LOCUS       NM_020271               2018 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pyridoxal (pyridoxine, vitamin B6) phosphatase (Pdxp),
            mRNA.
ACCESSION   NM_020271
VERSION     NM_020271.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Kim,J.E., Lee,D.S., Kim,T.H., Park,H., Kim,M.J. and Kang,T.C.
  TITLE     PLPP/CIN-mediated NF2-serine 10 dephosphorylation regulates F-actin
            stability and Mdm2 degradation in an activity-dependent manner
  JOURNAL   Cell Death Dis 12 (1), 37 (2021)
   PUBMED   33414453
  REMARK    GeneRIF: PLPP/CIN-mediated NF2-serine 10 dephosphorylation
            regulates F-actin stability and Mdm2 degradation in an
            activity-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2018)
  AUTHORS   Kim,J.E., Lee,D.S., Kim,T.H., Park,H., Kim,M.J. and Kang,T.C.
  TITLE     PLPP/CIN-mediated Mdm2 dephosphorylation increases seizure
            susceptibility via abrogating PSD95 ubiquitination
  JOURNAL   Exp Neurol 331, 113383 (2020)
   PUBMED   32561413
REFERENCE   5  (bases 1 to 2018)
  AUTHORS   Kim,J.E., Lee,D.S., Kim,M.J. and Kang,T.C.
  TITLE     PLPP/CIN-mediated NEDD4-2 S448 dephosphorylation regulates neuronal
            excitability via GluA1 ubiquitination
  JOURNAL   Cell Death Dis 10 (8), 545 (2019)
   PUBMED   31320629
  REMARK    GeneRIF: PLPP/CIN deletion inhibited NEDD4-2 ubiquitination, and
            diminished the responsiveness of
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
            by facilitating NEDD4-2-mediated ubiquitination of GluA1 subunit
            under physiological condition. PLPP/CIN overexpression reversed
            these effects. These PLPP/CIN-mediated processes were required for
            the increased seizure severity and its progression in response to
            kaini...
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2018)
  AUTHORS   Huang,T.Y., Minamide,L.S., Bamburg,J.R. and Bokoch,G.M.
  TITLE     Chronophin mediates an ATP-sensing mechanism for cofilin
            dephosphorylation and neuronal cofilin-actin rod formation
  JOURNAL   Dev Cell 15 (5), 691-703 (2008)
   PUBMED   19000834
REFERENCE   7  (bases 1 to 2018)
  AUTHORS   Gohla,A., Birkenfeld,J. and Bokoch,G.M.
  TITLE     Chronophin, a novel HAD-type serine protein phosphatase, regulates
            cofilin-dependent actin dynamics
  JOURNAL   Nat Cell Biol 7 (1), 21-29 (2005)
   PUBMED   15580268
REFERENCE   8  (bases 1 to 2018)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   9  (bases 1 to 2018)
  AUTHORS   Jang,Y.M., Kim,D.W., Kang,T.C., Won,M.H., Baek,N.I., Moon,B.J.,
            Choi,S.Y. and Kwon,O.S.
  TITLE     Human pyridoxal phosphatase. Molecular cloning, functional
            expression, and tissue distribution
  JOURNAL   J Biol Chem 278 (50), 50040-50046 (2003)
   PUBMED   14522954
  REMARK    GeneRIF: analysis of pyridoxal phosphatase cloning, expression and
            tissue distribution
REFERENCE   10 (bases 1 to 2018)
  AUTHORS   Fonda,M.L.
  TITLE     Purification and characterization of vitamin B6-phosphate
            phosphatase from human erythrocytes
  JOURNAL   J Biol Chem 267 (22), 15978-15983 (1992)
   PUBMED   1322411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX236940.1, BC069982.1 and AI845716.1.
            
            On Jan 27, 2006 this sequence version replaced NM_020271.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049107.1, BC046955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               CX236940.1         57-335
            280-1996            BC069982.1         52-1768
            1997-2018           AI845716.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..2018
                     /gene="Pdxp"
                     /gene_synonym="1600027H05Rik; PLPP"
                     /note="pyridoxal (pyridoxine, vitamin B6) phosphatase"
                     /db_xref="GeneID:57028"
                     /db_xref="MGI:MGI:1919282"
     exon            1..613
                     /gene="Pdxp"
                     /gene_synonym="1600027H05Rik; PLPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..930
                     /gene="Pdxp"
                     /gene_synonym="1600027H05Rik; PLPP"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.74"
                     /note="pyridoxal phosphate phosphatase; PLP phosphatase;
                     PLP-phosophatase; chronophilin; pyridoxal 5'-phosphate
                     phosphatase"
                     /codon_start=1
                     /product="chronophin"
                     /protein_id="NP_064667.2"
                     /db_xref="CCDS:CCDS27627.1"
                     /db_xref="GeneID:57028"
                     /db_xref="MGI:MGI:1919282"
                     /translation="MARCERLRGAALRDVLGQAQGVLFDCDGVLWNGERIVPGAPELL
                     QRLARAGKNTLFVSNNSRRARPELALRFARLGFAGLRAEQLFSSALCAARLLRQRLSG
                     PPDASGAVFVLGGEGLRAELRAAGLRLAGDPGEDPRVRAVLVGYDEQFSFSRLTEACA
                     HLRDPDCLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFQCI
                     TEDFSVDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSSLEEAQAYLTAGQRDLVP
                     HYYVESIADLMEGLED"
     exon            614..2001
                     /gene="Pdxp"
                     /gene_synonym="1600027H05Rik; PLPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1979..1984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdxp"
                     /gene_synonym="1600027H05Rik; PLPP"
                     /note="hexamer: AATAAA"
     polyA_site      2001
                     /gene="Pdxp"
                     /gene_synonym="1600027H05Rik; PLPP"
                     /note="major polyA site"
ORIGIN      
        1 cttgtccacg gagggagcgc agcgcgcgcg tgcgagcggc cagccggctg catggcgcgc
       61 tgcgagcggc tgcgcggcgc ggccctgcgc gacgtgctgg gccaggcgca gggagtcctg
      121 ttcgactgcg acggagtgct gtggaacggc gaacgcatcg tgccgggcgc ccctgagctg
      181 ctgcagcggc tggcgcgggc cggcaagaac acgctgttcg tgagcaacaa cagccggcgc
      241 gcgcggcccg agctggcgct gcgcttcgcc cgcctgggct tcgcggggct gcgcgccgag
      301 cagctcttca gctccgcgct gtgtgccgcg cgcctcctgc gccagcggct gtccgggccg
      361 cccgacgcat cgggcgcagt gttcgtgctg ggaggcgagg ggctgcgcgc tgagctgcgc
      421 gccgcggggc tgcgcctggc gggggacccc ggcgaggacc cgcgcgtgcg cgccgtgctc
      481 gtaggctacg acgagcagtt ttccttctcc aggttgaccg aggcgtgcgc gcacctgcgc
      541 gaccccgact gcctgctcgt ggccaccgat cgcgaccctt ggcacccgct cagcgacgga
      601 agccggaccc ccggtactgg aagcctggct gccgcggtgg agacagcctc gggacgccag
      661 gccctggtgg tgggcaagcc cagcccttac atgttccagt gcatcacaga agacttcagc
      721 gtggaccccg cccgcacgct gatggtgggg gaccgcctgg agaccgacat actctttggc
      781 caccgctgcg gcatgaccac cgtgctcacg ctcacgggcg tctccagcct cgaagaagcc
      841 caggcctacc tgacggctgg ccagcgtgac cttgtgcctc actactatgt ggagagcatt
      901 gcggacttga tggaggggct ggaggactga gcccacctcc cctgttgttc cctgatccca
      961 cagatggagg cgacgggcca tgagtcacat tcgggaccat gagctttctg gagtgggtgt
     1021 ctgtacccca gtgaagggag gctgggatcc aggaaggttt gtgggctttc acacccccct
     1081 cctagccgtg gctggacact ctgctcttca gaagctgtcc ccccacatct tgaaggttca
     1141 ccctggcctg accccaccag gtggccttat ttcctgccct gtcacctccc ttccttgggc
     1201 cccgaagcca aatgaagatt tttttttttc caacctttta agttcctccc actctctggg
     1261 atctctagtg ctctgtccct agagattgtt ggccaatcag agatctaggg aactccagcc
     1321 cgttcctggc ctgaccaggc ctctgggaag agctgctggc actgccggcc tatgtctcag
     1381 agtgggcctt tagtggagca agtaggagct taaagaatgc cttgcatatc ctggaacccc
     1441 agagcaccag tcagaggcta tgcgtccatc aggacaatta acgatcccac tggcctctta
     1501 gatgccaatt agaacaattt ccaagtccaa gagacttgtg aacttttgac aatcctagcc
     1561 tgactggatc ctgggaccag atgctggtag cacagggtga tgaatgccgg tatgtatagc
     1621 actcgggagg ttgaagcaag aggattgctg agtctggtga ccgggatggc agagtcagac
     1681 ctcatctcag acagagggtc atccttcaag tcaccccact ccacagactg ctcagtgggg
     1741 cacctctgtg gccctggggt agtgtggaga ggttcccact cataccttag caccgtccag
     1801 tgttgatggc tttttcggct tggagggggc cctccttttg tccccacctg cagtcagtgt
     1861 ttgcagtgcc accctcacct gcccattccc agctatttat ttatttattg tgtgccagtg
     1921 aaggtggggg tagggacctt cccaccccct ccacctgttg taaccggtcc ttgaacttaa
     1981 taaaatgtga attgaagtgt caaaaaaaaa aaaaaaaa
//
