LOCUS       NM_001024606            5671 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pyruvate dehydrogenase phosphatase catalytic subunit 2
            (Pdp2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001024606 XM_358697
VERSION     NM_001024606.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5671)
  AUTHORS   Kono,M., Yoshida,N., Maeda,K., Skinner,N.E., Pan,W., Kyttaris,V.C.,
            Tsokos,M.G. and Tsokos,G.C.
  TITLE     Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 115 (37), 9288-9293 (2018)
   PUBMED   30150402
  REMARK    GeneRIF: ICER was found to bind to the Pdp2 promoter and suppress
            its expression. Furthermore, forced expression of PDP2 in CD4(+)
            cells reduced the in vitro Th17 differentiation, whereas
            shRNA-based suppression of PDP2 expression increased in vitro Th17
            differentiation
REFERENCE   3  (bases 1 to 5671)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5671)
  AUTHORS   Yu,C., Ji,S.Y., Sha,Q.Q., Dang,Y., Zhou,J.J., Zhang,Y.L., Liu,Y.,
            Wang,Z.W., Hu,B., Sun,Q.Y., Sun,S.C., Tang,F. and Fan,H.Y.
  TITLE     BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition
            licensing factor in oocytes
  JOURNAL   Nat Struct Mol Biol 23 (5), 387-394 (2016)
   PUBMED   27065194
REFERENCE   5  (bases 1 to 5671)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (bases 1 to 5671)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 5671)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138617.4.
            
            On Jan 25, 2019 this sequence version replaced NM_001024606.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094946.1, SRR9219382.159198.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC138617.4         116105-116228
            125-5671            AC138617.4         118113-123659
FEATURES             Location/Qualifiers
     source          1..5671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..5671
                     /gene="Pdp2"
                     /gene_synonym="4833426J09Rik; Gm1705; mKIAA1348; PDP 2;
                     PDPC 2"
                     /note="pyruvate dehydrogenase phosphatase catalytic
                     subunit 2"
                     /db_xref="GeneID:382051"
                     /db_xref="MGI:MGI:1918878"
     exon            1..124
                     /gene="Pdp2"
                     /gene_synonym="4833426J09Rik; Gm1705; mKIAA1348; PDP 2;
                     PDPC 2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..5671
                     /gene="Pdp2"
                     /gene_synonym="4833426J09Rik; Gm1705; mKIAA1348; PDP 2;
                     PDPC 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1764
                     /gene="Pdp2"
                     /gene_synonym="4833426J09Rik; Gm1705; mKIAA1348; PDP 2;
                     PDPC 2"
                     /EC_number="3.1.3.43"
                     /note="pyruvate dehydrogenase phosphatase isoenzyme 2;
                     pyruvate dehydrogenase [acetyl-transferring]-phosphatase
                     2, mitochondrial; pyruvate dehyrogenase phosphatase
                     catalytic subunit 2"
                     /codon_start=1
                     /product="[Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 2, mitochondrial"
                     /protein_id="NP_001019777.1"
                     /db_xref="CCDS:CCDS22582.1"
                     /db_xref="GeneID:382051"
                     /db_xref="MGI:MGI:1918878"
                     /translation="MSSTVSYWIFNSARNRIALLRGGRRLYSRAATSRNLLKWRPFSP
                     ALASSALKCGSPPGGFALRKAYRHTSTEEEDFHLQLSPEQVSDLLRAGESSHKVLDFN
                     NGVPNSVLRFESNQLAANSPVEDRQGVATCVQTNGMMFGIFDGHGGHACAQAVSERLF
                     YYMAVSLMSHQTLEQMEEATENMKPLLPILRWLKHPGDSIYKDVTSVHLDHLRVYWQE
                     LLDLHMEMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGATACMAH
                     VNGVHLHVANAGDCRAILGVQEENGAWSCLPLTCDHNAWNEAELSRLKREHPESEDRT
                     LIIDDRLLGVLMPCRAFGDVQLKWSKELQRNVLARGFDTEALNIYQFTPPHYYTPPYL
                     TAKPEVTYHRLRRQDKFLVLASDGLWDMLGNEDVVRLVVGHLSKVGRHKPDLDQRPAN
                     LGLMQSLLLQRKASGLHAADQNTATHLIRHAIGSNEYGEMEPERLAAMLTLPEDVARM
                     YRDDITVMVVFFNSDSIDTYCKEG"
     regulatory      5651..5656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdp2"
                     /gene_synonym="4833426J09Rik; Gm1705; mKIAA1348; PDP 2;
                     PDPC 2"
                     /note="hexamer: AATAAA"
     polyA_site      5671
                     /gene="Pdp2"
                     /gene_synonym="4833426J09Rik; Gm1705; mKIAA1348; PDP 2;
                     PDPC 2"
                     /note="major polyA site"
ORIGIN      
        1 gcctctccag ggaagtaaaa cccagtcgca gcaaccgcgg aactgtgctc aggaccagag
       61 tgagccgaga ggatccgccg agtgccagcg gcgccagctg gggaggagag gacgaggata
      121 cgaggctgaa aaaacactcc acctccacct gccacttgtt tcagaatgtc aagtactgtg
      181 tcctactgga tcttcaattc tgcaaggaat cgtattgctc ttttacgagg tgggagacgc
      241 ctatactcaa gggctgccac gagtaggaac ctgctgaagt ggaggccctt ttctccggca
      301 ttggcatcat cagccctcaa gtgtggttct ccacctggtg gctttgccct gcggaaagcc
      361 tacagacaca catcaaccga ggaagaggat ttccacctac agctcagccc cgaacaggtc
      421 agtgacctgc tccgagctgg cgagtcatcc cacaaggtcc ttgatttcaa caacggagta
      481 ccaaattcag tgttaaggtt cgagagcaac cagctggctg ccaattcccc tgtggaggac
      541 cggcaaggtg tggctacctg cgtccaaacg aatgggatga tgttcggtat ttttgatgga
      601 cacgggggcc acgcgtgtgc gcaagcggtg agtgagaggc ttttctacta catggcggtg
      661 tccctgatgt cccatcagac cttggagcag atggaggaag caacggaaaa catgaagcct
      721 ttgctgccca tcctgcgttg gctcaagcac cccggagata gtatttataa ggacgtcacg
      781 tccgtgcatc tggaccacct ccgtgtctat tggcaggagc tccttgacct gcatatggaa
      841 atggggctga gcattgaaga agcattgatg tactccttcc agagactgga ttctgacatc
      901 tcgctagaaa tccaggctcc tctggaagat gaggtaacga gaaacttatc cctccaggtt
      961 gctttctctg gggcaacagc ctgcatggcc cacgtcaatg gagttcacct gcatgtagca
     1021 aatgctggtg actgccgggc tatcctcggt gtccaggaag aaaacggtgc ctggtcatgt
     1081 ttacctctta cctgtgacca caacgcctgg aatgaggctg agctgtcccg gcttaagagg
     1141 gaacaccccg agtccgagga caggacactc atcatagacg acaggcttct gggtgtcctc
     1201 atgccctgca gggccttcgg ggatgtccag ctaaagtgga gcaaagagct gcagcggaat
     1261 gtcctcgcaa ggggctttga tacggaggcc ctcaacatct accagtttac cccgccccac
     1321 tactacactc caccctacct gactgccaaa cctgaggtta cctaccacag gctaaggcgc
     1381 caggataagt tcctggtgct ggcctcagat ggcctgtggg acatgctggg gaatgaggac
     1441 gtggtgaggc tggtggtggg gcacctgtcc aaggtgggtc gccataagcc ggacctggac
     1501 caaagaccag ccaacctagg cctcatgcag agcctgctgc tgcagaggaa agccagtgga
     1561 ctccatgcgg ctgaccagaa cacagccacg catctgatca gacacgccat cgggagcaac
     1621 gagtacgggg agatggagcc ggagcggctg gctgccatgc tgacactgcc agaggatgtg
     1681 gccaggatgt accgggatga tatcactgtc atggtggtgt tttttaactc tgattcaatt
     1741 gatacctact gtaaagaggg ttaagagtct ccctctggtg ccaaggctaa caggaatgcc
     1801 ctttagacac ttcactcctt agtgagcaat ccaaacctta gtaaagaata ggcagacata
     1861 ggttgctgag taattaacaa aggaagagag ggaaaaccag ccttagtggt ggtgatggtg
     1921 ggggagacga ctacgaagac aacgatgatg acaggacaaa gacattagga gtgatttttt
     1981 tttttttttt tttttttttt ttgtcctgtg tgtgctggtc agctcttctg tgtagcaggc
     2041 agaataaaga ctaaaattgg cttaggctca cgtagcccat gtcctttata agactgttaa
     2101 attgtgtcat cccgtgcttt taaaggataa atttaatcat gagtctaaga ataaagaact
     2161 tcaggatctc ctgagaccca gttgcagatt ttacagatgc gattattcag aactctgtta
     2221 tgcccaaagt ctaggcgcta gtgtcttgtt ttttgttgtt gttgttgttg ttttttagtt
     2281 agggaagcct aggtttacaa agcaatcttc agaatcttca gggcactttt ctatatgtgt
     2341 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtcggaaatg accttgacaa
     2401 cattttgtac tgtttgcgtt ttttaacgct ggttaagttt attttaaaac tgaaccctcc
     2461 agctctcaag gaggactgcc agaagcacgt ttgggacctg ggtgaggaag agaggagcta
     2521 ggccctgggc cagctgaatt taattgtgca gctattgttc gcctccgttg agcctcacct
     2581 ctgaaccttc gaggcatccg tcctgggagg tgatttctgt ctaatcccta actcctgaca
     2641 cttttgctga gtaagccgtt cccccctccc ccacctcccc caggcttagc cacaggctac
     2701 tcataatttt aggttccttt tgattatagc cccaactctt gtttccccgt gacacaaccc
     2761 tacctctgct attctgtctg cctagcctca tcccgacgtt actggaaaat cttccccgtt
     2821 ctatcatcca gaggttggaa gaaagaaggt gatatggttg ggtggcagtt gacgacatgt
     2881 aggcaggact tcttcagtgg tttgtggagt tcagcctaga tctagagaag tgaaagtaag
     2941 gctttctctc tgcatcttgg aagggaggag ggaggcttat cagatgggcc acgcgcccct
     3001 gcctgttgaa ttgccgtcac tccgcctcgg ggaccatatt tagtgtgaga ggtaaaagct
     3061 aaaaatcatc tggccatagt cttcatgggt cactggtgtt tgaaaacgaa tccgcacgaa
     3121 tccggtttag aggataagtt ttctcctctg tcaggtggct gtggcattga acttcaggaa
     3181 atgtgtccct aaacacatgt ggttcttttt gggcagtttt aatttcctgc ccttgtcagc
     3241 acttcagcca tcgtcggcaa ggctcttgtt tccactgtat catccacaca ctaggtttgg
     3301 cccccttggc tttgcaggta gacattttgt tgagtttaga tggggctagc aaaatgactc
     3361 agtgggtaaa ggctgccagt ctcaaaaccc tgagttccat ccaggggacc cccgtgatga
     3421 aaggcttgag ttgaaagttg acctccgacc ttcatgtgtg caccgtggca tgtgaactca
     3481 cacaaaataa ataagaaaaa aaaaaaaaaa atcagagccg ggcagtgttg gtgcttgcct
     3541 ttagtgccag cattcgggaa gctgaggcag gtagatctct gagttcgaga ccagcctggt
     3601 ctagagagtt ccaggacagc tgggactaca cagagaaacc ctgtcttgac ccccaccccc
     3661 accaaaaaca aaatcaggat tgcttttgta tatttcctag tgtatctgtt tagtgatttt
     3721 tttttttaaa caaaaagaca agaaacagaa ctcttgggtc cttttgttct gaacctgatc
     3781 tcttagattt ttactcaaaa gtaaaatgta ggcagtcccc ctgaggagca gcccctctgc
     3841 ccccacactt gggtgggttt actctctgtg gctcctttct gagaggacca cgcttatgct
     3901 ctcaggtgtg gcctaccttc tgagtgcctc tttttcttaa ccttcatctt tacgcctatc
     3961 ctacataata acccccaact ctgccgcctc aaaataaagt agaaaatgaa aattttgggt
     4021 gtggtggcgc aggctttaat tgtagcactt gcgtgaccga gggaagaaca ccagaagttc
     4081 aaagagatac gtgagaccct tgtacaaaaa aatagtgtgt ccccagctag gcactaaggc
     4141 tacacagaga gaccttgcct caggaaacaa aacaaaacaa aaaaacccat aacccctaaa
     4201 catgagtcat tattagtcta gatttatggc ttgttatttg aatggaagac actattgaac
     4261 attttttttt ctttgctctt tgctttcggt actagctaaa gccaggagta tccttggagc
     4321 cttaactggt gttcggtgtc tgagctctgt tttggaggct ggcacgggtc ataaaaggtt
     4381 ctgaatccag taactaatcc tggagttgat aggacacaga cctcccttct gtgtctcctc
     4441 actgtctaat agatgtccct gctctccagc tgaaatattg agagagcaga aagggcaatt
     4501 tatagtctct ctttctctct ccctctgaac tcagcccctc tgtgcctgct ccagtgcgtg
     4561 ttgtcttctg gtcccttgcc agtgtcttgc tggctacggg tcttggcagc ggctcccttg
     4621 aagcaagtga gcctaagctt tgggccactg aaattaggaa ggagatccat ggtccctgtc
     4681 acttcttcca aagcgcttct cctccctctc atatcgagat tccagttatt agacttttac
     4741 attttaaata atgagactga ccgtttagta ttgcagatgt aatttttgaa agaagtatgt
     4801 cttggtgctt aaagtgacgc ttatgatttg gggtaagaga cagatggcaa tgatatcatt
     4861 tagatctttg ttttatgtgt aaacagtgcc gtgctgttga tttccaaagt taataaagct
     4921 gtaggaaaga ctagttttga atgtatatta gatcatgtta ataagattca gtcttctgag
     4981 atgttatttg taacattaaa gctaagttat tgtaatgtta actgagatgc tgtaatatat
     5041 ggacgttttc cccagaagta catttggctt aataaaagct aaaaagcttt ttaggcacaa
     5101 aacttgattg ggacacaatc aagttgacaa cttttaaaca cagatggctt gaccttcaga
     5161 taaagaaggg tataattatg tcgaacagca acattcaaag ggaggctggt tctgtccttt
     5221 tgaccgtcag tttctgttct tccttggaca gtggtaacct cccaggttaa accagaatat
     5281 tctggaatgg agccattgca gtgccgagtc tttgaagtgc tgcagctgct gtggaagcac
     5341 cctgttaact gaggatcaaa gctagtggtg cagttcatgc tgcaaatggt catgtgtgta
     5401 gcctggtggg ggaggcacgt ttaggctgct gtgtaactgt ttcctgagcc gctgaggtcc
     5461 cctgctttct tcctttggtt cccggtgtct aacttgcctc ctggaaaata tttcttacta
     5521 agcattttct tggaacaatc attaaccatg atctttaata attactggca tttgtatttc
     5581 aaactgtgta ccggtgtccc tatctgacac tgattttcta aactttgaag atatttaagt
     5641 agaactttta aataaaagat gcaaaatgaa a
//
