LOCUS       NM_001081064           11482 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus PDZ domain containing 2 (Pdzd2), mRNA.
ACCESSION   NM_001081064 XM_006520159 XM_127972
VERSION     NM_001081064.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11482)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11482)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   3  (bases 1 to 11482)
  AUTHORS   Fai So,D.H., Yan Chan,J.C., Tsui,M.G., Wai Tsang,P.S. and Yao,K.M.
  TITLE     Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a
            PKA-dependent mechanism
  JOURNAL   Mol Cell Endocrinol 518, 111026 (2020)
   PUBMED   32919022
  REMARK    GeneRIF: Secreted PDZD2 exerts an insulinotropic effect on INS-1E
            cells by a PKA-dependent mechanism.
REFERENCE   4  (bases 1 to 11482)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 11482)
  AUTHORS   Tsang,S.W., Shao,D., Cheah,K.S., Okuse,K., Leung,P.S. and Yao,K.M.
  TITLE     Increased basal insulin secretion in Pdzd2-deficient mice
  JOURNAL   Mol Cell Endocrinol 315 (1-2), 263-270 (2010)
   PUBMED   19932150
  REMARK    GeneRIF: Results provide the first evidence that Pdzd2 is required
            for normal regulation of basal insulin secretion.
REFERENCE   6  (bases 1 to 11482)
  AUTHORS   Shao,D., Baker,M.D., Abrahamsen,B., Rugiero,F., Malik-Hall,M.,
            Poon,W.Y., Cheah,K.S., Yao,K.M., Wood,J.N. and Okuse,K.
  TITLE     A multi PDZ-domain protein Pdzd2 contributes to functional
            expression of sensory neuron-specific sodium channel Na(V)1.8
  JOURNAL   Mol Cell Neurosci 42 (3), 219-225 (2009)
   PUBMED   19607921
  REMARK    GeneRIF: These findings reveal that Pdzd2 and p11 play
            collaborative roles in regulation of Na(V)1.8 expression in sensory
            neurons.
REFERENCE   7  (bases 1 to 11482)
  AUTHORS   Lad,H.V., Liu,L., Paya-Cano,J.L., Fernandes,C. and Schalkwyk,L.C.
  TITLE     Quantitative traits for the tail suspension test: automation,
            optimization, and BXD RI mapping
  JOURNAL   Mamm Genome 18 (6-7), 482-491 (2007)
   PUBMED   17619104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135292.2, AC150660.4 and AC133282.7.
            
            On or before Jul 12, 2018 this sequence version replaced
            XM_006520159.3, NM_001081064.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AC135292.2         60596-60871
            277-372             AC135292.2         84251-84346
            373-1202            AC150660.4         177923-178752       c
            1203-1704           AC133282.7         18525-19026
            1705-1847           AC133282.7         31159-31301
            1848-1980           AC133282.7         34212-34344
            1981-2136           AC133282.7         39565-39720
            2137-2251           AC133282.7         57252-57366
            2252-2397           AC133282.7         65671-65816
            2398-2517           AC133282.7         69445-69564
            2518-2632           AC133282.7         70243-70357
            2633-2706           AC133282.7         74113-74186
            2707-2935           AC133282.7         74301-74529
            2936-3053           AC133282.7         75271-75388
            3054-3186           AC133282.7         77513-77645
            3187-3268           AC133282.7         86775-86856
            3269-3303           AC133282.7         88246-88280
            3304-3460           AC133282.7         89131-89287
            3461-4248           AC133282.7         90876-91663
            4249-4393           AC133282.7         94081-94225
            4394-8327           AC133282.7         100444-104377
            8328-8445           AC133282.7         105118-105235
            8446-8547           AC133282.7         108104-108205
            8548-8818           AC133282.7         108744-109014
            8819-8953           AC133282.7         111062-111196
            8954-11482          AC133282.7         114585-117113
FEATURES             Location/Qualifiers
     source          1..11482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.9 cM"
     gene            1..11482
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /note="PDZ domain containing 2"
                     /db_xref="GeneID:68070"
                     /db_xref="MGI:MGI:1922394"
     exon            1..276
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            277..372
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            373..1202
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             727..9117
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /note="PDZ domain containing 3"
                     /codon_start=1
                     /product="PDZ domain-containing protein 2"
                     /protein_id="NP_001074533.1"
                     /db_xref="CCDS:CCDS37045.1"
                     /db_xref="GeneID:68070"
                     /db_xref="MGI:MGI:1922394"
                     /translation="MPITQDNALLHLPLLYEWLQNSLREGGDSPEQRLCQAAIQKLQE
                     YIQLNLAVEENTVPPEHSPPEMEICTVYLTKQLGDTETVGLSFGNIPVFGDYGEKRRG
                     GKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASY
                     LAEQCWNGGFIYLIMLRRFKQKAHLTYNGNSGNSSEPGETPTLELGDQTSKKGKRTRK
                     FGVISRPAIIKAPEDSKSNSGCDTADDPSSELENGTDSELGNGHAFELENGPNSLKDV
                     AGPHLERSEADREAELRVPKTEAPLSDSNDKRRFSKTGKTNFQSSDSLAREEVGRIWK
                     MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL
                     VGLSHEEAVAILRSATGMVQLVVASKESSAEDLLKLTSKSLPDLTSSVEDISSWTDNE
                     DQEAARDDEEGTGSAAVRGTMLGSEESQDVGSSEESKGNNLESPKQGNSKMKLKSRLS
                     GGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSTGTSQEYHIVKKST
                     RSLSTTHVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCVRGQMGIFVKTIFPN
                     GSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLLSPSLTP
                     CSTPTHMSRSSSPSFNSSGGAPAGGGQDEGGSASLGRKAPGPKDRIVMEVTLNKEPRV
                     GLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVH
                     AILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPSLGTPLKSPSL
                     AKKDSLLSESELSQYFVHDGQGSLSDFVVAGSEDEDHPGSGYETSEDGSLLTVPSAYR
                     ETGKARANSLVTLGSQRGSGLLHKQVTVARQASLPGSPQVLRNPLLRQRRVRCYDSND
                     GSDDEDFDGEGDCVSLPGVLPGPGRPLVQDDTRFALATSSKSIDVNKQDERLQKPLVS
                     KACSVPLLGSSLDSEHSIHGGTAGTPPKAASLPGSVETPKNGPGGSRRKEMSGSRSSP
                     KLEYRVPADTQSPRSPENGTSPPQKTENLVSRHKPVARISPHYKRSDAEEAPSETANG
                     PCAQDLKVQASSVKDPVAGHQPGGTAEKELRGNPTPGDSSVPTNCGPASTPCHPNTGL
                     PTENPQGAAPECGPHPGTGWDGSSDHPPSPGKSREVRPDSSETPAVTEQVLQPESLSQ
                     PVSPGTSEPESQGVSKMKPASQRSLSPREKASALPDSSRTWAGPGDSTPSTRRAAVPM
                     SIGETRATAIPHPSLLGQERSRDPSGPSKALETPGHCVPTSLKDRALLEETASASGKL
                     SHAGPSVPVTTDGTLSGSTESPVTDIDKFIGEAPEAWLSQSPQRADCRTHQDIFESQP
                     PGGAGGGSSHHGKTGGTGSPPPPQWTFQPSVLDSVHPDKQLAGNKNFLNNYSRNFSSF
                     HEDGVSEPSPSSMYGDAEDSSSDPESLVEDPRAAARNNWPAPPSHESSRKEGSSESED
                     EQIEICAPGGCPETPVPAQAPAQAAGGAVPSVQQTVREPVGDACEKACFMTGASNTCI
                     PGSSQPFSFLDVSSLEHETWAGVQTSRSHMPGCAEETLAVSSTGSVVGDSQPSQTTRP
                     CGNPPFVLRNPDMVNGLGQDLLDEGTPDKGADASHVMSSVYALGAEGPKNGEAVLANL
                     HIAKGGNLDGLLQKPKTTSRRPIMTWFKDINKDSQGAHLQSKSEKEQPSMLAMSPGSK
                     GNTVNPSHRKGMAVPKSPPPRQKSQENKDLSPKSPVETLSNCQKPKGSPKLKRLNSKS
                     KASPEAPVASPAKGGRTDHRKSLPSPQAAHKMLSKAVSHRLHIADQEEPKNTAGDTSK
                     PPQCVPESKPPLAASGSLRTSASDTSIRTITSPLTSPKPLPEQGANNRFHMAVYLESD
                     TSCPATSRPPRYGPEGKVPHANSGSVSPSASRTNIALAGVRQSKQFTHSRVDLVLTEA
                     AQPQGISEKGTEKMASDPLERTNQLKIIEISSERMPKNACGDKPPGSDRKGGFLTQSN
                     CQEKSSVRLRQSAESSPKQPHFPPSQASQGEQEMRWSYSMARLASSSPSAPQLPSKMP
                     DYSQGKSSQMPASVGVPKNGVPVGLAGEEPPYFTPRPATRTYSMPAQFSSHFGREGLS
                     PPSPSHSPQDPQVTAMSGSLSEKSAKGVTNEQGVYSVKPLLETLRNPPPVDVGDVSAV
                     PEASGLIPDKLKVTRRHYYCEQSWPHESTSFFSVKQRIKSFENLANSDRPAAKSATSP
                     FLSVSSKPPVNRRSSGSITSGRPSDGTARSLRRSLSSCSENQSEASSLLPQMTKSPSS
                     VTLTVSRQNPPETNNKGHSPDPKKSLVPVGIPISTGSPASPIKRNKSSVRHAQPSPVS
                     RSKLQELRALSMPDLDKLCSGEDYSASPGAVLFRTQLEITPRRSQGSPATSPASSPAR
                     GHADVNGSAFLSCPVNGGNRVYPKGNSSPTVPTGSREWGESLRAMPSGKSWSVNLDQL
                     LASVGYQQRLQAVLSLVGSKSPILPLIQEAKAQSENKEDICFIVLNKKEGSGLGFSVA
                     GGADVEPESVLVHRVFSQGVASQEGTVSQGDFLLSVNGTSLAGLSHSEVTKVLHQAEL
                     HKHVLMIIKKGNDQPRPSFRQEPPSANGKAPFPRRTLPLEPGAGRNGAAHDALCVEVL
                     KTSAGLGLSLDGGKSSIAGDGPLVIKRVYQGGAAEQAGTIEAGDEILAINGKPLVGLV
                     HFDAWNIMKSVPEGPVQLVIRKHRDS"
     exon            1203..1704
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1847
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1980
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2136
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2251
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2397
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2517
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2632
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2706
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2935
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3053
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3186
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3268
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3303
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3460
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..4248
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4393
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..8327
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8328..8445
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8446..8547
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8548..8818
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8819..8953
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8954..11482
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11460..11465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /note="hexamer: AATAAA"
     polyA_site      11482
                     /gene="Pdzd2"
                     /gene_synonym="4930537L06Rik; A930022H17Rik; Gm21706;
                     Gm82; Pdzk3"
                     /note="major polyA site"
ORIGIN      
        1 actcccagcg ccagtgcgta ctagcggcgg gcagtgggac gcggcggggc ggctgcggcg
       61 ggcgccctcc aagcgcccca ccgatcgcaa gacgctcggg atcgcgcctc cggcggcaac
      121 cagcaaaccc ctgcggcgcg gcttctcccg gcaggcgcgg caacagcacc ggtggtggtg
      181 gtggcagggg cggcggtagc tgcgccggca ccgccgggcg gcgcctgagt ctggacgctc
      241 caggagcggc tcgagcctcc gccgatccgc gaacagggta actggaacag gagctcttga
      301 tggcagatgg atcctccctg aagaggaatt caaagaccag ggtcgttttt tctgtcttcc
      361 tttctcaggg ttgtgtgaat gagcccaagc aagacctgac acctgctgaa gaaacagcca
      421 gatttccacg tcatttgcat gaaccctgct gtgaaatgaa ccaagcaagg acttgttaga
      481 tacttcctcc tttcccttgc tgagcactcc cgggccgttg tttcagtgtg gtttaattgt
      541 cctgtccttc ttttgccaag gcaaacaccc cagcctcaca ggaggcatcc ctagagctca
      601 tctgctggcc tgaacatgaa catgggcaga gctgatgatt gggagccttt ccaagggact
      661 tgggtcccca cggggtccag ggggaagcag gacctctcat gatgctggtg tctgggagtg
      721 agcaccatgc ccatcaccca ggacaatgct ttgctgcacc tgcccctcct gtacgagtgg
      781 ctgcagaaca gcctgcggga gggtggggac agtcccgagc agcggctctg ccaggcggcc
      841 atccagaagc tgcaggagta catccaactg aacttggctg tggaggagaa cacagtccca
      901 ccagagcaca gccccccaga gatggagatc tgtacggtgt acctcaccaa gcagctggga
      961 gacactgaaa ctgtggggct cagttttggc aacatccctg ttttcgggga ctatggagaa
     1021 aagcgtcgag ggggtaagaa gaggaaaacc caccaggggc cagtgctgga cgtgggctgc
     1081 atctgggtga cagagctgag gaagaacagc ccagcgggga agagcgggaa agttcggctc
     1141 cgggatgaga tcctttccct gaacggacag ctgatggtcg gagttgatgt cagtggggcc
     1201 agttacctcg ctgagcagtg ctggaatggc ggcttcatct acttgatcat gctgcggcgc
     1261 ttcaagcaga aagcccacct gacttacaat ggcaacagtg gcaacagctc agaacccgga
     1321 gagacaccga ccttggagct gggtgaccag acttccaaaa aggggaaaag aacaagaaag
     1381 tttggggtca tttccagacc ggctatcatc aaggcccctg aagactccaa gagcaacagt
     1441 ggttgtgaca ccgcagatga tcccagctcg gagttggaga acggtaccga ctccgaactt
     1501 ggaaatggcc atgcctttga gctagaaaat ggtccgaatt ctctcaagga tgtggctgga
     1561 ccccatctgg agaggtcaga agcggacaga gaggccgagc tcagagttcc aaagacggaa
     1621 gcccctctga gtgacagcaa tgacaaacgc cgtttctcaa aaactgggaa gaccaacttc
     1681 cagtccagtg actccctggc acgggaggaa gttggccgga tatggaagat ggaactgctc
     1741 aaagaatcag atgggctggg aattcaggtt agtggaggcc gaggatcaaa gcgctcacct
     1801 cacgctatcg ttgtcaccca agtgaaggaa ggaggtgccg ctcacaggga tggcaggctg
     1861 tccttaggag atgaactgct ggtgatcaat ggtcacttac tggtcgggct ctcccatgag
     1921 gaagctgtgg ctattctgcg ctcagccact gggatggtac agctggtggt ggccagcaag
     1981 gagagctcag cggaggacct tctgaagtta acatcgaaga gcttacctga cctgactagt
     2041 tcagtggagg acatatcctc ctggactgac aacgaagacc aggaggcagc cagggatgat
     2101 gaagagggga caggctcagc tgctgtccgg ggcacgatgc tcgggtcaga agagtctcaa
     2161 gacgtaggca gctctgagga atccaaaggg aacaacttgg aaagccccaa acagggcaac
     2221 agtaaaatga aactcaagag ccgactctca ggaggtgtcc accgcctaga gtctgttgaa
     2281 gaatataatg aactgatggt acgaaatggg gacccccgga tcagaatgct ggaggtctcc
     2341 cgagatggcc gcaagcactc tcttccccag ctgctggatt ctactgggac atcacaggaa
     2401 taccacattg tgaagaagtc tacccgttct ctgagcacca cccacgtgga atcgccgtgg
     2461 aggctcattc ggccatccgt tatttccatc attggactat acaaagagaa aggcaagggc
     2521 cttggcttta gcattgctgg agggcgagac tgtgttcgtg gccagatggg gatttttgtc
     2581 aagaccattt tcccaaacgg atcagctgca gaggacggca ggctcaaaga aggagatgaa
     2641 atcctagatg tgaatggaat accaataaag ggtttgacgt ttcaagaggc tattcacacc
     2701 ttcaagcaaa tccgaagcgg gctgttcgtc ctcacggtgc ggactaagct gctcagcccc
     2761 agcctcacac cctgctccac acccacacac atgagcagat ctagctcccc gagcttcaac
     2821 agcagtgggg gagccccggc aggaggaggc caagatgaag ggggttctgc atcccttggt
     2881 cggaaggctc ctgggcccaa agacagaatt gtcatggaag tcacgctcaa caaagagcca
     2941 agagttgggt tgggcatcgg tgcctgctgc ttagccttgg aaaacagccc tccaggtata
     3001 tacattcaca gccttgcccc tggatctgtg gccaagatgg agagcaacct gagccgggga
     3061 gaccaaatcc tggaagtaaa ttctgtgaac gtgcgccatg cagctttaag taaagtgcat
     3121 gccatcttaa gtaaatgccc cccaggaccc gttcgcctgg tcatcggccg acaccctaat
     3181 ccaaaggtct ccgagcagga aatggatgaa gtgatagcac gcagcactta ccaggaaagc
     3241 aaagaagcca actcctcacc cagcctaggt acccccttga agagtccctc tcttgccaaa
     3301 aaggactcac tcctctccga atctgagctc tcccagtact tcgtccatga tggccagggc
     3361 tccctttcag actttgtggt agctggctct gaggacgagg accaccctgg aagtggctat
     3421 gaaacctcag aggatggcag cctgctgacc gttccctctg cttacaggga gacaggcaaa
     3481 gccagggcca acagccttgt gacacttgga agccagaggg gctctgggct cttacacaag
     3541 caagtgacag tcgctcggca agccagtctc cccggaagcc cacaggtcct caggaacccc
     3601 cttctccgcc agaggagggt tcgttgctat gacagcaatg atggcagtga cgatgaagac
     3661 tttgatggtg agggggactg cgtctccctc ccgggagtcc tcccaggtcc cggcaggcct
     3721 ctggtacagg atgacactag gtttgccttg gcaacctctt ccaaaagtat tgatgtgaac
     3781 aagcaggatg aacgactcca gaaaccactg gtcagcaagg cctgctccgt gcctctcctt
     3841 ggcagctcgc tagactcaga gcacagcatc cacggtggga cggcgggtac ccctcccaag
     3901 gcagccagcc tgccaggctc tgtagaaacc cccaagaatg ggcccggagg ctccagaaga
     3961 aaggaaatgt cagggtcaag aagttcgccg aagctggaat acagggtccc tgcagacacc
     4021 cagagcccga ggagcccaga aaatggtacc tccccaccac agaagactga aaatctggtg
     4081 tccaggcaca agcccgtggc caggatcagc ccacactaca agagatctga tgctgaggag
     4141 gccccaagtg aaacagccaa tggaccgtgt gctcaggact tgaaagtcca ggcatcttcc
     4201 gtgaaagatc ctgtcgctgg tcatcagcca ggtggaactg cagagaagga acttcgggga
     4261 aatcccaccc cgggggacag ctctgtcccc accaactgtg gaccagccag taccccatgc
     4321 cacccaaaca ctggactccc cacagagaac ccgcagggag ctgcaccaga gtgcgggcca
     4381 caccctggga ctggatggga tgggtcctca gaccatcccc cttccccagg gaagagcagg
     4441 gaagttcgtc ctgactccag cgagactcct gcagtcaccg agcaagtcct ccaacctgag
     4501 agcctcagcc agcctgtgtc tcccgggacc tcggagcctg agtcccaggg cgtatctaaa
     4561 atgaagccag ccagccagag aagcctgtct cccagggaga aggcctcagc tcttcccgac
     4621 tccagcagga cttgggctgg ccctggggac agcactccca gcaccaggag agcagctgtc
     4681 cccatgagca taggagagac acgagctacg gccatccctc atccctccct cctgggtcag
     4741 gaaaggagcc gagacccctc gggtcccagc aaggccctgg aaactccagg acactgcgta
     4801 cctacaagct tgaaagatag ggctctgctt gaagaaacag cgtcagcatc tggaaagttg
     4861 tcacacgccg gtccctctgt gccagtgact actgatggga ccctgtcggg gagcacagag
     4921 agcccggtga cagacattga caagttcatt ggggaagccc cggaggcgtg gctttctcag
     4981 tctcctcaga gagcagactg caggactcac caggacattt ttgagagtca gccaccaggg
     5041 ggagctgggg gtggcagttc ccaccatggg aagaccggag gcacaggctc acccccaccc
     5101 cctcagtgga ccttccagcc ttccgttctg gattccgtcc atcctgacaa acagttggct
     5161 gggaacaaaa actttctgaa caactactcc agaaatttta gcagtttcca cgaagacggc
     5221 gtctcggaac cttcgccctc gtccatgtat ggcgatgctg aagactcgtc ttcagacccc
     5281 gagtctcttg ttgaagatcc acgagcagcg gccaggaaca actggccagc tcctccatct
     5341 catgagtcct cccgtaagga aggtagcagt gagtctgagg acgagcaaat agaaatctgt
     5401 gccccaggtg gttgtcctga gaccccagtg cctgcccaag ctcctgccca ggctgcaggc
     5461 ggcgcagttc cctcggtaca gcagactgtg agggagccgg tgggggacgc ctgcgagaaa
     5521 gcctgcttca tgacaggagc ctcgaacact tgcatcccgg gctcttccca gccattttcc
     5581 ttcctggatg taagctctct ggagcatgag acttgggcgg gcgtacagac ttcacggagc
     5641 cacatgcccg ggtgcgcaga ggaaaccttg gcggtcagca gcaccggctc agtcgtggga
     5701 gacagccagc cttctcaaac gaccagacct tgtggaaacc cgccatttgt gctcaggaac
     5761 ccagatatgg taaatggttt gggacaggac ctgctggatg agggaacccc agacaaagga
     5821 gcagatgcct ctcatgtcat gagcagtgtg tatgccctgg gggccgaggg ccctaagaat
     5881 ggagaggccg ttttggcaaa cctacacatt gccaagggcg gcaacctgga cggcttgcta
     5941 cagaaaccaa aaacgacctc caggaggcct atcatgacct ggtttaaaga cataaataaa
     6001 gacagccaag gcgcacatct gcagagcaaa tctgagaagg aacaaccctc aatgctggct
     6061 atgagtcctg gctcgaaagg caacacggtg aaccccagcc acagaaaggg aatggctgtg
     6121 cctaagagtc cacctccccg gcagaagagt caagaaaata aggacctatc ccctaaaagc
     6181 ccagtggaaa cactaagtaa ctgtcagaag cccaagggca gcccgaagct taagaggctg
     6241 aacagcaaaa gcaaagccag tccggaggca cctgtggcca gtcccgctaa gggcggcagg
     6301 accgaccaca ggaagtcctt gccttcaccc caggctgccc ataaaatgct ttctaaggca
     6361 gtgtcacaca ggctccacat agctgaccaa gaggagccta agaacactgc tggagacacc
     6421 tccaagcctc cccagtgtgt gccagagagc aagccacccc tggctgcctc tgggtcgctg
     6481 aggacctccg catctgacac aagcattaga accattactt ctcccctgac ctcccccaag
     6541 cctctccctg agcaaggtgc aaacaatagg ttccacatgg ctgtctacct ggaatctgac
     6601 acaagctgtc cagccacctc caggccccct aggtatggac cagagggcaa ggtgccccat
     6661 gctaactctg ggtcagtgag tccctccgca tcgaggacca atatagcctt ggcaggggtc
     6721 agacagagca agcagttcac acacagccga gtagacttgg tgttaacaga agcagcccag
     6781 ccccagggca tcagtgagaa aggaaccgaa aaaatggcta gtgatcctct ggaaaggaca
     6841 aaccagctaa aaatcattga gatttcttct gaaagaatgc caaagaatgc atgtggcgac
     6901 aagccacctg gtagtgacag aaagggcggg ttcttaaccc agagcaactg tcaggagaag
     6961 agttcggtcc gactcaggca gtcagcagaa tcgtccccaa agcagccgca cttccctccc
     7021 tcccaggcct cccaggggga acaggaaatg cgttggtcct acagcatggc cagactggcc
     7081 tcctcctccc cctccgcccc gcagctgccc tccaaaatgc cagattactc ccagggcaaa
     7141 tcaagccaaa tgccagcctc agtcggggtg cccaaaaatg gcgtacccgt aggcctggcc
     7201 ggagaagagc ccccctactt cacaccaagg ccagccacca ggacttattc catgccagcc
     7261 cagttctcga gccattttgg acgagaaggt ctttccccac ccagcccaag tcactcgcct
     7321 caggaccccc aggtcactgc aatgagtggc agtctctctg agaagtcagc caaaggcgtg
     7381 actaacgaac agggcgtgta cagtgtgaaa cctctactgg aaacacttag gaacccacca
     7441 ccagtggatg tgggggatgt cagtgcggtc cccgaggcaa gcggcctcat cccagacaaa
     7501 ctcaaagtca ccaggagaca ctactactgt gagcagagct ggccccatga atctacctcg
     7561 tttttctctg tgaagcaaag gatcaagtct ttcgagaacc tggccaattc tgaccggcct
     7621 gcggccaagt ctgccacatc cccgttctta tccgtgagct ccaagcctcc cgttaacaga
     7681 cggtcatctg gcagcatcac ttcggggaga cccagtgatg ggaccgcaag gtcactgaga
     7741 cgcagcttga gttcctgcag cgagaaccag agtgaggcca gcagccttct cccgcagatg
     7801 acaaagtccc cgtccagcgt gacgttgact gtctccaggc agaatccgcc agagactaat
     7861 aacaagggcc acagtccaga cccaaagaaa tcacttgtcc ccgtgggtat tcccatctcc
     7921 acagggagcc cagcctcacc catcaagagg aacaagtcct ctgtccgcca tgcccagccc
     7981 tccccagtgt cccgatccaa gctccaggag ctgagagcct tgagcatgcc agacctggac
     8041 aagctgtgta gtggcgagga ctactctgcc agcccagggg ctgtgctctt tagaacccaa
     8101 ctggagataa cccccagaag gtcgcaaggc tccccagcta cctctccagc cagctctcca
     8161 gctagaggcc acgcggatgt caatggatca gccttccttt cgtgtcctgt gaatggtggc
     8221 aacagagtct accccaaagg aaacagctct ccaacagtgc ccactggatc cagggaatgg
     8281 ggtgaatctc tgcgggccat gccttctggg aaaagctggt cagtgaattt ggatcaactc
     8341 cttgcctcag tggggtacca gcagagatta caggccgttt tatcattagt ggggtcaaaa
     8401 tcccccatcc tccctctcat tcaggaagcg aaggcacaat cagagaataa agaagacatt
     8461 tgctttatag tcttgaataa aaaagaaggc tcgggtctgg gattcagtgt ggcaggagga
     8521 gcagacgtgg agccagaatc agtcctggtc cacagggtgt tttctcaggg tgtggcttct
     8581 caggaaggga ctgtgagcca aggggacttc cttctctccg taaatggcac ctccttagct
     8641 ggcttatccc acagcgaggt cacaaaggtt ctgcaccagg cagagctgca caaacacgtc
     8701 ctcatgatta tcaagaaagg gaatgaccag cccaggccct ccttccggca ggagcctccc
     8761 tcagccaatg ggaaggcccc attccccaga aggaccttgc cgctggagcc aggagctggg
     8821 agaaacggag ctgctcacga cgctctgtgt gtggaagtgc tgaaaacctc tgctgggctg
     8881 gggttgagtc tggacggagg aaaatcatcc atagccggag atgggccgct ggtaattaaa
     8941 agggtgtacc aaggtggcgc ggcagaacaa gctggaacaa tagaagcggg tgatgagatc
     9001 cttgctatta acgggaagcc cttggttggg ctggtgcact tcgatgcctg gaacattatg
     9061 aagtctgttc cagaagggcc tgtgcagtta gtgattagaa agcacagaga ttcgtgaatt
     9121 tttacaggga atctcctccc ttagattcag ttctttatca gaatgacggg ttcttgaatt
     9181 gacaaacagc ttagacagat atctgtgatt gtacttttat atgaagcccg aactctggag
     9241 accacctacc tggactgtca gggctgggag ggcatcactt cgttcagtgc ctcggatcaa
     9301 gagctgagtg ctcttcatct ggaacaccta actgcacctt cacatctctc tatcacctct
     9361 cccagcatca gtcctggtga gtagggacca gagggtaaca caaatgcccc agctaaaatg
     9421 atagatgtat gtagatctat ataattttgt aagtaaatga tatagtgctt ttaggtacat
     9481 gcagtggaag gcagagctat ggggtctacg tatgttacct tgaaaaagga aaatgagact
     9541 taaagagaat gattttatga cctaattgtt aggcagagct caggaatcac ccaacagtga
     9601 aaaaaatgac aattttaaaa agtgctattt tttaatgaac gtaatgtatg atgagaacta
     9661 ggaagttctg atggttttct gtttcagagt gtaagttata aggctgttac agagcgacag
     9721 ttctgatgaa ttgcaataaa tagctgtgag cttccctgct tgggaggagg aagtcctagc
     9781 ctgaaaagca ccttgcatct agttttcaaa cttgagtaca tggtcgaatt caagactggt
     9841 caacacctca gcaggcaaag ttgtcagcgt tttttccgtt tccacacaca tggattttga
     9901 gagttaaatc cctcaaattg caaacgtagg cgttctgcgg tcggaactga ggagggtctt
     9961 agcatcctcg gggaaatgtt cttgttagtt tttctccttt ccccctccag acctaaagaa
    10021 gcatagagtt tgtagtccag ctctcccccc tgacagagct ctgtggtggc tcagcttctt
    10081 gctatttttg ttttctcctg ttttgcaaat tctttctctt gccaaaaccg gggtccccca
    10141 gaccattctg actcaagctg cttgtgaaac tcctccagct gccacgaacc tctccggagc
    10201 ctttcctcct cacaagctgg cttttctccc ttcgcgctga ccatcgtttt cttaaatccc
    10261 aaagtctcgc cagcttcatt taccaaacaa ggaaaatggg aaaacagggt gagtcattct
    10321 caaggaaaag gactatccag tgttcaccat gccatcctca ggtggtgcca cccagtgctg
    10381 ggtcctgggg tcttgggtgg aaacgcattt gcgaatcccg catgcgcaat gccacggttt
    10441 cgctgatctc gttaacagcc gggtgggtct aagaccgcta gctaaggtgc ttgagctgct
    10501 gttgcctttg aacattgtca tctgagccca tcctgctggc agcctgcaaa ggagacccag
    10561 agagggcctc gcaggtgggc gcaaaataac cggcttgttt tccaacaggt cccacaaaac
    10621 tacagtccag gagttagcta ggaaaacctg gttagcatct actcttcctt acagttacaa
    10681 gtaggagtct ctaagacgtc agtgcaaggt gcatgctagg ttgttgttta agtctccggg
    10741 tcagtttctt acctgaatga ttaatttgaa gtcagcacgg aaaaccattt ctttttcttt
    10801 cctttttctt tcttttttgc ctctactcct ttacagtcat gcctattaag tcctttgtga
    10861 acagacagga cctttgggag caatggtctc tctccaattg tccccgaagc tcctatctga
    10921 ggagtacact attaagtcac caggcatttg gagtggatct ttccagaagg tcttcccaac
    10981 tgagaatgta agggaagaag caagagctag ccccgtctct gaccctgaga tagaaagcta
    11041 tttatttgtg ttcagtgttc gaggcatgac tagtgttgct aattagtcta ataaatcccc
    11101 acacttcctg cagtgaacac taatggtatt gttctaaccc tttttctttc tttgtaagtg
    11161 gtcagtcatt cacagtaagc tatgacgtaa gctgtgttct aacatacaaa ccgtagttgt
    11221 aagacaattc cgtgaaggct cattcccacc cacccgcaca taccacattg cattgtaggg
    11281 ttgactttag ttggcaccgc acctgtacat tatacattat tctttattta tgtaaaaaaa
    11341 tgccttatat attaaaagag taagtgcaat aatatgaaat ggcctgtaca tttaaaaaac
    11401 gttgccaagt tatgtaaatc cacatctctg taaacaattt tttaaaataa ttttcaaaaa
    11461 ataaacactg cttactactt gg
//
