LOCUS       NM_001253736            1587 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus PDZ and LIM domain 2 (Pdlim2), transcript variant 2,
            mRNA.
ACCESSION   NM_001253736
VERSION     NM_001253736.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1587)
  AUTHORS   Li,L., Sun,F., Han,L., Liu,X., Xiao,Y., Gregory,A.D., Shapiro,S.D.,
            Xiao,G. and Qu,Z.
  TITLE     PDLIM2 repression by ROS in alveolar macrophages promotes lung
            tumorigenesis
  JOURNAL   JCI Insight 6 (5), 144394 (2021)
   PUBMED   33539325
  REMARK    GeneRIF: PDLIM2 repression by ROS in alveolar macrophages promotes
            lung tumorigenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1587)
  AUTHORS   Guo,Q., Xu,J., Shi,Q. and Wu,S.
  TITLE     PDLIM2 protects articular chondrocytes from
            lipopolysaccharide-induced apoptosis, degeneration and inflammatory
            injury through down-regulation of nuclear factor (NF)-kappaB
            signaling
  JOURNAL   Int Immunopharmacol 88, 106883 (2020)
   PUBMED   32805696
  REMARK    GeneRIF: PDLIM2 protects articular chondrocytes from
            lipopolysaccharide-induced apoptosis, degeneration and inflammatory
            injury through down-regulation of nuclear factor (NF)-kappaB
            signaling.
REFERENCE   3  (bases 1 to 1587)
  AUTHORS   Jodo,A., Shibazaki,A., Onuma,A., Kaisho,T. and Tanaka,T.
  TITLE     PDLIM7 Synergizes With PDLIM2 and p62/Sqstm1 to Inhibit
            Inflammatory Signaling by Promoting Degradation of the p65 Subunit
            of NF-kappaB
  JOURNAL   Front Immunol 11, 1559 (2020)
   PUBMED   32849529
  REMARK    GeneRIF: PDLIM7 Synergizes With PDLIM2 and p62/Sqstm1 to Inhibit
            Inflammatory Signaling by Promoting Degradation of the p65 Subunit
            of NF-kappaB.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1587)
  AUTHORS   Sun,F., Li,L., Yan,P., Zhou,J., Shapiro,S.D., Xiao,G. and Qu,Z.
  TITLE     Causative role of PDLIM2 epigenetic repression in lung cancer and
            therapeutic resistance
  JOURNAL   Nat Commun 10 (1), 5324 (2019)
   PUBMED   31757943
  REMARK    GeneRIF: By 19 months of age, all PDLIM2-/- mice, compared to less
            than 10% of wild-type (WT) mice, spontaneously developed tumors.
            50% of them were lung tumors. PDLIM2 -/- mice were also more
            sensitive to K-RasG12D-induced lung tumorigenesis
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1587)
  AUTHORS   Kimura,A., Kitajima,M., Nishida,K., Serada,S., Fujimoto,M.,
            Naka,T., Fujii-Kuriyama,Y., Sakamato,S., Ito,T., Handa,H.,
            Tanaka,T., Yoshimura,A. and Suzuki,H.
  TITLE     NQO1 inhibits the TLR-dependent production of selective cytokines
            by promoting IkappaB-zeta degradation
  JOURNAL   J Exp Med 215 (8), 2197-2209 (2018)
   PUBMED   29934320
REFERENCE   6  (bases 1 to 1587)
  AUTHORS   Tanaka,T., Grusby,M.J. and Kaisho,T.
  TITLE     PDLIM2-mediated termination of transcription factor NF-kappaB
            activation by intranuclear sequestration and degradation of the p65
            subunit
  JOURNAL   Nat Immunol 8 (6), 584-591 (2007)
   PUBMED   17468759
  REMARK    GeneRIF: PDLIM2 deficiency resulted in larger amounts of nuclear
            p65, defective p65 ubiquitination and augmented production of
            proinflammatory cytokines in response to innate stimuli
REFERENCE   7  (bases 1 to 1587)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 1587)
  AUTHORS   Ivins,S., Lammerts van Beuren,K., Roberts,C., James,C., Lindsay,E.,
            Baldini,A., Ataliotis,P. and Scambler,P.J.
  TITLE     Microarray analysis detects differentially expressed genes in the
            pharyngeal region of mice lacking Tbx1
  JOURNAL   Dev Biol 285 (2), 554-569 (2005)
   PUBMED   16109395
REFERENCE   9  (bases 1 to 1587)
  AUTHORS   Tanaka,T., Soriano,M.A. and Grusby,M.J.
  TITLE     SLIM is a nuclear ubiquitin E3 ligase that negatively regulates
            STAT signaling
  JOURNAL   Immunity 22 (6), 729-736 (2005)
   PUBMED   15963787
  REMARK    GeneRIF: SLIM is a novel ubiquitin E3 ligase whose targets include
            STAT proteins.
REFERENCE   10 (bases 1 to 1587)
  AUTHORS   Loughran,G., Healy,N.C., Kiely,P.A., Huigsloot,M., Kedersha,N.L.
            and O'Connor,R.
  TITLE     Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM
            domain protein that promotes cell attachment and migration and
            suppresses Anchorage-independent growth
  JOURNAL   Mol Biol Cell 16 (4), 1811-1822 (2005)
   PUBMED   15659642
  REMARK    GeneRIF: Knockdown of Mystique 2 with small interfering RNA
            abrogated both adhesion and migration in MCF10A and MCF-7 cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY072232.1, DV646822.1, BE634101.1 and AC151836.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.96235.1,
                                           ERR3363657.293846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BY072232.1         6-105
            101-741             DV646822.1         1-641
            742-1109            BE634101.1         164-531
            1110-1587           AC151836.3         162185-162662       c
FEATURES             Location/Qualifiers
     source          1..1587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.26 cM"
     gene            1..1587
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /note="PDZ and LIM domain 2"
                     /db_xref="GeneID:213019"
                     /db_xref="MGI:MGI:2384850"
     exon            1..137
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     exon            138..232
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1189
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /note="mystique; STAT-interacting LIM protein; PDZ-LIM
                     protein mystique"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 2"
                     /protein_id="NP_001240665.1"
                     /db_xref="CCDS:CCDS27248.1"
                     /db_xref="GeneID:213019"
                     /db_xref="MGI:MGI:2384850"
                     /translation="MALTVDVAGPAPWGFRISGGRDFHTPIIVTKVTERGKAEAADLR
                     PGDIIVAINGQSAENMLHAEAQSKIRQSASPLRLQLDRSQTASPGQTNGEGSLEVLAT
                     RFQGSLRTHRDSQSSQRSACFSPVSLSPRPCSPFSTPPPTSPVALSKEDMIGCSFQSL
                     THSPGLAAAHHLTYPGHPTSQQAGHSSPSDSAVRVLLHSPGRPSSPRFSSLDLEEDSE
                     VFKMLQENRQGRAAPRQSSSFRLLQEALEAEERGGTPAFVPSSLSSQASLPTSRALAT
                     PPKLHTCEKCSVNISNQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGNELYCEKH
                     ARQRYSMPGTLNSRA"
     exon            233..384
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     exon            385..454
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     exon            455..606
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     exon            607..685
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     exon            686..765
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     exon            766..893
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1011
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1587
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1564..1569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /note="hexamer: GATAAA"
     polyA_site      1574
                     /gene="Pdlim2"
                     /gene_synonym="4732462F18Rik; Slim"
                     /note="major polyA site"
ORIGIN      
        1 gagctctccc tagagtcgga cagacggctg cggtggaacg gcggcggctc ctcgtcctta
       61 ctccctccgt tcttccctcc ctccttccct ttcctggctg gcctgaccgc ccagcccgac
      121 aggcaagcgg cagccaggca tggcgttgac tgtggatgtg gcaggaccag caccttgggg
      181 cttccgaatt agcgggggca gagatttcca cacacccatc attgtgacca aggtcacaga
      241 gcggggcaag gctgaagcag ctgatctccg gcctggcgac atcattgtgg ccatcaatgg
      301 acagagtgca gagaacatgc tacacgcgga ggcccaaagc aagatccgac agagcgcctc
      361 acccctaaga ctgcagctgg accggtccca aacagcctct cctgggcaga ccaatgggga
      421 gggctccttg gaagtgctgg caaccagatt ccagggctcc ctgaggacac accgtgacag
      481 ccagtcttcc cagaggtctg cctgcttcag cccagtctct ctcagcccca ggccttgcag
      541 ccccttctcc accccacccc ctaccagccc agttgccctt tctaaagagg atatgattgg
      601 ctgtagtttc cagagtctga cacactctcc aggccttgct gctgctcacc acttgaccta
      661 ccctggccac cccaccagcc aacaggccgg ccacagcagc ccaagcgact ccgcagtgag
      721 ggtgctgctc cattccccag gacggccctc cagccctagg ttcagcagtt tggatctgga
      781 ggaagactca gaggtgttca agatgctgca ggagaaccgc cagggacggg ccgccccaag
      841 gcagtccagc tcttttcgac tcttacagga agccttggag gctgaggaga gaggtggcac
      901 acctgccttt gtgcccagct cgctgagctc ccaggcttcc ttgcccacct ccagggcctt
      961 ggccactcca cccaagctcc acacctgtga gaaatgcagc gtcaacatct cgaaccaggc
     1021 ggtccgcatc caggagggga ggtaccgaca ccctggctgc tacacttgcg cagactgtgg
     1081 gctgaacctg aagatgcgcg gccacttctg ggtgggcaat gagttgtact gcgagaagca
     1141 tgcccgccag cgctactcta tgcctggaac tctcaactct cgagcctgag cctcaaggtg
     1201 ctcggcctgt ctgcactctc agactctgca gacatgatta tactgagagc aagcagggaa
     1261 ggggtgatag caggtgatag atgatcttac atgaactaag gttggggagt cccctttgtc
     1321 cttgctgggt gaggccaagg gttgggacta atgtcaggtt gctagtgcta aggacagttc
     1381 cactctctct ggccttcctc ctgcaggcca ggttctgtat tacggtctac agtggctgcc
     1441 atgtttgaca cgaaagcgta tggggttggg catggataga agcatctaga agggaatggt
     1501 gggcctgagg taaatgatat tcatggtgtg aagtttctaa catatgaact ctatatacac
     1561 gtggataaaa ttaagtagtg tattttc
//
