LOCUS       NM_001033222            7076 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus PDZ domain containing 8 (Pdzd8), mRNA.
ACCESSION   NM_001033222
VERSION     NM_001033222.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7076)
  AUTHORS   Li,M., Wang,Y., Wei,X., Cai,W.F., Wu,J., Zhu,M., Wang,Y., Liu,Y.H.,
            Xiong,J., Qu,Q., Chen,Y., Tian,X., Yao,L., Xie,R., Li,X., Chen,S.,
            Huang,X., Zhang,C., Xie,C., Wu,Y., Xu,Z., Zhang,B., Jiang,B.,
            Wang,Z.C., Li,Q., Li,G., Lin,S.Y., Yu,L., Piao,H.L., Deng,X.,
            Han,J., Zhang,C.S. and Lin,S.C.
  TITLE     AMPK targets PDZD8 to trigger carbon source shift from glucose to
            glutamine
  JOURNAL   Cell Res 34 (10), 683-706 (2024)
   PUBMED   38898113
REFERENCE   2  (bases 1 to 7076)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7076)
  AUTHORS   Kurihara,Y., Mitsunari,K., Mukae,N., Shoji,H., Miyakawa,T. and
            Shirane,M.
  TITLE     PDZD8-deficient mice manifest behavioral abnormalities related to
            emotion, cognition, and adaptation due to dyslipidemia in the brain
  JOURNAL   Mol Brain 16 (1), 11 (2023)
   PUBMED   36658656
  REMARK    GeneRIF: PDZD8-deficient mice manifest behavioral abnormalities
            related to emotion, cognition, and adaptation due to dyslipidemia
            in the brain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7076)
  AUTHORS   Morita,K., Wada,M., Nakatani,K., Matsumoto,Y., Hayashi,N.,
            Yamahata,I., Mitsunari,K., Mukae,N., Takahashi,M., Izumi,Y.,
            Bamba,T. and Shirane,M.
  TITLE     PDZD8-deficient mice accumulate cholesteryl esters in the brain as
            a result of impaired lipophagy
  JOURNAL   iScience 25 (12), 105612 (2022)
   PUBMED   36465123
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7076)
  AUTHORS   O'Hare,J.K., Gonzalez,K.C., Herrlinger,S.A., Hirabayashi,Y.,
            Hewitt,V.L., Blockus,H., Szoboszlay,M., Rolotti,S.V., Geiller,T.C.,
            Negrean,A., Chelur,V., Polleux,F. and Losonczy,A.
  TITLE     Compartment-specific tuning of dendritic feature selectivity by
            intracellular Ca2+ release
  JOURNAL   Science 375 (6586), eabm1670 (2022)
   PUBMED   35298275
REFERENCE   6  (bases 1 to 7076)
  AUTHORS   Shirane,M., Wada,M., Morita,K., Hayashi,N., Kunimatsu,R.,
            Matsumoto,Y., Matsuzaki,F., Nakatsumi,H., Ohta,K., Tamura,Y. and
            Nakayama,K.I.
  TITLE     Protrudin and PDZD8 contribute to neuronal integrity by promoting
            lipid extraction required for endosome maturation
  JOURNAL   Nat Commun 11 (1), 4576 (2020)
   PUBMED   32917905
  REMARK    GeneRIF: Protrudin and PDZD8 contribute to neuronal integrity by
            promoting lipid extraction required for endosome maturation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7076)
  AUTHORS   Hirabayashi,Y., Kwon,S.K., Paek,H., Pernice,W.M., Paul,M.A.,
            Lee,J., Erfani,P., Raczkowski,A., Petrey,D.S., Pon,L.A. and
            Polleux,F.
  TITLE     ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in
            mammalian neurons
  JOURNAL   Science 358 (6363), 623-630 (2017)
   PUBMED   29097544
  REMARK    GeneRIF: PDZD8 represents a critical an endoplasmic reticulum
            -mitochondria tethering protein in metazoans.
REFERENCE   8  (bases 1 to 7076)
  AUTHORS   Klein,A.D., Ferreira,N.S., Ben-Dor,S., Duan,J., Hardy,J., Cox,T.M.,
            Merrill,A.H. Jr. and Futerman,A.H.
  TITLE     Identification of Modifier Genes in a Mouse Model of Gaucher
            Disease
  JOURNAL   Cell Rep 16 (10), 2546-2553 (2016)
   PUBMED   27568557
REFERENCE   9  (bases 1 to 7076)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 7076)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145020.1 and AC139040.8.
            
            On Jan 15, 2008 this sequence version replaced NM_001033222.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145020.1, BC141370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1563              AK145020.1         1-1563
            1564-7076           AC139040.8         79416-84928
FEATURES             Location/Qualifiers
     source          1..7076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.65 cM"
     gene            1..7076
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /note="PDZ domain containing 8"
                     /db_xref="GeneID:107368"
                     /db_xref="MGI:MGI:2677270"
     exon            1..1062
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..3637
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /codon_start=1
                     /product="PDZ domain-containing protein 8"
                     /protein_id="NP_001028394.2"
                     /db_xref="CCDS:CCDS29936.1"
                     /db_xref="GeneID:107368"
                     /db_xref="MGI:MGI:2677270"
                     /translation="MGLLLLILASAVLGSFLTLLAQFLLLYRRQPEPRADEAARAGDG
                     FRYLKPVPGLPLREYLYGGGAEELAACSSEAGASSTPTPDSPAPPTLETCYFLNATIL
                     FLFRELRDTALARRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGDTVPFIKTIR
                     LVRPVVASGTGEPDDPDGDALPATCPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLF
                     VKLSRVVGRLRFVLTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKK
                     IIKRKHTLPSYKIRFKPFFPYQALQGFEEDEELIHIQQWALTEGRLKVTLLECSRLFI
                     FGSYDRETNVHCTLELSSGVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGH
                     VIIETVAPNSPAAMADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYQRPAGQ
                     SSQDSLGQLEESFLSSSCQAAYEEDAAGLSADTENRDLDSEFEDLASDVRVQTELKEE
                     TQPLSHSPKRTPTTLSIKPLGAISPVLNRKLISGIHPPPQKLPSKEGNKPSTLKTSET
                     TEAAQVSKPQGPTFKPPVPPRPQGRVPLPPTDTSAQADPEAPEKPDKVLLPPPPADKP
                     AEKQVKSVDQGEDVAAGKQSSAKQEGVKDLPSESSAPTKDSSDDPQMWESSEVLYRNK
                     VGKWSRTRASCVFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEEVALGCLATS
                     NMEYLTKFRLEPPTPKAMVTRTALRNLSMQKGFNDKFCFGDITIHFKYLKEGEPDHHI
                     VPNVEKEKELHLVEEVSTLPKEEHFVGQMSLSENKHSFQDTQFQNPTWCDYCKKKVWT
                     KAASQCMFCAYVCHKKCQEKCLAETPLCGATERRIDRTLKNLRLEGQDPLLGLPPRVE
                     IEANKSVNKTTGLTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEG
                     SDTEVCGSNSPSKRGNSAGIKLMRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLE
                     FMLDKLQNEIDQELEHNNSLVREEKETNDTRKKSVLSAALAKSGERLQALTLLMIHYR
                     AGIEDIETLENLSLDQHSKKMNKYADDTEEDLDSEISQLIDSQPFSNISDDLFGPSES
                     V"
     exon            1063..1185
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1288
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1451
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..7076
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6126..6131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /note="hexamer: ATTAAA"
     polyA_site      6145
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /note="major polyA site"
     regulatory      7054..7059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /note="hexamer: ATTAAA"
     polyA_site      7074
                     /gene="Pdzd8"
                     /gene_synonym="A630041P07Rik; Pdzk8"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggcgc ggggccgcgg cgggctaagg cgccgccagg cagcgtcgga ctgcggacgc
       61 tcggttcggg cccagggagc cgctcatccg cgaccgatgt cctcaagatg gaggcggcgg
      121 gggcgacggc gtgaggagga gggcggcgcg gagagcgcgg gagcaggccg agggttgcgg
      181 cgggggcggc gggatggggc tgctgctcct gatcctggcg tcggccgtgc tgggctcgtt
      241 cctcacgctg ctcgcacagt tcctgctact ctaccgcaga cagcccgagc cgcgggcgga
      301 cgaagcggcc cgcgcgggcg acggcttccg ctaccttaag ccggtgccgg gcctgcccct
      361 cagggagtac ctttatggcg gcggcgccga ggagctcgct gcttgctcct ccgaggccgg
      421 cgccagctcg accccgaccc ccgacagccc ggccccgccg acgctggaga cctgctactt
      481 cctcaacgcc accatcctgt tcctgttccg ggagctgcgg gacaccgcgc tcgcccgccg
      541 ctgggtcacc aagaagatca aggtggagtt cgaggagctg ctgcagacca agacggccgg
      601 ccgcctgctg gaggggctga gtctgcgcga cgtgttcctg ggcgacacgg tgcccttcat
      661 caagaccatc cggctggtgc ggcccgtggt ggcctcgggc accggcgagc ccgacgaccc
      721 cgacggggac gcgctgcccg ccacctgccc ggaggagctg gcctttgaag cggaggtgga
      781 gtacaacggc ggtttccacc tggccatcga cgtggacctg gtgtttggca agtccgccta
      841 cctgttcgtg aagctgtctc gcgtggtggg gaggctgcgc ttcgtcctca cccgcgtgcc
      901 cttcacccac tggttcttct ccttcgtgga ggacccgctg attgacttcg aggtgcgctc
      961 ccagttcgag gggcggccca tgccccagct cacctccatc atcgtcaacc agctcaagaa
     1021 gatcatcaag cgcaagcaca ccctgcccag ttacaagatc aggtttaagc cgttttttcc
     1081 ataccaagcc ttgcaaggat ttgaagaaga tgaagaactt atccatattc aacaatgggc
     1141 acttactgaa ggccggctta aagttacatt gttagaatgt agcaggttat tcatttttgg
     1201 atcctatgac agagaaacaa atgttcattg cacacttgag ctgagcagtg gtgtttggga
     1261 agaaaaacaa aggagttcta ttaagacggt tgaattaata aaagggaatt tacaaagtgt
     1321 cggacttaca cttcgtcttg ttcagtcaac tgatgggtat gctgggcatg tcataatcga
     1381 aactgtggcc ccaaactcac ctgctgcgat ggcagatctt caacggggag atcggctcat
     1441 tgctattgga ggtgtgaaaa tcacatcgac cctgcaggtg ctgaagctca tcaagcaggc
     1501 tggggaccgc gtgctggtgt actaccagag gccggctggg cagagcagcc aagacagcct
     1561 gggccagttg gaagaaagct tcttgtccag ctcctgccag gcagcctacg aagaggacgc
     1621 tgctgggctg tcagcggaca ctgaaaacag agacctagat tctgaattcg aagacttggc
     1681 gagtgatgtc agagtacaga cagagttgaa agaggagaca cagccgttga gtcacagtcc
     1741 caaacgtact ccaacaacac tttctattaa accccttggc gctatatccc cggttttaaa
     1801 tcgtaaatta atttcaggaa tccacccacc accacaaaaa cttccatcca aagaaggaaa
     1861 taaaccatca actctaaaaa cttcagagac cacagaagca gcacaagtgt ccaaacccca
     1921 aggacccact ttcaaaccac ctgtgccacc gcgaccacag gggagagtgc ctctgcctcc
     1981 cactgacacc tcagcccaag cagacccgga agccccagaa aagccagaca aggtgctgct
     2041 ccctcctcct cctgcagata aacctgccga gaagcaagtg aagagtgtgg atcaaggaga
     2101 agatgtggca gcaggtaagc agtcttcagc gaagcaggaa ggagtgaaag atcttccttc
     2161 agaaagttct gctcctacta aagactcttc agatgaccct cagatgtggg aatcctcaga
     2221 ggttctatat cgcaacaagg tgggaaagtg gtcaagaacc agagcgtcct gtgtgtttga
     2281 catagaagcc tgccataggt acctgaacat cgcactgtgg tgcagggatc ctttcaagtt
     2341 aggaggtctc atctgtttgg ggcatgttag tttaaaactt gaggaagtgg ctttaggatg
     2401 tctagctaca tcaaacatgg aataccttac aaagttcaga ctggaacccc ctacacctaa
     2461 ggccatggtc actagaactg cactacgtaa tctgagtatg caaaagggct ttaatgacaa
     2521 attttgtttt ggtgacatta ctattcattt caagtatttg aaggaaggag aaccagacca
     2581 ccacatagtt cctaatgtag agaaagaaaa agaactccat ttggttgagg aggtttctac
     2641 actccctaaa gaagagcatt ttgtgggaca gatgagtttg tcagaaaata aacatagttt
     2701 ccaagatact cagttccaga acccaacttg gtgtgattac tgtaagaaaa aagtttggac
     2761 aaaagctgct tcccagtgta tgttctgtgc ttatgtttgt cataaaaaat gtcaggaaaa
     2821 gtgtctagct gagacacctc tttgtggagc aactgagagg cgaatagacc ggaccctgaa
     2881 aaacctcagg ctggaaggac aggacccact cttgggcctt cctcctcgtg ttgagataga
     2941 agctaacaag tcagtcaata aaacaacagg gttgacaagg cacatcatta atacgagctc
     3001 tcgtttacta aatctgcgtc aagtctctaa aactcgcctt tctgaaccag gaacagatct
     3061 tgtagaacct tcaccaaaac acacacccaa tacgtcagac aatgaaggca gtgacacaga
     3121 ggtctgtggt tcaaacagtc cttccaaacg aggaaacagt gcaggaataa agttaatgag
     3181 aaaggaagga gggctggatg acagtgtttt cattgcagta aaggaaattg gtcgtgatct
     3241 gtacagaggc ttgccgacag aagagaggat ccagaagctg gagttcatgt tggataagct
     3301 acagaatgaa attgatcagg agctggaaca caacaattcc cttgttagag aagaaaagga
     3361 aacaaatgat acaaggaaaa agtcagttct ttctgctgct ttagctaaat cgggagaaag
     3421 actacaagct ctgacacttc tgatgatcca ctacagagcg ggaatcgaag atattgaaac
     3481 cctagaaaat ctgtctttag accagcactc gaaaaagatg aacaagtacg cagatgatac
     3541 agaagaagac ctcgatagtg agataagcca gttgatagac tctcagccat tcagcaacat
     3601 ttccgatgac ttgttcggcc catctgagtc agtgtaatca ataagctatt tcaactttca
     3661 catggatgga ggggacaaga cgtatctgaa gtgccatggg tacagccacg ttcggttctc
     3721 tcatggtaca ctttggcctg cttctatagt tacttgcttg tatgagaaag aaaaggtagt
     3781 ttccagctaa aacatgacca gctcatcaaa ttggttgttt cgggttgtgc ttatagcttt
     3841 ggcttttttg gatttatact gggaattggg ttttattaat ttatttttaa ccttttctaa
     3901 ttatgtaagc caactttgtg tttgtgtatg tgtgatgtct cactgtcatt ttttttttct
     3961 ttcctcctgg ttttttaatt agtgttaaat aagatcctgt ctagattcct gaaatatttt
     4021 ctttcatttt catcacggtt ataacagcaa atttcttgca tgcctaaatt gacaataatc
     4081 attgagggaa caggtttgag tcttcttcct tctacgtttt gtggtttgtc agctgtactt
     4141 ccttgatgtt tttgttatac ggggcttggg ggatttttgt ttaattttat tttgctttta
     4201 ttgttgttgc caaatgtaaa tgaaagcaga ccctacagct ttaatctgtt atgcttatat
     4261 aatttttttt acatatattg cttgcttctt acgcttctgc gatattttta aagcttttat
     4321 gcagttgaaa tgtagtaaaa ttacagtgat taactaggag aggttgcatt gaatagagaa
     4381 taagtgcaaa gtccagttgg tcaagaattt tgtaggcagg ataataagat ttcattacag
     4441 taggattttg aaatatcttt caaatgttga tgctttcctt ttaagtggaa attacggaca
     4501 ctcatgatga cttcatctgt ggttctctca taggacataa agcatatgca aggacattta
     4561 caatcgcaca ggacttattc tgaaaatgac tgtattgata actggctttg tttgtatgat
     4621 gtggagagca attatacaga ctatgtttac tacatcatct ggtgtcttgt ggccttaaag
     4681 gactgtcggt cattctgaat actttagtag ttcagaccat ctttattcat tgtaaagaaa
     4741 actaaaaata gacagtatgc atagttcact aaatgaaggc ctgctatgac aaaaatgaag
     4801 gcctgctatg ctattgggcc catctagtgg atgctggtaa tgaacaactg agagaaatat
     4861 atgaacttaa cccctattga tatatcttaa aagtctaagc ttgttatacc tatagaatag
     4921 aaaagtgttt tcccccttta caggtaactt ctatgataac acataaacca actaaattaa
     4981 aaaatatatg gaatagctct ttggctgcag aaaaatgaat agtataatag taaaaaggct
     5041 tgcccaggct gtagcccaaa ctcccaacag gagtttcagg tcaagctcct tagtgagctg
     5101 tatagccaca ggcaggttac aaagggttct gcagcttccc cagctccaaa ggtccttaca
     5161 cttctcacag gactgttgtg aggaggacag gaacatcact gcaaaggcgc tttgaagagt
     5221 aaatgctgta aaaataagag gtattcctta cacaagaaaa catttctgag tatagaaaag
     5281 ttactccagt cataaactca atagctaact ctcacattat taagtgaaat attggggcac
     5341 agacctacct ttgtcaagtt tatagcaagg ctacatctgt gtaacctcac ccccactctt
     5401 ttactgttta tttaagcatg ctcacagttt aaaagaacac cacaatagaa ggacttccca
     5461 caataaatcc cagaagctaa agtgttcctc cattttacac ttgaaacaat ctgcccaatg
     5521 tatagccgtg tttcatcttg taaacaataa cttgccattg ctaccctgaa ggtggtatgg
     5581 ctgtaactgg ctggtgtgtt gatggatcaa actatggaag ttttagtggt gcccaagcat
     5641 gctcctgcac tgatgcattt ggaagagctg tagaaataat gcaaagcttt agttctaaga
     5701 atctactcat gctttaaagt atttatctct gtagaaccac aatcatggaa agctcaacag
     5761 tgctgctaat catgtttgta aaatatacct ttaatgtagt gcaatatttt tctattggga
     5821 gagacagtac aggcatcaca gttgggagct ccaataccct caagcatagt aagggataag
     5881 gcttcaattt aagagattgt gttatattac attactcatg taatcttgct gccatgctat
     5941 gttatcaata gctaaaataa taataaagac taccacggaa aataagaata tcttcatttg
     6001 atgacatcta aaaacaggtg attggttctc tggcattatt acctggtata atctggccat
     6061 gcagacaagc taacgatcca cttttactaa acaaatatgt agacctgtct cagaaaagaa
     6121 gaaaaattaa actatttgaa gtgtacgctc ttcattgttt ttaagttgaa tggctgagtt
     6181 agacaaaatg aataacattt tagtattatt ttgcaatcat ttatttgttt tttttttttt
     6241 tttttttttt atttatcgtg ttgctttttt gagacagagt ctctttggct tcaaactcag
     6301 tagagatctg tctgcctctc ctctggagtg ctggggttaa aggcatgcac caccatgcca
     6361 agttttacta tatttcttag caccagactt cgttcagtaa cactagaact tactgtgtag
     6421 atactttctc attctaagaa caggctaaaa ctttgagagt aaaatctacc ttaaaaaaac
     6481 aaacaaacaa aaaaacaaaa aaaaacccta taaagacatt ttaaacatat ttggttctaa
     6541 taagtaagat agtggagttt aatttttaag tcccctaaag tttttaaatc gcttcaattt
     6601 aaaaaaaaaa aaagtattac tttaatattt aaattgaagt gacagctttc cttaccctcc
     6661 cctcaaaagg caaacaaggg tggaaagggg ggttaccttc atcctttctg atcccttaat
     6721 gttccttaag gtctgagtaa accaggtctc taatcctgga aactacaatg tgtaccacct
     6781 tcaaaatgat ccttatttct aggtctttca gagcctgttc tgtcgtcata tagctaggaa
     6841 ttaccattct cttcatcaga aaattacctg ttcacagcaa ttagagcaat tcatttgagt
     6901 taaagtccag ggcaacttta ctgtttttcc acactgatag ggtataacaa gtctatattt
     6961 catttaaagg aagcagtggg aagccaaaga ggatggttta ccctagcctg gagtgacttg
     7021 cctgatgcct gcaaacacag agaatgcttt ttaattaaat acttacagcc aaaaca
//
