LOCUS       NM_178939               1235 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus p53 and DNA damage regulated 1 (Pdrg1), transcript
            variant 1, mRNA.
ACCESSION   NM_178939
VERSION     NM_178939.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1235)
  AUTHORS   Lin,L., Zhao,J., Kubota,N., Li,Z., Lam,Y.L., Nguyen,L.P., Yang,L.,
            Pokharel,S.P., Blue,S.M., Yee,B.A., Chen,R., Yeo,G.W., Chen,C.W.,
            Chen,L. and Zheng,S.
  TITLE     Epistatic interactions between NMD and TRP53 control progenitor
            cell maintenance and brain size
  JOURNAL   Neuron 112 (13), 2157-2176 (2024)
   PUBMED   38697111
REFERENCE   2  (bases 1 to 1235)
  AUTHORS   Luo,X., Huang,Y. and Sheikh,M.S.
  TITLE     Cloning and characterization of a novel gene PDRG that is
            differentially regulated by p53 and ultraviolet radiation
  JOURNAL   Oncogene 22 (46), 7247-7257 (2003)
   PUBMED   14562055
  REMARK    GeneRIF: Cloning and characterization of a novel gene PDRG that is
            differentially regulated by p53 and ultraviolet radiation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928862.13.
            
            On Mar 22, 2023 this sequence version replaced NM_178939.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031699.1, AK145939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL928862.13        19027-19182         c
            157-232             AL928862.13        17803-17878         c
            233-307             AL928862.13        16174-16248         c
            308-388             AL928862.13        14051-14131         c
            389-1235            AL928862.13        12683-13529         c
FEATURES             Location/Qualifiers
     source          1..1235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..1235
                     /gene="Pdrg1"
                     /gene_synonym="1110004D19Rik; Pdrg"
                     /note="p53 and DNA damage regulated 1"
                     /db_xref="GeneID:68559"
                     /db_xref="MGI:MGI:1915809"
     exon            1..156
                     /gene="Pdrg1"
                     /gene_synonym="1110004D19Rik; Pdrg"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..471
                     /gene="Pdrg1"
                     /gene_synonym="1110004D19Rik; Pdrg"
                     /note="isoform a is encoded by transcript variant 1; p53
                     and DNA damage-regulated protein 1"
                     /codon_start=1
                     /product="p53 and DNA damage-regulated protein 1 isoform
                     a"
                     /protein_id="NP_849270.1"
                     /db_xref="CCDS:CCDS16904.1"
                     /db_xref="GeneID:68559"
                     /db_xref="MGI:MGI:1915809"
                     /translation="MLSPEAERVLRYLVEVEELAEAVLSDKRQIVDLDTKRNQNREGL
                     RALQKDLSVSEDVMVCFGNMFIKMPHPKTKEMIQKDQEHLDKEIERLRSQLKVKVNRL
                     FEAQGKPELKGFNLNPLSPDEVKALKVILKG"
     exon            157..232
                     /gene="Pdrg1"
                     /gene_synonym="1110004D19Rik; Pdrg"
                     /inference="alignment:Splign:2.1.0"
     exon            233..307
                     /gene="Pdrg1"
                     /gene_synonym="1110004D19Rik; Pdrg"
                     /inference="alignment:Splign:2.1.0"
     exon            308..388
                     /gene="Pdrg1"
                     /gene_synonym="1110004D19Rik; Pdrg"
                     /inference="alignment:Splign:2.1.0"
     exon            389..1235
                     /gene="Pdrg1"
                     /gene_synonym="1110004D19Rik; Pdrg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdrg1"
                     /gene_synonym="1110004D19Rik; Pdrg"
                     /note="hexamer: AATAAA"
     polyA_site      1235
                     /gene="Pdrg1"
                     /gene_synonym="1110004D19Rik; Pdrg"
                     /note="major polyA site"
ORIGIN      
        1 agaacagcgc gtgcgcggaa ggagccaagg tgaagttgta gcagtgtgtc agaagaggtg
       61 cgtggcacca tgctgtcccc cgaggcggag cgggtgctgc ggtacctggt cgaagtagag
      121 gagttggccg aggccgtgct gtcggacaag cggcagattg tagacctgga caccaagagg
      181 aatcagaacc gagagggcct gagggcccta cagaaggacc tgagtgtctc tgaagatgtg
      241 atggtttgct ttgggaacat gttcatcaaa atgcctcacc ctaagacgaa ggaaatgatc
      301 cagaaagatc aagagcacct ggataaagaa atagaaaggc tgcggagtca acttaaagtg
      361 aaagttaacc gcctctttga agcccaagga aaaccggagc tgaaaggttt taacctgaat
      421 cccctcagcc cggatgaggt taaagccctc aaggtcatct tgaaaggatg agactcacag
      481 aagaatgggg gacctgtggt aggacttccc aactcccagc cttgagacct gcaagggcag
      541 gattgtctgt ttaaggggac aggcatcagg aatgtggctt ctgtacaaat ctttttctgt
      601 agtgcttggt tgctttgtgc aagagagaac ccttagtctg ttctgtgggc ttggcctggt
      661 caccagagct tggacacaag acctattgac aaaccctggc agctgtcagt aggtgtgtgg
      721 gtgtgtgaga atgtctgcag ccgacacttc tcaacagtag cctgctgttc acatgggcct
      781 ggccggggat ggagggaggg gaaggtggac tgggagcttc attccagctt tctgcacagc
      841 gaggcatttt caggcagtgt gtgtgacaac tggaataaag caggacactg accgttcact
      901 tctgcgtgaa gcagacctag tgctcctcac cagcttcagg tagacacatt tgtttcccca
      961 ctgctccagt tctgtccttt ttcctgctgg ctttctgtag tagaggtgct gccagtcacc
     1021 ctctgtgctt gctcttgagg tagaagtcct tatggagttc tggcccaggg ctggcaagca
     1081 gtaaccttcc tgatgtgact ggacgtggag tatcgtcccg acctctgcga gcagggcctg
     1141 cctggctggc tcgagatcat agtgtgaatg tggcgtgaga gcaaaactga cttccggtcc
     1201 ctgccgctca ataaacatga actgaacaaa caaca
//
