LOCUS       NP_034459                172 aa            linear   ROD 28-JAN-2025
DEFINITION  podoplanin isoform 1 precursor [Mus musculus].
ACCESSION   NP_034459 XP_920640
VERSION     NP_034459.2
DBSOURCE    REFSEQ: accession NM_010329.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 172)
  AUTHORS   Vallecillo-Garcia,P., Kuhnlein,M.N., Orgeur,M., Hansmeier,N.R.,
            Kotsaris,G., Meisen,Z.G., Timmermann,B., Giesecke-Thiel,C.,
            Hagerling,R. and Stricker,S.
  TITLE     Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel
            formation
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39221968
REFERENCE   2  (residues 1 to 172)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (residues 1 to 172)
  AUTHORS   Sheng,M., Sun,R., Fu,J. and Lu,G.
  TITLE     The podoplanin-CLEC-2 interaction promotes platelet-mediated
            melanoma pulmonary metastasis
  JOURNAL   BMC Cancer 24 (1), 399 (2024)
   PUBMED   38561690
  REMARK    GeneRIF: The podoplanin-CLEC-2 interaction promotes
            platelet-mediated melanoma pulmonary metastasis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 172)
  AUTHORS   Luo,J., Zhou,J., Luo,J.Z., Wang,H.L., Zhao,X.L. and Zhou,R.D.
  TITLE     Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model
            by Reducing the Expression of Pdpn
  JOURNAL   Curr Med Sci 44 (2), 369-379 (2024)
   PUBMED   38619683
  REMARK    GeneRIF: Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a
            Mouse Model by Reducing the Expression of Pdpn.
REFERENCE   5  (residues 1 to 172)
  AUTHORS   Wu,M., Shi,Y., Liu,Y., Huang,H., Che,J., Shi,J. and Xu,C.
  TITLE     Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma
  JOURNAL   CNS Neurosci Ther 30 (3), e14643 (2024)
   PUBMED   38470096
  REMARK    GeneRIF: Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma.
REFERENCE   6  (residues 1 to 172)
  AUTHORS   Ma,T., Yang,B., Matthay,M.A. and Verkman,A.S.
  TITLE     Evidence against a role of mouse, rat, and two cloned human t1alpha
            isoforms as a water channel or a regulator of aquaporin-type water
            channels
  JOURNAL   Am J Respir Cell Mol Biol 19 (1), 143-149 (1998)
   PUBMED   9651190
REFERENCE   7  (residues 1 to 172)
  AUTHORS   Webb,J.R., Campos-Neto,A., Ovendale,P.J., Martin,T.I.,
            Stromberg,E.J., Badaro,R. and Reed,S.G.
  TITLE     Human and murine immune responses to a novel Leishmania major
            recombinant protein encoded by members of a multicopy gene family
  JOURNAL   Infect Immun 66 (7), 3279-3289 (1998)
   PUBMED   9632596
REFERENCE   8  (residues 1 to 172)
  AUTHORS   Rishi,A.K., Joyce-Brady,M., Fisher,J., Dobbs,L.G., Floros,J.,
            VanderSpek,J., Brody,J.S. and Williams,M.C.
  TITLE     Cloning, characterization, and development expression of a rat lung
            alveolar type I cell gene in embryonic endodermal and neural
            derivatives
  JOURNAL   Dev Biol 167 (1), 294-306 (1995)
   PUBMED   7851650
REFERENCE   9  (residues 1 to 172)
  AUTHORS   Farr,A.G., Berry,M.L., Kim,A., Nelson,A.J., Welch,M.P. and
            Aruffo,A.
  TITLE     Characterization and cloning of a novel glycoprotein expressed by
            stromal cells in T-dependent areas of peripheral lymphoid tissues
  JOURNAL   J Exp Med 176 (5), 1477-1482 (1992)
   PUBMED   1402691
REFERENCE   10 (residues 1 to 172)
  AUTHORS   Nose,K., Saito,H. and Kuroki,T.
  TITLE     Isolation of a gene sequence induced later by tumor-promoting
            12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells
            (MC3T3-E1) and expressed constitutively in ras-transformed cells
  JOURNAL   Cell Growth Differ 1 (11), 511-518 (1990)
   PUBMED   2088477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611982.26.
            
            On Aug 30, 2006 this sequence version replaced NP_034459.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026551.1, AK158855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..172
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 77.29 cM"
     Protein         1..172
                     /product="podoplanin isoform 1 precursor"
                     /note="aggrus; PA2.26 antigen; transmembrane glycoprotein
                     E11; glycoprotein 38"
                     /calculated_mol_wt=15639
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2612
     mat_peptide     23..172
                     /product="Podoplanin. /id=PRO_0000021352"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62011.2)"
                     /calculated_mol_wt=15639
     Region          28..171
                     /region_name="Podoplanin"
                     /note="pfam05808"
                     /db_xref="CDD:461746"
     Site            37
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Region          49..132
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62011.2)"
     Site            51
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            52
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q86YL7; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            53
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            56
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            63
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            71
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            77
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            85
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) serine. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q62011.2)"
     Site            86
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            87
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) serine. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q62011.2)"
     Site            89
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            90
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) serine. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q62011.2)"
     Site            100
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            101
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            102
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            107
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            115
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62011.2)"
     Site            142..162
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62011.2)"
     Region          143..147
                     /region_name="Requires for dimerization and lipidd rafts
                     association. /evidence=ECO:0000250|UniProtKB:Q86YL7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62011.2)"
     Region          164..165
                     /region_name="Requires for interaction with MSN and EZR.
                     /evidence=ECO:0000250|UniProtKB:Q86YL7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62011.2)"
     CDS             1..172
                     /gene="Pdpn"
                     /gene_synonym="E11; Gp38; OTS-8; RANDAM-2; T1-alpha; T1a;
                     T1alpha"
                     /coded_by="NM_010329.4:218..736"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS38943.1"
                     /db_xref="GeneID:14726"
                     /db_xref="MGI:MGI:103098"
ORIGIN      
        1 mwtvpvlfwv lgsvwfwdsa qggtigvned divtpgtgdg mvppgiedki tttgatggln
       61 estgkaplvp tqrergtkpp leelstsats dhdhrehest ttvkvvtshs vdkktshpnr
      121 dnagdetqtt dkkdglpvvt lvgiivgvll aigfvggifi vvmkkisgrf sp
//
