LOCUS       NM_027959               2146 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein disulfide isomerase associated 6 (Pdia6),
            mRNA.
ACCESSION   NM_027959 XM_126809
VERSION     NM_027959.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Lay,A.J., Dupuy,A., Hagimola,L., Tieng,J., Larance,M., Zhang,Y.,
            Yang,J., Kong,Y., Chiu,J., Gray,E., Qin,Z., Schmidt,D., Maclean,J.,
            Hofma,B., Ellis,M., Kalev-Zylinska,M., Argon,Y., Jackson,S.P.,
            Hogg,P. and Passam,F.H.
  TITLE     Endoplasmic reticulum protein 5 attenuates platelet endoplasmic
            reticulum stress and secretion in a mouse model
  JOURNAL   Blood Adv 7 (9), 1650-1665 (2023)
   PUBMED   36508284
  REMARK    GeneRIF: Endoplasmic reticulum protein 5 attenuates platelet
            endoplasmic reticulum stress and secretion in a mouse model.
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   Xie,H., Wang,Y.H., Liu,X., Gao,J., Yang,C., Huang,T., Zhang,L.,
            Luo,X., Gao,Z., Wang,T., Yan,T., Liu,Y., Yang,P., Yu,Q., Liu,S.,
            Wang,Y., Xiong,F., Zhang,S., Zhou,Q. and Wang,C.Y.
  TITLE     SUMOylation of ERp44 enhances Ero1alpha ER retention contributing
            to the pathogenesis of obesity and insulin resistance
  JOURNAL   Metabolism 139, 155351 (2023)
   PUBMED   36427672
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Pakarinen,E., Lindholm,P., Saarma,M. and Lindahl,M.
  TITLE     CDNF and MANF regulate ER stress in a tissue-specific manner
  JOURNAL   Cell Mol Life Sci 79 (2), 124 (2022)
   PUBMED   35129674
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   Chhabra,N.F., Amend,A.L., Bastidas-Ponce,A., Sabrautzki,S.,
            Tarquis-Medina,M., Sachs,S., Rubey,M., Lorenz-Depiereux,B.,
            Feuchtinger,A., Bakhti,M., Lickert,H., Przemeck,G.K.H. and Hrabe de
            Angelis,M.
  TITLE     A point mutation in the Pdia6 gene results in loss of pancreatic
            beta-cell identity causing overt diabetes
  JOURNAL   Mol Metab 54, 101334 (2021)
   PUBMED   34487921
  REMARK    GeneRIF: A point mutation in the Pdia6 gene results in loss of
            pancreatic beta-cell identity causing overt diabetes.
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Luo,S., Mao,C., Lee,B. and Lee,A.S.
  TITLE     GRP78/BiP is required for cell proliferation and protecting the
            inner cell mass from apoptosis during early mouse embryonic
            development
  JOURNAL   Mol Cell Biol 26 (15), 5688-5697 (2006)
   PUBMED   16847323
REFERENCE   7  (bases 1 to 2146)
  AUTHORS   Liu,Y. and Hogan,B.L.
  TITLE     Differential gene expression in the distal tip endoderm of the
            embryonic mouse lung
  JOURNAL   Gene Expr Patterns 2 (3-4), 229-233 (2002)
   PUBMED   12617806
REFERENCE   8  (bases 1 to 2146)
  AUTHORS   Meunier,L., Usherwood,Y.K., Chung,K.T. and Hendershot,L.M.
  TITLE     A subset of chaperones and folding enzymes form multiprotein
            complexes in endoplasmic reticulum to bind nascent proteins
  JOURNAL   Mol Biol Cell 13 (12), 4456-4469 (2002)
   PUBMED   12475965
REFERENCE   9  (bases 1 to 2146)
  AUTHORS   Turano,C., Coppari,S., Altieri,F. and Ferraro,A.
  TITLE     Proteins of the PDI family: unpredicted non-ER locations and
            functions
  JOURNAL   J Cell Physiol 193 (2), 154-163 (2002)
   PUBMED   12384992
  REMARK    Review article
REFERENCE   10 (bases 1 to 2146)
  AUTHORS   Ferrari,D.M. and Soling,H.D.
  TITLE     The protein disulphide-isomerase family: unravelling a string of
            folds
  JOURNAL   Biochem J 339 (Pt 1) (Pt 1), 1-10 (1999)
   PUBMED   10085220
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159815.3.
            
            On Feb 20, 2019 this sequence version replaced NM_027959.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166111.1, AK133792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC159815.3         94704-94766
            64-205              AC159815.3         98511-98652
            206-263             AC159815.3         102060-102117
            264-390             AC159815.3         102499-102625
            391-497             AC159815.3         105313-105419
            498-628             AC159815.3         106629-106759
            629-743             AC159815.3         106951-107065
            744-884             AC159815.3         107694-107834
            885-969             AC159815.3         108493-108577
            970-1042            AC159815.3         108682-108754
            1043-1201           AC159815.3         109026-109184
            1202-1298           AC159815.3         111315-111411
            1299-2146           AC159815.3         112053-112900
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.06 cM"
     gene            1..2146
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /note="protein disulfide isomerase associated 6"
                     /db_xref="GeneID:71853"
                     /db_xref="MGI:MGI:1919103"
     exon            1..63
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1367
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide isomerase-related protein;
                     thioredoxin domain containing 7; protein
                     disulfide-isomerase A6; thioredoxin domain-containing
                     protein 7"
                     /codon_start=1
                     /product="protein disulfide-isomerase A6 precursor"
                     /protein_id="NP_082235.2"
                     /db_xref="CCDS:CCDS25826.1"
                     /db_xref="GeneID:71853"
                     /db_xref="MGI:MGI:1919103"
                     /translation="MARLVLGLVSCTFFLAVSGLYSSSDDVIELTPSNFNREVIQSDG
                     LWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVNADKHQSLGGQYGVQGFPTIK
                     IFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKK
                     DVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLA
                     AVDATMNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPP
                     ELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGW
                     LWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGR
                     GSTAPVGGGSFPTITPREPWDGKDGELPVEDDIDLSDVELDDLEKDEL"
     exon            64..205
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            206..263
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            264..390
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            391..497
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            498..628
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            629..743
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            744..884
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            885..969
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1042
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1201
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1298
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..2146
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /note="hexamer: AATAAA"
     polyA_site      1738
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /note="major polyA site"
     regulatory      2115..2120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /note="hexamer: AATAAA"
     polyA_site      2134
                     /gene="Pdia6"
                     /gene_synonym="1700015E05Rik; CaBP5; P5; Txndc7"
                     /note="major polyA site"
ORIGIN      
        1 agagccgagg cagcggcggc acggacagaa tgcgggtgat cggcatggct cgcctggtgc
       61 tcggtctggt gagctgcacc ttctttctag cagtcagcgg tctgtattct tctagtgatg
      121 atgtcatcga gttgacgcca tcaaatttca acagagaagt tattcagagt gacggcctgt
      181 ggcttgtaga attttatgca ccatggtgtg gtcactgcca gaggttaaca ccagaatgga
      241 agaaagcagc aacggctttg aaagatgttg ttaaagtcgg ggccgtcaat gcagacaaac
      301 atcagtccct gggaggtcag tatggtgtcc agggatttcc taccatcaag atatttggag
      361 ctaacaaaaa caagccagaa gattatcagg gtggcagaac gggagaagcc attgtagatg
      421 ccgccctcag tgccttgcgc cagctcgtca aggatcgcct tggtgggcgg agtggtgggt
      481 acagttctgg aaagcagggc agaggtgata gttcaagtaa gaaagacgtg gtagagctga
      541 cggatgacac ctttgataag aatgtccttg acagtgaaga cgtttggatg gttgagtttt
      601 atgctccgtg gtgtggacac tgcaaaaacc tggagccaga atgggctgct gcggctacag
      661 aagtaaagga gcaaacaaag ggaaaagtga aactggcagc tgtggatgcc accatgaatc
      721 aggttctggc cagccgatac gggattaaag gattccctac aatcaagata tttcagaaag
      781 gcgagtctcc tgtggactat gatggtggtc ggacgagatc tgacatagtg tcaagggccc
      841 tcgatttgtt ctctgataat gcccctcctc cagagctgct tgagataatc aacgaagaca
      901 tagccaagaa gacatgcgag gagcaccagc tctgtgtcgt ggccgtactg cctcacatcc
      961 tggacactgg agctgcaggc agaaactctt acttggaagt tcttctgaaa ctggctgaca
     1021 agtacaagaa gaagatgtgg gggtggctgt ggacagaagc tggagcccag tatgaactgg
     1081 agaacgcact agggattgga gggttcgggt accctgccat ggcagccatc aatgcacgca
     1141 agatgaaatt tgctcttctc aaggggtctt tcagtgaaca aggcatcaat gagtttctca
     1201 gggaactgtc tttcgggcgt ggctccacag cacccgtagg gggtggttcc tttcctacca
     1261 tcactcccag ggagccctgg gatggcaagg atggtgagct ccctgtggag gacgacattg
     1321 acctcagtga cgtggagctg gatgacctgg agaaggatga gttgtgagcc acggcccagc
     1381 cttccttggg ctttccttgg gagcgagcag ttttccagca gtgaaagttc ttccgggcag
     1441 ctgtctgccg ctggcctttc tgagcagcac atgcggccac tggaaactgc caacagtgaa
     1501 cctcagcgtc tcaagaaaac actgacgaat tctatgaatt gtagcagtga attggattgt
     1561 attctctggc atactttgaa gaaaactggg ctattgaaac atttttccct cctgactgct
     1621 gcttgaatgt tcctggaggc tgtttcttat gtatagggtt tttaaaatgt gattcctttg
     1681 tttgaatatt aatggctttt tccattaaag aataaaatga tattttggac aatgctgata
     1741 aatgtatgaa attagtagca cattataaaa ccagagtctg aggtttagcc taaaatctac
     1801 cagcactgtg acctgctggc tcacatctcc accttcctgt agaaatggct gtaagcggaa
     1861 acgcagacct tttggtaagg atgtggttct gtgtagaaaa cgtggtacca agtgagaaca
     1921 gcatttcatg tcctggagtc tgtctgcggc ttcactatta ggctcagggt ttcagggtgt
     1981 ttcattaatc tcccattaaa aaccccagtg ggttgccaag ttaacttcac ataaaactct
     2041 tgagagaaag tttggaatta acattagaac acaagaaaag actcaggact gagcacttta
     2101 ttgtaactta aaaaaataaa tacactctaa ctaacgtctg tgatta
//
