LOCUS       NM_001374652            1809 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus PDZ and LIM domain 3 (Pdlim3), transcript variant 1,
            mRNA.
ACCESSION   NM_001374652 XM_006509465
VERSION     NM_001374652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1809)
  AUTHORS   Yuan,H., Xie,B., Yu,X., Lin,C., Li,M., Zhang,Y., Zou,X., Lu,M.,
            Zhao,M. and Wen,X.
  TITLE     A potential role of p75NTR in the regulation of circadian rhythm
            and incremental growth lines during tooth development
  JOURNAL   Front Physiol 13, 981311 (2022)
   PUBMED   36213234
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1809)
  AUTHORS   Lopez-Tello,J., Perez-Garcia,V., Khaira,J., Kusinski,L.C.,
            Cooper,W.N., Andreani,A., Grant,I., Fernandez de Liger,E.,
            Lam,B.Y., Hemberger,M., Sandovici,I., Constancia,M. and
            Sferruzzi-Perri,A.N.
  TITLE     Fetal and trophoblast PI3K p110alpha have distinct roles in
            regulating resource supply to the growing fetus in mice
  JOURNAL   Elife 8, e45282 (2019)
   PUBMED   31241463
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1809)
  AUTHORS   Bang,M.L.
  TITLE     Animal Models of Congenital Cardiomyopathies Associated With
            Mutations in Z-Line Proteins
  JOURNAL   J Cell Physiol 232 (1), 38-52 (2017)
   PUBMED   27171814
  REMARK    Review article
REFERENCE   4  (bases 1 to 1809)
  AUTHORS   Lodder,E.M., Scicluna,B.P., Beekman,L., Arends,D., Moerland,P.D.,
            Tanck,M.W., Adriaens,M.E. and Bezzina,C.R.
  TITLE     Integrative genomic approach identifies multiple genes involved in
            cardiac collagen deposition
  JOURNAL   Circ Cardiovasc Genet 7 (6), 790-798 (2014)
   PUBMED   25217174
REFERENCE   5  (bases 1 to 1809)
  AUTHORS   Lui,J.H., Nowakowski,T.J., Pollen,A.A., Javaherian,A.,
            Kriegstein,A.R. and Oldham,M.C.
  TITLE     Radial glia require PDGFD-PDGFRbeta signalling in human but not
            mouse neocortex
  JOURNAL   Nature 515 (7526), 264-268 (2014)
   PUBMED   25391964
REFERENCE   6  (bases 1 to 1809)
  AUTHORS   Klaavuniemi,T., Kelloniemi,A. and Ylanne,J.
  TITLE     The ZASP-like motif in actinin-associated LIM protein is required
            for interaction with the alpha-actinin rod and for targeting to the
            muscle Z-line
  JOURNAL   J Biol Chem 279 (25), 26402-26410 (2004)
   PUBMED   15084604
  REMARK    GeneRIF: ZASP-like motif in actinin-associated LIM protein is
            required for interaction with the alpha-actinin rod and for
            targeting to the muscle Z-line
REFERENCE   7  (bases 1 to 1809)
  AUTHORS   Vallenius,T., Scharm,B., Vesikansa,A., Luukko,K., Schafer,R. and
            Makela,T.P.
  TITLE     The PDZ-LIM protein RIL modulates actin stress fiber turnover and
            enhances the association of alpha-actinin with F-actin
  JOURNAL   Exp Cell Res 293 (1), 117-128 (2004)
   PUBMED   14729062
REFERENCE   8  (bases 1 to 1809)
  AUTHORS   Pashmforoush,M., Pomies,P., Peterson,K.L., Kubalak,S., Ross,J. Jr.,
            Hefti,A., Aebi,U., Beckerle,M.C. and Chien,K.R.
  TITLE     Adult mice deficient in actinin-associated LIM-domain protein
            reveal a developmental pathway for right ventricular cardiomyopathy
  JOURNAL   Nat Med 7 (5), 591-597 (2001)
   PUBMED   11329061
REFERENCE   9  (bases 1 to 1809)
  AUTHORS   Jo,K., Rutten,B., Bunn,R.C. and Bredt,D.S.
  TITLE     Actinin-associated LIM protein-deficient mice maintain normal
            development and structure of skeletal muscle
  JOURNAL   Mol Cell Biol 21 (5), 1682-1687 (2001)
   PUBMED   11238905
REFERENCE   10 (bases 1 to 1809)
  AUTHORS   Xia,H., Winokur,S.T., Kuo,W.L., Altherr,M.R. and Bredt,D.S.
  TITLE     Actinin-associated LIM protein: identification of a domain
            interaction between PDZ and spectrin-like repeat motifs
  JOURNAL   J Cell Biol 139 (2), 507-515 (1997)
   PUBMED   9334352
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113469.9 and AC114558.18.
            
            On Mar 17, 2020 this sequence version replaced NM_001374652.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.10584.1,
                                           SRR5189673.119238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC113469.9         176725-176910
            187-338             AC113469.9         187986-188137
            339-423             AC113469.9         191713-191797
            424-491             AC114558.18        260919-260986       c
            492-755             AC114558.18        256045-256308       c
            756-886             AC114558.18        254746-254876       c
            887-998             AC114558.18        252436-252547       c
            999-1809            AC114558.18        250370-251180       c
FEATURES             Location/Qualifiers
     source          1..1809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 25.86 cM"
     gene            1..1809
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /note="PDZ and LIM domain 3"
                     /db_xref="GeneID:53318"
                     /db_xref="MGI:MGI:1859274"
     exon            1..186
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1188
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     actinin alpha 2 associated LIM protein; PDZ and LIM domain
                     protein 3"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 3 isoform 1"
                     /protein_id="NP_001361581.1"
                     /db_xref="CCDS:CCDS90393.1"
                     /db_xref="GeneID:53318"
                     /db_xref="MGI:MGI:1859274"
                     /translation="MPQNVVLPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLC
                     PGDVILAIDGFGTESMTHADAQDRIKAASYQLCLKIDRAETRLWSPQVSEDGKAHPFK
                     INLEAEPQDVNYFEHKHNIRPKPFIIPGRTSGCSTPSGVDCGSGRSTPSSVSTVSTIC
                     PGDLKVAAKMAPNIPLEMELPGVKIVHAQFNTPMQLYSDDNIMETLQGQVATALGETS
                     SMSEPTASVPPQSDVYRMLHDNRDDPAAPRQSGSFRVLQDLVNDGPDDRPAGTRSVRA
                     PVTKVHGGAGSAQRMPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFF
                     VEGELYCETHARARTRPPEGYDTVTLYPKA"
     exon            187..338
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /inference="alignment:Splign:2.1.0"
     exon            339..423
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /inference="alignment:Splign:2.1.0"
     exon            424..491
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /inference="alignment:Splign:2.1.0"
     exon            492..755
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /inference="alignment:Splign:2.1.0"
     exon            756..886
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /inference="alignment:Splign:2.1.0"
     exon            887..998
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1809
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1581..1586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /note="hexamer: AACAAA"
     polyA_site      1589
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /note="major polyA site"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /note="hexamer: AATAAA"
     polyA_site      1722
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /note="major polyA site"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
                     /note="hexamer: AAGAAA"
     polyA_site      1809
                     /gene="Pdlim3"
                     /gene_synonym="Actn2lp; ALP"
ORIGIN      
        1 aggtcgcagc cccaggagct aagtaggttg tccggttccg agacaagcgc tttgcagagc
       61 caccgtcgct ggacccactc gagggaaggc accatgcccc agaacgtagt tctcccgggt
      121 cctgcgccct ggggcttcag actctctggg ggcatagact tcaatcagcc tttggtcatc
      181 accaggatca ctccaggaag caaagcagca gctgccaacc tgtgtcctgg agatgtcatc
      241 ctagctattg atggctttgg tacggagtct atgactcatg ctgatgcaca ggacaggatt
      301 aaagcagcgt cctaccagtt gtgtctcaag attgacaggg cagaaactcg cttatggtcc
      361 ccgcaggtgt ctgaagatgg aaaagcacac cccttcaaaa tcaacttaga agctgaacca
      421 caggatgtga actactttga acacaagcac aatattcggc ccaaaccttt cataattcca
      481 ggccgaacca gtggctgcag cactccttcc ggtgttgact gtggcagtgg acgtagcacc
      541 ccttcttccg tcagtaccgt tagtacaatc tgcccgggtg acttgaaagt tgctgctaag
      601 atggccccta acattccttt ggaaatggaa cttccgggcg tgaagatcgt acacgctcag
      661 tttaacacgc ctatgcagtt gtactcagat gacaatatta tggaaacact tcagggtcag
      721 gttgccacag ctctagggga gacatcctcc atgagtgaac ccacagcttc agtgccccct
      781 cagtcggacg tgtaccgcat gctccatgac aaccgggatg acccagccgc tcctcgccag
      841 tcgggctcct tcagggtgct gcaggatctg gtgaatgacg ggcctgatga ccgtccggct
      901 ggaactcgaa gcgtgagggc tccggttacg aaagtccacg gtggggctgg cagtgcccag
      961 aggatgccgc tctgtgacaa gtgtgggagt ggtattgtag gtgctgtcgt caaggcccgg
     1021 gataagtacc ggcaccccga gtgctttgtg tgtgccgact gtaacctcaa cctcaagcag
     1081 aaaggctact tcttcgtgga gggggagctg tattgtgaga cgcacgcgag agcccgcacg
     1141 aggcccccag agggctacga caccgtcact ctgtacccca aagcttaaat cctttgcaga
     1201 caagaacact cacgcacaca tgcgcacacc cgcaaacacc ggctgatggt gtggaggact
     1261 tcaagaaaga gaagtgcgaa cagtcacctc ccactctaaa gccgaggctt ttagacattt
     1321 atcttgctgt gtagagaggg aaaaacacgg ggaggggagg caaaggcctg cctgctgaca
     1381 aaagacaagt attatctatg gattgcaatt ccttatcttt ggggacagca atagacattt
     1441 aaagcaataa tgtttccata ccatgctccc tctgttaccc agccatctga tatgtaaata
     1501 cctggatatt tgggggagtc tacttgtttt tccttccaag ttgcttttag taattgtagt
     1561 aagtaatgcc aaacactctt aacaaactcc gcaggtgtct gtgtctgtca ttcctaaagt
     1621 gcatgtcagg aagacacttc caggattgct ctattctaca tgcgaacagc tgtaccactg
     1681 gagaacgcaa gcaaaataaa tctgtggagc atgtttttgt aattcattgt gaagtagtag
     1741 ccaacagatt caggaagagg actcactcct ttcttagtgt ctaaatcaac aaatatttta
     1801 agaaatcta
//
