LOCUS       NM_001098230            4233 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus pyruvate dehydrogenase phosphatase catalytic subunit 1
            (Pdp1), transcript variant 2, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001098230
VERSION     NM_001098230.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4233)
  AUTHORS   Liang,Z., Ralph-Epps,T., Schmidtke,M.W., Kumar,V. and
            Greenberg,M.L.
  TITLE     Decreased pyruvate dehydrogenase activity in Tafazzin-deficient
            cells is caused by dysregulation of pyruvate dehydrogenase
            phosphatase 1 (PDP1)
  JOURNAL   J Biol Chem 300 (3), 105697 (2024)
   PUBMED   38301889
  REMARK    GeneRIF: Decreased pyruvate dehydrogenase activity in
            Tafazzin-deficient cells is caused by dysregulation of pyruvate
            dehydrogenase phosphatase 1 (PDP1).
REFERENCE   2  (bases 1 to 4233)
  AUTHORS   Mishra,A., Tavasoli,M., Sokolenko,S., McMaster,C.R. and
            Pasumarthi,K.B.S.
  TITLE     Atrial natriuretic peptide signaling co-regulates lipid metabolism
            and ventricular conduction system gene expression in the embryonic
            heart
  JOURNAL   iScience 27 (1), 108748 (2023)
   PUBMED   38235330
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4233)
  AUTHORS   Heo,H.J., Kim,H.K., Youm,J.B., Cho,S.W., Song,I.S., Lee,S.Y.,
            Ko,T.H., Kim,N., Ko,K.S., Rhee,B.D. and Han,J.
  TITLE     Mitochondrial pyruvate dehydrogenase phosphatase 1 regulates the
            early differentiation of cardiomyocytes from mouse embryonic stem
            cells
  JOURNAL   Exp Mol Med 48 (8), e254 (2016)
   PUBMED   27538372
  REMARK    GeneRIF: Mitochondrial PDP1 is a potential regulator that controls
            cardiac differentiation at an early differentiation stage in mouse
            embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4233)
  AUTHORS   Lu,G., Sun,H., She,P., Youn,J.Y., Warburton,S., Ping,P.,
            Vondriska,T.M., Cai,H., Lynch,C.J. and Wang,Y.
  TITLE     Protein phosphatase 2Cm is a critical regulator of branched-chain
            amino acid catabolism in mice and cultured cells
  JOURNAL   J Clin Invest 119 (6), 1678-1687 (2009)
   PUBMED   19411760
  REMARK    GeneRIF: defects in PP2Cm may be responsible for a subset of human
            maple syrup urine disease
REFERENCE   5  (bases 1 to 4233)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY101287.1, BB611000.1, AK137550.1, AK133542.1 and BB077113.2.
            
            [WARNING] On Apr 26, 2024 this sequence was replaced by
            NM_001098230.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and the
            5' coding region and initiates translation at an alternate start
            codon, compared to variant 4. Variants 2 and 5 encode the same
            isoform (b), which has a shorter and distinct N-terminus, compared
            to isoform d.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.111313.1,
                                           SRR1660817.160318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               BY101287.1         5-153
            150-609             BB611000.1         123-582
            610-1911            AK137550.1         548-1849
            1912-4078           AK133542.1         1820-3986
            4079-4233           BB077113.2         516-670
FEATURES             Location/Qualifiers
     source          1..4233
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.48 cM"
     gene            1..4233
                     /gene="Pdp1"
                     /gene_synonym="Gm1024; Ppm2c"
                     /note="pyruvate dehydrogenase phosphatase catalytic
                     subunit 1"
                     /db_xref="GeneID:381511"
                     /db_xref="MGI:MGI:2685870"
     exon            1..149
                     /gene="Pdp1"
                     /gene_synonym="Gm1024; Ppm2c"
                     /inference="alignment:Splign:2.1.0"
     exon            150..184
                     /gene="Pdp1"
                     /gene_synonym="Gm1024; Ppm2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1845
                     /gene="Pdp1"
                     /gene_synonym="Gm1024; Ppm2c"
                     /EC_number="3.1.3.43"
                     /note="isoform b is encoded by transcript variant 2;
                     protein phosphatase 2C, magnesium dependent, catalytic
                     subunit; [Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 1, mitochondrial; PDP
                     1; PDPC 1; pyruvate dehydrogenase phosphatase isoenzyme 2;
                     pyruvate dehyrogenase phosphatase catalytic subunit 1"
                     /codon_start=1
                     /product="[Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 1, mitochondrial
                     isoform b"
                     /protein_id="NP_001091700.1"
                     /db_xref="CCDS:CCDS51121.1"
                     /db_xref="GeneID:381511"
                     /db_xref="MGI:MGI:2685870"
                     /translation="MCVCPGPRRIGIPVRTSSLPLFSDAMPAPTQLFFPLVRNCELSR
                     IYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQK
                     FYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQT
                     RGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWH
                     KHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEA
                     QVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVT
                     LSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKR
                     VIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMH
                     RQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLI
                     RHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ"
     exon            185..4233
                     /gene="Pdp1"
                     /gene_synonym="Gm1024; Ppm2c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdp1"
                     /gene_synonym="Gm1024; Ppm2c"
                     /note="hexamer: AATAAA"
     polyA_site      2611
                     /gene="Pdp1"
                     /gene_synonym="Gm1024; Ppm2c"
                     /note="major polyA site"
     regulatory      4060..4065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdp1"
                     /gene_synonym="Gm1024; Ppm2c"
                     /note="hexamer: ATTAAA"
     polyA_site      4085
                     /gene="Pdp1"
                     /gene_synonym="Gm1024; Ppm2c"
                     /note="major polyA site"
ORIGIN      
        1 gccgggcgag gcaggggcgc ggagtgggct ggcctgggcc gagctgcagc gcgccggggt
       61 gctgcgtggt gctgagtgag ggaaggacgc gcacggaggg gtgcggccgc cacccggggc
      121 agaccgcagc gggtgctcga ctgtgcccgg agaatgtgtg tgtgtcccgg gcccagacga
      181 attggaatcc cagtcagaac gtccagtctg ccactgttct ctgatgccat gccagcacca
      241 actcaactgt tttttcctct cgtccgtaac tgtgaactga gcagaatcta tggcactgca
      301 tgttactgcc accacaaaca tctctgctgt tcaccaccat acattcctca gaatcgtctg
      361 aggtacacac cccatcctgc atatgctacc ttttgtaggc cacgggagaa ctggtggcag
      421 tatactcaag gaaggagata cgcttctaca ccgcagaaat tttacctcac acctccacaa
      481 gtcaacagca tccttaaagc taatgaatac agcttcaaag taccagaatt tgatggcaaa
      541 aatgtcagtt ccattcttgg atttgacagc aatcagctgc ctgcaaatgc acccatagag
      601 gaccggagaa gtgcagcaac ctgcttgcag accagaggga tgctcttggg ggtttttgat
      661 ggtcatgcag gctgtgcttg ttcccaggca gtcagtgaaa gactcttcta ttatattgct
      721 gtttccttgt tgccccatga gactttgcta gagattgaaa atgcagtgga gagtggtcgg
      781 gcactgctac ctatccttca gtggcacaag caccccaatg attacttcag taaggaggcg
      841 tccaaattgt atttcaacag cttgaggact tactggcaag aactcataga cctcaatact
      901 ggagaatcag ctgatattga tgttaaggag gctttaatta atgctttcaa gagactcgat
      961 aatgacattt cattggaggc tcaagttggt gatcctaatt cttttctaaa ttacctggtg
     1021 cttcgggtag cattttctgg ggctactgct tgtgtggccc atgtagatgg tgttgacctc
     1081 catgtggcta acactggtga tagtagagcc atgctaggtg tgcaagaaga agatggctct
     1141 tggtcagcag tcacactctc taatgaccac aatgctcaga atgaaagaga actagagcgt
     1201 ctgaaactgg aacacccaaa aaatgaggcc aagagcgtgg taaagcagga ccggctgctt
     1261 ggcttgctga tgccctttag ggcttttgga gatgtaaagt tcaaatggag cattgacctt
     1321 caaaagagag tgatagagtc tggcccagac cagttgaatg acaatgaata caccaagttt
     1381 atccctccta actatcatac acctccttat cttactgctg agccagaggt aacttatcac
     1441 agattaaggc cacaggataa attcctagtg ttagcaactg atgggttgtg ggagactatg
     1501 catagacagg atgtggttag gattgtgggt gaatacttaa ctggtatgca tcaccaacag
     1561 ccaatagcag ttggtgggta caaggtgact ctgggacaga tgcatggcct tttaacagaa
     1621 aggagagcaa agatgtcatc agtgtttgag gatcagaatg cagcaaccca tctcattcgc
     1681 catgctgtag gcaataatga atttggggct gttgatcatg aacgactctc taaaatgctt
     1741 agtcttcctg aagagcttgc tcggatgtat agagatgaca ttacaatcat tgtagttcag
     1801 ttcaattctc atgttgtagg ggcataccaa aaccaggaac agtaagtgaa attaccctgg
     1861 cagttcttca gttggaaggg cagatcgatg tttgaaagaa actaatatag ttaattttcc
     1921 aatggttcat tctaaacact tcatgtttga tactctagct agcccagtat tcatattgac
     1981 tatgcagcag atgatagctt catgagtgtc tgttctgtcc tgttggacct catggtaccc
     2041 acacttgagg cagcttgttt ccttacccag gtgtcttgta acagtgactc accaactgaa
     2101 gagtatgaag ataggcagat atgatcttga ataggtcaaa aacaaggatc ttcctggggg
     2161 tattagtaaa ggcaaaacaa acccattacc atgtccattt gcagacttct gccattataa
     2221 ggcttctagt gtacacaaga atatttactt actgcatttt tttaaaaaga taaacagttc
     2281 aggtaatcac atacatttat tttaacctaa agtgcaggtc tagtacttta agccataaat
     2341 gaccatgaac aaagaaatct ggatttgtaa gtttttgtga ttgtgtgata aaatatgctt
     2401 cctaaaagga aaaatcctaa actgttcttc ctcacccatg atttcctcag tgtaacagta
     2461 atattttgtt ttgctacacc taaaagacaa taaaggttct taggtttaat ttttcctagt
     2521 gaatgttaaa taaagggaaa atgtgttttt ctggtttgta ttcatggaaa cctctattta
     2581 gtttgaaata aagatacacg cagaatgaaa agagactgct atgtttaatt cttatcatct
     2641 atagttatca gcatgtcact gttctgtgtc ccccaaatct tggcaagcta gatgtgtgct
     2701 gagtaagcaa actgctgctg agaaattata cttatttatc ataggaattt ttatgaattt
     2761 tggagtttta agaacaacat gtaataagtt taagtatcaa tttgagtagt aagattttaa
     2821 tattgtatta tgacagtttg aggaaatttt ttgtttttcc ccacttaggc caattaaaac
     2881 aattggatct atattattaa atgctttaaa catactatag cttataatat atatgttaat
     2941 atatacacga gaaactttaa atcgtaacct gtgcatgcct ggtacagaac acttagtagc
     3001 atcaagtatt tgcagctgtg tctctaatta tatgcagtcc tttctaatac tgtcttaaag
     3061 taaatgaaaa taagtatatt cacataggct ttttaggagt tcatttgata tgcatcaaat
     3121 gatacttttg tttttacatt taatgctgat ctgtgtatag ctatgcatat attttcatca
     3181 attctaagaa aaagctatga ctttgtttaa aattcacgta gatttttata taaaacatga
     3241 ttagtttctg ttatataatt agttgacaat ataggggtcc atttggaatt ttgtagaatc
     3301 tgaactgtgt gttcaaggac tttggattgt gaatcctaaa tcaatatata gaagtattgg
     3361 ctgcaaaatt aggtccaaat gaaagtagac tcaggaagat tgcagctcag aacaggatag
     3421 aatttgtttt ctaaagtact ttttgttttt tgggtttttt tttttttttt gaagtcaact
     3481 tttaaaatac cacttacttc taaatgtctt cagagacact agagtctgaa accccatttt
     3541 tagtactgtt tggaatcgca ccaccatacc aaacatacca ccgtaggaga gttctgtgtt
     3601 atgtgctgac taacgtctca ttgcagtgta atacagagaa tatatatttt gcttcctata
     3661 cttgtgaaaa gacagtaatc ctcattagcc aagaagtttt atctacagtc tggaagccag
     3721 cctatgtgga tagaaatgta aatgcaatgt agaaaagatc aaaatagctg gatattcaca
     3781 agtttttaga tactgttatt taaaagcagt tgtgatttta ttgtgatttg tcatattcat
     3841 gacatgttta gaagtaaagt cagcttatgt aaattttcat gaaacttagt ctttcttaat
     3901 cttgttttat ttagactttc ttacatgtat tcaatttctg tatttatatt tagtcagtgc
     3961 ttcatgttac atgtactatg tcctgagcta gttaaaaagg aatggtggta tgatacttgg
     4021 tttgaatgct gtctatggtt agagaaacgc ccacggtgaa ttaaagcttt atacctgctt
     4081 tctgagatgc ctgtgtgggt ttttaaaaat agtagcattc actgtatgcc ttctatggga
     4141 ggttgtgttt aactttagga gccaataaat gaatagcatt ttagtcatta aagtcaagtt
     4201 ataatttcaa taaaattaaa aggctttaca tct
//
