LOCUS       NM_001346503            7314 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript
            variant 2, mRNA.
ACCESSION   NM_001346503 XM_006504902
VERSION     NM_001346503.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7314)
  AUTHORS   Arruda NL, Bryan AF and Dowen JM.
  TITLE     PDS5A and PDS5B differentially affect gene expression without
            altering cohesin localization across the genome
  JOURNAL   Epigenetics Chromatin 15 (1), 30 (2022)
   PUBMED   35986423
  REMARK    GeneRIF: PDS5A and PDS5B differentially affect gene expression
            without altering cohesin localization across the genome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7314)
  AUTHORS   Lai J, Mardiana S, House IG, Sek K, Henderson MA, Giuffrida L, Chen
            AXY, Todd KL, Petley EV, Chan JD, Carrington EM, Lew AM, Solomon
            BJ, Trapani JA, Kedzierska K, Evrard M, Vervoort SJ, Waithman J,
            Darcy PK and Beavis PA.
  TITLE     Adoptive cellular therapy with T cells expressing the dendritic
            cell growth factor Flt3L drives epitope spreading and antitumor
            immunity
  JOURNAL   Nat Immunol 21 (8), 914-926 (2020)
   PUBMED   32424363
REFERENCE   3  (bases 1 to 7314)
  AUTHORS   Viera A, Berenguer I, Ruiz-Torres M, Gomez R, Guajardo A, Barbero
            JL, Losada A and Suja JA.
  TITLE     PDS5 proteins regulate the length of axial elements and telomere
            integrity during male mouse meiosis
  JOURNAL   EMBO Rep 21 (6), e49273 (2020)
   PUBMED   32285610
  REMARK    GeneRIF: PDS5 proteins regulate the length of axial elements and
            telomere integrity during male mouse meiosis.
REFERENCE   4  (bases 1 to 7314)
  AUTHORS   Morales C, Ruiz-Torres M, Rodriguez-Acebes S, Lafarga V,
            Rodriguez-Corsino M, Megias D, Cisneros DA, Peters JM, Mendez J and
            Losada A.
  TITLE     PDS5 proteins are required for proper cohesin dynamics and
            participate in replication fork protection
  JOURNAL   J Biol Chem 295 (1), 146-157 (2020)
   PUBMED   31757807
REFERENCE   5  (bases 1 to 7314)
  AUTHORS   Cianciaruso C, Beltraminelli T, Duval F, Nassiri S, Hamelin R,
            Mozes A, Gallart-Ayala H, Ceada Torres G, Torchia B, Ries CH,
            Ivanisevic J and De Palma M.
  TITLE     Molecular Profiling and Functional Analysis of Macrophage-Derived
            Tumor Extracellular Vesicles
  JOURNAL   Cell Rep 27 (10), 3062-3080 (2019)
   PUBMED   31167148
REFERENCE   6  (bases 1 to 7314)
  AUTHORS   Maffini M, Denes V, Sonnenschein C, Soto A and Geck P.
  TITLE     APRIN is a unique Pds5 paralog with features of a chromatin
            regulator in hormonal differentiation
  JOURNAL   J Steroid Biochem Mol Biol 108 (1-2), 32-43 (2008)
   PUBMED   17997301
  REMARK    GeneRIF: APRIN, in addition to its Pds5 similarity, has the
            features and localization of a hormone-induced chromatin regulator.
REFERENCE   7  (bases 1 to 7314)
  AUTHORS   Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY and
            Milbrandt J.
  TITLE     Mice lacking sister chromatid cohesion protein PDS5B exhibit
            developmental abnormalities reminiscent of Cornelia de Lange
            syndrome
  JOURNAL   Development 134 (17), 3191-3201 (2007)
   PUBMED   17652350
  REMARK    GeneRIF: Mice lacking sister chromatid cohesion protein PDS5B
            exhibit developmental abnormalities reminiscent of Cornelia de
            Lange syndrome.
            GeneRIF: A paper used gene targeting in mice to demonstrate the
            function of PDS5B in embryonic development.
REFERENCE   8  (bases 1 to 7314)
  AUTHORS   Piechocki MP, Ho YS, Pilon S and Wei WZ.
  TITLE     Human ErbB-2 (Her-2) transgenic mice: a model system for testing
            Her-2 based vaccines
  JOURNAL   J Immunol 171 (11), 5787-5794 (2003)
   PUBMED   14634087
REFERENCE   9  (bases 1 to 7314)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 7314)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158558.6 and AC111126.16.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_001346503.2.
            
            On Oct 18, 2016 this sequence version replaced XM_006504902.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.159090.1,
                                           SRR1660813.229946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC158558.6         63905-64031         c
            128-254             AC158558.6         21329-21455         c
            255-458             AC158558.6         17832-18035         c
            459-545             AC158558.6         15477-15563         c
            546-643             AC158558.6         15283-15380         c
            644-770             AC158558.6         14487-14613         c
            771-851             AC158558.6         8884-8964           c
            852-992             AC158558.6         1439-1579           c
            993-1108            AC111126.16        138049-138164       c
            1109-1203           AC111126.16        133107-133201       c
            1204-1349           AC111126.16        130614-130759       c
            1350-1501           AC111126.16        129118-129269       c
            1502-1615           AC111126.16        127418-127531       c
            1616-1697           AC111126.16        122896-122977       c
            1698-1746           AC111126.16        120935-120983       c
            1747-1886           AC111126.16        118554-118693       c
            1887-2002           AC111126.16        116231-116346       c
            2003-2108           AC111126.16        112359-112464       c
            2109-2269           AC111126.16        107418-107578       c
            2270-2393           AC111126.16        101847-101970       c
            2394-2552           AC111126.16        99054-99212         c
            2553-2621           AC111126.16        98086-98154         c
            2622-2758           AC111126.16        96620-96756         c
            2759-2882           AC111126.16        94223-94346         c
            2883-3087           AC111126.16        88846-89050         c
            3088-3202           AC111126.16        86746-86860         c
            3203-3335           AC111126.16        85119-85251         c
            3336-3455           AC111126.16        84679-84798         c
            3456-3518           AC111126.16        83754-83816         c
            3519-3664           AC111126.16        82952-83097         c
            3665-3770           AC111126.16        80689-80794         c
            3771-4210           AC111126.16        76348-76787         c
            4211-4318           AC111126.16        76136-76243         c
            4319-4457           AC111126.16        71653-71791         c
            4458-7314           AC111126.16        66696-69552         c
FEATURES             Location/Qualifiers
     source          1..7314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..7314
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /note="PDS5 cohesin associated factor B"
                     /db_xref="GeneID:100710"
                     /db_xref="MGI:MGI:2140945"
     exon            1..127
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..254
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..4493
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     androgen-induced proliferation inhibitor; sister chromatid
                     cohesion protein PDS5 homolog B; androgen-induced prostate
                     proliferative shutoff associated protein AS3; PDS5,
                     regulator of cohesion maintenance, homolog B; Her-2 Tg"
                     /codon_start=1
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform 2"
                     /protein_id="NP_001333432.1"
                     /db_xref="CCDS:CCDS85012.1"
                     /db_xref="GeneID:100710"
                     /db_xref="MGI:MGI:2140945"
                     /translation="MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMD
                     MDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDK
                     LKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRT
                     LFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLA
                     KALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQ
                     LEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECV
                     KFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNF
                     VRERTLDKRWRVRKEAMMGLAQIYKKYSLQSAAGKDAAKQISWVKDKLLHIYYQNSID
                     DRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKD
                     LLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEAL
                     VSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQ
                     VNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDE
                     KVAEAALQIFKNTGSKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSK
                     ETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLL
                     MNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTT
                     ILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDE
                     CYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNITVRREY
                     LKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMA
                     KNENNSHAFIRKMVENIKQTKDAQGPDDTKMNEKLYTVCDVAMNIIMSKSTTYSLESP
                     KDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTANVLGAVNKPLSSAGKQSQ
                     TKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKREDP
                     DLVRSELEKPRSRKKAPVTDPEEKLGMDDLTKLVQEQKPKGSQRGRKRGRTASDSDEQ
                     QWPEEKRHKEELLENEDEQNSPPKKGKRGRPPKPLGGGTSKEEPTMKTSKKGNKKKLV
                     PPVVDDDEEEERQIGNTEHKSKSKQHRTSKRAQQRAESPETSAVESTQSTPQKGRGRP
                     SKAPSPSQPPKKIRVGRSKQVATKENDSSEEMDVLQASSPVSDDTTQEGAEEEDISVG
                     NVRRRSSKRERR"
     exon            255..458
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..545
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..643
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..770
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..851
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..992
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1108
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1203
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1349
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1501
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1615
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1697
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1746
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1886
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2002
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2108
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2269
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2393
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2552
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2621
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2758
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2882
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3087
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3202
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3335
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3455
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3518
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3664
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3770
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..4210
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4318
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4457
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..7314
                     /gene="Pds5b"
                     /gene_synonym="Aprin; AS3; mKIAA0979; Tg(Wap-ERBB2)229Wzw;
                     WAP-Her-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggctgcgg aaggggaggg ggggcgggag gaggcgattg gatgcggcgg cggcggcggc
       61 ggcggcgagg gcggcggatc cccgagatcg gaggagcgcg aggagtgtag gagccgggcg
      121 accggagggg tacagacatt tccatcatgg ctcattcaaa gacaaggacc aacgatggga
      181 aaattactta ccctcctgga gtcaaggaaa tctcagataa aatctctaaa gaggagatgg
      241 tgaggcggtt aaagatggtt gtaaaaactt tcatggacat ggaccaggac tctgaagagg
      301 aaaaggaact ttatctaaac ctagctttac atcttgcttc tgacttcttc ctcaagcatc
      361 ctgataaaga tgttcgttta ctggtggctt gctgccttgc tgatattttc aggatttatg
      421 ctcctgaggc tccttacacg tctcccgata aactaaagga tatatttatg tttataacaa
      481 ggcaactaaa gggactagaa gatacaaaga gccctcaatt taataggtat ttttatttac
      541 ttgagaacat tgcatgggtt aaatcatata acatatgctt tgagttagaa gatagcaatg
      601 aaatctttac tcaactttac agaacattat tctcagttat aaacaatggc cacaatcaga
      661 aagttcatat gcacatggtg gacctcatga gctctatcat ttgtgaaggt gataccgtat
      721 ctcaggagct cttagataca gttttagtaa atctggtacc tgcccataag aacttaaaca
      781 agcaagcata tgatttggca aaggctttgc tgaagaggac tgctcaagct attgaaccat
      841 atattaccaa tttttttaac caggttctga tgcttgggaa aacatctatc agtgatttgt
      901 ctgagcatgt ctttgatttg atcttggaac tctacaacat tgacagccat ttgctgcttt
      961 ctgttctgcc ccagcttgag tttaaattaa agagcaatga taatgaagaa cgcctccagg
     1021 ttgttaaact actggcgaaa atgtttgggg caaaggattc agaattggct tctcagaaca
     1081 aacccctctg gcagtgctac ctgggcaggt ttaatgatat ccatgtacca atacgcctgg
     1141 aatgtgtgaa atttgccagc cactgcctca tgaaccatcc tgatttagca aaggatttaa
     1201 cagagtatct taaagtgagg tcacatgatc ctgaggaagc tattagacat gatgttattg
     1261 tgtctatagt aacagctgct aaaaaggata ttcttcttgt caatgatcac ttactcaatt
     1321 ttgtgagaga gcgaacattg gacaaacggt ggagagtacg taaagaagcc atgatgggac
     1381 tggcccagat ttataagaaa tactctttac agtcagcagc tggcaaagat gctgcaaaac
     1441 agatatcctg ggtcaaggac aagctgctgc atatatacta tcagaacagc atcgacgacc
     1501 ggctacttgt tgagcggatc tttgctcagt acatggtccc tcacaatttg gaaacgacgg
     1561 aacggatgaa gtgcttgtat tacttgtacg ctacactgga cttgaatgct gtgaaagcat
     1621 tgaatgaaat gtggaaatgt caaaatctac tccgacatca agtaaaggat ttacttgatt
     1681 taattaaaca accaaaaaca gatgccagtg tcaaggccat attttctaaa gtgatggtta
     1741 tcacaagaaa tttgccagat cctggtaagg cccaagactt catgaagaag ttcacacaag
     1801 tgttggaaga tgatgagaaa atacggaaac agctggaagc ccttgttagt cccacatgtt
     1861 cctgcaagca ggctgaaggc tgtgtgcgtg aaataactaa gaagttgggc aaccctaagc
     1921 agcctacaaa ccctttcttg gaaatgatca agtttctctt ggagaggata gctcctgtac
     1981 acatagacac tgaatccatc agtgctctta tcaagcaagt gaataaatca atagatggaa
     2041 cagcagatga tgaggatgag ggtgttccaa ctgatcaagc tatcagggca ggccttgagc
     2101 tgctgaaggt gctgtctttt acgcacccta tctcctttca ctctgctgag acgtttgagt
     2161 cccttctggc ttgtctgaag atggatgatg agaaggtggc agaagctgca ctacaaattt
     2221 tcaaaaacac aggaagcaaa attgaagagg atttccctca catcagatca gccttgcttc
     2281 ctgtactaca tcacaaatcc aaaaaaggac cacctcggca ggccaaatac gccatccatt
     2341 gtattcatgc catattttct agtaaagaaa cccagtttgc acagatattt gagcctctgc
     2401 ataaaagcct agatccaagc aacctggagc atcttataac ccctctggtc actattggtc
     2461 atattgctct tctcgcacct gatcagttcg ctgctcctct gaagtctttg gtggcaactt
     2521 tcattgtgaa ggacctcctc atgaatgacc ggcttccagg aaaaaagaca actaagcttt
     2581 gggttccaga tgaggaagtc tcacctgaga caatggtcaa aattcaggct attaaaatga
     2641 tggttcgatg gctacttgga atgaagaata atcacagtaa gtcaggaact tccaccctca
     2701 gattactaac aacgatactg catagtgatg gggatttgac agaacaaggg aaaattagta
     2761 aaccagatat gtcacgcctg agacttgctg ctgggagtgc tattgtgaag ctggcacagg
     2821 agccctgtta ccacgagatc attacactgg agcagtacca gctgtgtgca ttagccatca
     2881 atgatgagtg ttatcaagtc aggcaggtgt tcgctcagaa acttcacaaa ggcctttccc
     2941 gcttacggct tccccttgag tacatggcca tctgtgctct ttgtgccaaa gaccctgtga
     3001 aagagaggcg agcccatgct agacagtgct tggtgaagaa catcactgtg aggagggagt
     3061 acctgaagca gcatgcagct gttagtgaaa aattattgtc tcttctacca gagtatgttg
     3121 ttccatatac aattcacctt ttggcacatg acccagatta tgtcaaagta caggatattg
     3181 aacaacttaa agatgtgaaa gaatgccttt ggtttgttct ggagatattg atggctaaaa
     3241 atgaaaacaa cagccatgca tttatcagaa aaatggtaga aaatattaaa cagacaaaag
     3301 atgctcaagg accagatgat acaaaaatga atgaaaaatt gtacaccgtg tgtgatgttg
     3361 ccatgaacat catcatgtcc aagagcacca cgtacagcct ggagtctcct aaggaccccg
     3421 tgctgccagc tcggtttttc acccagcctg acaagaattt tagtaacacc aaaaattacc
     3481 tgcctccaga aatgaaatca tttttcactc ctggaaaacc taaaacagcc aatgttctcg
     3541 gagcagttaa taagccactt tcatcagcag gcaaacagtc tcagaccaaa tcatcaagaa
     3601 tggaaactgt gagcaacgca agcagcagct ccaacccaag ctctcctgga aggatcaagg
     3661 ggaggcttga tagctctgaa atggatcaca gtgaaaatga agattataca atgtcttcac
     3721 ctttgccagg aaaaaaaagt gacaagagag aagaccctga tcttgtaagg tctgagttgg
     3781 agaagcctag aagtcggaaa aaagcacctg tcacagaccc tgaagagaaa ttaggtatgg
     3841 atgacctaac taagttggta caggaacaga aacctaaagg cagtcagcga ggccggaaaa
     3901 gaggccgtac agcttcagac tcagacgagc agcagtggcc tgaggagaag aggcacaaag
     3961 aggagctcct ggaaaatgag gatgagcaga acagcccacc aaaaaagggc aaaagaggca
     4021 ggccaccaaa acctcttggt ggggggacat cgaaggaaga gcccacaatg aaaacatcca
     4081 agaaaggaaa caagaaaaaa cttgtacctc ctgtagtaga cgacgatgaa gaagaagaaa
     4141 gacaaattgg aaacacagaa cataagtcaa aaagcaaaca gcaccgcaca tcaaagagag
     4201 cacaacagag agcagaatct cctgaaacaa gtgcagttga atccacacag tccacaccac
     4261 agaaaggacg aggaagacca tcaaaagcac catcaccatc acaacccccc aaaaaaatcc
     4321 gtgtaggacg ctccaaacag gtagccacta aagaaaacga ttcaagtgaa gaaatggatg
     4381 tgcttcaggc cagctctcct gtcagtgacg acactacaca ggaaggagca gaagaggagg
     4441 acatttctgt gggaaatgta cgacggcgaa gctccaaacg agagagacga tgaacacgtc
     4501 attaacttct attgtgaaag ctttgggggg aaaaaacatt ttttgtctaa atatgaggct
     4561 aaataaagcc ttggatgcac aaaccagaac tgccaaagcg tggacagttg gacttcggat
     4621 gaccatgggt ttgtggtcac acgtatcagc catccacaca gtgataacac tgactccaga
     4681 gtcttgtgaa agtgtcctgt gtgatggctg tgtagacaca aactaaagaa gacacatgta
     4741 aataatccca ctcccccatt tctgacttct aaagtgcttg tatagctttt atctgcggct
     4801 ttaaactgac aggacccagc tgcttaccgg atctgttcat ttgaaaagca tttgctaggg
     4861 tggatcttaa gcagtacgta gtctgtcagt gtttgtattt gaattctctg caattttact
     4921 gtgaaaattt gttttcaaca attggtgtca ttttctcaat gtcactgttt gttggagtta
     4981 aatggtttct tcctgcccct ctttgtagct catctatgtt tactccaggg cactgttgtc
     5041 ttctgaggtg ctaaagcatc tgccagcaca ctagaacatg cctctgtctg gggcacgaca
     5101 tggattgtga gatagtcctg agcttatctg atgacttcac acctcagtat tggtcccaga
     5161 attctctggc ctttcatggc aacgaaaatt ttaagaaaga gatttaaaat attttaattt
     5221 taaagagtgt gttataaaat aatgtactaa attctttatt ccattctatc atcttttttc
     5281 agtttatatt aatctactgt atcaataaaa ttctgtaatt tgaatgggct tttaatagtc
     5341 tagaatgtta ttgtgtatag atattacttc ttgaacatta tgttcagaaa tgcaaattat
     5401 tacactataa tataaaatct gatatataca cgttaggaaa gttctcattc tccataacca
     5461 tgtaaagtta atcagaaaca aaaaatttta ttgatgcagt gtatctttat aaatctgttc
     5521 ttgaaagcca agtgttttgt attttatagt gagttgcatg tttatgaaaa attgctgatc
     5581 atgagatgtg cttttctgta aattcatact tagccatagt atatgataga tgacccccta
     5641 acatagtttt tcatcaagag tttataattg tactttattt tggagccaaa aaaaaaattg
     5701 tttggtgggg gtggtggtac tgggtggcag tgatttatct agtttgggct gagactttag
     5761 gcgtcacact cacaaacact gagagagtcc cactgcatcc agaataggaa agatggaaat
     5821 ttgcctgggt ttaatttaga ggtctgcaaa gtctaaaaat ggattatcaa ggcagtgccc
     5881 tttacataga gtatgaacca aaatgtattg gttgctacct tatgctcacc tgaattaact
     5941 ttagatttac gggtgcaggg ttggttttgc acaattgtta acagtagaaa agaaaatgac
     6001 attttgagtt accaagttac tatatcaagt taacagagca gtttcatata gtacaccttt
     6061 atgtttccaa aattggatat aataaattgg gatgctataa agaagtgact attttagaaa
     6121 tgacatcatg ctattttcta gtatgtatcg caaatgatgt gattattttt ctttttaata
     6181 tttcctcatg tttatgaaac actttatttt ttaaaagatg tttgaattgt gtcttaatcc
     6241 ttcagtgttt aactttcttc atttgcaaca gtgttggcac cgtggtgatg ggaggcctct
     6301 gcctgtgagg acagctaagg ctgggttatg atactttgta ttttaaatgt ttcattaact
     6361 cagctctcca gacaatgatg tttcgatttc aacagtacag aagcatgttt ttaaacttac
     6421 agcataagta ataaaggata gcattgtatt tttgtcatca actaaacttc attggaaata
     6481 tttatggaaa tatatgttta aaaccatttt ataaaacaaa aaaaatatta tggaggattt
     6541 ttatttgcat gatcatagtt caccagattt cattgcacat taatgctgtg catcagttca
     6601 ttacagacat ggtcactgta gattttgttt gtgtccaatg ccaatgagcc tgtaatttta
     6661 caacccgcct gttcactttt gggaggatta taatgtaaaa tttccatttt tgtgtagaga
     6721 aataggtgca ataatgatca aagtttttat gtcctgagtc tccatcttgg gggcttatta
     6781 ttatgtttaa acttaacact tcctgtacta acacttggag agccacatac tttaaaataa
     6841 agctaagtat gtatacgaca ttaattgcta cagttgttag catactgcag tggtcgtact
     6901 cattttgaga acgtgtactg tctgacatta aggacctgta acaagctcat tgtaacaagc
     6961 cgactgtgga aggaatctgg tgactcccag gtgagccttg cttgctgcag taccccacta
     7021 agctctttca gtgatctcca ttctatgtgt aaattagaaa tgtgctgtaa aacttgttct
     7081 agacattaaa gtttaaatga ctttctacat cttcttacag cttgcaagtt tgacttttaa
     7141 aggttccttt tgcctactga aagaatattg gggatttaat gatttgttta acttaggcat
     7201 aaccttctac cacatagtat tatgttatca atgaacagtt ggttctagat gtccagtttt
     7261 cagacacagt tttggatttt ctgtgaactt aaataaatat agatgctcat gtaa
//
