LOCUS       NM_008814               2039 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus pancreatic and duodenal homeobox 1 (Pdx1), mRNA.
ACCESSION   NM_008814
VERSION     NM_008814.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2039)
  AUTHORS   Li,K.R., Yu,P.L., Zheng,Q.Q., Wang,X., Fang,X., Li,L.C. and Xu,C.R.
  TITLE     Spatiotemporal and genetic cell lineage tracing of endodermal
            organogenesis at single-cell resolution
  JOURNAL   Cell 188 (3), 796-813 (2025)
   PUBMED   39824184
REFERENCE   2  (bases 1 to 2039)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   3  (bases 1 to 2039)
  AUTHORS   Franks,N.E. and Allen,B.L.
  TITLE     Hedgehog-dependent and hedgehog-independent roles for growth arrest
            specific 1 in mammalian kidney morphogenesis
  JOURNAL   Development 151 (24) (2024)
   PUBMED   39629522
REFERENCE   4  (bases 1 to 2039)
  AUTHORS   Kadhim,A.Z., Vanderkruk,B., Mar,S., Dan,M., Zosel,K., Xu,E.E.,
            Spencer,R.J., Sasaki,S., Cheng,X., Sproul,S.L.J., Speckmann,T.,
            Nian,C., Cullen,R., Shi,R., Luciani,D.S., Hoffman,B.G., Taubert,S.
            and Lynn,F.C.
  TITLE     Transcriptional coactivator MED15 is required for beta cell
            maturation
  JOURNAL   Nat Commun 15 (1), 8711 (2024)
   PUBMED   39379383
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2039)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   6  (bases 1 to 2039)
  AUTHORS   Fiedorek,F.T. Jr. and Kay,E.S.
  TITLE     Mapping of the insulin promoter factor 1 gene (Ipf1) to distal
            mouse chromosome 5
  JOURNAL   Genomics 28 (3), 581-584 (1995)
   PUBMED   7490099
REFERENCE   7  (bases 1 to 2039)
  AUTHORS   Guz,Y., Montminy,M.R., Stein,R., Leonard,J., Gamer,L.W.,
            Wright,C.V. and Teitelman,G.
  TITLE     Expression of murine STF-1, a putative insulin gene transcription
            factor, in beta cells of pancreas, duodenal epithelium and
            pancreatic exocrine and endocrine progenitors during ontogeny
  JOURNAL   Development 121 (1), 11-18 (1995)
   PUBMED   7867492
REFERENCE   8  (bases 1 to 2039)
  AUTHORS   Jonsson,J., Carlsson,L., Edlund,T. and Edlund,H.
  TITLE     Insulin-promoter-factor 1 is required for pancreas development in
            mice
  JOURNAL   Nature 371 (6498), 606-609 (1994)
   PUBMED   7935793
REFERENCE   9  (bases 1 to 2039)
  AUTHORS   Ohlsson,H., Karlsson,K. and Edlund,T.
  TITLE     IPF1, a homeodomain-containing transactivator of the insulin gene
  JOURNAL   EMBO J 12 (11), 4251-4259 (1993)
   PUBMED   7901001
REFERENCE   10 (bases 1 to 2039)
  AUTHORS   Leonard,J., Peers,B., Johnson,T., Ferreri,K., Lee,S. and
            Montminy,M.R.
  TITLE     Characterization of somatostatin transactivating factor-1, a novel
            homeobox factor that stimulates somatostatin expression in
            pancreatic islet cells
  JOURNAL   Mol Endocrinol 7 (10), 1275-1283 (1993)
   PUBMED   7505393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127549.3, BC105642.1, AK020261.1 and BP771579.1.
            
            On May 12, 2018 this sequence version replaced NM_008814.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020261.1, BC105642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC127549.3         110771-110804       c
            35-1321             BC105642.1         1-1287
            1322-1763           AK020261.1         1293-1734
            1764-2039           BP771579.1         19-294              c
FEATURES             Location/Qualifiers
     source          1..2039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.84 cM"
     gene            1..2039
                     /gene="Pdx1"
                     /gene_synonym="IDX-1; IPF-1; Ipf1; Mody4; pdx-1; STF-1"
                     /note="pancreatic and duodenal homeobox 1"
                     /db_xref="GeneID:18609"
                     /db_xref="MGI:MGI:102851"
     exon            1..551
                     /gene="Pdx1"
                     /gene_synonym="IDX-1; IPF-1; Ipf1; Mody4; pdx-1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..997
                     /gene="Pdx1"
                     /gene_synonym="IDX-1; IPF-1; Ipf1; Mody4; pdx-1; STF-1"
                     /note="insulin promoter factor 1, homeodomain
                     transcription factor; islet/duodenum homeobox 1;
                     somatostatin-transactivating factor 1; pancreatic and
                     duodenal homeobox gene 1"
                     /codon_start=1
                     /product="pancreas/duodenum homeobox protein 1"
                     /protein_id="NP_032840.1"
                     /db_xref="CCDS:CCDS39398.1"
                     /db_xref="GeneID:18609"
                     /db_xref="MGI:MGI:102851"
                     /translation="MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPP
                     PPPPQFTSSLGSLEQGSPPDISPYEVPPLASDDPAGAHLHHHLPAQLGLAHPPPGPFP
                     NGTEPGGLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYTAEPEENKRTRTAYTRAQLL
                     ELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTPSGG
                     GGGEEPEQDCAVTSGEELLAVPPLPPPGGAVPPGVPAAVREGLLPSGLSVSPQPSSIA
                     PLRPQEPR"
     exon            552..2020
                     /gene="Pdx1"
                     /gene_synonym="IDX-1; IPF-1; Ipf1; Mody4; pdx-1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1998..2003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdx1"
                     /gene_synonym="IDX-1; IPF-1; Ipf1; Mody4; pdx-1; STF-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2020
                     /gene="Pdx1"
                     /gene_synonym="IDX-1; IPF-1; Ipf1; Mody4; pdx-1; STF-1"
                     /note="major polyA site"
ORIGIN      
        1 agcctctggt tccccaggag agcagtggag aactgtcaaa gcgatctggg gtggcgtaga
       61 gagtccgcga gccacccagc gcctaaggcc tggcttgtag ctccgacccg gggctgctgg
      121 cccccaagtg ccggctgcca ccatgaacag tgaggagcag tactacgcgg ccacacagct
      181 ctacaaggac ccgtgcgcat tccagagggg cccggtgcca gagttcagcg ctaacccccc
      241 tgcgtgcctg tacatgggcc gccagccccc acctccgccg ccaccccagt ttacaagctc
      301 gctgggatca ctggagcagg gaagtcctcc ggacatctcc ccatacgaag tgcccccgct
      361 cgcctccgac gacccggctg gcgctcacct ccaccaccac cttccagctc agctcgggct
      421 cgcccatcca cctcccggac ctttcccgaa tggaaccgag cctgggggcc tggaagagcc
      481 caaccgcgtc cagctccctt tcccgtggat gaaatccacc aaagctcacg cgtggaaagg
      541 ccagtgggca ggaggtgctt acacagcgga acccgaggaa aacaagagga cccgtactgc
      601 ctacacccgg gcgcagctgc tggagctgga gaaggaattc ttatttaaca aatacatctc
      661 ccggccccgc cgggtggagc tggcagtgat gttgaacttg accgagagac acatcaaaat
      721 ctggttccaa aaccgtcgca tgaagtggaa aaaagaggaa gataagaaac gtagtagcgg
      781 gaccccgagt gggggcggtg ggggcgaaga gccggagcaa gattgtgcgg tgacctcggg
      841 cgaggagctg ctggcagtgc caccgctgcc acctcccgga ggtgccgtgc ccccaggcgt
      901 cccagctgca gtccgggagg gcctactgcc ttcgggcctt agcgtgtcgc cacagccctc
      961 cagcatcgcg ccactgcgac cgcaggaacc ccggtgagga cagcagtctg agggtgagcg
     1021 ggtctgggac ccagagtgtg gacgtgggag cgggcagctg gataagggaa cttaacctag
     1081 gcgtcgcaca agaagaaaat tcttgagggc acgagagcca gttgggtata gccggagaga
     1141 tgctggcaga cttctggaaa aacagccctg agcttctgaa aactttgagg ctgcttctga
     1201 tgccaagcga atggccagat ctgcctctag gactctttcc tgggaccaat ttagacaacc
     1261 tgggctccaa actgaggaca ataaaaaggg tacaaacttg agcgttccaa tacggaccag
     1321 caggcgagct ggaccgggtg cctttgtctg cccagaaaca gaacggctga gcaagctaag
     1381 gttaagaata acgaaaggcg gctgttggag gtttcaaaga gagcgcttct tccaatcccc
     1441 cctcctcttc cccctccctc acctcctttt ccttatttcc ctttcctaga gtcgttcccc
     1501 ctcttcagcc aaatatttca ttaatctcta tccttcaacc tataccattt cctttgaaaa
     1561 tcagaaattc ttcacacccg gacctcctcg tgcccctaat gggacctcca gggtcctgag
     1621 ggacaaagat gcagaaggac atttgaagtt tctgttttag agcgcgaata tcctcctgaa
     1681 aggaaggcag gtgccctggt acaccttgga aaactagtca caacgccctg aattagaaga
     1741 tgggagagag gagcagggca aaactggttg ttttcattta aagcattaaa ttaaccattc
     1801 tttgccaaca ggtctacaat ttgaagtcag tcagttgctc ctttcaaggt ctgagccttg
     1861 tctttaggct gtttgtggaa aatgcttaat aaatatgaat agcaagagag gggttgaagg
     1921 caacctggct gatttcaaac cttcctagag gtcgatgttt ccatttcatt ttaaaatctt
     1981 aactagcgtt ttttctgatt aaaaaaaaaa tcttctttga aaaaaaaaaa aaaaaaaaa
//
