LOCUS       NM_027772               1773 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus prenyl (solanesyl) diphosphate synthase, subunit 2
            (Pdss2), transcript variant 1, mRNA.
ACCESSION   NM_027772 XM_618750 XM_892291 XM_900020 XM_900027 XM_900042
            XM_909012 XM_921090 XM_921094 XM_921098 XM_921111
VERSION     NM_027772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1773)
  AUTHORS   Yang,K., Song,H. and Yin,D.
  TITLE     PDSS2 Inhibits the Ferroptosis of Vascular Endothelial Cells in
            Atherosclerosis by Activating Nrf2
  JOURNAL   J Cardiovasc Pharmacol 77 (6), 767-776 (2021)
   PUBMED   33929387
  REMARK    GeneRIF: PDSS2 Inhibits the Ferroptosis of Vascular Endothelial
            Cells in Atherosclerosis by Activating Nrf2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1773)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   4  (bases 1 to 1773)
  AUTHORS   Kleiner,G., Barca,E., Ziosi,M., Emmanuele,V., Xu,Y.,
            Hidalgo-Gutierrez,A., Qiao,C., Tadesse,S., Area-Gomez,E.,
            Lopez,L.C. and Quinzii,C.M.
  TITLE     CoQ10 supplementation rescues nephrotic syndrome through
            normalization of H2S oxidation pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (11), 3708-3722 (2018)
   PUBMED   30251690
REFERENCE   5  (bases 1 to 1773)
  AUTHORS   Ben-Meir,A., Burstein,E., Borrego-Alvarez,A., Chong,J., Wong,E.,
            Yavorska,T., Naranian,T., Chi,M., Wang,Y., Bentov,Y., Alexis,J.,
            Meriano,J., Sung,H.K., Gasser,D.L., Moley,K.H., Hekimi,S.,
            Casper,R.F. and Jurisicova,A.
  TITLE     Coenzyme Q10 restores oocyte mitochondrial function and fertility
            during reproductive aging
  JOURNAL   Aging Cell 14 (5), 887-895 (2015)
   PUBMED   26111777
REFERENCE   6  (bases 1 to 1773)
  AUTHORS   Smoyer,W.E. and Kelly,C.J.
  TITLE     Inherited interstitial nephritis in kdkd mice
  JOURNAL   Int Rev Immunol 11 (3), 245-251 (1994)
   PUBMED   7930848
  REMARK    Review article
REFERENCE   7  (bases 1 to 1773)
  AUTHORS   Kelly,C.J., Korngold,R., Mann,R., Clayman,M., Haverty,T. and
            Neilson,E.G.
  TITLE     Spontaneous interstitial nephritis in kdkd mice. II.
            Characterization of a tubular antigen-specific, H-2K-restricted
            Lyt-2+ effector T cell that mediates destructive tubulointerstitial
            injury
  JOURNAL   J Immunol 136 (2), 526-531 (1986)
   PUBMED   2416810
REFERENCE   8  (bases 1 to 1773)
  AUTHORS   Neilson,E.G., McCafferty,E., Feldman,A., Clayman,M.D., Zakheim,B.
            and Korngold,R.
  TITLE     Spontaneous interstitial nephritis in kdkd mice. I. An experimental
            model of autoimmune renal disease
  JOURNAL   J Immunol 133 (5), 2560-2565 (1984)
   PUBMED   6384368
REFERENCE   9  (bases 1 to 1773)
  AUTHORS   Fernandes,G., Yunis,E.J., Miranda,M., Smith,J. and Good,R.A.
  TITLE     Nutritional inhibition of genetically determined renal disease and
            autoimmunity with prolongation of life in kdkd mice
  JOURNAL   Proc Natl Acad Sci U S A 75 (6), 2888-2892 (1978)
   PUBMED   275859
REFERENCE   10 (bases 1 to 1773)
  AUTHORS   Lyon,M.F. and Hulse,E.V.
  TITLE     An inherited kidney disease of mice resembling human
            nephronophthisis
  JOURNAL   J Med Genet 8 (1), 41-48 (1971)
   PUBMED   5098070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY733519.1, BC147693.1 and AC152922.5.
            
            On Nov 28, 2009 this sequence version replaced NM_027772.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147694.1, AB210840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               BY733519.1         2-224
            224-1709            BC147693.1         1-1486
            1710-1773           AC152922.5         19339-19402         c
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.91 cM"
     gene            1..1773
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /note="prenyl (solanesyl) diphosphate synthase, subunit 2"
                     /db_xref="GeneID:71365"
                     /db_xref="MGI:MGI:1918615"
     exon            1..575
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1482
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /EC_number="2.5.1.91"
                     /note="isoform 1 is encoded by transcript variant 1;
                     decaprenyl-diphosphate synthase subunit 2;
                     prenyltransferase-like mitochondrial protein;
                     solanesyl-diphosphate synthase subunit 2; decaprenyl
                     pyrophosphate synthetase subunit 2; decaprenyl
                     pyrophosphate synthase subunit 2;
                     all-trans-decaprenyl-diphosphate synthase subunit 2; all
                     trans-polyprenyl-diphosphate synthase PDSS2"
                     /codon_start=1
                     /product="all trans-polyprenyl-diphosphate synthase PDSS2
                     isoform 1"
                     /protein_id="NP_082048.2"
                     /db_xref="CCDS:CCDS35891.1"
                     /db_xref="GeneID:71365"
                     /db_xref="MGI:MGI:1918615"
                     /translation="MSLRQLLLRLSGYLGASGPPSRHWWYFRSLDSISSAGSWRGRSS
                     RSPAHWNQVVSEAEKIVGYPASFMSLRCLLSDELSNIAMQVRKLVGTGHPLLTTARAL
                     VHDSRHNLQLRGLVVLLISKAAGPSTRNAACQNYDMVSGVYSCQRSLAEITELIHTAL
                     LVHRGIVNLSELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKVVELLSS
                     ALMDLVHGVYQENSASTKENSIPDDIGISTWKEQTFLSHCALLAKSCQAAMELAKHDA
                     AVQDMAFQYGKHMAMSHKINADLQPFIKDKASDSKTFNLNSAPVVLHQEFLGRDLWIK
                     QIGEAQEKGSLNYSKLRETIKAGKGVTSAIDLCRYHGNKALEALESFPPSEARSALEN
                     IVFAVTRFS"
     exon            576..710
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /inference="alignment:Splign:2.1.0"
     exon            711..909
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /inference="alignment:Splign:2.1.0"
     exon            910..984
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1158
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1290
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1323
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1773
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /note="hexamer: AATATA"
     polyA_site      1619
                     /gene="Pdss2"
                     /gene_synonym="5430420P03Rik; Gm60; kd; mDLP1; Plmp"
                     /note="major polyA site"
ORIGIN      
        1 atgcctccaa catggcgccc cccatgtagg cactggctgt ggttaccagc gcaggtatcc
       61 agtgcagttc tgagcagccg ctggggttac gccagtctgc gctgcagaag cagcaaacgt
      121 tattcctggt tacggctcca gaaagccata cttctctgag ggtttggaat cgccgtctcc
      181 tgttagattc tgaaagtttc tcctcagccc ttgtttgctt cccgtgtcat ttctggccac
      241 cttcctcagg tccccgaccc tctcagactc aaaactatga gcctccggca gctgctgttg
      301 cgcttgtccg gttacctcgg ggcttcaggt ccccccagtc gccactggtg gtacttcaga
      361 tccctcgaca gcatctcctc ggcgggctcc tggcgcgggc gctcctccag gtcaccggcc
      421 cattggaacc aggtggtgtc cgaggcggag aagatcgtgg gctaccccgc atccttcatg
      481 agcctgcgct gcctgctgag cgacgagctc agcaatatcg ccatgcaggt gcggaagctg
      541 gtggggacgg gacaccctct gcttaccact gccagggccc tcgtgcacga cagccggcat
      601 aacctacaac tgcggggcct ggtcgtgctc ctcatatcaa aggctgcggg gcccagcact
      661 cggaacgctg cgtgtcagaa ctacgacatg gtcagtgggg tatactcatg tcaaagaagt
      721 ttggcagaga tcacagaact tatccatact gctctcctgg tgcatcgtgg gatagtaaac
      781 ttaagtgaat tacagtcatc tgatggacca ctgaaagaca tgcagtttgg aaacaaaata
      841 gctatcctga gtggagactt ccttctagca aatgcatgca atggactagc tcttctacag
      901 aacaccaagg ttgtggagct tttatcaagt gctcttatgg acttggtgca tggagtatac
      961 caggagaact ctgcttccac caaggaaaat tctatcccag atgatattgg aatctcgacc
     1021 tggaaggagc agactttcct gtcccattgt gccttgctag cgaagagctg ccaggctgca
     1081 atggagttag caaagcatga tgctgcggtc caagacatgg cattccagta tgggaagcac
     1141 atggccatga gtcacaagat caatgctgac ctccagcctt ttattaaaga caaggccagt
     1201 gactctaaga cttttaacct aaactcagca cctgtagtct tacatcagga gtttcttgga
     1261 agagatttgt ggattaagca gattggagag gctcaagaga aaggaagctt gaactacagt
     1321 aagttgcgag aaacaatcaa agctggcaaa ggtgtgactt cagctattga cctgtgtcgt
     1381 taccatggaa acaaggcact agaggccctg gagagcttcc ctccctcaga ggccagatcg
     1441 gctttagaaa acattgtgtt tgctgtgacc agattttctt gacaccaaat taaaaagaca
     1501 ctattgttcc ttagctgaaa aacccagaga atgaggcgga caggagagct tttggtgatg
     1561 aaataagtaa cgtgtttaat gactttagaa atatatgtat tttttttttc tgtcctttat
     1621 ctgactgctt aatgaatcta tcctttggaa ccactacaaa caaaacgaga aggaaaaagg
     1681 tcacgcggtt ttcacttgtc acgccagagc acacttgagg cttcagcaac agaaataatt
     1741 aatgagactc gctcccgtga cctcagcaaa tgg
//
