LOCUS       NM_010329               1839 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Mus musculus podoplanin (Pdpn), transcript variant 1, mRNA.
ACCESSION   NM_010329 XM_915547
VERSION     NM_010329.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1839)
  AUTHORS   Sheng,M., Sun,R., Fu,J. and Lu,G.
  TITLE     The podoplanin-CLEC-2 interaction promotes platelet-mediated
            melanoma pulmonary metastasis
  JOURNAL   BMC Cancer 24 (1), 399 (2024)
   PUBMED   38561690
  REMARK    GeneRIF: The podoplanin-CLEC-2 interaction promotes
            platelet-mediated melanoma pulmonary metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1839)
  AUTHORS   Wu,M., Shi,Y., Liu,Y., Huang,H., Che,J., Shi,J. and Xu,C.
  TITLE     Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma
  JOURNAL   CNS Neurosci Ther 30 (3), e14643 (2024)
   PUBMED   38470096
  REMARK    GeneRIF: Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma.
REFERENCE   3  (bases 1 to 1839)
  AUTHORS   Shi,C.Y., Elcavage,L.E., Chivukula,R.R., Stefano,J., Kleaveland,B.
            and Bartel,D.P.
  TITLE     ZSWIM8 destabilizes many murine microRNAs and is required for
            proper embryonic growth and development
  JOURNAL   Genome Res 33 (9), 1482-1496 (2023)
   PUBMED   37532519
REFERENCE   4  (bases 1 to 1839)
  AUTHORS   Chen,S.Y. and Liu,F.C.
  TITLE     The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497597
REFERENCE   5  (bases 1 to 1839)
  AUTHORS   Tarnick,J., Elhendawi,M., Holland,I., Chang,Z. and Davies,J.A.
  TITLE     Innervation of the developing kidney in vivo and in vitro
  JOURNAL   Biol Open 12 (8) (2023)
   PUBMED   37439314
REFERENCE   6  (bases 1 to 1839)
  AUTHORS   Ma,T., Yang,B., Matthay,M.A. and Verkman,A.S.
  TITLE     Evidence against a role of mouse, rat, and two cloned human t1alpha
            isoforms as a water channel or a regulator of aquaporin-type water
            channels
  JOURNAL   Am J Respir Cell Mol Biol 19 (1), 143-149 (1998)
   PUBMED   9651190
REFERENCE   7  (bases 1 to 1839)
  AUTHORS   Webb,J.R., Campos-Neto,A., Ovendale,P.J., Martin,T.I.,
            Stromberg,E.J., Badaro,R. and Reed,S.G.
  TITLE     Human and murine immune responses to a novel Leishmania major
            recombinant protein encoded by members of a multicopy gene family
  JOURNAL   Infect Immun 66 (7), 3279-3289 (1998)
   PUBMED   9632596
REFERENCE   8  (bases 1 to 1839)
  AUTHORS   Rishi,A.K., Joyce-Brady,M., Fisher,J., Dobbs,L.G., Floros,J.,
            VanderSpek,J., Brody,J.S. and Williams,M.C.
  TITLE     Cloning, characterization, and development expression of a rat lung
            alveolar type I cell gene in embryonic endodermal and neural
            derivatives
  JOURNAL   Dev Biol 167 (1), 294-306 (1995)
   PUBMED   7851650
REFERENCE   9  (bases 1 to 1839)
  AUTHORS   Farr,A.G., Berry,M.L., Kim,A., Nelson,A.J., Welch,M.P. and
            Aruffo,A.
  TITLE     Characterization and cloning of a novel glycoprotein expressed by
            stromal cells in T-dependent areas of peripheral lymphoid tissues
  JOURNAL   J Exp Med 176 (5), 1477-1482 (1992)
   PUBMED   1402691
REFERENCE   10 (bases 1 to 1839)
  AUTHORS   Nose,K., Saito,H. and Kuroki,T.
  TITLE     Isolation of a gene sequence induced later by tumor-promoting
            12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells
            (MC3T3-E1) and expressed constitutively in ras-transformed cells
  JOURNAL   Cell Growth Differ 1 (11), 511-518 (1990)
   PUBMED   2088477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158855.1 and AL611982.26.
            
            [WARNING] On Apr 26, 2024 this sequence was replaced by
            NM_010329.4.
            
            On Mar 20, 2014 this sequence version replaced NM_010329.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158855.1, M73748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-955               AK158855.1         1-955
            956-1839            AL611982.26        54753-55636         c
FEATURES             Location/Qualifiers
     source          1..1839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 77.29 cM"
     gene            1..1839
                     /gene="Pdpn"
                     /gene_synonym="E11; Gp38; OTS-8; RANDAM-2; T1-alpha; T1a;
                     T1alpha"
                     /note="podoplanin"
                     /db_xref="GeneID:14726"
                     /db_xref="MGI:MGI:103098"
     exon            1..376
                     /gene="Pdpn"
                     /gene_synonym="E11; Gp38; OTS-8; RANDAM-2; T1-alpha; T1a;
                     T1alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..828
                     /gene="Pdpn"
                     /gene_synonym="E11; Gp38; OTS-8; RANDAM-2; T1-alpha; T1a;
                     T1alpha"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; aggrus; PA2.26 antigen; transmembrane
                     glycoprotein E11; glycoprotein 38"
                     /codon_start=1
                     /product="podoplanin isoform 1 precursor"
                     /protein_id="NP_034459.2"
                     /db_xref="CCDS:CCDS38943.1"
                     /db_xref="GeneID:14726"
                     /db_xref="MGI:MGI:103098"
                     /translation="MWTVPVLFWVLGSVWFWDSAQGGTIGVNEDDIVTPGTGDGMVPP
                     GIEDKITTTGATGGLNESTGKAPLVPTQRERGTKPPLEELSTSATSDHDHREHESTTT
                     VKVVTSHSVDKKTSHPNRDNAGDETQTTDKKDGLPVVTLVGIIVGVLLAIGFVGGIFI
                     VVMKKISGRFSP"
     exon            377..513
                     /gene="Pdpn"
                     /gene_synonym="E11; Gp38; OTS-8; RANDAM-2; T1-alpha; T1a;
                     T1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            514..670
                     /gene="Pdpn"
                     /gene_synonym="E11; Gp38; OTS-8; RANDAM-2; T1-alpha; T1a;
                     T1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            671..709
                     /gene="Pdpn"
                     /gene_synonym="E11; Gp38; OTS-8; RANDAM-2; T1-alpha; T1a;
                     T1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            710..821
                     /gene="Pdpn"
                     /gene_synonym="E11; Gp38; OTS-8; RANDAM-2; T1-alpha; T1a;
                     T1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1839
                     /gene="Pdpn"
                     /gene_synonym="E11; Gp38; OTS-8; RANDAM-2; T1-alpha; T1a;
                     T1alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcggtcc tagatctccg ggaccacctg acgcccaccc gctcccgccc cgggaccgga
       61 gacataaatg ccgactgtgc cgagaggttg ccagctgcca agtttgctgt gcttgctgcc
      121 tctgcgagtc cagaaagccc gggcactctc tggcgctgag acttttgctc agcgccttcc
      181 aacctcctcc cgagctcttc ccggctgggc ctgtggcttc gaagtttttt gttttgtttt
      241 gttttgtttt tcatcttttc acaacccaca aaaaaaccca ctagctgctg aggctccaac
      301 gagatcaaga tgtggaccgt gccagtgttg ttctgggttt tggggagcgt ttggttctgg
      361 gactctgcgc agggagggac tataggcgtg aatgaagatg atattgtgac cccaggtaca
      421 ggagacggca tggtgccccc aggtatagaa gacaaaataa caaccacagg tgctactgga
      481 gggcttaatg aatctactgg caaggcacct ctggtaccaa cgcagagaga gcgtgggacg
      541 aagcctccct tagaggaact gtccacctca gcaacctcag accatgatca cagagaacac
      601 gagagtacaa ccactgtcaa agtggtgact agccactctg tggacaagaa aacaagtcac
      661 cccaatagag ataatgcagg ggatgaaacg cagacaacag ataagaaaga tggcttgcca
      721 gtagtcaccc tggttggaat catagttggc gtcttgttag ccattggctt cgtcggaggg
      781 atcttcattg ttgttatgaa gaagatttct ggaaggttct cgccctaaag agctaaacag
      841 aacaggttgt tctcccaaca catctgaaaa taagagagct tccaacttgc cctgttcccc
      901 atcctcttcc tgtggaggaa gatgacccat ggcgtgccca cccaccccac ccacagccat
      961 ggtgacccct ccgcttggcc agcagtacca aaggaaagat acaggacaag ccacagcccc
     1021 tcaaagcatc tgcctttgga aaactaaatt tttaacataa atgttatgat cgatgattca
     1081 aaagacaaca tgcttagaaa atggagcaaa gccaagacag tatcgccagc tttagcaact
     1141 gtaaccatgg gttcaccctg gccagtccct attactgtta agaggcatag agtctggaaa
     1201 tgttacatca cagaggcatg ggtccttttg cagttgccaa cttgtaactg cacttgatac
     1261 atacacattc cagcccagtc ctaagcatcc actgtgcctt cagttccggg aagacactgc
     1321 tttttttttt tttttttttt ttacaagtct ccaaaccatc tctaagcctc cgatgagttg
     1381 aggagccacg tcctcatctc cctaggactc aagccctcag atcagctgca tctttctgga
     1441 taatagagac ctcatcctgg atgctgagaa cactgttgga tgtcacaaga tgctaaaagg
     1501 ctcagccgct gtagaaccaa gaacatttca gtagaagtga ctcatgttgg ctttagtata
     1561 ggaagtcaga ccgaccagtt tctaacacct gccttctgct tctcaggaca gacagggaaa
     1621 gcaaaaataa tcttgtataa tcttaactgc ttttatgggg tggatgtaaa ggtttgcggt
     1681 taatagaaga tatttccagt cttcgtgaca cggggactca gtgttgctgg gacagagctg
     1741 tagtgtcttg gtcgtctgtg ttggtaccca atacagtgta gacatctttt caaataaaac
     1801 ctgattgtgt ccaagaatga ggccaacatt tgacacttc
//
