LOCUS       NM_011062               7175 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus 3-phosphoinositide dependent protein kinase 1 (Pdpk1),
            transcript variant 1, mRNA.
ACCESSION   NM_011062
VERSION     NM_011062.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7175)
  AUTHORS   Feng,H., Yang,S., Zhang,L., Zhu,J., Li,J. and Yang,Z.
  TITLE     A new Prdm1-Cre line is suitable for studying the second heart
            field development
  JOURNAL   Dev Biol 514, 78-86 (2024)
   PUBMED   38880275
REFERENCE   2  (bases 1 to 7175)
  AUTHORS   Huang,Y., Feng,Q., Zhang,Y., Zeng,Y., Shi,N., Chen,Y., Tang,X. and
            Li,Z.
  TITLE     The effect of PDK1 in maintaining immune cell development and
            function
  JOURNAL   Biochem Biophys Res Commun 721, 150106 (2024)
   PUBMED   38795634
  REMARK    GeneRIF: The effect of PDK1 in maintaining immune cell development
            and function.
REFERENCE   3  (bases 1 to 7175)
  AUTHORS   Imamori,M., Hosooka,T., Imi,Y., Hosokawa,Y., Yamaguchi,K., Itoh,Y.
            and Ogawa,W.
  TITLE     Thrombospondin-1 promotes liver fibrosis by enhancing TGF-beta
            action in hepatic stellate cells
  JOURNAL   Biochem Biophys Res Commun 693, 149369 (2024)
   PUBMED   38091840
REFERENCE   4  (bases 1 to 7175)
  AUTHORS   Luo,H., Yang,Z., Li,J., Jin,H., Jiang,M. and Shan,C.
  TITLE     Deletion of PDK1 Caused Cardiac Malmorphogenesis and Heart Defects
            Due to Profound Protein Phosphorylation Changes Mediated by SHP2
  JOURNAL   J Cardiovasc Transl Res 16 (5), 1220-1231 (2023)
   PUBMED   36988860
  REMARK    GeneRIF: Deletion of PDK1 Caused Cardiac Malmorphogenesis and Heart
            Defects Due to Profound Protein Phosphorylation Changes Mediated by
            SHP2.
REFERENCE   5  (bases 1 to 7175)
  AUTHORS   Li,C., Zhou,Y., Niu,Y., He,W., Wang,X., Zhang,X., Wu,Y., Zhang,W.,
            Zhao,L., Zheng,H., Song,W. and Gao,H.
  TITLE     Deficiency of Pdk1 drives heart failure by impairing taurine
            homeostasis through Slc6a6
  JOURNAL   FASEB J 37 (9), e23134 (2023)
   PUBMED   37561545
REFERENCE   6  (bases 1 to 7175)
  AUTHORS   Yamada,T., Katagiri,H., Asano,T., Tsuru,M., Inukai,K., Ono,H.,
            Kodama,T., Kikuchi,M. and Oka,Y.
  TITLE     Role of PDK1 in insulin-signaling pathway for glucose metabolism in
            3T3-L1 adipocytes
  JOURNAL   Am J Physiol Endocrinol Metab 282 (6), E1385-E1394 (2002)
   PUBMED   12006370
  REMARK    GeneRIF: findings suggest the presence of a signaling pathway for
            insulin-stimulated glucose transport in which PDK1 to PKB or aPKC
            is not involved
REFERENCE   7  (bases 1 to 7175)
  AUTHORS   Dong,L.Q., Ramos,F.J., Wick,M.J., Lim,M.A., Guo,Z., Strong,R.,
            Richardson,A. and Liu,F.
  TITLE     Cloning and characterization of a testis and brain-specific isoform
            of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1
            beta
  JOURNAL   Biochem Biophys Res Commun 294 (1), 136-144 (2002)
   PUBMED   12054753
  REMARK    GeneRIF: cloning and characterization of a splice variant of mouse
            PDK-1, mPDK-1 beta; mPDK-1 beta is highly expressed in the testis
            and various functional regions of the brain
REFERENCE   8  (bases 1 to 7175)
  AUTHORS   Wick,M.J., Wick,K.R., Chen,H., He,H., Dong,L.Q., Quon,M.J. and
            Liu,F.
  TITLE     Substitution of the autophosphorylation site Thr516 with a
            negatively charged residue confers constitutive activity to mouse
            3-phosphoinositide-dependent protein kinase-1 in cells
  JOURNAL   J Biol Chem 277 (19), 16632-16638 (2002)
   PUBMED   11877406
  REMARK    GeneRIF: Substitution of the autophosphorylation site Thr516 with a
            negatively charged residue confers constitutive activity to mouse
            3-phosphoinositide-dependent protein kinase-1 in cells
REFERENCE   9  (bases 1 to 7175)
  AUTHORS   Cenni,V., Doppler,H., Sonnenburg,E.D., Maraldi,N., Newton,A.C. and
            Toker,A.
  TITLE     Regulation of novel protein kinase C epsilon by phosphorylation
  JOURNAL   Biochem J 363 (Pt 3), 537-545 (2002)
   PUBMED   11964154
  REMARK    GeneRIF: The contribution of the phosphoinositide-dependent kinase
            1 (PDK-1) and activity in controlling the phosphorylation of
            Thr(566) and Ser(729)of PKC epsilon.
REFERENCE   10 (bases 1 to 7175)
  AUTHORS   Dong,L.Q., Zhang,R.B., Langlais,P., He,H., Clark,M., Zhu,L. and
            Liu,F.
  TITLE     Primary structure, tissue distribution, and expression of mouse
            phosphoinositide-dependent protein kinase-1, a protein kinase that
            phosphorylates and activates protein kinase Czeta
  JOURNAL   J Biol Chem 274 (12), 8117-8122 (1999)
   PUBMED   10075713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY257456.1, AK147149.1, AK147835.1, CT010502.14 and BQ175596.1.
            
            On Oct 26, 2007 this sequence version replaced NM_011062.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.16483.1,
                                           SRR10223969.17471.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY257456.1         2-10
            10-680              AK147149.1         2-672
            681-1667            AK147835.1         656-1642
            1668-1955           AK147149.1         1660-1947
            1956-6962           CT010502.14        110661-115667
            6963-7175           BQ175596.1         1-213               c
FEATURES             Location/Qualifiers
     source          1..7175
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.23 cM"
     gene            1..7175
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /note="3-phosphoinositide dependent protein kinase 1"
                     /db_xref="GeneID:18607"
                     /db_xref="MGI:MGI:1338068"
     exon            1..158
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1814
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /EC_number="2.7.11.1"
                     /note="isoform A is encoded by transcript variant 1; Pkb
                     kinase"
                     /codon_start=1
                     /product="3-phosphoinositide-dependent protein kinase 1
                     isoform A"
                     /protein_id="NP_035192.2"
                     /db_xref="CCDS:CCDS28474.1"
                     /db_xref="GeneID:18607"
                     /db_xref="MGI:MGI:1338068"
                     /translation="MARTTSQLYDAVPIQSSVVLCSCPSPSMVRSQTEPGSSPGIPSG
                     VSRQGSTMDGTTAEARPSTNPLQQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLA
                     RELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYF
                     GLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE
                     DMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIY
                     QLVAGLPPFRAGNEYLIFQKIIKLEYHFPEKFFPKARDLVEKLLVLDATKRLGCEEME
                     GYGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVS
                     SSSSSHSLSTVETSLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNP
                     WHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELR
                     PEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQYQSNPDAAVQ"
     exon            159..428
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..471
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..609
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..754
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..852
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..928
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..997
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1094
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1268
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1486
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1544
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1697
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..7160
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7138..7143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /note="hexamer: AATAAA"
     polyA_site      7158
                     /gene="Pdpk1"
                     /gene_synonym="Pdk1"
                     /note="major polyA site"
ORIGIN      
        1 gggggcggca ggcggcgggg cgggcgcagg atgagggcgg ccattgctgg ggctccgccg
       61 cggggaggag gacgctgagg aggcgccgag cagcgcaacg ctgcggggga ggcgcccgcg
      121 ccgacttggg gctcatggcc aggaccacca gccagctgta tgacgctgtg cccattcagt
      181 ccagtgtggt gctatgttcc tgcccatccc catcaatggt gaggtcccag actgagcccg
      241 gttcgtcccc tggcattcct agtggtgtta gcaggcaggg atccaccatg gatggcacca
      301 cagctgaagc ccgaccaagc accaacccct tgcagcagca ccctgcccag ctgccaccac
      361 agcctcgcaa gaaacgccct gaagacttca agtttgggaa aattcttggc gagggctctt
      421 tttcaacagt tgttctggcc cgagaactgg ccacttccag agaatatgct attaaaattc
      481 tggagaaacg tcatattata aaagaaaaca aagttccgta tgtaactaga gagagagatg
      541 tgatgtcacg cctggatcac cccttctttg tgaaacttta ttttacattt caggacgacg
      601 aaaagctgta ttttggcctt agttatgcca aaaatggaga gctacttaaa tacatccgca
      661 aaattggctc atttgatgag acctgtaccc ggttttacac ggctgagatt gtgtctgctt
      721 tagagtactt gcatggcaag ggcatcattc acagagacct taaaccagaa aacattttgt
      781 taaatgaaga catgcacatc cagatcacag attttggaac agcaaaagtg ttatccccag
      841 agagcaaaca agccagggcc aactcatttg taggaacagc acagtatgtt tctccagagc
      901 tgctcacaga gaagtcggcg tgtaaaagtt cagacctttg ggcccttgga tgtataatct
      961 atcagctcgt ggcaggactc ccaccattca gagccgggaa tgaatatctt atatttcaga
     1021 agatcattaa gctggaatat catttcccag aaaaattctt ccctaaggct agagatcttg
     1081 tggaaaaact cttggtttta gatgccacaa agcgtttagg ctgtgaagag atggaagggt
     1141 acgggcctct caaagctcat ccattctttg agaccatcac ttgggagaat ttgcaccagc
     1201 agacacctcc gaagctcaca gcttacctac cagccatgtc agaggatgat gaagactgct
     1261 atggcaacta cgacaatctc ctgagccagt ttggcttcat gcaggtgtca tcctcctcct
     1321 cttcccactc cctgtctacg gtggaaacca gcctgcccca gaggtcgggc agcaacatag
     1381 agcagtacat ccatgatttg gacactaact cttttgaact agacttacag ttttcagaag
     1441 atgaaaaaag gttgttattg gaaaagcaag ccggtggaaa cccttggcac cagtttgtag
     1501 aaaataatct aatattaaaa atgggtccag tggataagcg aaagggttta tttgcaagac
     1561 gacgacagtt attactcaca gaagggccac atttatatta tgttgatcct gtcaacaagg
     1621 tcttgaaagg tgaaatccca tggtcacaag aactccgacc agaagccaag aattttaaaa
     1681 ctttctttgt ccacacgcct aacaggacgt actacctgat ggatccaagc gggaatgctc
     1741 acaagtggtg cagaaagatc caggaggttt ggaggcagca gtaccagagc aatccagatg
     1801 ctgctgtgca gtgacgtggc ctgcggccgg gctgcctatt gctgccagga tacctgcccc
     1861 agcgcggctc ggccgccacc caggacgctt ccagaccacc tgccagccat ctcgtggaga
     1921 acatagatgg cagaaatctt gcagcttttt tatttaaaag aaaagaaaaa aaagaaccca
     1981 accacacaaa gaacaaaaca aatagccaac aaacaggaat tcagggtcgc tttgcttgct
     2041 ctctgtgctc tgtggtggct tccatgcact gctgtggcca tggagaccca gctccttgca
     2101 cggtagccca gcttttgccc agaccagtgg ccagatttgg catcacccgc ccctcttagc
     2161 atccacagga actgcatgcc tgcctctacc tttccccacc tgatacacac agctcctgct
     2221 gtgactgagg gacggggtgt atctggccta ccctagttgt tgcagaatcc ttccccagga
     2281 gccccttcac tcctgctggg gtagtcacca gcttactgtg ggtacagggc tcttagcttg
     2341 tatgtgttct cccttccttg aatctcttgt atggccctag aactttggtc aggtgtgttt
     2401 atggtgacat gatttctgtg gttcctgcct tacagcaggc aggttgtatg gtgagaagaa
     2461 tgaaggctgt tgtagttaca ggtgctctta ctgggctctg ctctagtgtt ccacttccta
     2521 gaagtttatc cagtgaacta gacactaagc caagcacatg tccaggaggg ttgctgtcgc
     2581 actagcacct aggtaacacc aactagatta ttatcaggta cagaatcctg tcctgaacct
     2641 gggcaaggct ggaggtactg tagagaatcc agcttgggcc actgcttcca tgtagagaag
     2701 tgggacagca ggccctcctt ggagtttctg cacaggttta ggtgagtaga ccacatgccc
     2761 tatgaggcaa gcaccgagca aaccctaggg tgtgcctcac ctgcgatgct gtgggcaaac
     2821 acttctcagc tggtccattt ttacaacgat tgaaaatcta gaagccttct catgttgcct
     2881 ggtcacctac tccataaagt gtgggccttg cctggaaagg atgttatcac tgtcctgctc
     2941 acaggaacag ccctcttaat ctgagcctgc ctatgctggc attctttgcc agtaatggga
     3001 cacttctttt ggcatttctt gcagagtgct tttgagggac ttggctgtac ctctctttga
     3061 ctaggatatc cctgaaagtt ggcccttggt gtctagtgga gaaaagtagg catctcccat
     3121 ctgctcacag tagcacctca gactcctatg tcccaatggc agcaacaatt ttgccatttc
     3181 tattgacttt cacataggcg cccccaaaca cacacaacaa cagaggttac cctgttctgt
     3241 ctactctaca gtgactacct gtgggccagg ccatctaaac tgagaggggg aaagattcta
     3301 cttcaaatct ttaacaacaa gagtgattct gttcagctgg ggtagagtga ggatgaaaag
     3361 tcagccacca ctctgtggca gggttgctgg gtgggaacag ggattttatt tagactcagc
     3421 tagatcgtgt gagaagagct tcaggtgagc aaggagcagg acctcacttg ccagtagaac
     3481 ccacagaaca ggtatggcct aggatgctgt cagcctgaga gtgaaagtgg gcactcattt
     3541 ctcctggttt ttgaagagcc tgttaagtac acttggctat ttcctccttg gagtcctgtt
     3601 cttgctcacg ccttgtggct attttgccct cagagtgccc tgtatcctac atttgtacat
     3661 gtaagtaaga gtggcttcct gtctctcagg tgcatgcaga cacagggaaa gcatctttga
     3721 gggcatttaa ctacagggga gcagtggact gaggcttggc ttgaattaga ccacaaagct
     3781 ggctgtatat gggagagtcc tttgttgctt ccttccctgg agagcaacac tacctcctgg
     3841 gctttaccaa gcaccaccct aacctctaaa atcagagttc agctgagcta ttagtagtgg
     3901 gtggtcacca tgactgccca agctacaaca gctgatctct tcccaggtca cctttgtcct
     3961 tactgccccc ttttccttga tttttttttc ctttaatgaa ccatgtacat tcatttctta
     4021 acctggctta aatcaccttc atttttccag tcatccttag agccgtcacc ctgtgtgaag
     4081 gtgccttact ttgtaggaca ggatgtggat gtcagtttgt acaactcgtg tgtgtgtgtg
     4141 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgaaacag taaatttggg
     4201 atgtatgtaa ggagagagag aaataccctg ttagtacctc tagaaatcat gtgtcctagg
     4261 aatggcaagg atggaaagaa agttgaagac tgttctctgg cttctcctac ctaggtacag
     4321 cagactgtag tacctcacag cccacttgag ccctggcttc tctcagcatc acagatgaaa
     4381 cttagcttga atgggtcaat tccacctgtt tttctgtgct ccagctgggc agtgggctcc
     4441 ccatgtagag ctgagcctct ccacttcagg gtgtggcatc atggctcaga tgtcattttg
     4501 agctaaaacc cagttagatg cagtaaaaaa ccactttgag agatggcttg tgttaggctg
     4561 aaactgatag aaacgttaac tgctgcagct ctctttgggc caccctagtg tttgtgattc
     4621 atgcttgaag taaccttgcc gacagttgtg tggcacagac tcccagtacc agcaaggggg
     4681 ccgtaggtaa ttgtgtgctt tcttaaagaa gtgtatgttt tctgaaagca aaagaataaa
     4741 ggaaggcccg tcattcagag accactgtga acatttggat gtagatgctg ttctccctaa
     4801 ctctttgttc cagtgctggg aattgaatag tgaggttcag gattgctaag cgagtgctct
     4861 accactgatg tgcatcctta gtccttgttt gctttctaaa ccaaactggg aacacataca
     4921 acattcatca ttttacatcc agctttttca cttgacttgt tttctcttaa gcatttctcc
     4981 atgccgtggc cgtgagtagt tcttcaaaag catgtttttg ataattgtgg agtcaagtgg
     5041 ttgtaaattt ataagttatg cagttgtttc cctgttgtaa aacattcaga tggtttttgg
     5101 tttcctttgt gttttgtttt tgtttttgct atttaaataa tgctgtggtg aatatacttc
     5161 taagtctttg attttttatt ctgattttgc cccttcctca cacacctgaa gtggtatttt
     5221 gggtattttt tcctcctcct cggtctgatg tttagaccct ctgagttcca gttacaaacc
     5281 taccttcctt gtgtcctacg gactttgaac acatcagttc ttgctaagtt gtgtgttctc
     5341 aagaaagttt gactatggct gcttttgttt ttaatgctaa aaatgtcatt actgcagatt
     5401 cctttgtgac agattttttt tccaaaagcc agtcttttca tttgcattgc aagaatctgc
     5461 tcctgcatgt tacttctttt ccatctttgc tctaaggctt ccaagtgctt ggtgatgttt
     5521 tcagaatctt gtactttgtg tccacgatgg tactgaatct gcttctacac agtcagcaga
     5581 gataaagtgt tgaactgacc ttgctacatg cctaatggat aattcataat taagtttata
     5641 gactcagaaa tgcatttggg ccatttggga atcagtagca aagcagaata gcaaagctct
     5701 tcttggaaaa gaaaccacac agatgattga gttttactaa aagtacagct gtgagtgttc
     5761 ttgctccaca cctcaggtct tggttcagga cagcacagtg gctaggcttt gtcattgcca
     5821 aggatgggta tccccactga tgcttatgta aaccttcttg tgcgctgcag tgctgcacgg
     5881 aactgtagtg cccacccaaa tcagatagta gctttatctg tgttgggtgg ggcctgctgg
     5941 ttcaatttgg aaacatgcag cagagatttt ctgtgttact tgactgtcag agcttagggc
     6001 tggagatgtg tagaaatcag tttcctgccc tcctctgcct caaggcttct ccccattgtt
     6061 ctatagacct ggggtgttca tctgagactt gggaggccac agcaactctg aatatggtga
     6121 agatactcct atacacgttt ctatttgttt taatgcaaaa cccaacataa actggtgctg
     6181 atgccagtgg gtgtagcacc tcgtgggtag aaggtaagac aagggccctg acattgaaca
     6241 gggctggaac cactctcaga acctctgaag atacctagct tctggcctaa cacttcaggg
     6301 ttataagtca gaatgtggaa aaatggcctg caatgtgagg gaagctgttt ctgtcaaaag
     6361 cacttttgca gcagtaagca aatgaattaa ccaatatgaa tacctgaaaa ttccctgtaa
     6421 ctcatttctt ccatatgaag aatccaaact gaacaaaagt ttttacaaat agcaaaattt
     6481 tccctcccca tgtagtccac cctagtttaa tcatctgggt taatgactac aagtaggtca
     6541 ttgtgcaggt taaagccacg accatagtgt gattggacat gtgcaaatta aaaactgtta
     6601 cagtatttag agctgctgcg gctggtccat tagccacgta cagtaggatg aattgctgtc
     6661 attcaggttg gtggcagtca gttagaacat gtgtaatatt ctctacctgt tctgtagctg
     6721 taactgtgat gtacaggcaa aggaaaaatt aaaaatactt atgaaaacag ataatgcaat
     6781 gatactggga tatacacttt tgtattttta ttcttatata aggttatttg ctggctattg
     6841 tcggcctcta gttcagtctg tgttatttaa attctaatat atgaattatt tggattgaat
     6901 tcatgtttgg ggccacgttg ttgtatgtat tgatgtacag ccttgagtgt gaataattat
     6961 tgtaaactat attttacaac ttttttcctg gctttattat ataaattttc tatttggtca
     7021 tggtttaatc atataattta atgaaacaac ttttcttttt tttgtttttt tcaaatatct
     7081 gtgctttaga tgtaattacc ggatgatgga tttccctcgt atgctcggta gtcttgtaat
     7141 aaaagcatgt agagtgtaca aaaaaaaaaa aaaaa
//
