LOCUS       NM_198308               2904 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus pyruvate dehydrogenase phosphatase regulatory subunit
            (Pdpr), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_198308 XM_284441
VERSION     NM_198308.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2904)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2904)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2904)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2904)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2904)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY223867.1.
            
            On Dec 17, 2003 this sequence version replaced XM_284441.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY223867.1, AK129472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.95 cM"
     gene            1..2904
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /note="pyruvate dehydrogenase phosphatase regulatory
                     subunit"
                     /db_xref="GeneID:319518"
                     /db_xref="MGI:MGI:2442188"
     exon            1..82
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            83..359
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2772
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /EC_number="1.5.8.4"
                     /note="pyruvate dehydrogenase phosphatase regulatory
                     subunit, mitochondrial"
                     /codon_start=1
                     /product="pyruvate dehydrogenase phosphatase regulatory
                     subunit, mitochondrial precursor"
                     /protein_id="NP_938050.1"
                     /db_xref="CCDS:CCDS22670.1"
                     /db_xref="GeneID:319518"
                     /db_xref="MGI:MGI:2442188"
                     /translation="MLYRLLSIVQRQRTSPGWQTWSSARSSTSTAEAHSIALPAQAQV
                     VICGGGIMGTSVAYHLSKMGWQDIVLLEQGRLAAGSTRFCAGILSTARHSSVEQKMAN
                     YSNKLYHQLEQETGIQTGYLRTGSISLAQTQDRLISLKRINSRLNVVGIPSEIISPKK
                     VAELHPLLNVHDLVGAMYVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVLIKK
                     GQVTGVETDKGQIECQYFVNCAGQWAYELGLSNEEPLSIPLHACEHFYLLTRPWDTPL
                     QSNTPTIVDADGRIYIRNWQGGILSGGFEKNPKPIFTEGKNQLEIQNLREDWDHFEPL
                     LSSLLRRMPALETLEILKLVNCPETFTPDMKCIMGESPVVQGYFVLAGMNSAGLSLGG
                     GAGKFLAEWMVYGYPSENVWELDLQRFGALQSSRTFLRHRVMEVMPLIYDLKVPRWDF
                     QTGRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVPPNKDLLALEQSKTFYKPDWFDI
                     VESEVKCCKEAVCVIDMSSFTKFEITSTGDEALESLQYLFCNDLDVPVGHIVHTGMLN
                     EYGGYENDCSIARLTKRSFFMISPTDQQVHCWAWLNKYLPKDSNLLLEDVTWKYTALN
                     LIGPRAVDVLSELSYAPMTPDHFPTLFCKEMSVGYANGIRVMSMTHTGEPGFMLYIPI
                     EYALHVYNEVMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECGGESRV
                     KLEKGIDFIGRDALLQQKQTGVYKRLAMFILDDHDTDLDLWPWWGEPIYRNGKYAGKT
                     TSSAYSYTLERHVCLGYVHNFSEDSGEEQVVTTDFINRGEYEIDIAGHRFQAKAKLYP
                     VTSFFTHKRRKDDVELSDFHGK"
     exon            360..493
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            494..575
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            576..739
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            740..861
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            862..979
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1129
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1322
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1447
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1603
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1737
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1886
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1999
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2094
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2184
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2367
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2904
                     /gene="Pdpr"
                     /gene_synonym="4930402E16Rik; mKIAA1990"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccctctt cagcggctgg gctgcccttc acttccgccg ggcgttgctg agcgcgctgc
       61 ccgcgagtcg cgggcccgtg agttcatatt ctttggatct tctcagctga gtgaaaacgt
      121 atcttccagg tggtgatgct ttaccggttg ctctctattg tgcaaagaca aaggactagc
      181 ccaggatggc agacctggtc atcagcgaga agcagcacgt ccactgcgga ggcacattct
      241 attgctctgc ctgcccaggc ccaggtggtc atctgtggag gtggaatcat gggtacatcc
      301 gtggcctatc acctctccaa aatgggatgg caagatattg tccttttgga gcagggcagg
      361 ctggctgctg gctcaacaag gttctgtgct ggcatcctaa gcactgctag gcattcaagc
      421 gttgagcaga agatggctaa ctattcaaac aaactctacc atcagttaga acaagaaaca
      481 gggatccaaa caggttactt aaggacaggc tcaatctctc tggcccagac tcaggaccgg
      541 ttgatctctc tgaagcgtat caactcaagg ctgaatgttg taggtatccc ttctgagatc
      601 atctccccga agaaagtggc tgaacttcac cctctcctca atgtgcatga tctggtcggg
      661 gccatgtacg ttcctgagga tgcagtagtg tcctctgctg atgtggctct ggccctggca
      721 agtgctgcct cccagaatgg tgttcagatt tatgaccgga caagtgttct tcacgtactg
      781 atcaaaaaag gtcaagttac tggtgtggag acagacaaag gacagatcga atgccagtat
      841 tttgtcaact gtgccgggca gtgggcatat gagctgggtc tgtccaacga ggagccgctt
      901 agtatcccgc tacacgcctg tgaacacttc taccttctga ctcgtccctg ggacacccct
      961 ctgcagagca acacaccaac cattgtggat gctgatggaa gaatttacat taggaactgg
     1021 cagggtggca tcttgtctgg aggctttgag aagaacccca aacctatttt cactgaaggc
     1081 aagaaccagt tggaaattca gaaccttcgt gaagactggg atcactttga gcccctgctg
     1141 agttccctcc tgcgtaggat gccagcattg gagactctgg agattttgaa gttggtgaat
     1201 tgccctgaga ccttcacacc agacatgaag tgcatcatgg gcgagtctcc tgtagtacag
     1261 ggctactttg tcctggcagg gatgaactct gctggcctgt cgttgggtgg aggagctgga
     1321 aagttcctag cagaatggat ggtatatggt tatccctctg aaaatgtctg ggagttggat
     1381 ttgcagcgct tcggagccct ccagagcagc cgcacctttc tgcgccaccg ggtcatggaa
     1441 gttatgcctc tgatatatga tctgaaggtt ccccgttggg atttccagac tggaaggcag
     1501 ttacgtacat ctcctcttta tgaccggctg gatgctcaag gagccagatg gatggagaaa
     1561 catggatttg agaggccaaa gtactttgtt ccacccaaca aggaccttct tgcattagaa
     1621 cagagcaaga ctttctacaa gccagattgg tttgatattg tggagtcaga agtcaaatgc
     1681 tgcaaggaag ctgtgtgtgt cattgacatg tcctctttca caaaatttga aataacttcc
     1741 actggggacg aggcgttaga aagtctgcag taccttttct gcaatgacct tgatgtacct
     1801 gtaggccaca tcgttcatac tggcatgctc aatgaatatg gaggatacga aaacgactgc
     1861 agcatcgcac gcctgaccaa acgcagtttc tttatgattt ctccaaccga tcagcaggtc
     1921 cactgttggg cctggcttaa caaatacttg ccgaaagaca gcaacttgct gctggaggac
     1981 gtcacctgga aatacacagc cctcaatctg attggccctc gagccgtgga tgtgctatct
     2041 gagctgtcct atgcccctat gactccagat cactttccaa cgctcttctg caaggagatg
     2101 agtgtgggct atgcaaatgg gatccgggtg atgagtatga cgcacacggg agagccaggc
     2161 ttcatgctgt atatccccat agagtacgct ctgcatgtct acaatgaggt gatgagtgtt
     2221 ggacagaaat atggaatccg gaatgctggg tattatgccc tcagaagtct ccgaattgag
     2281 aagttttttg ctttctgggg tcaggactta aacaccctta ccacgccttt ggaatgtgga
     2341 ggagaatctc gagtgaagtt agagaagggc atagacttca ttggtcggga tgccctgctg
     2401 cagcagaagc agaccggggt atataagcgc cttgctatgt tcattctgga cgaccatgac
     2461 acagaccttg atttgtggcc ttggtgggga gaacccattt accggaacgg aaagtatgct
     2521 ggcaagacca ccagtagtgc ctatagctac acactggagc gccatgtatg cctgggttat
     2581 gtacacaatt tttctgagga cagtggggaa gagcaggtgg tgacaacaga tttcatcaac
     2641 cgaggagaat atgaaattga cattgcagga catcggtttc aggccaaggc caagctctac
     2701 cctgtcacct cttttttcac tcacaagcgt agaaaggacg atgtggagct gagcgacttt
     2761 catgggaagt aacgcaagac actcccttcc cacattcttg ccatgaggag catcgttctc
     2821 agagccgagt ttccctccgt cctggtctcc tcactgaagg tacctttgtc cttgcctagg
     2881 ttcaatttga cctaaacttt ttcc
//
