LOCUS       NM_001329869            2556 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus proliferation and apoptosis adaptor protein 15A
            (Pea15a), transcript variant 3, mRNA.
ACCESSION   NM_001329869 XM_017319302
VERSION     NM_001329869.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Verschoor PJ, Greig FH, Rochford JJ, Levate G, Delibegovic M,
            Thompson D, Leeson-Payne A, Dekeryte R, Banks R, Ramos JW and Nixon
            GF.
  TITLE     Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator
            of adipose tissue expansion
  JOURNAL   Sci Rep 11 (1), 6949 (2021)
   PUBMED   33772049
  REMARK    GeneRIF: Phosphoprotein enriched in astrocytes (PEA)-15 is a novel
            regulator of adipose tissue expansion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2556)
  AUTHORS   Yong JI, Kim DW, Shin MJ, Jo HS, Park JH, Cho SB, Lee CH, Yeo HJ,
            Yeo EJ, Choi YJ, Kim JA, Hwang JS, Kim DS, Kim HA, Cho YJ, Lee KW,
            Han KH, Park J, Eum WS and Choi SY.
  TITLE     PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK
            in macrophages and animal models
  JOURNAL   Immunobiology 223 (11), 709-717 (2018)
   PUBMED   30049418
  REMARK    GeneRIF: this study shows that PEP-1-PEA15 suppresses inflammatory
            responses by regulation of MAPK in macrophages and animal models
REFERENCE   3  (bases 1 to 2556)
  AUTHORS   Perruolo G, Viggiano D, Fiory F, Cassese A, Nigro C, Liotti A,
            Miele C, Beguinot F and Formisano P.
  TITLE     Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic
            mice
  JOURNAL   Sci Rep 6, 29967 (2016)
   PUBMED   27426254
  REMARK    GeneRIF: the neurological and neurochemical phenotype of transgenic
            mice overexpressing PED/PEA-15 (tgPED), were analyzed.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2556)
  AUTHORS   Wei Y.
  TITLE     On the Quest of Cellular Functions of PEA-15 and the Therapeutic
            Opportunities
  JOURNAL   Pharmaceuticals (Basel) 8 (3), 455-473 (2015)
   PUBMED   26263999
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2556)
  AUTHORS   Ramos JW, Townsend DA, Piarulli D, Kolata S, Light K, Hale G and
            Matzel LD.
  TITLE     Deletion of PEA-15 in mice is associated with specific impairments
            of spatial learning abilities
  JOURNAL   BMC Neurosci 10, 134 (2009)
   PUBMED   19917132
  REMARK    GeneRIF: We suggest PEA-15 may be an essential regulator of
            ERK-dependent spatial learning.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2556)
  AUTHORS   Underhill DA, Vogan KJ, Underhill TM and Gros P.
  TITLE     Identification of a novel, alternatively spliced isoform and single
            nucleotide polymorphisms in the murine Pea-15 gene
  JOURNAL   Mamm Genome 12 (2), 172-174 (2001)
   PUBMED   11210189
REFERENCE   7  (bases 1 to 2556)
  AUTHORS   Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay
            G, Myambo K and Collins CC.
  TITLE     Assignment of HMAT1, the human homolog of the murine mammary
            transforming gene (MAT1) associated with tumorigenesis, to 1q21.1,
            a region frequently gained in human breast cancers
  JOURNAL   Genomics 42 (3), 540-542 (1997)
   PUBMED   9205133
REFERENCE   8  (bases 1 to 2556)
  AUTHORS   Estelles A, Yokoyama M, Nothias F, Vincent JD, Glowinski J, Vernier
            P and Chneiweiss H.
  TITLE     The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs
            conserved on their full length in mouse and human
  JOURNAL   J Biol Chem 271 (25), 14800-14806 (1996)
   PUBMED   8662970
REFERENCE   9  (bases 1 to 2556)
  AUTHORS   Danziger N, Yokoyama M, Jay T, Cordier J, Glowinski J and
            Chneiweiss H.
  TITLE     Cellular expression, developmental regulation, and phylogenic
            conservation of PEA-15, the astrocytic major phosphoprotein and
            protein kinase C substrate
  JOURNAL   J Neurochem 64 (3), 1016-1025 (1995)
   PUBMED   7861130
REFERENCE   10 (bases 1 to 2556)
  AUTHORS   Bera TK, Guzman RC, Miyamoto S, Panda DK, Sasaki M, Hanyu K, Enami
            J and Nandi S.
  TITLE     Identification of a mammary transforming gene (MAT1) associated
            with mouse mammary carcinogenesis
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9789-9793 (1994)
   PUBMED   7937892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074310.29, AK153141.1 and
            BE992884.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by
            NM_001329869.2.
            
            On Aug 7, 2016 this sequence version replaced XM_017319302.1.
            
            Summary: This gene encodes an adaptor protein that functions as a
            negative regulator of apoptosis induced by tumor necrosis
            factor-alpha, tumor necrosis factor-related apoptosis-inducing
            ligand, and Fas, through its interaction with fas-associated
            protein with death domain and caspase-8. It also regulates
            proliferation signaling by relocating the extracellular
            signal-regulated protein kinases 1 and 2 to the cytosol. The
            protein encoded by this gene contains an N-terminal death effector
            domain and a long, flexible C-terminal tail. In humans, the encoded
            protein is an endogenous substrate for protein kinase C. This
            protein is overexpressed in type 2 diabetes mellitus, where it may
            contribute to insulin resistance in glucose uptake. Multiple
            pseudogenes of this gene have been identified. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2016].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longer isoform (2). Both variants 2 and
            3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1660123.1,
                                           SRR1660825.133431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC074310.29        20597-20842
            247-2536            AK153141.1         119-2408
            2537-2556           BE992884.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..2556
                     /gene="Pea15a"
                     /gene_synonym="Mat1; PEA-15; Pea15; Pkcs15"
                     /note="proliferation and apoptosis adaptor protein 15A"
                     /db_xref="GeneID:18611"
                     /db_xref="MGI:MGI:104799"
     exon            1..246
                     /gene="Pea15a"
                     /gene_synonym="Mat1; PEA-15; Pea15; Pkcs15"
                     /inference="alignment:Splign:2.1.0"
     exon            247..420
                     /gene="Pea15a"
                     /gene_synonym="Mat1; PEA-15; Pea15; Pkcs15"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..641
                     /gene="Pea15a"
                     /gene_synonym="Mat1; PEA-15; Pea15; Pkcs15"
                     /note="isoform 2 is encoded by transcript variant 3;
                     astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein
                     enriched in astrocytes; phosphoprotein enriched in
                     astrocytes 15; mammary transforming gene 1; phosphoprotein
                     enriched in astrocytes 15A"
                     /codon_start=1
                     /product="astrocytic phosphoprotein PEA-15 isoform 2"
                     /protein_id="NP_001316798.1"
                     /db_xref="CCDS:CCDS15510.1"
                     /db_xref="GeneID:18611"
                     /db_xref="MGI:MGI:104799"
                     /translation="MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSA
                     WFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEEELDTKLTRI
                     PSAKKYKDIIRQPSEEEIIKLAPPPKKA"
     exon            421..576
                     /gene="Pea15a"
                     /gene_synonym="Mat1; PEA-15; Pea15; Pkcs15"
                     /inference="alignment:Splign:2.1.0"
     exon            577..2539
                     /gene="Pea15a"
                     /gene_synonym="Mat1; PEA-15; Pea15; Pkcs15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccccgcc cctccccggc tctgacatca ccggccagtc gggtggggtg aggcggtgct
       61 gggctcaagc tctgctccac gggcggaaga ggcggcggcg gcaggatcgg cggcagcggt
      121 ggcaggagcc aaggagcagg ctccagacgc tgcttaggaa ccggggaccc gggagtgccc
      181 gcaccctgag ctctcagctc cggaggcggt gagaggggca gagggaagat gtgtcgtggg
      241 gaggagtcat ggcagagtac ggaactctcc ttcaggacct gaccaacaac atcacccttg
      301 aagatctgga acagctcaag tcagcctgca aggaggacat ccccagtgag aagagtgagg
      361 agatcaccac aggcagtgcc tggtttagct tcctggagag ccacaacaag ctggacaaag
      421 acaacctctc ctacattgag cacatctttg agatatctcg ccgtcctgac ctcctcacta
      481 tggtggttga ctacagaacc cgtgtgctga agatctctga ggaggaggag ctggacacca
      541 agctaacccg tattcccagt gccaagaagt acaaagacat tatccggcag ccctctgaag
      601 aagaaatcat caaattggct cccccaccaa agaaggcctg aacaaggggg aggaagagga
      661 ggaaggttgg atcttcatca gaccactccc ttccccatcc tcaatgggag gggctagggc
      721 aaccccctgc tccgtaccca tttactaact tggtcctaac ccttactatg cgcgtgtgtg
      781 tgcgtgtgcg cacgctctgg ctgtctgtct gtctagctca tctagttcct cctcctcatg
      841 aggggattgg aggcaaggga gggggggctt aaatcccccc actatagggg gaggtggacg
      901 ctttttctat gtaaacagaa attggcacat tcctcctcct tctccccttt cctccactct
      961 tcccccacat ctttatggaa gcagaaagga cctgcatttt cctacactga ggagctatgg
     1021 tgaagatgag gtatgggaga gatggttgta tctaaagaaa accagtgggg aaggaaggta
     1081 aagaggccac tcaacctcca cctggtaagg gacaaagaaa agccaggact cagtgtttgt
     1141 atctctatgc tggactggtt agaagccagc ttcctgctgt tcccttaggc tgaggtcctg
     1201 agtgccaatg ggccctcctt atgcccttgt tatgggcctg ggatgcggat gagccagaaa
     1261 tcttaatgag aagaccactc gatcctttcc tggtcccaaa gatcaaaccc caatggagaa
     1321 gccagcattt actgtccccc aaccttctgc tctggagaga cgatgccggg accatgcact
     1381 actgagcctg agctagggac gcaggcagag acaggcccac tttctgctcc tcagtttcta
     1441 aatacagact gttggataaa ctgacctgga gcctagggag attgggggat gagatcctta
     1501 ggttttaacc ccaacctgcc cacaacctac agagtattgt aggcaacctt tccactctcc
     1561 agtttagaat tctccaagca agtagttaat tacagtgttt cctttgcact gaccaccacc
     1621 ctgattcaat ccaggaaggg actggtaacc tttctcattt gggtttgtgg atgccacaca
     1681 gtcaagtcac tagagtgcag tgagtgaacc cagcctcctc cctgtcccaa gatgcccttc
     1741 cccatcttga ccgtgctaac tgtgtgtaca tatatattct acatatatgt atattaaacc
     1801 cgcactgcca tgtctgccct tttttgtggt ttttagcatt aacttattgt ctaggccaga
     1861 gcgggagtgg gaggggatgc cacagaaagg aagtggcaga gccaaattgt tacagagtcc
     1921 aaacagaaaa gaacacattt caactaacca caacaaatgt tacatttaca tgtgagctaa
     1981 gagacaattt agagaaagat gaaggtaggt gcttttagga tgtgggagca aaacttcaca
     2041 gggaggggag gaatggctgt cagaagaggg ttcttgaagc cagactgact agagcaccct
     2101 cagttcctag ctgagcccag attgcccatc tcctctggcc actgctgcag acacctgcct
     2161 taactctcac acctcgaaga ctccagcttt gccttaaagg tccttcctaa atctccctag
     2221 tcttgcctgg catctccttt aagacaagaa atccttgtac aactgggtgg gagaaaggaa
     2281 ctctgggtaa catccttcct tctggggtgt tccatgggag caggagtgag acggcgcttc
     2341 ccttatggaa gagggaggag acagggtgct tctcagaagc ttctctgtaa ggcaaaaacc
     2401 aaactttaaa cagactaacc tgccctaata tactcacccc ctcgtgctgc tgtgaggttg
     2461 ctcctagcct gtgctcctct gtctgcagcg tgcacagcct tgttctaacc ctggaataaa
     2521 ggtgactgac tctaccgtaa aaaaaaaaaa aaaaaa
//
