LOCUS       NM_021517               2417 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus PDZ domain containing 1 (Pdzk1), transcript variant 1,
            mRNA.
ACCESSION   NM_021517
VERSION     NM_021517.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2417)
  AUTHORS   Shao,Y., Zhang,H., Guan,H., Wu,C., Qi,W., Yang,L., Yin,J.,
            Zhang,H., Liu,L., Lu,Y., Zhao,Y., Zhang,S., Zeng,C., Wang,G.,
            Bai,X. and Cai,D.
  TITLE     PDZK1 protects against mechanical overload-induced chondrocyte
            senescence and osteoarthritis by targeting mitochondrial function
  JOURNAL   Bone Res 12 (1), 41 (2024)
   PUBMED   39019845
  REMARK    GeneRIF: PDZK1 protects against mechanical overload-induced
            chondrocyte senescence and osteoarthritis by targeting
            mitochondrial function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2417)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2417)
  AUTHORS   Lu,S., Chen,X., Chen,Y., Zhang,Y., Luo,J., Jiang,H., Fang,L. and
            Zhou,H.
  TITLE     Downregulation of PDZK1 by TGF-beta1 promotes renal fibrosis via
            inducing epithelial-mesenchymal transition of renal tubular cells
  JOURNAL   Biochem Pharmacol 220, 116015 (2024)
   PUBMED   38158021
  REMARK    GeneRIF: Downregulation of PDZK1 by TGF-beta1 promotes renal
            fibrosis via inducing epithelial-mesenchymal transition of renal
            tubular cells.
REFERENCE   4  (bases 1 to 2417)
  AUTHORS   Jaballah,N., Tsurudome,Y., Murakami,C., Matsunaga,N., Ushijima,K.,
            Koyanagi,S. and Ohdo,S.
  TITLE     The scaffold protein PDZK1 governs diurnal localization of CNT2 on
            the plasma membrane in mouse intestinal epithelial cells
  JOURNAL   J Biochem 174 (2), 193-201 (2023)
   PUBMED   37159505
  REMARK    GeneRIF: The scaffold protein PDZK1 governs diurnal localization of
            CNT2 on the plasma membrane in mouse intestinal epithelial cells.
REFERENCE   5  (bases 1 to 2417)
  AUTHORS   Christians,A., Weiss,A.C., Martens,H., Klopf,M.G., Hennies,I.,
            Haffner,D., Kispert,A. and Weber,R.G.
  TITLE     Inflammation-like changes in the urothelium of Lifr-deficient mice
            and LIFR-haploinsufficient humans with urinary tract anomalies
  JOURNAL   Hum Mol Genet 29 (7), 1192-1204 (2020)
   PUBMED   32179912
REFERENCE   6  (bases 1 to 2417)
  AUTHORS   Kocher,O., Pal,R., Roberts,M., Cirovic,C. and Gilchrist,A.
  TITLE     Targeted disruption of the PDZK1 gene by homologous recombination
  JOURNAL   Mol Cell Biol 23 (4), 1175-1180 (2003)
   PUBMED   12556478
  REMARK    GeneRIF: While PDZK1-deficient mice developed normally, did not
            display any gross phenotypic abnormalities, and were fecund, lack
            of PDZK1 resulted in modulation of expression of selective ion
            channels in the kidney, as well as increased serum cholesterol
            levels.
REFERENCE   7  (bases 1 to 2417)
  AUTHORS   Bodnar,J.S., Chatterjee,A., Castellani,L.W., Ross,D.A., Ohmen,J.,
            Cavalcoli,J., Wu,C., Dains,K.M., Catanese,J., Chu,M., Sheth,S.S.,
            Charugundla,K., Demant,P., West,D.B., de Jong,P. and Lusis,A.J.
  TITLE     Positional cloning of the combined hyperlipidemia gene Hyplip1
  JOURNAL   Nat Genet 30 (1), 110-116 (2002)
   PUBMED   11753387
REFERENCE   8  (bases 1 to 2417)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
REFERENCE   9  (bases 1 to 2417)
  AUTHORS   Wang,S., Yue,H., Derin,R.B., Guggino,W.B. and Li,M.
  TITLE     Accessory protein facilitated CFTR-CFTR interaction, a molecular
            mechanism to potentiate the chloride channel activity
  JOURNAL   Cell 103 (1), 169-179 (2000)
   PUBMED   11051556
REFERENCE   10 (bases 1 to 2417)
  AUTHORS   Kocher,O., Comella,N., Gilchrist,A., Pal,R., Tognazzi,K.,
            Brown,L.F. and Knoll,J.H.
  TITLE     PDZK1, a novel PDZ domain-containing protein up-regulated in
            carcinomas and mapped to chromosome 1q21, interacts with cMOAT
            (MRP2), the multidrug resistance-associated protein
  JOURNAL   Lab Invest 79 (9), 1161-1170 (1999)
   PUBMED   10496535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW259368.1, AK012070.1 and AC127297.4.
            
            On Sep 26, 2017 this sequence version replaced NM_021517.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF220100.1, AK012070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AW259368.1         1-11
            12-2182             AK012070.1         2-2172
            2183-2417           AC127297.4         80154-80388         c
FEATURES             Location/Qualifiers
     source          1..2417
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.0 cM"
     gene            1..2417
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /note="PDZ domain containing 1"
                     /db_xref="GeneID:59020"
                     /db_xref="MGI:MGI:1928901"
     exon            1..92
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..304
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1654
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /note="PDZ domain-containing protein 1; CFTR-associated
                     protein of 70 kDa; sodium-hydrogen exchanger regulatory
                     factor 3; na/Pi cotransporter C-terminal-associated
                     protein 1; Na(+)/H(+) exchanger regulatory factor 3"
                     /codon_start=1
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF3"
                     /protein_id="NP_067492.2"
                     /db_xref="CCDS:CCDS17649.1"
                     /db_xref="GeneID:59020"
                     /db_xref="MGI:MGI:1928901"
                     /translation="MASTFNPRECKLSKQEGQNYGFFLRIEKDTDGHLIRVIEEGSPA
                     EKAGLLDGDRVLRINGVFVDKEEHAQVVELVRKSGNSVTLLVLDGDSYEKAVKNQVDL
                     KELDQSQREAALNDKKPGPGMNGAVEPCAQPRLCYLVKEGNSFGFSLKTIQGKKGVYL
                     TNIMPQGVAMKAGVLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLVDKETAR
                     CHSEQKTQFKRETASLKLLPHQPRVVVIKKGSNGYGFYLRAGPEQKGQIIKDIEPGSP
                     AEAAGLKNNDLVVAVNGKSVEALDHDGVVEMIRKGGDQTTLLVLDKEAESIYSLARFS
                     PLLYCQSQELPNGSVKEGPAPIPAPLEATGSEPTEDAEGHKPKLCRLLKEDDSYGFHL
                     NAIRGQPGSFVKEVQQGGPADKAGLENEDVIIEVNGENVQEEPYDRVVERIKSSGKHV
                     TLLVCGKMAYSYFQAKKIPIVSSMAEPLVAGPDEKGETSAESEHDAHPAKDRTLSTAS
                     HSSSNSEDTEM"
     exon            305..554
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..691
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..887
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1084
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1309
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1600
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..2417
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /note="hexamer: ATTAAA"
     polyA_site      1966
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /note="major polyA site"
     regulatory      2391..2396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
                     /note="hexamer: AATAAA"
     polyA_site      2413
                     /gene="Pdzk1"
                     /gene_synonym="1700023D20Rik; 2610507N21Rik;
                     4921513F16Rik; D3Ertd537e; mPDZK1; naPi-Cap1; NHERF-3;
                     Nherf3; Pdzd1"
ORIGIN      
        1 aatcaatctt tgtccaaagt ccagtgagtt ccaagactag tagtgttcac agcggggaga
       61 atttccagtg cggagcggat ccttcgccac agaaatggcc tccaccttca accccagaga
      121 gtgtaaattg tccaaacaag aggggcagaa ctatggcttc tttctccgaa ttgagaagga
      181 cactgatggt cacctgatcc gggtgattga ggaggggagc ccagcagaga aggcggggct
      241 cctggacggt gacagggtgc tcaggatcaa tggtgtcttt gtcgacaagg aggagcatgc
      301 gcaggtggtg gagctggtca gaaagagtgg gaattcagtg actctgctgg tcctggatgg
      361 agactcctat gagaaggctg tgaaaaatca ggtggatttg aaagagctgg atcaaagcca
      421 gagggaggcc gctctgaatg ataagaaacc gggccctggg atgaacggag cggtggagcc
      481 gtgtgcccag ccacggctct gctacctggt gaaggagggc aacagctttg gcttctctct
      541 gaaaactatc caaggtaaaa agggtgtgta cttgactaat ataatgcctc agggcgtggc
      601 catgaaagct ggtgttctgg ctgatgatca cttgattgaa gtgaatggag aaaatgtaga
      661 gaacgccagc catgaggaag tggttgaaaa ggtgacaaag tcaggaagcc gtatcatgtt
      721 cctccttgtg gacaaagaaa ctgccaggtg ccatagtgaa cagaagacac aattcaagag
      781 ggagacagcc agtttgaaac tgctgcccca ccagccccgg gtggtagtga tcaagaaggg
      841 cagcaatggc tatggcttct atctgagggc ggggcctgaa cagaaaggtc aaatcattaa
      901 ggacatagaa cccgggagcc cagcagaggc agctggcttg aagaacaatg acttggtagt
      961 tgctgtcaat ggcaagtctg tggaagctct tgatcatgac ggtgtggtgg aaatgattag
     1021 aaaaggtgga gaccagacta ctctgttggt gctggacaaa gaggcagaga gcatctatag
     1081 cctggctcgg ttctctccac ttctttactg ccaaagtcaa gaactgccta atggttctgt
     1141 caaggaaggc ccagctccga tccctgctcc tctggaggcc acaggctcag agcccacaga
     1201 ggacgcggag ggtcacaagc ccaagctctg caggctgctt aaagaggacg atagctacgg
     1261 ctttcacctg aatgccattc ggggtcagcc tggctccttt gtcaaagagg tacagcaggg
     1321 tggccctgct gacaaggctg ggctggagaa tgaggacgtc atcatcgaag tgaacgggga
     1381 gaacgtgcaa gaggaaccct acgacagagt ggtggagaga atcaagagca gcgggaagca
     1441 cgtcactctg ttggtctgtg gaaagatggc ctacagctac ttccaagcta agaaaatccc
     1501 catcgtttcc tccatggccg agcccctggt ggctggccct gatgaaaaag gagagacgtc
     1561 tgcggagtcc gagcatgacg cccacccagc aaaagaccga actctcagca cagcctcgca
     1621 ctcttcgtct aactctgaag acacggagat gtgaagagaa caaatgatgc ttcctcttga
     1681 gggcccagga actgcctctc cgaggaatga gccctgccga ccccgtcaga cctcctctgg
     1741 accatctgtc ccccagactg tctgttgttg taagggctgc tactgcaggt tgcttattta
     1801 agctcaactt agccagagga gggaccaggt tcagggtctt tctatgtggt atcttccaaa
     1861 gtgcaacttt tcacttctgt tgatgagacc tcttccttct gcaggcttga gcacctggga
     1921 tgattcactg tccatgtgag cgctgctaat taaagaatca agcagatgcc tgttatagaa
     1981 gtgtgctttt gtagcaatgc tgtggctgag cagcattgct aagtgcttct gagttgtttg
     2041 caacttccct gttggctaat agaatccgaa tagtgtcttt gttccataca aacatttcat
     2101 gctttctcat ttgcttccag aagcccaaaa catgcaaaat acacactgtg gtcttagtaa
     2161 taaagggagg cttccaggaa atatacttca gcattttctt atgttacatt tgagtattaa
     2221 aaaaaaacct caacaccttc cttttactgt cggagggctt atgtttcaga acaggaaagg
     2281 gcttgttcca gttaacgtct acctccagcg ctgaggcaga gggaaagcca acccgagcca
     2341 gccactgctg gattagcacg gaacattcac tcttctctaa tttaagagga aataaagatt
     2401 ggtataccta aaatcta
//
