LOCUS       NM_053181               3233 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pyridoxal-dependent decarboxylase domain containing 1
            (Pdxdc1), transcript variant 1, mRNA.
ACCESSION   NM_053181
VERSION     NM_053181.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3233)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3233)
  AUTHORS   Song,Y.Q., Hu,S.D., Lin,X., Meng,X.H., Wang,X., Zhang,Y.H.,
            Peng,C., Gong,R., Xu,T., Zhang,T., Li,C.Z., Pan,D.Y., Yang,J.Y.,
            Greenbaum,J., Shen,J. and Deng,H.W.
  TITLE     Identification of PDXDC1 as a novel pleiotropic susceptibility
            locus shared between lumbar spine bone mineral density and birth
            weight
  JOURNAL   J Mol Med (Berl) 100 (5), 723-734 (2022)
   PUBMED   35314877
  REMARK    GeneRIF: Identification of PDXDC1 as a novel pleiotropic
            susceptibility locus shared between lumbar spine bone mineral
            density and birth weight.
REFERENCE   3  (bases 1 to 3233)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3233)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107769.7, AK054329.1, AK030613.1, AK033107.1 and BY469248.1.
            
            On Mar 21, 2014 this sequence version replaced NM_053181.2.
            
            Transcript Variant: This variant (1) lacks the terminal exon used
            in variant 4 and its 3' terminal exon extends past a splice site
            that is used in variant 4. This results in a novel 3' coding region
            and 3' UTR, compared to variant 4. It encodes isoform 1 which is
            shorter and has a distinct C-terminus, compared to isoform 4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033107.1, AK030613.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC107769.7         79527-79544
            19-170              AK054329.1         2-153
            171-2262            AK030613.1         2-2093
            2263-2654           AK033107.1         2094-2485
            2655-3179           AK030613.1         2486-3010
            3180-3233           BY469248.1         407-460
FEATURES             Location/Qualifiers
     source          1..3233
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.64 cM"
     gene            1..3233
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /note="pyridoxal-dependent decarboxylase domain containing
                     1"
                     /db_xref="GeneID:94184"
                     /db_xref="MGI:MGI:1920909"
     exon            1..231
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            232..305
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            306..371
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            372..452
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            453..599
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            600..789
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            790..858
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            859..937
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1022
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1071
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1173
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1299
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1350
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1414
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1503
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1609
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1781
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1900
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2022
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2115
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2212
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2317
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..3233
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2667..2672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /note="hexamer: GATAAA"
     polyA_site      2694
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /note="major polyA site"
     regulatory      3154..3159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
                     /note="hexamer: AATAGA"
     polyA_site      3174
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
     polyA_site      3233
                     /gene="Pdxdc1"
                     /gene_synonym="2210010A19Rik; Kiaa0251-hp"
ORIGIN      
        1 gggaggcccc gcccacccga cgggcctagc cccgccttca gcaagccgca ggatacctgc
       61 gggccgcgct gcggggcagc tcctcctcct ctccgccccg ccggctgcgg gcggggagga
      121 cgtcagcgct gccagcgtgg aaaccgctgc gggccgcggg aggcggaagt agtgcccagc
      181 accgcgggcc cagcaccgga cgcctcagcc atggacgcgt ccctggagaa gatagcagac
      241 cctacattag ctgaaatggg aaaaaacttg aaagaggcga tgcggatgct ggagaagagc
      301 ccgagaagaa cagaggagga aaatggaaag aagccagtat ctgaggatat tccagggcca
      361 ctccaaggca gtggacaaga tatggtgagc atcctccagt tagttcaaaa tctgatgcat
      421 ggagatgaag atgaggagcc ccagagcacc cgaatccaaa atattggaga gcaaggtcac
      481 atggctttgt tgggtcatag cctcggtgcc tatatttcaa ctctggataa agagaagctg
      541 agaaagctca caaccaggat actttcagac actaccttat ggctacgccg gattttcagg
      601 tacgaaaatg gatgtgcata tttccacgag gaagagaggg aaggacttgc taagatctgt
      661 aggcttgcca ttcattctcg ctatgaagac tttgttgtag atggattcaa cgtgttatat
      721 aacaaaaagc ctgtcatata tcttagtgct gccgctagac ctggcctggg ccaatacctt
      781 tgtaatcagc ttggcttacc cttcccctgc ctgtgccgtg tgccctgtaa cactatgttt
      841 ggatcccagc atcagatgga cgttgccttt ctcgagaaac tgatcaaaga tgacgtagaa
      901 agaggaagac tgcccttgct gcttgttgca aatgctggaa ctgcagcagt tggacacaca
      961 gacaagattg gacgtttgaa ggaactctgt gagcagtacg gcatttggct tcatgtggaa
     1021 ggtgtgaatc tggcaacatt ggctctaggt tatgtctcct catctgtgct ggctgcaacc
     1081 aagtgcgata gcatgacact aactcctggc ctatggctag gtttgccagc tgttcctgca
     1141 gtgacactct acaaacatga cgatcctgcc ttgacactag ttgctggtct tacatcaaat
     1201 aagcctgcag acaaactccg agccctacca ctctggttgt ctctacagta cttgggactt
     1261 gatggcattg tggagagaat aaagcatgct tgtcatctga gtcaacggtt gcaagaaagt
     1321 ttgaagaaag tggaccacat caaaatcttg gtggaagatg agctcagttc tccagtagtg
     1381 gtgttcaggt ttttccagga attaccagcc tcagattcag cgtttaaagc tgttcctgta
     1441 tccaacatag cacctgcagc agttggccgg gaaagacact cctgtgatgc actgaaccgc
     1501 tggttgggtg aacagttgaa acagttggtg cctcagtgtg gcctcactgt catagacctg
     1561 gaggtagatg gcacatgtgt tcggttcagc cctctgatga cagcagaagg gttaggaact
     1621 cgaggagagg atgtcgatca gctcattacc tgcatccaaa gcaaactacc agtcctgacc
     1681 tgcacactac agcttcggga agaattcaag caggaggtag aggggacagc agggctcctg
     1741 tatgttgatg accccaactg gcctggaatc ggggttgtca ggtatgagca tgcgaatgat
     1801 gatgacacca gtttgaaatc tgatccagag ggggaaaaaa tacacactgg acttctgaaa
     1861 aagttaaatg aactggaatc tgacctcaca tttaaaatag gccctgagta caaaagcatg
     1921 aagagctgca tttacattgg catggcaagt gatgatgtgg acgtttctga gctagtggag
     1981 accattgcag tcacagcccg ggaaattgag gagaactcaa ggcttctaga gaacatgaca
     2041 gaagttgttc ggaagggaat tcaggaggca caggttcagc tacagaaggc aaatgaggag
     2101 cggcttctgg aagagggagt gttgcggcaa atccctgtag taggatccgt gctgaattgg
     2161 ttttctccag tccaggcttc acagaaggga agaagtttta acttaacagc aggctctctg
     2221 gagtccacag aatacaccta tgtccacaaa gtacaaggta ctggggtgac accacctccc
     2281 acacccctag gcactcgaag caaacagagg cttccaggtc agaagccttt taaaaggtcc
     2341 ctgagaggct cggatgctgt gagtgagacc agctcagtca gccacattga agacctggaa
     2401 aaggtggaac agctgtccag tgggctagag catgacaacc tagaggccca cagccctgag
     2461 cagcctccca gggccactga tctcacggcc agacagactg aggccctgca gaaccaggcc
     2521 cagcatcagg aagatgacca ttcacaggta gaggaactgg agcgcttaag ataagctcag
     2581 tagtgctggg ctggaggctg tactaactgt cgtttcaggg aaggtgaagt tctatggaag
     2641 acgtgaacta tgccacatgt taatatgata aaaacttttg ttgtttgtgc taaactggga
     2701 gttttgcaca gacacatgtc agaaaagcgg gctttctagg gggcaattaa ttattttatc
     2761 tgtaagtaga acaaatgaca attgactatt ttggcctgtc caacataggc ataccctttc
     2821 ttcctgtacc acacattttg tactgagaac cgtggccttc aagcacctgc cacttgaaac
     2881 actgctctca tggctctgaa gctaatcgtg atgaagctgc atacagtgac tctccaggtt
     2941 ctcctccgtc tgtcgtagta gctctgtagg tcagccgagt tgtggtaggt gcctgcctca
     3001 ctggttggca tcaggagctc ctctgcctct gtccccactg ctgcttctcc gggagcctaa
     3061 gtaaggactg tccacatgag ctgtggctag gactgcccct tgctgcacct tttctcctta
     3121 cactctgtaa acaaatgtaa ggactcacct gttaatagag taattaactc ttaagatctc
     3181 ttcctgacca tatttaagtg tatttttaaa cactggtaat gcttttaagt tgg
//
