LOCUS       NM_001114088            2626 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus PDZ and LIM domain 7 (Pdlim7), transcript variant a,
            mRNA.
ACCESSION   NM_001114088
VERSION     NM_001114088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2626)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2626)
  AUTHORS   Falahati,H., Wu,Y., Feuerer,V., Simon,H.G. and De Camilli,P.
  TITLE     Proximity proteomics of synaptopodin provides insight into the
            molecular composition of the spine apparatus of dendritic spines
  JOURNAL   Proc Natl Acad Sci U S A 119 (42), e2203750119 (2022)
   PUBMED   36215465
REFERENCE   3  (bases 1 to 2626)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2626)
  AUTHORS   Jodo,A., Shibazaki,A., Onuma,A., Kaisho,T. and Tanaka,T.
  TITLE     PDLIM7 Synergizes With PDLIM2 and p62/Sqstm1 to Inhibit
            Inflammatory Signaling by Promoting Degradation of the p65 Subunit
            of NF-kappaB
  JOURNAL   Front Immunol 11, 1559 (2020)
   PUBMED   32849529
  REMARK    GeneRIF: PDLIM7 Synergizes With PDLIM2 and p62/Sqstm1 to Inhibit
            Inflammatory Signaling by Promoting Degradation of the p65 Subunit
            of NF-kappaB.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2626)
  AUTHORS   Brinegar,A.E., Xia,Z., Loehr,J.A., Li,W., Rodney,G.G. and
            Cooper,T.A.
  TITLE     Extensive alternative splicing transitions during postnatal
            skeletal muscle development are required for calcium handling
            functions
  JOURNAL   Elife 6, e27192 (2017)
   PUBMED   28826478
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2626)
  AUTHORS   Jung,C.R., Lim,J.H., Choi,Y., Kim,D.G., Kang,K.J., Noh,S.M. and
            Im,D.S.
  TITLE     Enigma negatively regulates p53 through MDM2 and promotes tumor
            cell survival in mice
  JOURNAL   J Clin Invest 120 (12), 4493-4506 (2010)
   PUBMED   21060154
  REMARK    GeneRIF: the LIM domain protein Enigma directly interacts with MDM2
            to form a ternary complex with p53 in embryonic fibroblasts
REFERENCE   7  (bases 1 to 2626)
  AUTHORS   Fang,P., Wang,X., Zhang,L., Yuan,G., Chen,Z. and Zhang,Q.
  TITLE     Immunohistochemical localization of LIM mineralization protein 1
            during mouse molar development
  JOURNAL   J Mol Histol 41 (4-5), 199-203 (2010)
   PUBMED   20706776
  REMARK    GeneRIF: LMP-1 showed spatiotemporal expression patterns during
            molar development.[LMP-1]
REFERENCE   8  (bases 1 to 2626)
  AUTHORS   Barres,R., Gonzalez,T., Le Marchand-Brustel,Y. and Tanti,J.F.
  TITLE     The interaction between the adaptor protein APS and Enigma is
            involved in actin organisation
  JOURNAL   Exp Cell Res 308 (2), 334-344 (2005)
   PUBMED   15946664
REFERENCE   9  (bases 1 to 2626)
  AUTHORS   Guy,P.M., Kenny,D.A. and Gill,G.N.
  TITLE     The PDZ domain of the LIM protein enigma binds to beta-tropomyosin
  JOURNAL   Mol Biol Cell 10 (6), 1973-1984 (1999)
   PUBMED   10359609
REFERENCE   10 (bases 1 to 2626)
  AUTHORS   Boden,S.D., Liu,Y., Hair,G.A., Helms,J.A., Hu,D., Racine,M.,
            Nanes,M.S. and Titus,L.
  TITLE     LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone
            formation
  JOURNAL   Endocrinology 139 (12), 5125-5134 (1998)
   PUBMED   9832452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY262003.1, AK167476.1 and CT009762.8.
            
            On Sep 27, 2013 this sequence version replaced NM_001114088.1.
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4827178.1, AK167476.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY262003.1         178-185
            9-1583              AK167476.1         1-1575
            1584-2626           CT009762.8         34261-35303
FEATURES             Location/Qualifiers
     source          1..2626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..2626
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /note="PDZ and LIM domain 7"
                     /db_xref="GeneID:67399"
                     /db_xref="MGI:MGI:1914649"
     exon            1..80
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            81..187
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1465
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /note="isoform a is encoded by transcript variant a;
                     protein enigma; LIM mineralization protein"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 7 isoform a"
                     /protein_id="NP_001107560.1"
                     /db_xref="CCDS:CCDS49275.1"
                     /db_xref="GeneID:67399"
                     /db_xref="MGI:MGI:1914649"
                     /translation="MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGV
                     AVGDWVLNIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKALTPPADPP
                     RYTFAPSASLNKTARPFGAPPPTDSTLRQNGQLLRQPVPDASKQRLMEDTEDWRPRPG
                     TGQSRSFRILAHLTGTEFMQDPDEEFMKKSSQVPRTEAPAPASTIPQESWPGPTTPSP
                     TSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQNRTSIVQAAAGGGTGGGSNN
                     GKTPVCHQCHKIIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPSCYD
                     VRYAPNCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGAPYCERDY
                     EKMFGTKCRGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDKPLCK
                     SHAFSHV"
     exon            188..339
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            340..370
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            371..489
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            490..626
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            627..663
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            664..725
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            726..960
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1141
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1262
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1378
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..2626
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1678..1683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /note="hexamer: AATAAA"
     polyA_site      1699
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /note="major polyA site"
     regulatory      2604..2609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
                     /note="hexamer: ATTAAA"
     polyA_site      2626
                     /gene="Pdlim7"
                     /gene_synonym="LMP"
ORIGIN      
        1 ggaggcgggg tcagagcgca gcggcggatc ccatcgctgc tcccggaggc tgccaggcag
       61 cggcccaggc gggcactcag gagcaggcac gatggattcc ttcaaggtgg tgctggaagg
      121 gccagcccct tggggcttcc gtctgcaagg gggcaaggac ttcaatgtgc ccctctctat
      181 ctctcggctc acgcccggag gcaaagctgc acaggccggt gtggctgtgg gagactgggt
      241 actgaatatt gacggtgaga acgcgggcag cctcacgcac atcgaagccc agaacaagat
      301 ccgcgcctgt ggggagcgcc tcagcctggg tcttagcaga gcccagcctg ttcagagcaa
      361 accacagaag gccctgaccc ctcccgccga ccccccgagg tacacttttg caccaagcgc
      421 ctccctcaac aagacggccc ggcccttcgg ggcaccccca cctactgaca gcaccctgcg
      481 gcagaatgga cagttgctca gacagccggt ccccgatgcc agcaagcagc ggctgatgga
      541 ggataccgaa gactggcggc cgcggccggg gacaggccag tcccgctcct tccgcatcct
      601 tgcccacctc acgggcacag agttcatgca agacccggat gaggaattca tgaagaagtc
      661 aagccaggtg cccaggacag aagccccagc cccagcctca actatacccc aggaatcctg
      721 gcctggcccc accactccca gccccaccag ccgcccaccc tgggctgtgg atcctgcatt
      781 tgctgagcgc tatgccccag acaaaaccag cacagtgctg acccggcaca gccagccagc
      841 cacacccacg cctctgcaga accgcacctc catagtgcag gccgcagctg gagggggcac
      901 aggagggggc agcaacaacg gcaagactcc tgtatgccac cagtgccaca agatcatccg
      961 cggccgctac ctggtagcac tgggccacgc ataccatccc gaggagtttg tgtgcagcca
     1021 gtgtggaaag gtcctggaag agggtggctt cttcgaggag aagggagcta tcttttgccc
     1081 ctcctgctat gatgtgcgct atgcacccaa ctgtgccaaa tgcaagaaga agatcactgg
     1141 agagatcatg catgctctga agatgacctg gcacgtccat tgcttcacct gtgctgcctg
     1201 caaaacgcca attcgcaaca gagcctttta catggaagaa ggggccccct actgcgagcg
     1261 agactatgag aagatgtttg gcacaaaatg tcgaggctgt gacttcaaga ttgatgctgg
     1321 agaccgcttc ctggaagcgc tgggcttcag ctggcatgac acatgctttg tttgcgcaat
     1381 atgtcagatc aacttggaag gaaagacctt ctactccaag aaggacaagc ccctctgcaa
     1441 gagccacgcc ttctctcacg tatgagtacc tcacgagatt gccaccctac tccgccgaaa
     1501 gggtggaaaa ctagagagat caccctcgac ctgcctgggt agggctggca gtagctgtcc
     1561 cagcctcagc tcctggcccg gtcctggggt tccctcttca cagtccccgt tcccacactt
     1621 cctccaccat cactcactca ctggtgctgg cctagcccca gttcactctg gtgccacaat
     1681 aaacctgtat ctagctgtgt gctctgtgcc tccccgcttt gcatccggaa tggtgggact
     1741 tgagacagga ggaggatgag ggttaagatg gtgcttgggg ccgagccttt tcatcctcct
     1801 ggggatgtgg aagctgcagg atccctgaga tgaagtgcag tgtggagcct gtgtcctggg
     1861 cttactgctg cccacagatg tgaaggcagc cactggtggg agttaggggt ggaggtggga
     1921 tgtggctgcc aggtgagaca cggcatcatc tgtgcggcat ctgccttcca ccatccacac
     1981 ctagagaact agaacggagg gaagatcaag ctgggaggga gggagcctgg agtgctaggc
     2041 tcaagcccta gatggggatc tgcaatgtcc ctgggacagt gtggacacag agaggtgccc
     2101 aggaaaggca gtgttggaga gaggacccag ggacgagccc cagcatcctt tgacaatgtt
     2161 gctaggtatc ttattacaaa ccagaggctg cctactcgtc ctactcatgc catgttccca
     2221 tccacctcgc caggtggctg cgagtctttt tttttttttt ttaagaggta tttttatgta
     2281 tgagtgtttt gcccatatgc atgtatgtat gtacaccatt tgcatacttg gtgcccatgg
     2341 agggtaggag accatcgtcg tcgtcattag agtctctgga gctctagatt gttgtgagcc
     2401 accgtggtgg agtccagacc tcagacctct gcaagggcaa gggcaagggc tcttgagctc
     2461 tgagccttct tgccagctgt ttgttgtttg tttttgagac agggtgtctc tctgtagtcc
     2521 tggctgtcct agggctcagt ctgtagacta agatggcctc cagctccctg agacccccct
     2581 gcctctccct ttggagtact gagattaaag gcctgcagca caccga
//
