LOCUS       NM_172134               5110 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pyridoxal (pyridoxine, vitamin B6) kinase (Pdxk),
            mRNA.
ACCESSION   NM_172134 XM_488563 XM_489917
VERSION     NM_172134.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5110)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5110)
  AUTHORS   Zhang,W., Zhang,R., Wu,L., Zhu,C., Zhang,C., Xu,C., Zhao,S.,
            Liu,X., Guo,T., Lu,Y., Gao,Z., Yu,X., Li,L., Chen,Z.J., Qin,Y. and
            Jiao,X.
  TITLE     NLRP14 deficiency causes female infertility with oocyte maturation
            defects and early embryonic arrest by impairing cytoplasmic UHRF1
            abundance
  JOURNAL   Cell Rep 42 (12), 113531 (2023)
   PUBMED   38060382
REFERENCE   3  (bases 1 to 5110)
  AUTHORS   Xu,Z., Qiao,S., Qian,W., Zhu,Y., Yan,W., Shen,S. and Wang,T.
  TITLE     Card9 protects fungal peritonitis through regulating Malt1-mediated
            activation of autophagy in macrophage
  JOURNAL   Int Immunopharmacol 110, 108941 (2022)
   PUBMED   35850054
REFERENCE   4  (bases 1 to 5110)
  AUTHORS   Kasaragod,V.B., Pacios-Michelena,A., Schaefer,N., Zheng,F.,
            Bader,N., Alzheimer,C., Villmann,C. and Schindelin,H.
  TITLE     Pyridoxal kinase inhibition by artemisinins down-regulates
            inhibitory neurotransmission
  JOURNAL   Proc Natl Acad Sci U S A 117 (52), 33235-33245 (2020)
   PUBMED   33318193
REFERENCE   5  (bases 1 to 5110)
  AUTHORS   Chen,C.C., Li,B., Millman,S.E., Chen,C., Li,X., Morris,J.P. 4th,
            Mayle,A., Ho,Y.J., Loizou,E., Liu,H., Qin,W., Shah,H., Violante,S.,
            Cross,J.R., Lowe,S.W. and Zhang,L.
  TITLE     Vitamin B6 Addiction in Acute Myeloid Leukemia
  JOURNAL   Cancer Cell 37 (1), 71-84 (2020)
   PUBMED   31935373
REFERENCE   6  (bases 1 to 5110)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 5110)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 5110)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   9  (bases 1 to 5110)
  AUTHORS   Chern,C.J. and Beutler,E.
  TITLE     Purification and characterization of human erythrocyte pyridoxine
            kinase
  JOURNAL   Clin Chim Acta 61 (3), 353-365 (1975)
   PUBMED   238769
REFERENCE   10 (bases 1 to 5110)
  AUTHORS   Hamfelt,A.
  TITLE     Pyridoxal kinase activity in blood cells
  JOURNAL   Clin Chim Acta 16 (1), 7-18 (1967)
   PUBMED   6036925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI143426.1, BC032171.1 and BC027745.1.
            
            On Sep 7, 2007 this sequence version replaced NM_172134.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032171.1, BC027745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BI143426.1         28-57
            31-32               BC032171.1         1-2
            33-1802             BC027745.1         70-1839
            1803-5110           BC032171.1         1774-5081
FEATURES             Location/Qualifiers
     source          1..5110
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..5110
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /note="pyridoxal (pyridoxine, vitamin B6) kinase"
                     /db_xref="GeneID:216134"
                     /db_xref="MGI:MGI:1351869"
     exon            1..188
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1040
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /EC_number="2.7.1.35"
                     /note="pyridoxine kinase"
                     /codon_start=1
                     /product="pyridoxal kinase"
                     /protein_id="NP_742146.1"
                     /db_xref="CCDS:CCDS23965.1"
                     /db_xref="GeneID:216134"
                     /db_xref="MGI:MGI:1351869"
                     /translation="MEGECRVLSIQSHVVRGYVGNRAAMFPLQVLGFEVDAVNSVQFS
                     NHTGYAHWKGQVLKSQELHELYEGLKVNDVNKYDYVLTGYTRDKSFLAMVVDIVRELK
                     QQNSRLVYVCDPVMGDKWNGEGSMYVPQDLLPVYRDKVVPVADIITPNQFEAELLSGR
                     KIHSQEEAFEVMDMLHCMGPDTVVITSSDLPSSQGSDYLIALGSQRMRKPDGSTVTQR
                     IRMEMRKVEAVFVGTGDLFAAMLLAWTHKHPDNLKVACEKTVSAMQHVLQRTIRCAKA
                     EAGEGQKPSPAQLELRMVQSKRDIEDPEIVVQATVL"
     exon            189..243
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            244..348
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            349..432
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            433..479
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            480..565
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            566..611
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..723
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            724..860
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            861..927
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            928..5094
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5076..5081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5094
                     /gene="Pdxk"
                     /gene_synonym="2310036D04Rik"
                     /note="major polyA site"
ORIGIN      
        1 tgcgcgtgct taaagcgctc ggagcagaat ccgagcgagc ggcctgagca accccagcct
       61 gtgacaccac ctggaccacg cgccactaca gctttcccgg catggagggc gaatgccggg
      121 tgctctccat ccagagccat gttgtccgtg gctacgtggg taacagagcg gccatgttcc
      181 ctctgcaggt tttgggattt gaggttgatg ccgtgaactc tgtgcagttt tcaaaccaca
      241 caggctacgc ccattggaag ggccaggtgc tgaagtccca ggaacttcat gagctgtacg
      301 agggtctcaa ggtgaacgat gtcaataagt atgactacgt gctcactggt tacacgagag
      361 acaagtcttt cctggccatg gtggtggaca ttgtgcggga gctgaagcaa cagaactctc
      421 gccttgtgta tgtgtgtgac cctgtgatgg gcgacaagtg gaatggggaa ggctccatgt
      481 acgttcccca ggacctcctc cccgtgtaca gggacaaagt ggtacccgtg gctgacatca
      541 tcactcccaa ccagtttgag gctgagttgc tgagtggcag aaaaatccac agccaagaag
      601 aagccttcga ggtgatggac atgctgcact gtatgggtcc cgacactgtg gtcatcacca
      661 gctctgacct gccctcctca cagggcagcg actacctgat cgcgctgggt agccagagga
      721 tgcggaaacc tgacggctcc acggtgaccc agcgcatccg gatggagatg cgcaaagtgg
      781 aagctgtctt cgtgggcacc ggggacctct tcgctgccat gcttctggcg tggacacaca
      841 agcacccgga caatctcaag gtggcctgtg agaaaaccgt gtctgccatg cagcacgtcc
      901 tacagaggac catccggtgt gcaaaagctg aagcaggaga aggacagaag cccagccccg
      961 ctcagctgga gctgaggatg gtccagagca aaagggacat cgaggacccc gagatcgtcg
     1021 tgcaggccac agtgctgtga ggaccacacc cactcgcccc gacacacagc cagctgaggt
     1081 gtccgtctcc atccctgtga aaagctgtaa cgtctgcctt agagccatga ctgaaactcg
     1141 acatccgtgt tccttcccga gagtcgggtc tcagccagtc tctagcgtga aaaatgtgcc
     1201 attgtgctat ttttttaaaa aatgacaaag ccgtcgtaga aatgtgtgat tcacaaccat
     1261 ggtcccttcc ccaaaggccc tgggcctctg actgcctcat gttgcctcat aggtatgtgg
     1321 aaggtaggtg gaggagacca gcctgctgcc tctggacctt tctgttggtc actggctgcc
     1381 attgccccct gtgtatgtat acacagtcct gattgtgtat agactctgcc tgtgtcggcg
     1441 ctgtctttaa aatggggtta ggtcttaacc gttggcattg gaagaattat gccaaatatc
     1501 ttctttgcca ttctggtctt tcccttgttc ctgcattaga gtttctgtgt ctctgctgct
     1561 ctttgggtgg tgtcccagaa tgtcagacga atgcagctgc tggtctgcga gggaaggttt
     1621 catatccccg tgcttgcaca agcatgcggt cactgtgaca gggacctttt aaggaacggg
     1681 aacattccag gacatctgca agccgtctgg gtgtctgcag ggtctcctgt aactctggag
     1741 ctgagtgcag ggcagcttgg gaattcaggg aagtttgcct cactgggctt tttttttttt
     1801 ttggttttgg ttttggtttt gatttttcaa gacaaggttt ctctgtgtag ccctggctgt
     1861 cctggaactc actttgtaga ccaggctgac cacaaactca gaaatccgcc tgcctctgcc
     1921 tcccgagtgc tggtattaaa ggcgtggacc accatgcccg gctctcactg ggctcttgtg
     1981 ggcactcaca cagcccctgc aggactgtca ggtggcagtt cacctgccac atgctgctgg
     2041 ggacagtgca ttgctgcaca gggggttgga cagacaggga aggagagaca gaggtggctc
     2101 ctgccccctg gtggcagact gaagtgcggg ttttctccac tcccctcacc ctcatttctg
     2161 gattctgtgc ccacctcatg ctgaggggcc aggggccctg atgtgaagcc agggcctctg
     2221 cctccttgga aggtcttctc ctctacagag cacattggca ttgtgtatgc aggggcagct
     2281 cttagacccc agctggggac tgtgacgtgt cccattgtct actgctcggg ggtgaacttc
     2341 ctggctctgc tttccagagt ttagggtccc taatcatggc tgcgagccgc acccatatcc
     2401 ctgctcctca gtccttaaga tatctatctt ctgagaagcc acagcctaag gagaccaggg
     2461 agactgggag aggtgaagag tgcattatgc ctacctcttc cccagaagca tagggtctcc
     2521 atggagctct gagagcgaca ccctttcccc attatgatgc cccagatgga ggagatagat
     2581 gctggtccac atggacctga accagcccgt attctgaggt gtccgttaat aagcctttta
     2641 cagctttgaa ggaagcagag aactgggctc tctctctctc tctctctctc tctctctctc
     2701 tctctctctc tctctctctc tctctctctc tctgtcacac acacacaatg taattttaaa
     2761 aagtactttg gtcatcagta ccccaggaca agattagcaa gctctctgtt aaggccatga
     2821 agcctgacat gtgtccaaac ctggtgccaa tgtggcacct ctgagcccca agaaaaaaga
     2881 aagcaaagac agcaggcccc tagtatccaa atcagaattg gcttttactt ttactttatt
     2941 ttagtaagga agtaatgtgc ttgggaagga agctgcatta gcccagggtt agccgcttcc
     3001 tattggggac attgattctg tctcaaagta tctccttcca cctcctgaat actaggaagg
     3061 aatcaccaca ccacatatga ccagtgctcc cttttattgc tgctatctgg ggtgcctctc
     3121 ttccagacat ccacgcagct acctgcactg agaggtcctg gaaagccatg tctgtccatg
     3181 tgacagatgg atgctgacca caaaagccac cagtggatgc taagaatggg tgtccctcca
     3241 aggggcagtt ctgggaggtc aggttcaatg tgaggttaca atagagctgc agtctctgta
     3301 gggaaagcgg tgagtcaggg aaggcttgaa cctggttccc aggtctgagt gaatgtcact
     3361 ccccaacccc ctgaatgata gagacgcacc ctgggatgga ggtgcggctg gacatgcatg
     3421 tgccagtcct gatgctttcc cacactttct gtgacagctg tagatggtgc cagtcctgca
     3481 gaaccagaga agagaggttt ctacctccac ttgcagtttc agtatccacc agcaggggtc
     3541 ggggtggagc cggagcagtg tcagaggccc aggtggatgc tggtaccagc agattaaaca
     3601 gcagccatcc tgctgggaga tttggtggtt gttttttact gtgtacatct ttctgttggg
     3661 cctcagactt ggcgttgtgc aacacctgac agtaagtggg agtcagtgtg tccccaggtc
     3721 agcctgacat cccaggaagc cattgtgtcg tcagcatggc cagaactgac agtttgtgtt
     3781 tccttgctga ctctggttta ttcttgtggc aggcacccta gaggctgagg cagcaggaga
     3841 gctatggagt aagacaccca cactcacacc gcccacccac ccacctaccc actcttgcct
     3901 ccttccttac atcctccctc cctcccttct tccttctctt cctttctttt ttaatttcta
     3961 gtggaataaa cacaatttta agattcccca ctattgaagc aggcagagga tatcctcaga
     4021 gcaggcgtct ccatctccct tggattacct ccctgcttgt ggctgagctc ccctgggcca
     4081 gcatctcctc attccttccc ctgtttcacc atcaggcagt ttctggtctt tgtgcaatag
     4141 gatacacatt ccaggtggaa aaggtctccc tgatgccgtg ggaaccccac tctgtccccg
     4201 tgggaacccc accctgtccc cgtcagctct tgaatagcca gttagggctg cctctgccct
     4261 gaagctacag atgggtggga acagacatcc atggctggaa gctcccagaa ggccttgggt
     4321 ataaccttgg ccatacctca ctgcccatcc tatagagcca gcaggtccca tgagacgttg
     4381 ggtaaagcca tgactgcacc tcatggcctg ccttgcaggg ctaggcagtg ccccatgcag
     4441 gcaggtgtag gtgacttgga ctgggggctc tggaagcctc tgagctgcca gtttcatgcc
     4501 tgacatggag gatatgtccg gggggggggg ggcggtgaca gaacacaata gaggacatgg
     4561 gcttagcata tccttctcat atcccacaga gcaggaagat cccctcaaag ctcaggcctg
     4621 agtgagtccc aaaaaaacat cctgaaacca ttttctgaat gatgggggag gggtcagtgt
     4681 tttgtgaatg gaggatgaga cacaggctcc tcaaatgctc ctagcttcat agctgcccat
     4741 tcctgacaca cagcctgtca gaacttcagc cgtgtgttga gaacctggac caattggagg
     4801 atgggctgca cctgtggggc tggcccgacc ctgctagtcc tccccagaga ccacccctct
     4861 gtggagtccc ctggccttca gagcaaagca cagttggccc ctcagtccct gctgcgcagg
     4921 aggggtgtgc tccgggctca ggtggtctcc tgcccaagtc cccaagccct gtgtactgtg
     4981 tcccctgtca atgtgtttgt ggacatgagc acctgtcagc actgtgtagc tgtgtctgtt
     5041 ttgtgctggt ctgttgtctt ctatgactat ccacaaataa atattttcat tgcaaaaaaa
     5101 aaaaaaaaaa
//
