LOCUS       NM_019501               1539 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus prenyl (solanesyl) diphosphate synthase, subunit 1
            (Pdss1), transcript variant 1, mRNA.
ACCESSION   NM_019501
VERSION     NM_019501.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1539)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1539)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   3  (bases 1 to 1539)
  AUTHORS   Saiki,R., Nagata,A., Kainou,T., Matsuda,H. and Kawamukai,M.
  TITLE     Characterization of solanesyl and decaprenyl diphosphate synthases
            in mice and humans
  JOURNAL   FEBS J 272 (21), 5606-5622 (2005)
   PUBMED   16262699
  REMARK    GeneRIF: murine and human solanesyl and decaprenyl diphosphate
            synthases are heterotetramers composed of newly characterized hDPS1
            (mSPS1) and hDLP1 (mDLP1) [DLP1]
REFERENCE   4  (bases 1 to 1539)
  AUTHORS   Rotig,A., Appelkvist,E.L., Geromel,V., Chretien,D., Kadhom,N.,
            Edery,P., Lebideau,M., Dallner,G., Munnich,A., Ernster,L. and
            Rustin,P.
  TITLE     Quinone-responsive multiple respiratory-chain dysfunction due to
            widespread coenzyme Q10 deficiency
  JOURNAL   Lancet 356 (9227), 391-395 (2000)
   PUBMED   10972372
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030013.7.
            
            On Jan 28, 2022 this sequence version replaced NM_019501.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026820.1, AB210841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               CT030013.7         74854-74996
            144-208             CT030013.7         80515-80579
            209-329             CT030013.7         80987-81107
            330-460             CT030013.7         86029-86159
            461-602             CT030013.7         91834-91975
            603-714             CT030013.7         94436-94547
            715-824             CT030013.7         94649-94758
            825-905             CT030013.7         108774-108854
            906-1019            CT030013.7         108978-109091
            1020-1100           CT030013.7         114793-114873
            1101-1539           CT030013.7         119057-119495
FEATURES             Location/Qualifiers
     source          1..1539
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 15.17 cM"
     gene            1..1539
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /note="prenyl (solanesyl) diphosphate synthase, subunit 1"
                     /db_xref="GeneID:56075"
                     /db_xref="MGI:MGI:1889278"
     exon            1..143
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1241
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /EC_number="2.5.1.91"
                     /note="isoform 1 is encoded by transcript variant 1;
                     decaprenyl-diphosphate synthase subunit 1; subunit 1 of
                     solanesyl diphosphate synthase; solanesyl-diphosphate
                     synthase subunit 1; decaprenyl pyrophosphate synthetase
                     subunit 1; decaprenyl pyrophosphate synthase subunit 1;
                     trans-prenyltransferase 1; all
                     trans-polyprenyl-diphosphate synthase PDSS1;
                     all-trans-decaprenyl-diphosphate synthase subunit 1"
                     /codon_start=1
                     /product="all trans-polyprenyl-diphosphate synthase PDSS1
                     isoform 1"
                     /protein_id="NP_062374.2"
                     /db_xref="CCDS:CCDS38057.1"
                     /db_xref="GeneID:56075"
                     /db_xref="MGI:MGI:1889278"
                     /translation="MAMRWSCWRRGCSWRPTAVGSPRRERPGCVEPLGTRAASDTRAQ
                     IPYFSLMKILMSASPTMHSISQFHQRTPAMCSCRQTQSGEKYSDPFKLGWRDLKGLYE
                     DIRKELHISTRELKDMSEYYFDGKGKAFRPIIVVLMARACNIHHNNAREMQASQRSIA
                     LVAEMIHTATLVHDDVIDDASSRRGKHTVNKIWGEKKAVLAGDLILSAASVALARIGN
                     TAVVSMLAQVIEDLVRGEFLQLGSKENENERFAHYLEKTFKKTASLIANSCKAVSVLG
                     CPDPVVHEIAYQYGKNVGIAFQLIDDVLDFTSCSDQMGKPTSADLKLGIATGPVLFAC
                     QQFPEMNAMIMRRFSLPGDVDRARQYVLQSDGVQQTTYLAQQYCHKAVREIRKLRPST
                     ERDALIQLSESVLTRDK"
     exon            144..208
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..329
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..460
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..602
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..714
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..824
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..905
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1019
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1100
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1539
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /note="hexamer: ATTACA"
     regulatory      1523..1528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /note="hexamer: AATAAT"
     polyA_site      1534
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
     polyA_site      1539
                     /gene="Pdss1"
                     /gene_synonym="2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1;
                     Tprt; TPT; TPT 1"
                     /note="major polyA site"
ORIGIN      
        1 agacttgaac catggctatg cgctggtcgt gctggcggcg tggctgctcc tggaggccga
       61 ccgcggtcgg gagcccgcgg cgggaacgac ctggctgtgt ggagcctctc ggaacacgtg
      121 ccgcctcgga cacccgcgcg cagataccct attttagtct tatgaagatt ttaatgtctg
      181 cctccccaac tatgcatagt atatcacagt ttcatcaaag gacaccagca atgtgcagtt
      241 gtcgtcaaac tcagagtggt gagaaataca gtgatccttt taaacttggc tggagagact
      301 tgaaaggtct gtatgaagac attagaaagg agctgcacat ctccaccaga gaactaaagg
      361 acatgtccga atactacttc gatggcaaag gaaaagcctt tagaccgatt attgtggtgc
      421 taatggcccg agcgtgtaat attcatcata ataatgcccg agagatgcaa gccagccagc
      481 gctccatagc cttagttgca gaaatgatcc acactgctac tctggttcat gatgacgtta
      541 ttgatgatgc aagttctcga agaggaaaac atacagttaa taaaatctgg ggtgagaaaa
      601 aggctgttct tgctggagat ttaattcttt ctgcagcgtc tgtagctctg gcacggattg
      661 gaaacacagc tgttgtatct atgttagccc aagttattga agatttggtg cgtggtgaat
      721 ttcttcagct agggtcaaaa gaaaatgaga atgaaaggtt tgcccactac cttgagaaga
      781 ccttcaagaa gacagccagc ctgatagcca acagttgtaa agcagtctct gtcctgggtt
      841 gccctgaccc agtggtgcat gagatagcct atcagtatgg gaaaaatgtt ggaatagctt
      901 ttcagctcat agatgatgta ttggatttca cctcatgttc tgaccagatg ggcaagccaa
      961 catctgcaga cctgaagcta ggcatagcca ctggccctgt cttgtttgct tgccagcagt
     1021 tcccagaaat gaatgctatg ataatgagac ggttcagttt gccaggagat gtggacagag
     1081 cacgacagta tgtattacag agtgatggcg tgcagcaaac aacctacctc gcccagcagt
     1141 actgccacaa agctgtgaga gagatcagga agcttagacc atctacagaa agggacgccc
     1201 tcattcagct ttcagaaagt gtgctcacca gagataaatg acaattcctc ctcttctttc
     1261 tggcagctat tttaccagac tgtgcctaat gattttgtga aacactattt gcttcatgtg
     1321 cagaaaacca aaaatcattt taagaaataa tttcaacctt attgatgggc aatttttatt
     1381 ggcaaagttt ttcggaaaac tttttaaatg taattaaacc agtgtcatta tagtcctata
     1441 aattctaatc gaggtatcct gatggttata tgtggtattg tttacactgt taatgcccac
     1501 atgtaaagcc attacacaaa taaataatca acgttaaaa
//
