LOCUS       NM_001164557            1129 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus PDZK1 interacting protein 1 (Pdzk1ip1), transcript
            variant 1, mRNA.
ACCESSION   NM_001164557
VERSION     NM_001164557.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1129)
  AUTHORS   Morello,F., Borshagovski,D., Survila,M., Tikker,L., Sadik-Ogli,S.,
            Kirjavainen,A., Estartus,N., Knaapi,L., Lahti,L., Toronen,P.,
            Mazutis,L., Delogu,A., Salminen,M., Achim,K. and Partanen,J.
  TITLE     Molecular Fingerprint and Developmental Regulation of the Tegmental
            GABAergic and Glutamatergic Neurons Derived from the Anterior
            Hindbrain
  JOURNAL   Cell Rep 33 (2), 108268 (2020)
   PUBMED   33053343
REFERENCE   2  (bases 1 to 1129)
  AUTHORS   Ikeno,S., Nakano,N., Sano,K., Minowa,T., Sato,W., Akatsu,R.,
            Sakata,N., Hanagata,N., Fujii,M., Itoh,F. and Itoh,S.
  TITLE     PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and
            suppresses transforming growth factor-beta (TGF-beta) signaling
  JOURNAL   J Biol Chem 294 (13), 4966-4980 (2019)
   PUBMED   30718277
  REMARK    GeneRIF: These findings indicate that PDZK1IP1 interacts with Smad4
            and thereby suppresses the TGF-beta signaling pathway.
REFERENCE   3  (bases 1 to 1129)
  AUTHORS   Tijssen,M.R., Cvejic,A., Joshi,A., Hannah,R.L., Ferreira,R.,
            Forrai,A., Bellissimo,D.C., Oram,S.H., Smethurst,P.A., Wilson,N.K.,
            Wang,X., Ottersbach,K., Stemple,D.L., Green,A.R., Ouwehand,W.H. and
            Gottgens,B.
  TITLE     Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL
            binding in megakaryocytes identifies hematopoietic regulators
  JOURNAL   Dev Cell 20 (5), 597-609 (2011)
   PUBMED   21571218
REFERENCE   4  (bases 1 to 1129)
  AUTHORS   Seidler,U., Singh,A., Chen,M., Cinar,A., Bachmann,O., Zheng,W.,
            Wang,J., Yeruva,S. and Riederer,B.
  TITLE     Knockout mouse models for intestinal electrolyte transporters and
            regulatory PDZ adaptors: new insights into cystic fibrosis,
            secretory diarrhoea and fructose-induced hypertension
  JOURNAL   Exp Physiol 94 (2), 175-179 (2009)
   PUBMED   18931049
  REMARK    GeneRIF: Knockout mice for 3 members of the sodium-hydrogen
            regulatory factor (NHERF) family of PDZ adaptor proteins, NHERF1
            (EBP50), NHERF2 (E3KARP) and NHERF3 (PDZK1), have helped to show
            that NHERF1 is essential for both normal and mutant CFTR function
            [review]
            Review article
REFERENCE   5  (bases 1 to 1129)
  AUTHORS   Hu,S., Song,E., Tian,R., Ma,S., Yang,T., Mu,Y., Li,Y., Shao,C.,
            Gao,S. and Gao,Y.
  TITLE     Systematic analysis of a simple adaptor protein PDZK1: ligand
            identification, interaction and functional prediction of complex
  JOURNAL   Cell Physiol Biochem 24 (3-4), 231-242 (2009)
   PUBMED   19710538
  REMARK    GeneRIF: Systematic analysis of Pdzk1ip1 is reported.
REFERENCE   6  (bases 1 to 1129)
  AUTHORS   Pribanic,S., Gisler,S.M., Bacic,D., Madjdpour,C., Hernando,N.,
            Sorribas,V., Gantenbein,A., Biber,J. and Murer,H.
  TITLE     Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in
            renal proximal tubular cells
  JOURNAL   Am J Physiol Renal Physiol 285 (4), F784-F791 (2003)
   PUBMED   12837682
  REMARK    GeneRIF: MAP17 1) interacts with PDZK1 only, 2) associates with the
            NH2 terminus of NaPi-IIa within the PDZK1/NaPi-IIa/MAP17 complex,
            and 3) acts as an apical anchoring site for PDZK1.
REFERENCE   7  (bases 1 to 1129)
  AUTHORS   Silver,D.L., Wang,N. and Vogel,S.
  TITLE     Identification of small PDZK1-associated protein, DD96/MAP17, as a
            regulator of PDZK1 and plasma high density lipoprotein levels
  JOURNAL   J Biol Chem 278 (31), 28528-28532 (2003)
   PUBMED   12754212
  REMARK    GeneRIF: membrane associated protein 17 may be an endogenous
            regulator of cellular PDZ domain containing 1(PDZK1) levels by
            regulating PDZK1 turnover
REFERENCE   8  (bases 1 to 1129)
  AUTHORS   Gottgens,B., Barton,L.M., Chapman,M.A., Sinclair,A.M., Knudsen,B.,
            Grafham,D., Gilbert,J.G., Rogers,J., Bentley,D.R. and Green,A.R.
  TITLE     Transcriptional regulation of the stem cell leukemia gene
            (SCL)--comparative analysis of five vertebrate SCL loci
  JOURNAL   Genome Res 12 (5), 749-759 (2002)
   PUBMED   11997341
REFERENCE   9  (bases 1 to 1129)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   10 (bases 1 to 1129)
  AUTHORS   Gottgens,B., Gilbert,J.G., Barton,L.M., Grafham,D., Rogers,J.,
            Bentley,D.R. and Green,A.R.
  TITLE     Long-range comparison of human and mouse SCL loci: localized
            regions of sensitivity to restriction endonucleases correspond
            precisely with peaks of conserved noncoding sequences
  JOURNAL   Genome Res 11 (1), 87-97 (2001)
   PUBMED   11156618
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670035.15, AK007936.1, EH108199.1 and DV058382.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV058382.1, AK007936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL670035.15        197729-197743
            16-906              AK007936.1         2-892
            907-1125            EH108199.1         33-251              c
            1126-1129           DV058382.1         816-819
FEATURES             Location/Qualifiers
     source          1..1129
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 52.75 cM"
     gene            1..1129
                     /gene="Pdzk1ip1"
                     /gene_synonym="0610007F13Rik; 2700030M23Rik; Map17"
                     /note="PDZK1 interacting protein 1"
                     /db_xref="GeneID:67182"
                     /db_xref="MGI:MGI:1914432"
     exon            1..505
                     /gene="Pdzk1ip1"
                     /gene_synonym="0610007F13Rik; 2700030M23Rik; Map17"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..783
                     /gene="Pdzk1ip1"
                     /gene_synonym="0610007F13Rik; 2700030M23Rik; Map17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane-associated protein 17 (Map17); 17 kDa
                     membrane-associated protein"
                     /codon_start=1
                     /product="PDZK1-interacting protein 1 isoform 1"
                     /protein_id="NP_001158029.1"
                     /db_xref="CCDS:CCDS51272.1"
                     /db_xref="GeneID:67182"
                     /db_xref="MGI:MGI:1914432"
                     /translation="MGGGQFLFTSLPVLPPRPLSTSALPNPTSPLESDCSPADLIQTP
                     QTSSSSRSQKHQQWTEVLQLPAAMLAFSLLVLGLLAEVAPASCQQGLGNLQPWMQGLI
                     AVAVFLVLVAIVFAVNHFWCQEEPEPGSTVMIIGNKADGVLVGMDGRYSSMASGFRSS
                     EHKNAYENVLEEEGRVRSTPM"
     exon            506..614
                     /gene="Pdzk1ip1"
                     /gene_synonym="0610007F13Rik; 2700030M23Rik; Map17"
                     /inference="alignment:Splign:2.1.0"
     exon            615..710
                     /gene="Pdzk1ip1"
                     /gene_synonym="0610007F13Rik; 2700030M23Rik; Map17"
                     /inference="alignment:Splign:2.1.0"
     exon            711..1129
                     /gene="Pdzk1ip1"
                     /gene_synonym="0610007F13Rik; 2700030M23Rik; Map17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1074..1079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdzk1ip1"
                     /gene_synonym="0610007F13Rik; 2700030M23Rik; Map17"
                     /note="hexamer: AATAAA"
     polyA_site      1099
                     /gene="Pdzk1ip1"
                     /gene_synonym="0610007F13Rik; 2700030M23Rik; Map17"
                     /note="major polyA site"
ORIGIN      
        1 gggctcattc aaggcagggc tgaaaatgtc acacctttcc ctgggagcct agccccattg
       61 ccaggaaagg tgagctcaga agaagacttc tgaggcagag tgagtgtcgg agaaggcggg
      121 gactttcccc ttacttcccc agttccctgg gcccaccccc agaactggtt tctaaagggg
      181 taccttaaat gccagttcgt cgggctgggc ataagccagg cccggcagct catttccatg
      241 ggaggagggc agtttctctt caccagtctg ccagtccttc ctccccgccc tctttccact
      301 tctgccttac ccaatccaac ctctccttta gagtcagact gctctccagc tgatctcata
      361 caaacacccc agacctccag cagctccagg agtcaaaaac accagcagtg gaccgaggtc
      421 ctacagctgc ctgcagccat gttggccttc agtctgctcg tgctgggtct gctcgcggaa
      481 gtggcacctg ccagctgtca acaaggtcta ggaaaccttc agccctggat gcaaggcctc
      541 attgctgtcg ctgtgttctt ggtccttgtt gcaatcgtct tcgccgtcaa ccacttctgg
      601 tgccaggagg agccggagcc tgggagcaca gtgatgatca ttggaaacaa ggcagatggg
      661 gtcctggtgg gaatggatgg cagatactcc tcaatggcat ctggttttag gtccagcgag
      721 cacaagaatg cctacgagaa tgttctggag gaagagggca gggtccgcag cacacccatg
      781 tgacaagctt ctctgtggcc ctagtcccca ggctacaggg aacatagagt tgatccccac
      841 catctcaccc agccactgct ctacaggaat ctactgaaac aagctgactc cctcacctct
      901 ctagaatcac agtcatctca ggccaggact cagaccaagc ccagcacacc atgtgctgtg
      961 accctgggct ttcctgggtc ttctacccag ttctgaggag ccttgtgaag ggtggctcag
     1021 ctcctcccct ccccttgctc ctgcaactat ggaagtggct cttatttctg tgaaataaag
     1081 actttttata cttctgggat ggagactctg acccagcttc caggctcta
//
