatattt aatgcagaat gttccctagg
     7861 ctcctctgtt tgttctgtct gtagaaatct ctctcttttt tttcctgtta tcttagatcc
     7921 agccttcttt cacactatag tagaaaaagt gtgcacactt ctgctaccat tgtctcactg
     7981 cattggtaag ctgagcatcc tccctccacg tgactctcac tattcttatg accgcactag
     8041 tgaaggacaa agatgaaaac cagctaatag gaaaagagcg tccgactttc tagagacagg
     8101 agttaattct gtctggggga tggccacaga atgagggcag ggaagaaggt gtccaggtta
     8161 ggtcagagca gagacaagaa ctacatctct aggcaagaag tccatcaggt ggtcctctga
     8221 gcatttctca aaataacgaa attcagtcca tataacattg tcatagccac tgcacgtttc
     8281 catttagatt cactcactaa ctggaaggaa accctcccct ctgcagccac acacacacat
     8341 tttatatata catatattat gaatttggga gtgttactag tatagcactt gaagttttca
     8401 caagtaacat ctgtattgac tggattcttt ttttcttttc tattaaagtc tatgccatag
     8461 attcttccat ttctgttgag agtttgaaca actaagcccc actggaactt tcccttaagc
     8521 cacatggaca gtctctctct cggcacatgt aggtgctaga gaaacaggac tgtggcgaga
     8581 gcaggcaaga gcaagaatcg ctgtccctca gagtgccttg ttagcatagt aacctagcca
     8641 tggagagaat agccccccgt gccccagaca gctcttgggg aatgcatgca accacgtagt
     8701 gtgcaaaaga tcaccataaa ggacagcagc tgatgagcaa atgaacaatc aaatagacat
     8761 gtggagtagg ccatgaagtt cctgaaaatc accaacccca gggccgagtt agattggaag
     8821 gcacacggat agcagagggc ttcaggggtt gttctcagga catggactgg ataaggtcat
     8881 gggggagtga gtgcccctca ccgctggtgc tgagggccaa ggagaaaccc tcaagaacta
     8941 gtcagcgcag ccttccttcg tcatgctaga ggagcctttt ctgcctctga gctcagggtg
     9001 ttcatgaaga tgggactcta aagctctggg aagccatgcc tctaggagca aagcctcagc
     9061 catcaaaatc cccatgcaca atcttgaagc ccactcagta gtgggtcatg caagctttcc
     9121 aagtttgatt tatccagtat tgggaaatca gcaaatatta gctggtaacc tacagtgagg
     9181 atttcccaaa gcctttacct agagtgatct gaaaagatgc aggctagtct cagaaactgg
     9241 gatggattta ggaagcttca ttatattcta agtaattcta ggcttataaa gcatccacac
     9301 agtgggaaac aggacagaac tcggctctct gggccagctc tggcatgctt gttatttctc
     9361 tcactagtgg ataaggattg ggattctggt ccagcctcgt aactaaacag aatggctgcc
     9421 cataaaactg ggttattaga tttacctcat tgaagctcat tttctgagag acccaaagtg
     9481 ctgcgctgag acaaacccaa gtgcaccgaa gtccatccgc tcatgctcac agcggtgcac
     9541 aggtggggac gccatggacc aaagccaatg ccccaaggga agtcagaaga gccataatgc
     9601 aggaccctag acaggttata ccaaagaaaa caagccttcc tcatcctgct gcttctcaga
     9661 tgacggggtg agctgtgaca gatgccagag gaagggtttg caaacattcc atggtcaagg
     9721 tgttcaacgg gtaagtccat ccccaaacca gtaaaataaa ataaaaagaa gggttctctg
     9781 ttagttagtt tcacgcaggc cgtttgtacg tcagaagaaa aggtgtaggg agcggcagca
     9841 gccagagcag atggcaaaaa aaaaaaaatt ctctgctatc ttaagaagga gcttttaacc
     9901 ggcgcactct caccacacct ggctagtgcc agaccttatg cacgggagca ccgcatctgt
     9961 aatatcaaag cttgggttta tggtgatttt tttttttcct aaaaagaggt gctgtcaaga
    10021 gatttgttta aagaactctt gggaaatttt cttaacccac tgtaccattt tatgaacctc
    10081 cccacaaaaa tgactctcac tcagcatccc catcatctaa catgtaagta cccagactgt
    10141 ctaaggtgct atacagctgt tacacaccta cccctgcagc tgttttaaat tagagacttc
    10201 tgcatcagct gccactggac gttttgccca tgcagatggg ccacaggggt ctgcattctg
    10261 agcgtccttt atacattccc ccttcagcag cctctatgtc tgtccctgtc cctgcttccc
    10321 atcccatctc acccatccca tggtttttta aatcaagaaa gtttcaggga atcaaaagag
    10381 gttgggattt ttttttaacc cagcagaatc gcagagttat atattttgct atgaacattg
    10441 ttgtggtaca gaaaatccac tttgcctgtt ggtttgtggc aagtctgtgt gtctgcactc
    10501 ttggtaactt gaatgtcgag ccagccctat ggcttcaatg tagtgttgtt gaaagattaa
    10561 accacacagc ttcaggaagc ctactcaagt tgttccttcc ttatttccca tccctgacca
    10621 gttctggaga gcggtgtgta tagacactgg gctgggtttt ctgttcatga cacagagggc
    10681 attttgttgg gaggtggagg cagaagcaag atgtcacctg tctcagtgaa ttgaatcatg
    10741 acagtcctta ttctaatatc actaattctc catggcactg ccctcattct gctttgggaa
    10801 atcttgtttc tcttccttcg gccctttacc catctcctct cgtattttta caattgtatg
    10861 aatcaataac aggtccctgt gtcaccagtg gcgcctccct ttggtttgct gtggtacttt
    10921 gctgtgtatt ctgtggcctc acgttactgt gtaaataaat tctgtttaat atacactaaa
    10981 aaaaaaaaaa aaaa
//
