LOCUS       NM_175310               7311 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript
            variant 1, mRNA.
ACCESSION   NM_175310 XM_359314
VERSION     NM_175310.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7311)
  AUTHORS   Arruda NL, Bryan AF and Dowen JM.
  TITLE     PDS5A and PDS5B differentially affect gene expression without
            altering cohesin localization across the genome
  JOURNAL   Epigenetics Chromatin 15 (1), 30 (2022)
   PUBMED   35986423
  REMARK    GeneRIF: PDS5A and PDS5B differentially affect gene expression
            without altering cohesin localization across the genome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7311)
  AUTHORS   Lai J, Mardiana S, House IG, Sek K, Henderson MA, Giuffrida L, Chen
            AXY, Todd KL, Petley EV, Chan JD, Carrington EM, Lew AM, Solomon
            BJ, Trapani JA, Kedzierska K, Evrard M, Vervoort SJ, Waithman J,
            Darcy PK and Beavis PA.
  TITLE     Adoptive cellular therapy with T cells expressing the dendritic
            cell growth factor Flt3L drives epitope spreading and antitumor
            immunity
  JOURNAL   Nat Immunol 21 (8), 914-926 (2020)
   PUBMED   32424363
REFERENCE   3  (bases 1 to 7311)
  AUTHORS   Viera A, Berenguer I, Ruiz-Torres M, Gomez R, Guajardo A, Barbero
            JL, Losada A and Suja JA.
  TITLE     PDS5 proteins regulate the length of axial elements and telomere
            integrity during male mouse meiosis
  JOURNAL   EMBO Rep 21 (6), e49273 (2020)
   PUBMED   32285610
  REMARK    GeneRIF: PDS5 proteins regulate the length of axial elements and
            telomere integrity during male mouse meiosis.
REFERENCE   4  (bases 1 to 7311)
  AUTHORS   Morales C, Ruiz-Torres M, Rodriguez-Acebes S, Lafarga V,
            Rodriguez-Corsino M, Megias D, Cisneros DA, Peters JM, Mendez J and
            Losada A.
  TITLE     PDS5 proteins are required for proper cohesin dynamics and
            participate in replication fork protection
  JOURNAL   J Biol Chem 295 (1), 146-157 (2020)
   PUBMED   31757807
REFERENCE   5  (bases 1 to 7311)
  AUTHORS   Cianciaruso C, Beltraminelli T, Duval F, Nassiri S, Hamelin R,
            Mozes A, Gallart-Ayala H, Ceada Torres G, Torchia B, Ries CH,
            Ivanisevic J and De Palma M.
  TITLE     Molecular Profiling and Functional Analysis of Macrophage-Derived
            Tumor Extracellular Vesicles
  JOURNAL   Cell Rep 27 (10), 3062-3080 (2019)
   PUBMED   31167148
REFERENCE   6  (bases 1 to 7311)
  AUTHORS   Maffini M, Denes V, Sonnenschein C, Soto A and Geck P.
  TITLE     APRIN is a unique Pds5 paralog with features of a chromatin
            regulator in hormonal differentiation
  JOURNAL   J Steroid Biochem Mol Biol 108 (1-2), 32-43 (2008)
   PUBMED   17997301
  REMARK    GeneRIF: APRIN, in addition to its Pds5 similarity, has the
            features and localization of a hormone-induced chromatin regulator.
REFERENCE   7  (bases 1 to 7311)
  AUTHORS   Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY and
            Milbrandt J.
  TITLE     Mice lacking sister chromatid cohesion protein PDS5B exhibit
            developmental abnormalities reminiscent of Cornelia de Lange
            syndrome
  JOURNAL   Development 134 (17), 3191-3201 (2007)
   PUBMED   17652350
  REMARK    GeneRIF: Mice lacking sister chromatid cohesion protein PDS5B
            exhibit developmental abnormalities reminiscent of Cornelia de
            Lange syndrome.
            GeneRIF: A paper used gene targeting in mice to demonstrate the
            function of PDS5B in embryonic development.
REFERENCE   8  (bases 1 to 7311)
  AUTHORS   Piechocki MP, Ho YS, Pilon S and Wei WZ.
  TITLE     Human ErbB-2 (Her-2) transgenic mice: a model system for testing
            Her-2 based vaccines
  JOURNAL   J Immunol 171 (11), 5787-5794 (2003)
   PUBMED   14634087
REFERENCE   9  (bases 1 to 7311)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 7311)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY243250.1, BF471938.1, BC096539.1, AK047172.1 and CX210004.1.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_175310.7.
            
            On Aug 22, 2007 this sequence version replaced NM_175310.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY102267.1, SRR1660821.85622.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               BY243250.1         89-197
            110-705             BF471938.1         13-608
            706-4360            BC096539.1         569-4223
            4361-7119           AK047172.1         394-3152
            7120-7311           CX210004.1         410-601
FEATURES             Location/Qualifiers
     source          1..7311
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..7311
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /note="PDS5 cohesin associated factor B"
                     /db_xref="GeneID:100710"
                     /db_xref="MGI:MGI:2140945"
     exon            1..127
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..254
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..4487
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     androgen-induced proliferation inhibitor; sister chromatid
                     cohesion protein PDS5 homolog B; androgen-induced prostate
                     proliferative shutoff associated protein AS3; PDS5,
                     regulator of cohesion maintenance, homolog B; Her-2 Tg"
                     /codon_start=1
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform 1"
                     /protein_id="NP_780519.3"
                     /db_xref="CCDS:CCDS39412.1"
                     /db_xref="GeneID:100710"
                     /db_xref="MGI:MGI:2140945"
                     /translation="MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMD
                     MDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDK
                     LKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRT
                     LFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLA
                     KALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQ
                     LEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECV
                     KFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNF
                     VRERTLDKRWRVRKEAMMGLAQIYKKYSLQSAAGKDAAKQISWVKDKLLHIYYQNSID
                     DRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKD
                     LLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEAL
                     VSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQ
                     VNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDE
                     KVAEAALQIFKNTGSKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSK
                     ETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLL
                     MNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTT
                     ILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDE
                     CYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNITVRREY
                     LKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMA
                     KNENNSHAFIRKMVENIKQTKDAQGPDDTKMNEKLYTVCDVAMNIIMSKSTTYSLESP
                     KDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTANVLGAVNKPLSSAGKQSQ
                     TKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKREDP
                     DLSELEKPRSRKKAPVTDPEEKLGMDDLTKLVQEQKPKGSQRGRKRGRTASDSDEQQW
                     PEEKRHKEELLENEDEQNSPPKKGKRGRPPKPLGGGTSKEEPTMKTSKKGNKKKLVPP
                     VVDDDEEEERQIGNTEHKSKSKQHRTSKRAQQRAESPETSAVESTQSTPQKGRGRPSK
                     APSPSQPPKKIRVGRSKQVATKENDSSEEMDVLQASSPVSDDTTQEGAEEEDISVGNV
                     RRRSSKRERR"
     exon            255..458
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..545
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..643
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..770
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..851
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..992
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1108
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1203
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1349
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1501
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1615
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1697
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1746
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1886
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2002
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2108
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2269
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2393
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2552
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2621
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2758
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2882
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3087
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3202
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3335
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3455
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3518
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3664
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3764
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..4204
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4205..4312
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4313..4451
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4452..7308
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggctgcgg aaggggaggg ggggcgggag gaggcgattg gatgcggcgg cggcggcggc
       61 ggcggcgagg gcggcggatc cccgagatcg gaggagcgcg aggagtgtag gagccgggcg
      121 accggagggg tacagacatt tccatcatgg ctcattcaaa gacaaggacc aacgatggga
      181 aaattactta ccctcctgga gtcaaggaaa tctcagataa aatctctaaa gaggagatgg
      241 tgaggcggtt aaagatggtt gtaaaaactt tcatggacat ggaccaggac tctgaagagg
      301 aaaaggaact ttatctaaac ctagctttac atcttgcttc tgacttcttc ctcaagcatc
      361 ctgataaaga tgttcgttta ctggtggctt gctgccttgc tgatattttc aggatttatg
      421 ctcctgaggc tccttacacg tctcccgata aactaaagga tatatttatg tttataacaa
      481 ggcaactaaa gggactagaa gatacaaaga gccctcaatt taataggtat ttttatttac
      541 ttgagaacat tgcatgggtt aaatcatata acatatgctt tgagttagaa gatagcaatg
      601 aaatctttac tcaactttac agaacattat tctcagttat aaacaatggc cacaatcaga
      661 aagttcatat gcacatggtg gacctcatga gctctatcat ttgtgaaggt gataccgtat
      721 ctcaggagct cttagataca gttttagtaa atctggtacc tgcccataag aacttaaaca
      781 agcaagcata tgatttggca aaggctttgc tgaagaggac tgctcaagct attgaaccat
      841 atattaccaa tttttttaac caggttctga tgcttgggaa aacatctatc agtgatttgt
      901 ctgagcatgt ctttgatttg atcttggaac tctacaacat tgacagccat ttgctgcttt
      961 ctgttctgcc ccagcttgag tttaaattaa agagcaatga taatgaagaa cgcctccagg
     1021 ttgttaaact actggcgaaa atgtttgggg caaaggattc agaattggct tctcagaaca
     1081 aacccctctg gcagtgctac ctgggcaggt ttaatgatat ccatgtacca atacgcctgg
     1141 aatgtgtgaa atttgccagc cactgcctca tgaaccatcc tgatttagca aaggatttaa
     1201 cagagtatct taaagtgagg tcacatgatc ctgaggaagc tattagacat gatgttattg
     1261 tgtctatagt aacagctgct aaaaaggata ttcttcttgt caatgatcac ttactcaatt
     1321 ttgtgagaga gcgaacattg gacaaacggt ggagagtacg taaagaagcc atgatgggac
     1381 tggcccagat ttataagaaa tactctttac agtcagcagc tggcaaagat gctgcaaaac
     1441 agatatcctg ggtcaaggac aagctgctgc atatatacta tcagaacagc atcgacgacc
     1501 ggctacttgt tgagcggatc tttgctcagt acatggtccc tcacaatttg gaaacgacgg
     1561 aacggatgaa gtgcttgtat tacttgtacg ctacactgga cttgaatgct gtgaaagcat
     1621 tgaatgaaat gtggaaatgt caaaatctac tccgacatca agtaaaggat ttacttgatt
     1681 taattaaaca accaaaaaca gatgccagtg tcaaggccat attttctaaa gtgatggtta
     1741 tcacaagaaa tttgccagat cctggtaagg cccaagactt catgaagaag ttcacacaag
     1801 tgttggaaga tgatgagaaa atacggaaac agctggaagc ccttgttagt cccacatgtt
     1861 cctgcaagca ggctgaaggc tgtgtgcgtg aaataactaa gaagttgggc aaccctaagc
     1921 agcctacaaa ccctttcttg gaaatgatca agtttctctt ggagaggata gctcctgtac
     1981 acatagacac tgaatccatc agtgctctta tcaagcaagt gaataaatca atagatggaa
     2041 cagcagatga tgaggatgag ggtgttccaa ctgatcaagc tatcagggca ggccttgagc
     2101 tgctgaaggt gctgtctttt acgcacccta tctcctttca ctctgctgag acgtttgagt
     2161 cccttctggc ttgtctgaag atggatgatg agaaggtggc agaagctgca ctacaaattt
     2221 tcaaaaacac aggaagcaaa attgaagagg atttccctca catcagatca gccttgcttc
     2281 ctgtactaca tcacaaatcc aaaaaaggac cacctcggca ggccaaatac gccatccatt
     2341 gtattcatgc catattttct agtaaagaaa cccagtttgc acagatattt gagcctctgc
     2401 ataaaagcct agatccaagc aacctggagc atcttataac ccctctggtc actattggtc
     2461 atattgctct tctcgcacct gatcagttcg ctgctcctct gaagtctttg gtggcaactt
     2521 tcattgtgaa ggacctcctc atgaatgacc ggcttccagg aaaaaagaca actaagcttt
     2581 gggttccaga tgaggaagtc tcacctgaga caatggtcaa aattcaggct attaaaatga
     2641 tggttcgatg gctacttgga atgaagaata atcacagtaa gtcaggaact tccaccctca
     2701 gattactaac aacgatactg catagtgatg gggatttgac agaacaaggg aaaattagta
     2761 aaccagatat gtcacgcctg agacttgctg ctgggagtgc tattgtgaag ctggcacagg
     2821 agccctgtta ccacgagatc attacactgg agcagtacca gctgtgtgca ttagccatca
     2881 atgatgagtg ttatcaagtc aggcaggtgt tcgctcagaa acttcacaaa ggcctttccc
     2941 gcttacggct tccccttgag tacatggcca tctgtgctct ttgtgccaaa gaccctgtga
     3001 aagagaggcg agcccatgct agacagtgct tggtgaagaa catcactgtg aggagggagt
     3061 acctgaagca gcatgcagct gttagtgaaa aattattgtc tcttctacca gagtatgttg
     3121 ttccatatac aattcacctt ttggcacatg acccagatta tgtcaaagta caggatattg
     3181 aacaacttaa agatgtgaaa gaatgccttt ggtttgttct ggagatattg atggctaaaa
     3241 atgaaaacaa cagccatgca tttatcagaa aaatggtaga aaatattaaa cagacaaaag
     3301 atgctcaagg accagatgat acaaaaatga atgaaaaatt gtacaccgtg tgtgatgttg
     3361 ccatgaacat catcatgtcc aagagcacca cgtacagcct ggagtctcct aaggaccccg
     3421 tgctgccagc tcggtttttc acccagcctg acaagaattt tagtaacacc aaaaattacc
     3481 tgcctccaga aatgaaatca tttttcactc ctggaaaacc taaaacagcc aatgttctcg
     3541 gagcagttaa taagccactt tcatcagcag gcaaacagtc tcagaccaaa tcatcaagaa
     3601 tggaaactgt gagcaacgca agcagcagct ccaacccaag ctctcctgga aggatcaagg
     3661 ggaggcttga tagctctgaa atggatcaca gtgaaaatga agattataca atgtcttcac
     3721 ctttgccagg aaaaaaaagt gacaagagag aagaccctga tctttctgag ttggagaagc
     3781 ctagaagtcg gaaaaaagca cctgtcacag accctgaaga gaaattaggt atggatgacc
     3841 taactaagtt ggtacaggaa cagaaaccta aaggcagtca gcgaggccgg aaaagaggcc
     3901 gtacagcttc agactcagac gagcagcagt ggcctgagga gaagaggcac aaagaggagc
     3961 tcctggaaaa tgaggatgag cagaacagcc caccaaaaaa gggcaaaaga ggcaggccac
     4021 caaaacctct tggtgggggg acatcgaagg aagagcccac aatgaaaaca tccaagaaag
     4081 gaaacaagaa aaaacttgta cctcctgtag tagacgacga tgaagaagaa gaaagacaaa
     4141 ttggaaacac agaacataag tcaaaaagca aacagcaccg cacatcaaag agagcacaac
     4201 agagagcaga atctcctgaa acaagtgcag ttgaatccac acagtccaca ccacagaaag
     4261 gacgaggaag accatcaaaa gcaccatcac catcacaacc ccccaaaaaa atccgtgtag
     4321 gacgctccaa acaggtagcc actaaagaaa acgattcaag tgaagaaatg gatgtgcttc
     4381 aggccagctc tcctgtcagt gacgacacta cacaggaagg agcagaagag gaggacattt
     4441 ctgtgggaaa tgtacgacgg cgaagctcca aacgagagag acgatgaaca cgtcattaac
     4501 ttctattgtg aaagctttgg ggggaaaaaa cattttttgt ctaaatatga ggctaaataa
     4561 agccttggat gcacaaacca gaactgccaa agcgtggaca gttggacttc ggatgaccat
     4621 gggtttgtgg tcacacgtat cagccatcca cacagtgata acactgactc cagagtcttg
     4681 tgaaagtgtc ctgtgtgatg gctgtgtaga cacaaactaa agaagacaca tgtaaataat
     4741 cccactcccc catttctgac ttctaaagtg cttgtatagc ttttatctgc ggctttaaac
     4801 tgacaggacc cagctgctta ccggatctgt tcatttgaaa agcatttgct agggtggatc
     4861 ttaagcagta cgtagtctgt cagtgtttgt atttgaattc tctgcaattt tactgtgaaa
     4921 atttgttttc aacaattggt gtcattttct caatgtcact gtttgttgga gttaaatggt
     4981 ttcttcctgc ccctctttgt agctcatcta tgtttactcc agggcactgt tgtcttctga
     5041 ggtgctaaag catctgccag cacactagaa catgcctctg tctggggcac gacatggatt
     5101 gtgagatagt cctgagctta tctgatgact tcacacctca gtattggtcc cagaattctc
     5161 tggcctttca tggcaacgaa aattttaaga aagagattta aaatatttta attttaaaga
     5221 gtgtgttata aaataatgta ctaaattctt tattccattc tatcatcttt tttcagttta
     5281 tattaatcta ctgtatcaat aaaattctgt aatttgaatg ggcttttaat agtctagaat
     5341 gttattgtgt atagatatta cttcttgaac attatgttca gaaatgcaaa ttattacact
     5401 ataatataaa atctgatata tacacgttag gaaagttctc attctccata accatgtaaa
     5461 gttaatcaga aacaaaaaat tttattgatg cagtgtatct ttataaatct gttcttgaaa
     5521 gccaagtgtt ttgtatttta tagtgagttg catgtttatg aaaaattgct gatcatgaga
     5581 tgtgcttttc tgtaaattca tacttagcca tagtatatga tagatgaccc cctaacatag
     5641 tttttcatca agagtttata attgtacttt attttggagc caaaaaaaaa attgtttggt
     5701 gggggtggtg gtactgggtg gcagtgattt atctagtttg ggctgagact ttaggcgtca
     5761 cactcacaaa cactgagaga gtcccactgc atccagaata ggaaagatgg aaatttgcct
     5821 gggtttaatt tagaggtctg caaagtctaa aaatggatta tcaaggcagt gccctttaca
     5881 tagagtatga accaaaatgt attggttgct accttatgct cacctgaatt aactttagat
     5941 ttacgggtgc agggttggtt ttgcacaatt gttaacagta gaaaagaaaa tgacattttg
     6001 agttaccaag ttactatatc aagttaacag agcagtttca tatagtacac ctttatgttt
     6061 ccaaaattgg atataataaa ttgggatgct ataaagaagt gactatttta gaaatgacat
     6121 catgctattt tctagtatgt atcgcaaatg atgtgattat ttttcttttt aatatttcct
     6181 catgtttatg aaacacttta ttttttaaaa gatgtttgaa ttgtgtctta atccttcagt
     6241 gtttaacttt cttcatttgc aacagtgttg gcaccgtggt gatgggaggc ctctgcctgt
     6301 gaggacagct aaggctgggt tatgatactt tgtattttaa atgtttcatt aactcagctc
     6361 tccagacaat gatgtttcga tttcaacagt acagaagcat gtttttaaac ttacagcata
     6421 agtaataaag gatagcattg tatttttgtc atcaactaaa cttcattgga aatatttatg
     6481 gaaatatatg tttaaaacca ttttataaaa caaaaaaaat attatggagg atttttattt
     6541 gcatgatcat agttcaccag atttcattgc acattaatgc tgtgcatcag ttcattacag
     6601 acatggtcac tgtagatttt gtttgtgtcc aatgccaatg agcctgtaat tttacaaccc
     6661 gcctgttcac ttttgggagg attataatgt aaaatttcca tttttgtgta gagaaatagg
     6721 tgcaataatg atcaaagttt ttatgtcctg agtctccatc ttgggggctt attattatgt
     6781 ttaaacttaa cacttcctgt actaacactt ggagagccac atactttaaa ataaagctaa
     6841 gtatgtatac gacattaatt gctacagttg ttagcatact gcagtggtcg tactcatttt
     6901 gagaacgtgt actgtctgac attaaggacc tgtaacaagc tcattgtaac aagccgactg
     6961 tggaaggaat ctggtgactc ccaggtgagc cttgcttgct gcagtacccc actaagctct
     7021 ttcagtgatc tccattctat gtgtaaatta gaaatgtgct gtaaaacttg ttctagacat
     7081 taaagtttaa atgactttct acatcttctt acagcttgca agtttgactt ttaaaggttc
     7141 cttttgccta ctgaaagaat attggggatt taatgatttg tttaacttag gcataacctt
     7201 ctaccacata gtattatgtt atcaatgaac agttggttct agatgtccag ttttcagaca
     7261 cagttttgga ttttctgtga acttaaataa atatagatgc tcatgtaaaa a
//
