LOCUS       NM_018884               4106 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus PDZ domain containing RING finger 3 (Pdzrn3), mRNA.
ACCESSION   NM_018884 XM_916644
VERSION     NM_018884.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4106)
  AUTHORS   Jiao,B., Zhang,H., Jiang,H., Liu,S., Wang,Y., Chen,Y., Duan,H.,
            Niu,Y., Shen,M., Wang,H. and Dai,Y.
  TITLE     Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions
            activity exacerbating skin damage in trichloroethylene
            hypersensitivity syndrome
  JOURNAL   Ecotoxicol Environ Saf 274, 116174 (2024)
   PUBMED   38471344
  REMARK    GeneRIF: Granulysin-mediated reduction of PDZRN3 induces Cx43 gap
            junctions activity exacerbating skin damage in trichloroethylene
            hypersensitivity syndrome.
REFERENCE   2  (bases 1 to 4106)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4106)
  AUTHORS   Zhou,Z., Pan,Y., Zhou,S., Wang,S., Zhang,D., Cao,Y., Jiang,X.,
            Li,J., Zhu,L., Zhao,L., Gu,S., Lin,G., Dong,Z. and Sun,H.X.
  TITLE     Single-cell analysis reveals specific neuronal transition during
            mouse corticogenesis
  JOURNAL   Front Cell Dev Biol 11, 1209320 (2023)
   PUBMED   38020907
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4106)
  AUTHORS   Gueniot,F., Rubin,S., Bougaran,P., Abelanet,A., Morel,J.L.,
            Bontempi,B., Proust,C., Dufourcq,P., Couffinhal,T. and Duplaa,C.
  TITLE     Targeting Pdzrn3 maintains adult blood-brain barrier and central
            nervous system homeostasis
  JOURNAL   J Cereb Blood Flow Metab 42 (4), 613-629 (2022)
   PUBMED   34644209
  REMARK    GeneRIF: Targeting Pdzrn3 maintains adult blood-brain barrier and
            central nervous system homeostasis.
REFERENCE   5  (bases 1 to 4106)
  AUTHORS   Pernot,M., Jaspard-Vinassa,B., Abelanet,A., Rubin,S., Forfar,I.,
            Jeanningros,S., Cetran,L., Yu,M.H., Balse,E., Hatem,S.,
            Dufourcq,P., Couffinhal,T. and Duplaa,C.
  TITLE     Decrease of Pdzrn3 is required for heart maturation and protects
            against heart failure
  JOURNAL   Sci Rep 12 (1), 8 (2022)
   PUBMED   34996942
  REMARK    GeneRIF: Decrease of Pdzrn3 is required for heart maturation and
            protects against heart failure.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4106)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   7  (bases 1 to 4106)
  AUTHORS   Honda,T., Yamamoto,H., Ishii,A. and Inui,M.
  TITLE     PDZRN3 negatively regulates BMP-2-induced osteoblast
            differentiation through inhibition of Wnt signaling
  JOURNAL   Mol Biol Cell 21 (18), 3269-3277 (2010)
   PUBMED   20668165
REFERENCE   8  (bases 1 to 4106)
  AUTHORS   Lu,Z., Je,H.S., Young,P., Gross,J., Lu,B. and Feng,G.
  TITLE     Regulation of synaptic growth and maturation by a
            synapse-associated E3 ubiquitin ligase at the neuromuscular
            junction
  JOURNAL   J Cell Biol 177 (6), 1077-1089 (2007)
   PUBMED   17576800
REFERENCE   9  (bases 1 to 4106)
  AUTHORS   Ko,J.A., Kimura,Y., Matsuura,K., Yamamoto,H., Gondo,T. and Inui,M.
  TITLE     PDZRN3 (LNX3, SEMCAP3) is required for the differentiation of C2C12
            myoblasts into myotubes
  JOURNAL   J Cell Sci 119 (Pt 24), 5106-5113 (2006)
   PUBMED   17118964
REFERENCE   10 (bases 1 to 4106)
  AUTHORS   Ishikawa,A., Kitajima,S., Takahashi,Y., Kokubo,H., Kanno,J.,
            Inoue,T. and Saga,Y.
  TITLE     Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression
            in the PSM under the control of Notch signaling
  JOURNAL   Mech Dev 121 (12), 1443-1453 (2004)
   PUBMED   15511637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152954.1, AK143226.1 and AC117994.12.
            
            On Sep 1, 2009 this sequence version replaced NM_018884.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF127084.1, AK173098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               AC152954.1         201380-201866       c
            488-3076            AK143226.1         2-2590
            3077-4106           AC117994.12        75441-76470
FEATURES             Location/Qualifiers
     source          1..4106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 46.95 cM"
     gene            1..4106
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /note="PDZ domain containing RING finger 3"
                     /db_xref="GeneID:55983"
                     /db_xref="MGI:MGI:1933157"
     exon            1..732
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..3201
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /EC_number="2.3.2.27"
                     /note="semaphorin cytoplasmic domain-associated protein
                     3A; PDZ domain-containing RING finger protein 3; PDZ
                     domain containing RING finger 3A; RING-type E3 ubiquitin
                     transferase PDZRN3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase PDZRN3"
                     /protein_id="NP_061372.2"
                     /db_xref="CCDS:CCDS20392.1"
                     /db_xref="GeneID:55983"
                     /db_xref="MGI:MGI:1933157"
                     /translation="MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLP
                     WVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGRVVKLQDLPEHL
                     ERCDFAPARCRHAGCGQLLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGH
                     CCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQK
                     KFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPCVDNQDGS
                     SSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQ
                     VLRRTPRTKMFTPASESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPA
                     SHDYYDPNDYMGDIHQDMDREELELEEVGLYRMNSQDKLGLTVCYRTDDEDDIGIYIS
                     EIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLD
                     EGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHE
                     KDSGVGRTDESTRNDESSEQENNGEDATASANPLAGQRKLTCSQDTLGSGDLPFSNES
                     FISADCTDVDYLGIPEDECERFRELLELKCQVQSASPYSLYYPSSPLDAAGKSDPESV
                     DKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHHSGFRNYNTSVDVRRHE
                     LSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRVAEGSSEGATANIEAY
                     RPSPKNLLAITEDPEVSTPSYNPSAKELDPSQALEIKERRGSDGSRSPTASPKLGNAY
                     LPSYHHSPYKHAHIPAHAQHYQSYMHLIQQKSAVEYAQSQMSLVSMCKDLNSSNSVEP
                     RMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSK
                     EERKQHLVKAKEQRRRREFMMQSRLDCLKEQQASDDRKEMNILELSHKKMMKKRNKKI
                     FDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV"
     exon            733..819
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     exon            820..927
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1175
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1263
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1362
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1425
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1527
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1644
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..4106
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4076..4081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /note="hexamer: AATAAA"
     polyA_site      4099
                     /gene="Pdzrn3"
                     /gene_synonym="1110020C07Rik; LNX3; SEMACAP3; Semcap3"
                     /note="major polyA site"
ORIGIN      
        1 gccgccacca tgggtttcga gttggatcgc ttcgacggcg acgtggaccc tgatctgaag
       61 tgcgccttgt gccacaaggt cctggaggac ccgctgacca ccccgtgcgg ccacgtattc
      121 tgcgccggct gcgtgctgcc ctgggtagtg caggagggca gctgccccgc gcgttgtcgc
      181 ggtcgcctat cggccaagga gctcaaccac gtcctgcccc tcaagcgtct catcctcaag
      241 ttggacatca agtgcgcgca cgcggcgcgg ggctgcggcc gggtggtcaa gttgcaggac
      301 ttgcccgagc acctggagcg ctgcgacttc gcgcccgcgc gctgccgcca cgcgggctgc
      361 ggccagctgc tgctgcgacg cgacgtggag gcccacatgc gcgacgcgtg cgacgcgcgg
      421 cccgtgggtc gctgccagga gggctgcggg ctgccgctga cgcacggcga gcagcgggcg
      481 ggcggccact gctgcgcgcg ggctctgcgg gcgcacaacg gagcgctgca ggcccgcctg
      541 ggcgcgctgc acaaggcgct caagaaggag gcgctgcggg ccggcaagcg cgagaagtcg
      601 ctggtggcgc agctggccgc cgcgcagctc gaactgcaga tgaccgcgct gcgctaccag
      661 aagaagttca ccgagtacag cgcgcgcctc gactcgctca gccgctgcgt ggccgcgccg
      721 ccaggcggca agggagaaga gaccaaaagc ctgactcttg tcctgcatcg ggactctggc
      781 tccctgggat tcaatatcat tggcggccga ccctgtgtgg acaatcaaga tggatcctcc
      841 agtgaaggaa tctttgtatc caaaatagtt gacagcgggc ctgctgccaa ggaaggaggc
      901 ctgcaaattc atgacaggat tattgaggtc aacggcaaag acttatcccg agcaactcat
      961 gaccaggctg tggaagcttt caagacagcc aaggagccca ttgtggtgca ggtgttgagg
     1021 aggacacctc gaaccaagat gttcacgcct gcctcagagt cgcagctggt agacacgggc
     1081 acccaaaccg acatcacctt tgagcacatc atggccctga caaagatgtc ttctcccagc
     1141 ccacctgtgc tagaccccta cctgctgcct gaagagcatc ccgcatccca tgactactat
     1201 gatcccaatg actacatggg ggatatccat caggacatgg acagagaaga gctggagctg
     1261 gaagaagtgg gcctctacag gatgaacagc caggacaagc tgggtctcac tgtgtgctac
     1321 cggacggatg acgaagatga cattgggata tatataagtg agattgaccc taacagcatt
     1381 gcagccaagg atggacggat ccgtgaagga gatcgcatca tccagattaa tggcatcgaa
     1441 gtacagaacc gtgaagaggc cgtggcgctt ctaaccagtg aagaaaacaa gaacttttca
     1501 ttgctgattg caaggcctga gctccagctg gatgagggct ggatggacga cgacaggaac
     1561 gacttcctgg atgacttaca catggacatg ctggaggaac agcatcacca ggccatgcag
     1621 ttcaccgcca gtgtgctcca gcagaagaag catgaggaag acggtgggac cacagacaca
     1681 gccaccatct tatccaacca gcacgagaaa gacagtggtg tcgggcgaac ggatgagagc
     1741 acccgcaatg atgagagctc agaacaggag aataacggtg aagatgctac ggcatccgcc
     1801 aacccgctgg caggccagag gaagctgacc tgtagccagg acaccctggg cagtggcgac
     1861 ctgcctttca gcaatgagtc cttcatctct gcggactgta ccgatgtgga ctacctgggc
     1921 atcccagagg atgagtgcga gcgttttcgc gaactgctgg agctcaagtg ccaagtgcag
     1981 agcgccagcc cctacagcct gtactaccct agcagcccac tggatgctgc tggcaagagt
     2041 gaccccgaga gcgtggacaa ggagctggag ctactcaatg aggagttgcg cagcatcgag
     2101 ctggagtgcc tgagcatcgt gcgcgcgcac aagatgcaac agctcaagga acagtaccgt
     2161 gagtcctgga tgctgcacca cagtggcttc cgcaactaca acaccagtgt ggacgtgcgc
     2221 cgccatgagc tctcggacat cactgagctg ccggagaagt cagacaagga tagttcaagc
     2281 gcctacaaca cgggggagag ctgcagaagt accccactca ccctggagat ctctccggac
     2341 aactccctgc ggagagtagc cgagggcagt agtgaagggg ccacagctaa catcgaagct
     2401 tacaggccat cccccaagaa tctgctcgcc atcactgagg accctgaagt aagcacccca
     2461 agctataacc ctagtgccaa agagctggac cccagccagg ctttggagat caaagaacgc
     2521 cgaggtagcg atggcagcag gagccccacc gccagcccaa agctgggcaa tgcctacctg
     2581 ccctcatacc accactcccc ctacaaacac gcgcacatcc cagctcacgc gcaacactac
     2641 cagagctaca tgcacctgat ccagcagaag tcagcagtgg agtatgcgca gagccagatg
     2701 agcctggtga gcatgtgcaa ggacttgaac tcttctaact ctgtggaacc caggatggaa
     2761 tggaaagtga agatccgcag tgacgggacg cgctacatca ccaagaggcc ggtgcgtgac
     2821 aggctgctgc gggagcgtgc gctgaagatc cgcgaggagc gcagtggcct gaccacggat
     2881 gatgacgcca tgagtgagat gaagatgggg cgctactgga gcaaggagga gcgcaagcaa
     2941 catctggtga aggccaagga gcagaggcgg aggcgcgagt ttatgatgca gagcaggctg
     3001 gattgtctga aggagcagca ggcctccgac gacaggaagg agatgaacat cctggaactg
     3061 agccacaaaa agatgatgaa gaagaggaac aaaaagatct ttgacaattg gatgactatc
     3121 caagaactct taacccacgg cacaaaatcg ccagacggca ctagggtata caattccttc
     3181 ctgtcggtga ctactgtata actctcactt gtgtacatac gagagaccac taccattggg
     3241 gtagacatcc ctgcctcgtt caatgcggca agtttttgta tatataagcc cggccatcat
     3301 gttgatagtc taaatttgcc actcctgcaa ctttgggtgt cctggctctg ttttcagtgg
     3361 agggaaaata cacccttact ctcttagaag gcaatattaa caagcagctt tttttcaaat
     3421 agcaatggta attttttact tgttaacctt tttcataaag tgtttaaatt tccaaaagat
     3481 cttttattaa gcatactttc acagaataat ttgtttaaac tatattcata taaaagaagg
     3541 ttaaacacgc tttttttctg cctaaaacac aaaatgcaac tgccagtatg tatttttaat
     3601 gggtccctat tttgtaatgt cacttcgctg aatgtgtttc atacaagtca ccattcattc
     3661 atacagctta tatcagttgg ggtttcaaca caaaccagcc aaagtctggt tggtgatttg
     3721 acacacacac acatacatac acacacacac acacacacta accaaactag cagcatttct
     3781 agtcgggata tccattttta acatttttat ggttaaggtt cccaagaaga gtgtcaaggt
     3841 tttaacagaa agcaaaattt cctgcagctt tgtggacgct taaagcatgt ttgcaaatat
     3901 tgccgcctgt tggaagaatt tgcatgtaca gggaagtcgc ggatggagac ctgtttgtgg
     3961 agttttaagt gctcattgtt gtagaccttt gctttgtaga ttggaaggga cagacttaac
     4021 caagcaagtt cacaggatca tgattagtta caaacatcaa gtaaaatgaa gttaaaataa
     4081 attattattt tctatttgac ctgctc
//
