LOCUS       NM_019808               5039 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus PDZ and LIM domain 5 (Pdlim5), transcript variant 1,
            mRNA.
ACCESSION   NM_019808
VERSION     NM_019808.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5039)
  AUTHORS   Gan,P., Wang,Z., Morales,M.G., Zhang,Y., Bassel-Duby,R., Liu,N. and
            Olson,E.N.
  TITLE     RBPMS is an RNA-binding protein that mediates cardiomyocyte
            binucleation and cardiovascular development
  JOURNAL   Dev Cell 57 (8), 959-973 (2022)
   PUBMED   35472321
REFERENCE   2  (bases 1 to 5039)
  AUTHORS   Shi,Y., Wang,X., Xu,Z., He,Y., Guo,C., He,L., Huan,C., Cai,C.,
            Huang,J., Zhang,J., Li,Y., Zeng,C., Zhang,X., Wang,L., Ke,Y. and
            Cheng,H.
  TITLE     PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes
            the migration and invasion of lung cancer cells
  JOURNAL   J Biol Chem 295 (40), 13798-13811 (2020)
   PUBMED   32737199
REFERENCE   3  (bases 1 to 5039)
  AUTHORS   Huang,J., Cai,C., Zheng,T., Wu,X., Wang,D., Zhang,K., Xu,B.,
            Yan,R., Gong,H., Zhang,J., Shi,Y., Xu,Z., Zhang,X., Zhang,X.,
            Shang,T., Zhou,J., Guo,X., Zeng,C., Lai,E.Y., Xiao,C., Chen,J.,
            Wan,S., Liu,W.H., Ke,Y. and Cheng,H.
  TITLE     Endothelial Scaffolding Protein ENH (Enigma Homolog Protein)
            Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat
            Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS
            (Endothelial NO Synthase) Promoting Vascular Remodeling
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (7), 1705-1721 (2020)
   PUBMED   32268790
  REMARK    GeneRIF: Endothelial Scaffolding Protein ENH (Enigma Homolog
            Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and
            Leucine-Rich Repeat Protein Phosphatase 2)-Mediated
            Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase)
            Promoting Vascular Remodeling.
REFERENCE   4  (bases 1 to 5039)
  AUTHORS   Qiu,H., Liu,N., Luo,L., Zhong,J., Tang,Z., Kang,K., Qu,J., Peng,W.,
            Liu,L., Li,L. and Gou,D.
  TITLE     MicroRNA-17-92 regulates myoblast proliferation and differentiation
            by targeting the ENH1/Id1 signaling axis
  JOURNAL   Cell Death Differ 23 (10), 1658-1669 (2016)
   PUBMED   27315298
  REMARK    GeneRIF: These results reveal a E2F1/miR-17-92/ENH1/Id1 regulatory
            axis during myogenesis.
REFERENCE   5  (bases 1 to 5039)
  AUTHORS   Cheng,H., Kimura,K., Peter,A.K., Cui,L., Ouyang,K., Shen,T.,
            Liu,Y., Gu,Y., Dalton,N.D., Evans,S.M., Knowlton,K.U.,
            Peterson,K.L. and Chen,J.
  TITLE     Loss of enigma homolog protein results in dilated cardiomyopathy
  JOURNAL   Circ Res 107 (3), 348-356 (2010)
   PUBMED   20538684
  REMARK    GeneRIF: Deletion of ENH leads to destabilization of this protein
            complex and dilated cardiomyopathy in mice.
REFERENCE   6  (bases 1 to 5039)
  AUTHORS   Yamazaki,T., Walchli,S., Fujita,T., Ryser,S., Hoshijima,M.,
            Schlegel,W., Kuroda,S. and Maturana,A.D.
  TITLE     Splice variants of enigma homolog, differentially expressed during
            heart development, promote or prevent hypertrophy
  JOURNAL   Cardiovasc Res 86 (3), 374-382 (2010)
   PUBMED   20097676
  REMARK    GeneRIF: Antagonistic splice variants of enigma may play a central
            role in the adaptive changes of the link between mechanical
            stress-sensing and signalling occurring during embryonic
            development and/or heart hypertrophy.
REFERENCE   7  (bases 1 to 5039)
  AUTHORS   Barres,R., Gonzalez,T., Le Marchand-Brustel,Y. and Tanti,J.F.
  TITLE     The interaction between the adaptor protein APS and Enigma is
            involved in actin organisation
  JOURNAL   Exp Cell Res 308 (2), 334-344 (2005)
   PUBMED   15946664
  REMARK    GeneRIF: These results identify Enigma as a novel APS-binding
            protein and suggest that the APS/Enigma complex plays a critical
            role in actin cytoskeleton organisation.
REFERENCE   8  (bases 1 to 5039)
  AUTHORS   Niederlander,N., Fayein,N.A., Auffray,C. and Pomies,P.
  TITLE     Characterization of a new human isoform of the enigma homolog
            family specifically expressed in skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 325 (4), 1304-1311 (2004)
   PUBMED   15555569
  REMARK    GeneRIF: Western blot studies of muscle tissues revealed that ENH4
            is present only in skeletal muscle and there is a specific
            distribution of ENH members between skeletal and cardiac muscles,
            which is different in human and mouse.
REFERENCE   9  (bases 1 to 5039)
  AUTHORS   Norman,B., Davis,J. and Piatigorsky,J.
  TITLE     Postnatal gene expression in the normal mouse cornea by SAGE
  JOURNAL   Invest Ophthalmol Vis Sci 45 (2), 429-440 (2004)
   PUBMED   14744882
REFERENCE   10 (bases 1 to 5039)
  AUTHORS   Nakagawa,N., Hoshijima,M., Oyasu,M., Saito,N., Tanizawa,K. and
            Kuroda,S.
  TITLE     ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific
            protein, associates with cytoskeletal proteins through the PDZ
            domain
  JOURNAL   Biochem Biophys Res Commun 272 (2), 505-512 (2000)
   PUBMED   10833443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158581.2, BY227455.1, AK147999.1, AC139128.6 and DV551664.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_019808.4.
            
            On Jul 2, 2010 this sequence version replaced NM_019808.2.
            
            Transcript Variant: This variant (1) uses a different splice site
            and lacks alternate segments, compared to variant 4. The resulting
            protein (isoform ENH1) is shorter when it is compared to isoform
            ENH1e. This isoform has also been called ENH1/1a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089779.1, AK147999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC158581.2         84187-84216         c
            31-401              BY227455.1         2-372
            402-3245            AK147999.1         342-3185
            3246-4648           AC139128.6         127267-128669
            4649-5039           DV551664.1         1-391
FEATURES             Location/Qualifiers
     source          1..5039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.69 cM"
     gene            1..5039
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /note="PDZ and LIM domain 5"
                     /db_xref="GeneID:56376"
                     /db_xref="MGI:MGI:1927489"
     exon            1..111
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            112..249
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1929
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /note="isoform ENH1 is encoded by transcript variant 1;
                     PDZ and LIM domain protein 5; enigma homolog; enigma-like
                     PDZ and LIM domains protein"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 5 isoform ENH1"
                     /protein_id="NP_062782.2"
                     /db_xref="CCDS:CCDS17875.1"
                     /db_xref="GeneID:56376"
                     /db_xref="MGI:MGI:1927489"
                     /translation="MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKASQAHV
                     RIGDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASAAAKSEPVSVQKGEPKE
                     VVKPVPITSPAVSKVTSTTNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHAATSSH
                     ASPTPVAAATPLHLSASGLHVSANLSADQCSSPPNTGKPAVNVPRQPTVTSVCSESAQ
                     ELAEGQRRGSQGDIKQQNGPPRKHIVERNTEFYHIPTHSDASKKRLIEDTEDWRPRTG
                     TTQSRSFRILAQITGTEHLTESENDNTKKANSTQEPSQQPASSGASPLSASEGPESPG
                     SSRPSVAGLRSAAAFKPVGSTSVKSPSWQRPNQAAPSTGRISNNARSSGTGASVGPPQ
                     PSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAY
                     IGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIR
                     NNVFHLEDGEPYCETDYYALFGTICRGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCE
                     SLEGQTFFSKKDKPLCKKHAHSVNF"
     exon            250..401
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            402..444
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            445..863
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1036
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1073
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1258
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1421
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1602
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1723
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1839
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..5024
                     /gene="Pdlim5"
                     /gene_synonym="1110001A05Rik; Enh; Enh1; Enh2; Enh3; LIM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagcgcg gaggcggaag ttccccaccg gcttgagagg gacggcgcag gcaccgcgag
       61 ccacttgtca gcgctggtct gaggcggagg gtgcgccgcg ccggtcagga gtttctttca
      121 ttttctagaa ctgcacgttg aaccctggga accatgagca actacagtgt gtcattggtc
      181 ggcccagctc cttggggttt ccggctccaa ggtggcaagg atttcaacat gcctctgaca
      241 atctctagtc tgaaggatgg tggcaaggca tctcaggcac atgtcagaat aggggacgtg
      301 gttctcagca tcgatgggat cagtgcacag ggaatgacgc atcttgaagc ccagaacaag
      361 attaaggctt gtacgggctc cttgaatatg actctacaaa gagcttcagc tgcagccaag
      421 agtgagccgg tttccgtcca gaagggtgaa cctaaggaag tagttaagcc tgtgcccatt
      481 acatctcctg ctgtatccaa agtcacttcc actaccaaca tggcctacaa taaagcacca
      541 cggccctttg gttctgtgtc ttcaccaaaa gtcacatcca tcccatcacc atcgtctgcg
      601 ttcaccccag cccatgccgc cacttcatca catgcttccc ccacacctgt ggccgctgcc
      661 actcccctcc acctctctgc atccggactg catgttagtg ccaatcttag tgctgaccag
      721 tgttcatctc caccgaacac tggtaaacct gcagttaatg tcccacggca gcccacagtc
      781 accagcgtgt gttccgagtc tgctcaggag ctagcagagg gacagagaag aggatcccag
      841 ggtgacatta agcagcaaaa tggcccacca agaaaacaca ttgtggagcg caacacggag
      901 ttttatcaca tacccactca cagtgatgcc agcaagaaac ggctgattga ggacactgag
      961 gactggcgcc cccggactgg aacgactcag tctcgttctt tccggatcct tgcccagatc
     1021 actgggactg agcatctgac agaatctgaa aatgacaata cgaagaaggc aaatagcacc
     1081 caggagcctt ctcagcaacc ggcgtcatct ggagcttcac ctctgagcgc gtctgagggc
     1141 cccgagagcc caggttccag caggccctcg gtggctggcc tccgctccgc tgctgctttc
     1201 aagcctgtag gatccaccag cgtcaagtca cctagctggc agcgtccaaa ccaagcagca
     1261 ccttctactg ggagaatttc aaacaatgca cgttcttcag gtacaggggc gtctgtgggg
     1321 cctccccagc caagtgacca agacacactt gtgcagagag cggaacacat tccagcgggc
     1381 aagcggaccc ccatgtgtgc ccactgcaac caagttatca ggggaccttt tcttgtggct
     1441 ctggggaagt cctggcatcc agaagaattt aactgtgctc attgcaaaaa cacaatggcc
     1501 tacataggct ttgtagagga gaagggagca ctgtactgtg agctatgcta tgagaagttc
     1561 tttgctcctg aatgtggccg gtgccaaagg aagatccttg gagaagtcat caatgctttg
     1621 aagcagacct ggcatgtgtc ctgttttgtg tgtgtggcct gtggaaaacc cattcgtaat
     1681 aatgttttcc acttggaaga tggcgagccc tactgtgaga cagactacta cgcccttttt
     1741 ggaacaatat gtcgtggatg tgaattcccc atagaggctg gtgacatgtt cctggaagct
     1801 ctgggataca cttggcatga tacttgcttt gtgtgctctg tgtgttgtga aagtttggaa
     1861 gggcagacat ttttctccaa gaaggacaag ccactttgca aaaaacatgc tcattctgtg
     1921 aatttttgaa aatcagtggt tccaggaaag agaagaaatt tgaagaaaaa gcaaaatcaa
     1981 aattaccatt taatttttag tttaatattt atatggagtt ctcaaatagt aatagccctg
     2041 aaggcacaga ctccaacttt aaaaatcaaa tctgagaaaa cgtttggttt agaaagccac
     2101 agacagtttg gcatttgtta tgaattgcca gtattttctg cacatgaaat agcttttata
     2161 aaaatcaatt tcctggctat taagttcatc ttagaataaa ttagcaaagt attacatttt
     2221 agaattaaaa tccctagcct ctatgctgaa ataatacttt gtggggcggg tagtagctat
     2281 gagaatccac agaaggcaat aaaagtgcct taaaccttat taataagaat aattgtttaa
     2341 taaaaccatt ttatctttaa aatagtaagt agaaatctaa ataaatttta tgagtaggca
     2401 gtaacttttc tgtttagtga gtgtacttgc tttgctctta tcattggtct tacctttcag
     2461 taagatgggc catggaaatt cttgatcaaa gtgtgtcgtg ccagtaagag attgttgtga
     2521 tctcttctga tgttctccca gatgctggcc gccttcagat ggggcagttt gtttgtgttg
     2581 tgtatggctg cctggtccag accgccatgc ttttcatctc ttatgctgac atgaagatat
     2641 ttcaatagcg ttagactcta atagttttgt ctccttttta gaaaagagta ggtggaagat
     2701 aaaggaatta tggaaataaa gtcattgtaa gtagaaagtt aaaaggacca cttcccactt
     2761 tcagataatg aactgactga tttttacatc ttatgtctct aactgaaggt tcaaaacctc
     2821 cttgcccggt tcttggttct tttttctttt tggttcgttt tagattgagg attatgataa
     2881 gagccaactg tatattgtta ctgtgttttt gcttatttgg agttgtttgg gggattttgt
     2941 ttcttgtttt ttgtttggga ttcttttcta tcagtaagta aatcccctcc agctgtgtga
     3001 tcgctgactt agacaacttt gggtctcggg cctttggtag taagggagaa ccatgatgca
     3061 gctctcccat gctcccgtca tctgttcgtc ctgagagagc acagcatcat gcaggcaccg
     3121 cctgtagtca ggaaagtgac tttgagacag ccgtgtagtt tgcctcacta cctagggaga
     3181 aaagaaatga tggcgtttcg tgttttcttc gtttctataa tgaataaaag cgtgtgatcc
     3241 tgctgagtta cagcttaaat ctgtggggac aaggtgcttt caaattccag atagagttcc
     3301 caggttcctg ctgccccatc acccaagtgt acttgtgcat cgtgtgtgtg tgtgtgtgtg
     3361 tgtgtgtgtg tgcgcgtgtg cctgttaaaa aagacgtctt agactacagt atttgtttaa
     3421 cctccctaag aactttcaag gcatctgtcc tgaaagctgc taatctatgg tctagtgaat
     3481 ttatattata tgcagatagt aatgaactgg gagatcaatg aacagcaagg gtgataccac
     3541 attgcaaaat ggaagcttct ccagtagcgg cccaggttgc ctcctcacct gtgcttgtag
     3601 ggaggcagga aatgtcttca gaagtcaatg ctggggcttt gtccgttagg tctttgtgct
     3661 gctgcagtga tcagtatcag acttgataac tcatgttatc aagttagtta tagtgttatt
     3721 tcagatctga atgtcaggct ttggcttatg cgacaaaata agttggggtt ttgttttgat
     3781 gtggtagttt tgttttgtct tttagatgat gtacaaagat aatatttgaa aactcattgg
     3841 catttgcata ctcaaaggct tttctttgag ttggagttct tataaaattt tcttttacca
     3901 aggatatcaa ttttattaag cctttacttc tatgtgttat ttgtagagta taacgctgca
     3961 ttctataatg ctggatttct ctaaatttaa tctgtaaaag ctagtgtggc ttggtaattt
     4021 ggcattgtgt ctgtattctt tgcctgtttt atggcaagtt gtatatccat acctaaaaca
     4081 gtgacctctg ggaggtgagt tctaaccata gccagaagct ctgtctgcag tggggattgc
     4141 tatgttttgt ttaccagcat gggtctgtag atacctggca ctttaccctt ctggcgagct
     4201 ccctgggtat ttattagaag tcttctgtgt cggtagcatt gttttttcac tagtaagttt
     4261 tcaccataga accccgagct ttcctcctgc tagatgtatg tttagaaggc tgcactcgat
     4321 aaagcccaga tggaaaccat agtgcatgac tttaagtccc tcctccaatt tctcattgtt
     4381 caggcttgga tggtcctaca ttgatactgt ctctctaatt gttcggtctg actgctgcct
     4441 gttgaagtag taaagtgttt ctcttccttg tgattccatg ttttccaggg gtcaggttac
     4501 cttccccatg taaaaccaaa gcctaattct ttggccatcg tattaaagca aaagtaacca
     4561 tttgtttaca agagatttgt aaacaaaatc ctttgaatat tgatataaaa ctatgtttta
     4621 aattatctac agcaaaatgt actctttcca aggaactcga ggttagaggc acttccacgg
     4681 aaaagtgatt cccgcagtgc aagttcagtg gaacattaat gcttttgtgc atgtgcagct
     4741 cagtcatctc cattggagca gaggcaactc acacaaatgt acccttactc cagtctgtcc
     4801 ctcacctcca ttgtctaagg tattggactt agatgcttat gtgtaatatg ttgaacctgt
     4861 cagttgctgt ctttttcctt cttcgcattt taaagtttgt gtatagctgc tcttttgctt
     4921 ttggatatat ttttaattaa aaaaatcaca tgagaaatgt aatctgtata gtgatacttt
     4981 aataagcaca tactcaataa acaactgcaa tgatgtcgac agcaaaaaaa aaaaaaaaa
//
