LOCUS       NM_019417               1189 bp    mRNA    linear   ROD 12-SEP-2023
DEFINITION  Mus musculus PDZ and LIM domain 4 (Pdlim4), mRNA.
ACCESSION   NM_019417
VERSION     NM_019417.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1189)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1189)
  AUTHORS   Ulmke PA, Sakib MS, Ditte P, Sokpor G, Kerimoglu C, Pham L, Xie Y,
            Mao X, Rosenbusch J, Teichmann U, Nguyen HP, Fischer A, Eichele G,
            Staiger JF and Tuoc T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   3  (bases 1 to 1189)
  AUTHORS   Yoo JY, Jung NC, Lee JH, Choi SY, Choi HJ, Park SY, Jang JS, Byun
            SH, Hwang SU, Noh KE, Park Y, Lee J, Song JY, Seo HG, Lee HS and
            Lim DS.
  TITLE     Pdlim4 is essential for CCR7-JNK-mediated dendritic cell migration
            and F-actin-related dendrite formation
  JOURNAL   FASEB J 33 (10), 11035-11044 (2019)
   PUBMED   31287961
  REMARK    GeneRIF: Pdlim4 is required for dendritic cell migration via
            CCR7-JNK, dendrite formation, and subsequent development of
            functional T-cell responses.
REFERENCE   4  (bases 1 to 1189)
  AUTHORS   Fu C, Li Q, Zou J, Xing C, Luo M, Yin B, Chu J, Yu J, Liu X, Wang
            HY and Wang RF.
  TITLE     JMJD3 regulates CD4 T cell trafficking by targeting actin
            cytoskeleton regulatory gene Pdlim4
  JOURNAL   J Clin Invest 129 (11), 4745-4757 (2019)
   PUBMED   31393857
  REMARK    GeneRIF: findings have identified Pdlim4 as a JMJD3 target gene
            that affects T-cell trafficking by cooperating with S1P1, and
            provided insights into the molecular mechanisms by which JMJD3
            regulates genes involved in T cell trafficking.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1189)
  AUTHORS   Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S,
            Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ,
            Jones AR, Amaral DG, Sestan N, Gage FH and Lein ES.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 1189)
  AUTHORS   Vallenius T, Scharm B, Vesikansa A, Luukko K, Schafer R and Makela
            TP.
  TITLE     The PDZ-LIM protein RIL modulates actin stress fiber turnover and
            enhances the association of alpha-actinin with F-actin
  JOURNAL   Exp Cell Res 293 (1), 117-128 (2004)
   PUBMED   14729062
REFERENCE   7  (bases 1 to 1189)
  AUTHORS   Cuppen E, van Ham M, Wansink DG, de Leeuw A, Wieringa B and
            Hendriks W.
  TITLE     The zyxin-related protein TRIP6 interacts with PDZ motifs in the
            adaptor protein RIL and the protein tyrosine phosphatase PTP-BL
  JOURNAL   Eur J Cell Biol 79 (4), 283-293 (2000)
   PUBMED   10826496
REFERENCE   8  (bases 1 to 1189)
  AUTHORS   Zhu Y, Jong MC, Frazer KA, Gong E, Krauss RM, Cheng JF, Boffelli D
            and Rubin EM.
  TITLE     Genomic interval engineering of mice identifies a novel modulator
            of triglyceride production
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1137-1142 (2000)
   PUBMED   10655497
REFERENCE   9  (bases 1 to 1189)
  AUTHORS   Cuppen E, Gerrits H, Pepers B, Wieringa B and Hendriks W.
  TITLE     PDZ motifs in PTP-BL and RIL bind to internal protein segments in
            the LIM domain protein RIL
  JOURNAL   Mol Biol Cell 9 (3), 671-683 (1998)
   PUBMED   9487134
REFERENCE   10 (bases 1 to 1189)
  AUTHORS   Kiess M, Scharm B, Aguzzi A, Hajnal A, Klemenz R, Schwarte-Waldhoff
            I and Schafer R.
  TITLE     Expression of ril, a novel LIM domain gene, is down-regulated in
            Hras-transformed cells and restored in phenotypic revertants
  JOURNAL   Oncogene 10 (1), 61-68 (1995)
   PUBMED   7824279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596444.10, AB221672.1 and AI385555.1.
            
            [WARNING] On Nov 20, 2023 this sequence was replaced by
            NM_019417.4.
            
            On Jul 8, 2009 this sequence version replaced NM_019417.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030068.1, Y08361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL596444.10        28565-28649
            86-1078             AB221672.1         1-993
            1079-1189           AI385555.1         1-111               c
FEATURES             Location/Qualifiers
     source          1..1189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.13 cM"
     gene            1..1189
                     /gene="Pdlim4"
                     /gene_synonym="Ril"
                     /note="PDZ and LIM domain 4"
                     /db_xref="GeneID:30794"
                     /db_xref="MGI:MGI:1353470"
     exon            1..178
                     /gene="Pdlim4"
                     /gene_synonym="Ril"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1078
                     /gene="Pdlim4"
                     /gene_synonym="Ril"
                     /note="reversion induced LIM; LIM protein RIL;
                     reversion-induced LIM protein"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 4"
                     /protein_id="NP_062290.2"
                     /db_xref="CCDS:CCDS24690.1"
                     /db_xref="GeneID:30794"
                     /db_xref="MGI:MGI:1353470"
                     /translation="MTHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALC
                     PGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPENKNWPSAPDDKAQAHRIH
                     IDPESQDCSPATSRRSSVSGISLEDNRSGLGSPYGQPPRLPVPHNGSSNEATLPAQMS
                     ALHVSPPTSADTARVLPRNRDCRVDLGSEVYRMLREPAEPTASEPKQSGSFRYLQGML
                     EAGEGGDRPGSGGPRNLKPAASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHP
                     ECFMCSDCGLNLKQRGYFFLDERLYCENHAKARVKPPEGYDVVAVYPNAKVELV"
     exon            179..330
                     /gene="Pdlim4"
                     /gene_synonym="Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            331..409
                     /gene="Pdlim4"
                     /gene_synonym="Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            410..591
                     /gene="Pdlim4"
                     /gene_synonym="Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            592..755
                     /gene="Pdlim4"
                     /gene_synonym="Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            756..873
                     /gene="Pdlim4"
                     /gene_synonym="Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1185
                     /gene="Pdlim4"
                     /gene_synonym="Ril"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggggcgcg gcggccaggc ggcggcaaca gcggcggcga ctcctccgtg tccggctcca
       61 gctctggctg cagctccggc ccgcgatgac ccactcggtg accctgcgcg gcccttcacc
      121 ctggggcttc cgcctggtgg gcggccggga cttcagtgct cccctcacca tctcgcgggt
      181 tcatgctggg agcaaagcgg ccctggctgc cctgtgccca ggtgacttga tccaagccat
      241 caacggcgag agcactgagc tcatgacaca cctggaggcc cagaaccgca ttaaaggctg
      301 ccacgatcat cttacgctct cggtcagcag gcctgagaat aagaactggc ccagtgctcc
      361 tgatgacaag gctcaagcac ataggatcca cattgaccct gagtcccagg actgcagtcc
      421 agccaccagc aggcgctcct cagtctctgg gattagtctg gaggacaaca gatcgggcct
      481 gggatctcca tatggtcagc cacctcgcct tccagtccct cacaatggca gcagcaacga
      541 ggccaccctg ccagcccaga tgagcgctct gcatgtgtct ccacccacca gtgccgacac
      601 agccagggtt ctccctcgga accgggactg cagggtagac ctgggttcag aggtatacag
      661 gatgttaagg gagccagcag agcccacagc ctcggagccg aaacagtcag gatccttccg
      721 ctacctgcag ggcatgctag aggctggcga gggcggggat cggcctgggt ctggtggtcc
      781 ccggaacctc aaaccagcag ccagcaagct cggtgctcca ctgagtggcc tgcaggggct
      841 accagagtgc acgcgctgcg gccacgggat cgtgggaacc attgtcaagg cgagagacaa
      901 gctctaccat ccggagtgct tcatgtgcag cgactgcggc ctgaatctca aacagcgtgg
      961 gtacttcttc ctagatgaac ggctgtactg tgagaatcac gccaaggctc gagtcaagcc
     1021 gccggaggga tatgatgtgg tggctgtata ccccaatgct aaggtggaac ttgtctgagc
     1081 tggaaaatct tgtcttgcct ctgcttcact taatgttccc tcatggcctg tgtaaatata
     1141 tgtcctcctg gcctttctaa taaagtcctt ctgcttgctc tggaaaaaa
//
