LOCUS       NM_016861               1524 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus PDZ and LIM domain 1 (elfin) (Pdlim1), mRNA.
ACCESSION   NM_016861 XM_915347
VERSION     NM_016861.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1524)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1524)
  AUTHORS   Chen,Z., Zhao,Q., Zhang,R., Chen,L., Gao,S., Wang,Y., Li,T. and
            Xue,J.
  TITLE     Direct Knockdown of PDZ and LIM Domain 1 Using an Adenoviral
            Delivery System Accelerates Osteogenesis and Fracture Healing in
            Mice
  JOURNAL   Hum Gene Ther 34 (13-14), 649-661 (2023)
   PUBMED   37212284
  REMARK    GeneRIF: Direct Knockdown of PDZ and LIM Domain 1 Using an
            Adenoviral Delivery System Accelerates Osteogenesis and Fracture
            Healing in Mice.
REFERENCE   3  (bases 1 to 1524)
  AUTHORS   Xie,P., You,Q., Zhu,J., Xie,W., Wei,P., Zhu,S., Du,Y. and Gao,X.
  TITLE     PDLIM1 inhibits cell migration and invasion in diabetic retinopathy
            via negatively regulating Wnt3a
  JOURNAL   Sci Rep 13 (1), 5820 (2023)
   PUBMED   37037887
  REMARK    GeneRIF: PDLIM1 inhibits cell migration and invasion in diabetic
            retinopathy via negatively regulating Wnt3a.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1524)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1524)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   6  (bases 1 to 1524)
  AUTHORS   Xu,X., Mannik,J., Kudryavtseva,E., Lin,K.K., Flanagan,L.A.,
            Spencer,J., Soto,A., Wang,N., Lu,Z., Yu,Z., Monuki,E.S. and
            Andersen,B.
  TITLE     Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal
            homeostasis and maintenance of hair follicle stem cells
  JOURNAL   Dev Biol 312 (2), 484-500 (2007)
   PUBMED   17991461
  REMARK    GeneRIF: Clim1 protein plays an important role in the homeostasis
            of corneal epithelium and hair follicles.
REFERENCE   7  (bases 1 to 1524)
  AUTHORS   Remedios,R., Subramanian,L. and Tole,S.
  TITLE     LIM genes parcellate the embryonic amygdala and regulate its
            development
  JOURNAL   J Neurosci 24 (31), 6986-6990 (2004)
   PUBMED   15295034
REFERENCE   8  (bases 1 to 1524)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1524)
  AUTHORS   Kioussi,C., Briata,P., Baek,S.H., Rose,D.W., Hamblet,N.S.,
            Herman,T., Ohgi,K.A., Lin,C., Gleiberman,A., Wang,J., Brault,V.,
            Ruiz-Lozano,P., Nguyen,H.D., Kemler,R., Glass,C.K.,
            Wynshaw-Boris,A. and Rosenfeld,M.G.
  TITLE     Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway
            mediating cell-type-specific proliferation during development
  JOURNAL   Cell 111 (5), 673-685 (2002)
   PUBMED   12464179
REFERENCE   10 (bases 1 to 1524)
  AUTHORS   Kotaka,M., Lau,Y.M., Cheung,K.K., Lee,S.M., Li,H.Y., Chan,W.Y.,
            Fung,K.P., Lee,C.Y., Waye,M.M. and Tsui,S.K.
  TITLE     Elfin is expressed during early heart development
  JOURNAL   J Cell Biochem 83 (3), 463-472 (2001)
   PUBMED   11596114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158992.1, AK076285.1 and AF053367.2.
            
            On Oct 25, 2007 this sequence version replaced NM_016861.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF053367.2, AK146399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AK158992.1         1-102
            103-972             AK076285.1         2-871
            973-1524            AF053367.2         889-1440
FEATURES             Location/Qualifiers
     source          1..1524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.24 cM"
     gene            1..1524
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /note="PDZ and LIM domain 1 (elfin)"
                     /db_xref="GeneID:54132"
                     /db_xref="MGI:MGI:1860611"
     exon            1..271
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..423
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..508
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..702
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..854
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..972
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1505
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1483..1488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /note="hexamer: AATAAA"
     polyA_site      1505
                     /gene="Pdlim1"
                     /gene_synonym="Clim1; CLP36; mClim1"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgcag cgacgcggcc ggggcggatc tgtccccgcc ctcgctcgcg accccgcccg
       61 tcccaggatc tcccaactcc cgccgcgcgc tctttctccg acagctgctc cgggagcccc
      121 gcgcgccgtg cagttctgtg ccttgcctgt ctgtcccttc cgattgtgcc tagcgatgac
      181 cacccagcag attgttctcc agggcccggg tccctggggt ttccgcctcg tgggcggcaa
      241 ggacttcgaa caacctctcg ccatttcccg ggtcactccc ggaagcaagg ctgctatagc
      301 gaatttatgt attggagatt taatcacagc catcgatggg gaagatacca gcagcatgac
      361 acacttggaa gctcagaaca aaatcaaggg ctgcgcagac aacatgacgc tcacagtatc
      421 caggtctgaa cagaagattt ggtctcctct agtgaccgag gaggggaaac gtcatcccta
      481 caagatgaat ttagcgtcgg aaccccaaga agtcctgcac ataggaagtg cccacaaccg
      541 aagtgccatg ccatttactg cctcacctgc tcccagcacc cgggtcatca caaaccagta
      601 caacagccca actggcctct actcatccga aaacatctct aacttcaaca atgctgtgga
      661 gtcgaagacc tcagccagtg gggaggaggc gaacagcagg cccgtggttc agcctcatcc
      721 ctccggcagc cttatcattg acaaggactc tgaagtttac aagatgcttc aggagaagca
      781 agaattaaac gagcccccca aacagtccac atccttcctg gttctgcagg agatcctgga
      841 gtcagatggg aaaggggatc ccaacaagcc atcaggattt agaagtgtta aagctccagt
      901 caccaaagtg gctgcatctg ttggaaatgc tcagaagctg cccatctgtg acaaatgtgg
      961 aactggtatt gttggtgtgt ttgtgaagct gagggatcac catcgccacc ctgaatgcta
     1021 tgtgtgcacc gactgtggca tcaacctgaa acagaagggc catttctttg tagaggatca
     1081 gatctactgt gaaaagcatg cccgggagcg ggtcactccg cctgagggct acgatgtggt
     1141 cacagtgttc cgcgagtgat ggagaggacc tgccctgtct actgccctcc agccagcctg
     1201 ctgcacctgg ttctcggaat attctggctc tctcctccct gacagtcctg tgcttactta
     1261 gtgttagtca tgcgcaataa acattgggtt tcgtctgggc tgactgactc ccactggcag
     1321 ggtgacatct gcttttatat tattgggaga tggttttgtc cctgtccctt cacccacacc
     1381 tcaatgcacc ttcttcactt ggagtcttct ctgctgcaaa tggacattgg tccattggaa
     1441 ctaagccaaa tgtagtatct ctgatgttac ttggttttac ttaataaatt tagactttaa
     1501 agcaaaaaaa aaaaaaaaaa aaaa
//
