LOCUS       NM_172665               5202 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_172665
VERSION     NM_172665.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5202)
  AUTHORS   Sun,X., Wu,T., Yang,Z., Chen,S., Zhao,Z., Hu,C., Wu,S., Wu,J.,
            Mao,Y., Liu,J., Guo,C., Cao,G., Xu,X., Huang,S. and Liang,G.
  TITLE     Regulatory role of PDK1 via integrated gene analysis of
            mitochondria-immune response in periodontitis
  JOURNAL   Gene 918, 148476 (2024)
   PUBMED   38657876
  REMARK    GeneRIF: Regulatory role of PDK1 via integrated gene analysis of
            mitochondria-immune response in periodontitis.
REFERENCE   2  (bases 1 to 5202)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5202)
  AUTHORS   Qiu,X., Jiang,Z., Luo,Y., Tian,D., Song,T. and Li,Q.
  TITLE     PPP3CB Inhibits Cell Proliferation and the Warburg Effect in
            Bladder Cancer by Blocking PDHK1
  JOURNAL   Front Biosci (Landmark Ed) 29 (2), 48 (2024)
   PUBMED   38420800
  REMARK    GeneRIF: PPP3CB Inhibits Cell Proliferation and the Warburg Effect
            in Bladder Cancer by Blocking PDHK1.
REFERENCE   4  (bases 1 to 5202)
  AUTHORS   Hitosugi,T., Fan,J., Chung,T.W., Lythgoe,K., Wang,X., Xie,J.,
            Ge,Q., Gu,T.L., Polakiewicz,R.D., Roesel,J.L., Chen,G.Z.,
            Boggon,T.J., Lonial,S., Fu,H., Khuri,F.R., Kang,S. and Chen,J.
  TITLE     Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase
            kinase 1 is important for cancer metabolism
  JOURNAL   Mol Cell 44 (6), 864-877 (2011)
   PUBMED   22195962
  REMARK    GeneRIF: The tyrosine phosphorylation enhances PDHK1 kinase
            activity by promoting ATP and PDC binding.
REFERENCE   5  (bases 1 to 5202)
  AUTHORS   Dunford,E.C., Herbst,E.A., Jeoung,N.H., Gittings,W., Inglis,J.G.,
            Vandenboom,R., LeBlanc,P.J., Harris,R.A. and Peters,S.J.
  TITLE     PDH activation during in vitro muscle contractions in PDH kinase 2
            knockout mice: effect of PDH kinase 1 compensation
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 300 (6), R1487-R1493 (2011)
   PUBMED   21411764
REFERENCE   6  (bases 1 to 5202)
  AUTHORS   Jian,B., Wang,D., Chen,D., Voss,J., Chaudry,I. and Raju,R.
  TITLE     Hypoxia-induced alteration of mitochondrial genes in
            cardiomyocytes: role of Bnip3 and Pdk1
  JOURNAL   Shock 34 (2), 169-175 (2010)
   PUBMED   20160671
  REMARK    GeneRIF: Pdk1 enzyme is critical in conserving mitochondrial
            function by diverting metabolic intermediates to glycolysis
REFERENCE   7  (bases 1 to 5202)
  AUTHORS   Hyvarinen,J., Hassinen,I.E., Sormunen,R., Maki,J.M.,
            Kivirikko,K.I., Koivunen,P. and Myllyharju,J.
  TITLE     Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2
            hypomorphic mice show protection against acute ischemia-reperfusion
            injury
  JOURNAL   J Biol Chem 285 (18), 13646-13657 (2010)
   PUBMED   20185832
REFERENCE   8  (bases 1 to 5202)
  AUTHORS   Osafune,K., Takasato,M., Kispert,A., Asashima,M. and
            Nishinakamura,R.
  TITLE     Identification of multipotent progenitors in the embryonic mouse
            kidney by a novel colony-forming assay
  JOURNAL   Development 133 (1), 151-161 (2006)
   PUBMED   16319116
REFERENCE   9  (bases 1 to 5202)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   10 (bases 1 to 5202)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046805.1, AK153649.1, AK165090.1 and BE994546.1.
            
            On Nov 28, 2013 this sequence version replaced NM_172665.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153649.1, AK046805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1117              AK046805.1         2-1118
            1118-2552           AK153649.1         1071-2505
            2553-3328           AK046805.1         2554-3329
            3329-5172           AK165090.1         736-2579
            5173-5202           BE994546.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..5202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 42.84 cM"
     gene            1..5202
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /note="pyruvate dehydrogenase kinase, isoenzyme 1"
                     /db_xref="GeneID:228026"
                     /db_xref="MGI:MGI:1926119"
     exon            1..342
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            343..484
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            485..556
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            557..741
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            742..831
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            832..909
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            910..986
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1085
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1196
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1310
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..5185
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3286..3291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3313
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /note="major polyA site"
     regulatory      5150..5155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5169
                     /gene="Pdk1"
                     /gene_synonym="B830012B01; D530020C15Rik"
ORIGIN      
        1 gtggttccag cgagggggcg gtggccgcag cgctgacagc agctccccgc ccccgcggcc
       61 agccacgtcc cgcacgtagc gcccgggcag cggcatacag ccgcaggttg gcgcccggag
      121 ctccggctcc tccggcgggg ctcggtatga ggctggcaag gctgctgcgg ggcggcacga
      181 gcgtcaggcc gctctgcgcc gtcccctgcg ccagccgtag cctggcctcg gcctcggcct
      241 cgggttccgg gccggcgtcg gagcttggcg ttccgggcca ggtggacttc tatgcgcgct
      301 tctcgccgtc gccactctcc atgaagcagt tcctggactt cgggtcagtg aatgcttgtg
      361 aaaagacctc gtttatgttt ctgcgacaag agttgcctgt tagattggca aatataatga
      421 aagaaatcag cctcctcccc gacaatcttc tcaggacccc atccgtacag ctggtgcaaa
      481 gttggtatat ccaaagcctt caggagttgc ttgattttaa agacaaaagt gctgaagatg
      541 ctaaaactat ttatgaattc acagacacag tgataaggat cagaaaccgg cacaatgatg
      601 tcattcccac catggcccag ggtgtgactg aatacaagga gagcttcggg gtggatcctg
      661 tcaccagcca aaatgttcag tactttttgg atcgattcta catgagtcgc atctcaatta
      721 gaatgctact caaccagcac tccttattgt tcggtggaaa aggaagtcca tctcatcgaa
      781 agcacattgg aagcataaat ccaaactgcg acgtggtgga ggtcattaaa gatggctatg
      841 agaacgctag gcggctttgt gatttgtatt atgttaactc tcctgaactt gaacttgaag
      901 aactaaatgc gaaatcacca ggacagacaa tacaagtggt ttatgtacca tcccatctct
      961 atcacatggt gtttgaactg ttcaagaatg ccatgagagc gaccatggag caccacgcgg
     1021 acaaaggcgt ttatcccccg attcaggttc acgtcacgct gggcgaggag gatctgactg
     1081 tgaagatgag tgaccgggga ggcggtgttc cactgaggaa gatcgacaga ctcttcaact
     1141 acatgtactc aaccgcaccc cggcctcgtg ttgaaacgtc ccgtgctgtg cccctggctg
     1201 ggtttggtta cggattgccc atatcacgcc tctatgcaca gtacttccag ggagacctaa
     1261 agctgtattc cttagagggc tacgggacag atgcggttat ctacattaag gctctgtcga
     1321 cagaatccgt cgagagactc cctgtgtaca ataaagccgc ctggaagcat tacaaagcca
     1381 accacgaggc tgacgactgg tgtgtgccca gccgagagcc gaaagacatg accacattcc
     1441 gaagctctta aacgcacatg ggacgcctgg cacatccaca tgtggtttct gctaaatttg
     1501 gaagacatgt atttggaacc acactgttcc aaatatttca cgtgtgatct tcacaattag
     1561 tgtttgctga agctcctaaa ggatcggtta tgccaactgt attctgatgt gttgggttaa
     1621 ttgggcgtgg ttttgaacac acataatttt ggtcaactac ccttggtatg gtatggggtg
     1681 tgaagttcct ggtttctgta ggaagctgag tatttctttc aagttttcac ttacttctgc
     1741 tagaagcatc tgaagaacgt ggagtagctg gctagcggcc tctctgcttt tggagttcta
     1801 tcatctgtga gtggtgacac ctagtcagat ggtcttctta tctcccacga agaacaacac
     1861 agtgatccgt tagaacccac acaggttgtc agagtgctga aatgaattga tcatggcatc
     1921 atttttttgc agtggattgt aatgactggt tccccatgga gctaagtcca gagcgtggtt
     1981 atcgagttta ctgtcagcac aagggatttt ctttaaaaac aaagtctcac tgtgtagccc
     2041 cagctggcct tgagcttaca aagccctcgg tgtcctgagc gctggaatga gaagggtgtg
     2101 ccaccacatc tggcttacaa gagaaacgtt agtcccaaaa caagccaaat ggcagcagag
     2161 agtaaactgt ttgggaagca ccaagtggcc caggccgagc tgaccgactg ctgaggtgat
     2221 ctgaggatga gcgtgagatt ctctgggtcc cacccaggga tccagaggct gaaggccagg
     2281 gaccaggtga ggctcatggc tggcctggct ggaactatat ttgggagtga atcgtgacta
     2341 ctgctgttgt cagagtgaca gactagattg ggaagcttgt cgggttgcta cacattaggg
     2401 gacataatct gaatctcaag cctggtgcaa gctaaagcat tagcgggaag accagggtga
     2461 cagcgagagg tcaggtgacc aaaggctcag ccaccttggt ttccagtggt gactaagaac
     2521 atgtattttt ctaaaatatc cagatttttt ttttaaatca aagaaaagtc agcttatatt
     2581 aactacagaa ttcatttgca gctatgtgtt gatttaaagt ctgcaacaaa cgctttgaag
     2641 tattgatgtt atttgtgtta gaatacaaac ctatggagca ggtaatgaca cctgggttct
     2701 ctctcagtga cccagagtca cacagaattg gtgccccagc ctgagctgtc tctgctgatc
     2761 actgtccact gtctgggata tttataacct cctctgttag gtgatgggga agtacttgga
     2821 aaacatgctt tgccacttgc ctagagggat ttgggggttt ggtttggaaa atgtagtgag
     2881 ttaaaacatg tcactcttga catgttttat ccagtcttca ctctgtgtcc tacacataca
     2941 tacatctgta atacaaaagc caaatcatgt gacatggcac aaaatagaac tttggtgcca
     3001 gtgataggaa catgcagcct gagcatgcgc cagggtggtc agcccagatc cttagctgag
     3061 aggtgagggg cctgaaactc aggtcctatt ggcccagggt ttttagctaa tactaccaaa
     3121 tgttggaaaa tatacaccgt atacctgctg tttctaattg aggactttgt aagaaataat
     3181 agatcatgct cctgagtggc atttattcag tgtattgcac ttactagctt tcaattacac
     3241 tttactgcaa tgatgaaata ttttggaatc ttttgtacaa ctgtcaataa acgtactatt
     3301 tttacttgtg aaatactttg ccctctccaa ggaattaaaa aaaattatcc ccctctctgc
     3361 ttaagagcta agaaatgttt tcagacaaga agaatttaaa attagtttac tttagattct
     3421 ttttaaggtg tagcaccttt ttgctctgtt gtaatggtaa tggatggaga caatgtgaca
     3481 aagctctagg ggacgctttc cagagttact tttaaagaca cctggaaggt ttttagattc
     3541 ttaaggtgag ccattttgtc tgccagcgat agttttatgt ggtttaggta tgaaaataga
     3601 gttgatggtt ggggaatgga cagcaagtga tttttataac ctgggcagtt agtgagtgtg
     3661 ccagtgtagt gtaggaaagg attgtaagaa tatttcacca ggcagtggtg gcgcacgcct
     3721 ttaatcccaa cacatgggag gcagaggcag gcggatttct gaggctagcc tggtctacag
     3781 aatgagttcc agggcagcca gggctataca gagaaaccct gtctcgaaaa ataaaagact
     3841 attccacact gtaattccaa atgctggctg gttttgatgc ctttacattt aataatggtc
     3901 agtgtcttac actgagattt ctacatgaag acatagaagc agaattctac cgcagcgtgg
     3961 tgcattttcg gggtgactga aaactgaaaa gatggatcag ctttaaaaaa aaatttgagc
     4021 cacttaagga tcttagaaat atactcgtgt cctttagaca gcagtctgtt tcatcatcaa
     4081 gactcaatat ctgtacaggt tcaacgaatt gtaactagtt gccagcactg gctcagtggg
     4141 taaaagcatg gccatcaagc ctgggttagg gatagggttg gagatctttc ctcagcacga
     4201 atggtggaat tagagaaaga accaaccatc ctgtgagtta tctgtggttc tccacacgtg
     4261 cactgtgcac atgcgcatcc cctacataca ccacactaat aactgtagcc aggtgtcttg
     4321 cactctcaac catctcctag cagtgcttga ggcaggcttg cactgtagat agcctagtgg
     4381 gcaaagcagg tagagttcgt gtgcttagag ttatcctaga tttccctttt ctaatacact
     4441 gccaatgatt gacatgtgct ggagaactgg tggataattt tgaagagctg tataagtaag
     4501 tcattttcca cagtagaaat aacagtaggg aaaggcttag tgtaactggc actgccttct
     4561 actcaacact ggtggaatct cctttagtca agacagagta tgtcctattg ctcgttgata
     4621 gcgtgggtcc accacgcctg cctttcaccg ttacagcggc atggcggcac acacctgtaa
     4681 gtagatctct gagcttgagc cagcctggtc aacataggga gtttcaggtt agccaaggct
     4741 acatgtacgg accctgtgtg ctgtattttt ttttttttta aatcaatgag gtctaaaaca
     4801 actacagagg aggaaagagt tgtgtggttc tatgaaactc agtgagtggc taattagaga
     4861 gggaccccag ccagcaacct tctcttatgt catcaggttt acaaggaagt acaaagcttg
     4921 aaaggagagg tggccagggt taggtttggt tgttttaact gaaggaactt ctcatatccg
     4981 attaacttgt gttctcaata ctattaattc ttctctcagt caaacccaag acactataaa
     5041 aaaaatagaa ttaatgcttt gtgaaggaaa acaacgcatt gctattttac acaatcctgg
     5101 cattcttaaa tgactgtatc acttgttcta ccttttgtgt ttgcaaagaa ttaaacagtg
     5161 tgctgtccac ttttctttgc ctgtaaaaaa aaaaaaaaaa aa
//
